公开(公告)号：WO03057149B1

公开(公告)日：2004-02-19

申请号：PCT/US0241428

申请日：2002-12-27

Applicant: BAYER AG ,  SCOTT WILLIAM J ,  BIERER DONALD E ,  STOLLE ANDREAS ,  CHEN YUANWEI

Inventor： SCOTT WILLIAM J ,  BIERER DONALD E ,  STOLLE ANDREAS ,  CHEN YUANWEI

IPC: A61P11/06 ,  A61P19/10 ,  C07D487/04 ,  C07D495/04 ,  C07D239/70 ,  A61K31/517

CPC classification number: C07D487/04 ,  C07D495/04

Abstract: The invention relates to 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B (PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma. The invention also relates to processes for preparing 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones and processes for preparing compositions containing the same.

Abstract translation: 本发明涉及4-取代的稠合异嘧啶和稠合杂-4-嘧啶酮，含有它们的药物组合物及其用于治疗或预防由磷酸二酯酶7B（PDE7B）介导的疾病和病症的用途。 PDE7B介导的疾病和病症包括骨质疏松症，骨质减少和哮喘。 本发明还涉及制备4-取代的稠合异嘧啶和稠合异-4-嘧啶的方法及其制备含有它们的组合物的方法。

公开(公告)号：WO1999036419A1

公开(公告)日：1999-07-22

申请号：PCT/EP1999000023

申请日：1999-01-05

Applicant: BAYER AKTIENGESELLSCHAFT ,  STOLLE, Andreas ,  ANTONICEK, Horst-Peter ,  LENSKY, Stephan ,  VOERSTE, Arnd ,  MÜLLER, Thomas ,  BAUMGARTEN, Jörg ,  VON DEM BRUCH, Karsten ,  MÜLLER, Gerhard ,  STROPP, Udo ,  HORVATH, Ervin ,  DE VRY, Jean-Marie-Viktor ,  SCHREIBER, Rudy

Inventor： BAYER AKTIENGESELLSCHAFT

IPC: C07D309/18

CPC classification number: C07D309/18 ,  C07D307/28 ,  C07D307/30

Abstract: The invention relates to novel substituted alpha -lactones, to methods for producing said alpha -lactones, and to their use for preventing and/or treating diseases caused by the hyper- or hypofunction of the glutamatergic system, especially cerebral ischaemia, cranial/cerebral trauma, pain or CNS-mediated cramps.

Abstract translation: 本发明涉及新的α-取代酯类，它们的制备方法以及它们用于它们通过过度或不足功能谷氨酸能系统的引起特别的脑缺血，颅/脑外伤，疾病的预防和/或治疗，疼痛的状态过程 或CNS惊厥确定。

公开(公告)号：WO03057149A2

公开(公告)日：2003-07-17

申请号：PCT/US0241428

申请日：2002-12-27

Applicant: BAYER AG ,  SCOTT WILLIAM J ,  BIERER DONALD E ,  STOLLE ANDREAS

Inventor： SCOTT WILLIAM J ,  BIERER DONALD E ,  STOLLE ANDREAS

IPC: A61P11/06 ,  A61P19/10 ,  C07D487/04 ,  C07D495/04 ,  A61K

CPC classification number: C07D487/04 ,  C07D495/04

Abstract: The invention relates to 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B (PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma. The invention also relates to processes for preparing 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones and processes for preparing compositions containing the same.

Abstract translation: 本发明涉及4-取代的稠合异嘧啶和稠合杂-4-嘧啶酮，含有它们的药物组合物及其用于治疗或预防由磷酸二酯酶7B（PDE7B）介导的疾病和病症的用途。 PDE7B介导的疾病和病症包括骨质疏松症，骨质减少和哮喘。 本发明还涉及制备4-取代的稠合异嘧啶和稠合异-4-嘧啶的方法及其制备含有它们的组合物的方法。

公开(公告)号：WO2003057149A3

公开(公告)日：2003-07-17

申请号：PCT/US2002/041428

申请日：2002-12-27

Applicant: BAYER CORPORATION ,  SCOTT, William, J. ,  BIERER, Donald, E. ,  STOLLE, Andreas ,  CHEN, Yuanwei

Inventor： SCOTT, William, J. ,  BIERER, Donald, E. ,  STOLLE, Andreas ,  CHEN, Yuanwei

IPC: C07D239/70

Abstract: The invention relates to 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7 B (PDE7 B ). Diseases and conditions mediated by PDE7 B include osteoporosis, osteopenia and asthma. The invention also relates to processes for preparing 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones and processes for preparing compositions containing the same.

公开(公告)号：WO2003011842A1

公开(公告)日：2003-02-13

申请号：PCT/US2002/023614

申请日：2002-07-25

Applicant: BAYER CORPORATION ,  LOWE, Derek, B. ,  WICKENS, Philip, L. ,  MA, Xin ,  ZHANG, Mingbao ,  BULLOCK, William, H. ,  COISH, Philip, D.G. ,  MUGGE, Ingo, A. ,  STOLLE, Andreas ,  WANG, Ming ,  WANG, Yamin ,  ZHANG, Chengzhi ,  ZHANG, Hai-Jun ,  ZHU, Lei ,  TSUTSUMI, Manami ,  LIVINGSTON, James, N.

Inventor： LOWE, Derek, B. ,  WICKENS, Philip, L. ,  MA, Xin ,  ZHANG, Mingbao ,  BULLOCK, William, H. ,  COISH, Philip, D.G. ,  MUGGE, Ingo, A. ,  STOLLE, Andreas ,  WANG, Ming ,  WANG, Yamin ,  ZHANG, Chengzhi ,  ZHANG, Hai-Jun ,  ZHU, Lei ,  TSUTSUMI, Manami ,  LIVINGSTON, James, N.

