公开(公告)号：WO2004014821A1

公开(公告)日：2004-02-19

申请号：PCT/DK2003/000537

申请日：2003-08-12

Applicant: H. LUNDBECK A/S ,  TAOKA, Naoaki ,  KATO, Takahisa ,  YAMAMOTO, Shogo ,  YOSHIDA, Takashi ,  TAKEDA, Toshihiro ,  UEDA, Yasuyoshi ,  PETERSEN, Hans ,  DANCER, Robert ,  AHMADIAN, Haleh ,  LYNGSØ, Lars, Ole

Inventor： TAOKA, Naoaki ,  KATO, Takahisa ,  YAMAMOTO, Shogo ,  YOSHIDA, Takashi ,  TAKEDA, Toshihiro ,  UEDA, Yasuyoshi ,  PETERSEN, Hans ,  DANCER, Robert ,  AHMADIAN, Haleh ,  LYNGSØ, Lars, Ole

IPC: C07B57/00

CPC classification number: C07B57/00 ,  C07B2200/07 ,  C07C253/30 ,  C07C253/34 ,  C07C255/34 ,  C07C255/59 ,  C07D307/87 ,  C12P7/22 ,  C12P13/001 ,  C12P13/002 ,  C12P13/008 ,  C12P13/02 ,  C12P41/007

Abstract: The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation.

Abstract translation: 本发明涉及一种制备具有式（II）的二醇中间体和/或具有式（Ⅳ）的酰化二醇的相反对映异构体的新方法，其用于制备涉及选择性酶酰化或脱酰基化的依他普仑。

公开(公告)号：WO1996020188A1

公开(公告)日：1996-07-04

申请号：PCT/JP1995002673

申请日：1995-12-25

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  KANOU, Fumihiko ,  TAKEDA, Toshihiro ,  MORI, Natsuki ,  KAN, Kazunori

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: C07D333/34

CPC classification number: C07D333/34

Abstract: A process for producing 3-(2-thienylthio)butyric acid comprising converting a compound represented by general formula (III), whereby the formation of by-product 3-(3-thienylthio)butyric acid as a positional isomer of the target compound can be reduced to 0.1 % by mole or below, wherein R represents a linear or branched C1-C4 alkyl. The obtained 3-(2-thienylthio)butyric acid is useful as an intermediate of medicinal compounds.

Abstract translation: 一种生产3-（2-噻吩硫基）丁酸衍生物的方法，该方法包括将通式（III）的化合物转化为使副产物3-（3-噻吩硫基） ）作为目标化合物的位置异构体的丁酸可以降低至等于或低于0.1摩尔％的值。 在所述式（III）中，R表示直链或支链C 1-4烷基。 这样得到的3-（2-噻吩硫基）丁酸可以用作医药化合物的中间体。

公开(公告)号：WO1996020189A1

公开(公告)日：1996-07-04

申请号：PCT/JP1995002674

申请日：1995-12-25

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  KANOU, Fumihiko ,  TAKEDA, Toshihiro ,  MORI, Natsuki ,  KAN, Kazunori

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: C07D333/34

CPC classification number: C07D333/34

Abstract: A process for producing 3-(2-thienylthio)butyric acid comprising converting a compound represented by general formula (III), whereby the formation of by-product 3-(3-thienylthio)butyric acid as a positional isomer of the target compound can be reduced to 0.1 % by mole or below, wherein R represents a linear or branched C1-C4 alkyl. The obtained 3-(2-thienylthio)butyric acid is useful as an intermediate of medicinal compounds.

Abstract translation: 一种制备3-（2-噻吩硫基）丁酸的方法，包括将通式（III）表示的化合物转化为由此形成作为目标化合物的位置异构体的副产物3-（3-噻吩硫基）丁酸可以 降低至0.1摩尔％以下，其中R表示直链或支链C 1 -C 4烷基。 得到的3-（2-噻吩硫基）丁酸可用作药物化合物的中间体。