摘要:
The present invention provides an improved process for the preparation of Deferasirox of Formula - I substantially free from 'hydrazino impurity' by the condensation of 2-(2-hydrophenyl)-4 H -1,3-benzoxazin-4-one of Formula - IV with 4-hydrazino benzoic acid of Formula - V in a polar solvent.
摘要:
The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要:
The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPARγ) and alpha (PPARα), processes of preparing the same, and pharmaceutical compositions containing the same as an active agent.
摘要:
The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
摘要:
Compounds of Formulae (I) and (II), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as fungicides wherein Z is O, S(O)n or NR ; n is 0, 1, or 2; Q is O or S; G is, together with the two linking carbons, a substituted fused phenyl or a substituted fused 5- or 6-membered aromatic heterocyclic ring; and R , R and R are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formulae (I) and (II) and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formulae (I) or (II).
摘要:
Herpesvirus protease inhibitor 4H-3,1-benzoxazin-4-one, 4H-thieno[3,2-d][1,3]oxazin-4-one, or 4H-thieno[2,3-d][1,3]oxazin-4-one; derivatives which are 2-substituted by C(XY)-R1, C(XY)-CH2-R1, C(XY)-C2H4-R1, or CX=CY-R1 wherein one of X and Y is hydrogen or halo or an alkyl substituent and the other is hydrogen or an alkyl substituent, and R1 is aryl or heteroaryl substituted by ZR4 wherein Z is CO, NRxCO, NRxCOCO, NRxCOCH2, or NRxSO2 wherein Rx is hydrogen or alkyl and R4 is aryl or heteroaryl.
摘要翻译:疱疹病毒蛋白酶抑制剂4H-3,1-苯并恶嗪-4-酮,4H-噻吩并[3,2-d] [1,3]恶嗪-4-酮或4H-噻吩并[2,3-d] 3]恶嗪-4-酮; 由C(XY)-R1,C(XY)-CH2-R1,C(XY)-C2H4-R1或CX = CY-R1 2-取代的衍生物,其中X和Y中的一个是氢或卤素或 烷基取代基,另一个是氢或烷基取代基,并且R 1是被ZR 4取代的芳基或杂芳基,其中Z是CO,NR x CO,NR x COCO,NR x COCH 2或NR x SO 2,其中R x是氢或烷基,且R 4是芳基或杂芳基。
摘要:
Compounds of general formula (I) wherein X is an oxygen or sulfur atom; Y is alkylene or cycloalkylene; A is hydroxy, alkoxy, acyloxy, mercapto, alkyl-sulfonyloxy, phenyl-sulfonyloxy, (a) or (b) wherein R3 is an alkyl or alkylene group omega -substituted by 2,3-dihydro-4H-1,3-benzoxazin-4-one-N-yl; R is hydrogen, alkyl or phenyl; R1 and R2 are independently hydrogen, halogen, alkoxy, trifluoromethyl or alkyl; and the pharmaceutically acceptable acid and base salts thereof, are useful as therapeutically active substances.
摘要:
This invention relates to a process for the production of compounds of the 2-phenyl-benzoxazin-4-one (2PB4) type by reacting the corresponding isatoic anhydride with benzoic anhydride at elevated temperature, optionally in the presence of a solvent. The process has the advantage that the reaction is carried out without resorting to the use of acid halides or nitrogeneous bases. The 2PB4 type products are useful as bleach activators.