IPC: C07D263/32

CPC classification number: C07D277/32 ,  C07B2200/07 ,  C07C51/412 ,  C07C51/44 ,  C07C59/72 ,  C07C67/303 ,  C07C69/732 ,  C07C69/734 ,  C07C69/738 ,  C07C2602/08 ,  C07D263/32 ,  C07D277/24 ,  C07D277/40 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  Y02P20/582

Abstract: This invention relates to novel indane acetic acid derivatives of formula (I) which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates of formula (II) and (III) of indane acetic derivatives and to methods of preparation.

Abstract translation: 本发明涉及式（I）的新型茚满乙酸衍生物，其可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病。 本发明还涉及二氢化茚衍生物的式（II）和（III）的中间体和制备方法。

公开(公告)号：WO1999003846A1

公开(公告)日：1999-01-28

申请号：PCT/EP1998004252

申请日：1998-07-08

Applicant: BAYER AKTIENGESELLSCHAFT ,  BARTEL, Stephan ,  GUARNIERI, Walter ,  RIEDL, Bernd ,  HÄBICH, Dieter ,  STOLLE, Andreas ,  RUPPELT, Martin ,  RADDATZ, Siegfried ,  ROSENTRETER, Ulrich ,  WILD, Hanno ,  ENDERMANN, Rainer ,  KROLL, Hein-Peter

Inventor： BAYER AKTIENGESELLSCHAFT

IPC: C07D263/24

CPC classification number: C07D263/20 ,  C07D263/24 ,  C07D413/04 ,  C07D413/10 ,  C07D491/04

Abstract: The invention relates to tricyclically substituted oxazolidinones of general formula (I), wherein R represents azido, hydroxy or a group of formula -OR , O-SO2RO , -(CO)aNR R , D-R or -CO-R and A represents a radical of formula (a), (b), (c), (d), (e), or (f) wherein E represents an oxygen or a sulphur atom, or the CO-, CH2-, SO- or SO2 group, or a group of formula -NR , C=NR or -C=N-NR R . The invention also relates to a method for producing the tricyclically substituted oxazolidinones, and to their use as medicaments, especially as antibacterial medicaments.

Abstract translation: 本发明涉及三环通式（I）中R <1>是叠氮基，羟基，或下式基团-OR <2>的取代的恶唑烷酮，O- SO 2 <3>， - （CO）ANR <4> [R <5> DR <6>或-CO-R <7>中，a表示的基团式（a），（b），（C），（D），（e）或（f）为， 其中E表示氧或硫原子，或CO，CH 2，SO或SO 2基团，或一个式的基团-NR <14>，C = NR <15>或-C = N-NR < 16> - [R <17>表示。 其制备方法及其作为药物的应用，特别是抗菌药物。

公开(公告)号：WO0050017A3

公开(公告)日：2001-02-01

申请号：PCT/EP0001204

申请日：2000-02-14

Applicant: BAYER AG ,  HINZ VOLKER ,  HANING HELMUT ,  RIEDL BERND ,  HENNING ROLF ,  STOLLE ANDREAS ,  KELDENICH JOERG ,  BRUECK ANTJE ,  SCHUHMACHER JOACHIM

Inventor： HINZ VOLKER ,  HANING HELMUT ,  RIEDL BERND ,  HENNING ROLF ,  STOLLE ANDREAS ,  KELDENICH JOERG ,  BRUECK ANTJE ,  SCHUHMACHER JOACHIM

IPC: A61K31/192 ,  A61K31/195 ,  A61K31/24 ,  A61K31/4035 ,  A61K31/423 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/502 ,  A61K31/53 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  C07D253/04

CPC classification number: A61K31/53 ,  A61K31/192 ,  A61K31/195 ,  A61K31/24 ,  A61K31/4035 ,  A61K31/423 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/502

Abstract: Use of subtsituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives for the Treatment of Cerebral Diseases, pharmaceutical compositions containing them, and a process for using them. The compounds of the invention have the generalized formula (I): (T)xA-B-D-E-CO2H, wherein A is an aryl or heteroaryl rings; B is an aryl or heteroaryl ring or a bond; each T is a substituent group; x is 0,1, or 2; the group D represents (a), or (b), the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and each of the substituents on E is an independent substituent; and includes pharmaceutically acceptable salts thereof.

Abstract translation: 使用4-二芳基丁酸和5-双芳基戊酸衍生物用于治疗脑疾病，含有它们的药物组合物及其使用方法。 本发明的化合物具有通式（I）：（T）xA-B-D-E-CO 2 H，其中A是芳基或杂芳基环; B是芳基或杂芳基环或键; 每个T是取代基; x是0,1或2; 组D代表（a）或（b），组E代表一个或三个带有一个到三个独立的或参与环形成的取代基的碳链，可能的结构在文本和权利要求中示出; 并且E上的每个取代基是独立的取代基; 并且包括其药学上可接受的盐。

公开(公告)号：WO1995033383A1

公开(公告)日：1995-12-14

申请号：PCT/EP1995001180

申请日：1995-03-30

Applicant: STEMMLER, Heinz, Jr. ,  STOLLE, Andreas ,  LIEBICH, Hans-G.

IPC: A23B04/027

CPC classification number: A23B4/12 ,  A23B4/0235 ,  A23B4/027

Abstract: The invention concerns an agent for increasing the keeping quality of slaughtered-animal carcasses, parts of such carcasses and hamburger petties, a method of using the agent, as well as carcasses, carcass parts and hamburger petties obtained by the method.

Abstract translation: 本发明涉及一种用于增强屠宰的动物体，胎体部件和汉堡肉饼，对于其应用的过程以及胎体，胎体部件和汉堡肉饼，这是通过该方法获得的保存质量。