公开(公告)号：WO2017091661A1

公开(公告)日：2017-06-01

申请号：PCT/US2016/063485

申请日：2016-11-23

申请人： STROVEL, Jeffrey William ,  YOSHIOKA, Makoto ,  MALONEY, David J. ,  YANG, Shyh Ming ,  JADHAV, Ajit ,  URBAN, Daniel Jason

发明人： STROVEL, Jeffrey William ,  YOSHIOKA, Makoto ,  MALONEY, David J. ,  YANG, Shyh Ming ,  JADHAV, Ajit ,  URBAN, Daniel Jason

IPC分类号： C07D413/14 ,  C07D401/04 ,  C07D239/84 ,  C07D413/04 ,  C07D471/04 ,  C07D471/10 ,  A61K31/4706 ,  A61K31/517 ,  A61P19/02 ,  A61P25/28 ,  A61P31/18 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07D239/84 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10

摘要： The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.

摘要翻译： 本发明涉及结合并调节含溴结构域蛋白质的活性的化合物，涉及制备这些化合物的方法，涉及含有这些化合物的药物组合物，以及涉及将这些化合物用于 治疗各种各样的疾病和病症。

公开(公告)号：WO2014159837A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/025289

申请日：2014-03-13

申请人： CONVERGENE LLC ,  VANKAYALAPATI, Hariprasad ,  YOSHIOKA, Makoto ,  STROVEL, Jeffrey William ,  PADIA, Janak Khimchand

发明人： VANKAYALAPATI, Hariprasad ,  YOSHIOKA, Makoto ,  STROVEL, Jeffrey William ,  PADIA, Janak Khimchand

IPC分类号： A61K31/5517 ,  A61K31/4738 ,  A61K31/47 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07C217/84 ,  C07D215/22 ,  C07D215/227 ,  C07D215/38 ,  C07D261/08 ,  C07D265/22 ,  C07D265/26 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.

摘要翻译： 本发明涉及结合并另外调节含有溴结构域的蛋白质的活性，制备这些化合物的方法，含有这些化合物的药物组合物的化合物，以及使用这些化合物治疗各种各样的病症和障碍的方法 。

公开(公告)号：WO2003105758A2

公开(公告)日：2003-12-24

申请号：PCT/US2003/018400

申请日：2003-06-11

申请人： AVALON PHARMACEUTICALS, INC. ,  STROVEL, Jeffrey, William ,  EBNER, Reinhard

发明人： STROVEL, Jeffrey, William ,  EBNER, Reinhard

IPC分类号： A61K

CPC分类号： G01N33/5023 ,  C07K14/4748 ,  G01N33/57449 ,  G01N2500/10

摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.

公开(公告)号：WO2003105758A3

公开(公告)日：2003-12-24

申请号：PCT/US2003/018400

申请日：2003-06-11

申请人： AVALON PHARMACEUTICALS, INC. ,  STROVEL, Jeffrey, William ,  EBNER, Reinhard

发明人： STROVEL, Jeffrey, William ,  EBNER, Reinhard

IPC分类号： C07H21/04

摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.