公开(公告)号：WO2007143540A9

公开(公告)日：2008-05-02

申请号：PCT/US2007070206

申请日：2007-06-01

Applicant: APPLERA CORP ,  SONG MAENGSEOK ,  YANG JOON MO ,  LEE JULIE C ,  BEARD NIGEL P ,  CHIANG YUH-MIN ,  TAN ROY H ,  SCHEMBRI CAROL

Inventor： SONG MAENGSEOK ,  YANG JOON MO ,  LEE JULIE C ,  BEARD NIGEL P ,  CHIANG YUH-MIN ,  TAN ROY H ,  SCHEMBRI CAROL

IPC: B01L3/02

CPC classification number: B01L3/502723 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/086 ,  C12Q1/6806 ,  Y10T436/2575

Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation or dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.

Abstract translation: 微流体装置可以包括样品分配网络，其包括多个样品室，其被配置为装载用于在样品室中的生物样品的生物测试的生物样品。 样品分配网络还可以包括多个入口通道，每个入口通道与生物样品流动连通并配置成将生物样品流动到相应的样品室，以及多个出口通道，每个出口通道处于流动连通状态并被配置为 从相应的样品室流动生物样品。 至少一些样品室可以包括物理修饰，其被配置为控制弯液面的运动，以便控制气泡形成或位于靠近入口通道的至少一些样品室内的干燥试剂，其与至少一些样品 室。

公开(公告)号：WO2007143540A2

公开(公告)日：2007-12-13

申请号：PCT/US2007/070206

申请日：2007-06-01

Applicant: APPLERA CORPORATION ,  SONG, Maengseok ,  YANG, Joon Mo ,  LEE, Julie C. ,  BEARD, Nigel P. ,  CHIANG, Yuh-min ,  TAN, Roy H. ,  SCHEMBRI, Carol

Inventor： SONG, Maengseok ,  YANG, Joon Mo ,  LEE, Julie C. ,  BEARD, Nigel P. ,  CHIANG, Yuh-min ,  TAN, Roy H. ,  SCHEMBRI, Carol

IPC: B01L3/02

CPC classification number: B01L3/502723 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/086 ,  C12Q1/6806 ,  Y10T436/2575

Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation or dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.

Abstract translation: 微流体装置可以包括样品分配网络，其包括多个样品室，其被配置为装载用于在样品室中的生物样品的生物测试的生物样品。 样品分配网络还可以包括多个入口通道，每个入口通道与生物样品流动连通并配置成将生物样品流动到相应的样品室，以及多个出口通道，每个出口通道处于流动连通状态并被配置为 从相应的样品室流动生物样品。 至少一些样品室可以包括物理修饰，其被配置为控制弯液面的运动，以便控制气泡形成或位于靠近入口通道的至少一些样品室内的干燥试剂，其与至少一些样品 室。

公开(公告)号：WO2006012105A1

公开(公告)日：2006-02-02

申请号：PCT/US2005/021856

申请日：2005-06-21

Applicant: APPLERA CORPORATION ,  FUERNKRANZ, Hans, A. ,  TAN, Roy, H.

Inventor： FUERNKRANZ, Hans, A. ,  TAN, Roy, H.

IPC: C12Q1/68

CPC classification number: G01N33/5308

Abstract: Methods of detecting targets in a sample are provided. Methods of quantitating targets in a sample are provided. Methods of determining the specificity of a first molecule for a second molecule are prpovided. Methods of detecting inhibitors or enhancers of an interaction between a first molecule and a second molecule are provided. Methods of measuring the affinity of two different molecules for a different third molecule are provided.

Abstract translation: 提供检测样品中靶标的方法。 提供了定量样品中靶标的方法。 确定第二分子的第一分子的特异性的方法。 提供检测第一分子和第二分子之间相互作用的抑制剂或增强子的方法。 提供了测量两种不同分子对于不同第三分子的亲和力的方法。

公开(公告)号：WO2007011549A1

公开(公告)日：2007-01-25

申请号：PCT/US2006/026501

申请日：2006-06-30

Applicant: APPLERA CORPORATION ,  BAHATT, Dar ,  PATEL, Chirag, J. ,  PROTHO, Derek, K. ,  TAN, Roy, H.

Inventor： BAHATT, Dar ,  PATEL, Chirag, J. ,  PROTHO, Derek, K. ,  TAN, Roy, H.

IPC: G01N21/25 ,  C12Q1/68 ,  C12M1/34

CPC classification number: G01N21/253 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0278 ,  G01J3/0294 ,  G01J3/12 ,  G01J3/2803 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2021/6423 ,  G01N2021/6441

Abstract: Systems, including methods, apparatus, and algorithms, for spectrally imaging a two-dimensional array of samples.

Abstract translation: 用于对二维样本阵列进行光谱成像的系统，包括方法，装置和算法。

公开(公告)号：WO2006086620A2

公开(公告)日：2006-08-17

申请号：PCT/US2006/004714

申请日：2006-02-10

Applicant: APPLERA CORPORATION ,  TAN, Roy, H.

Inventor： TAN, Roy, H.

IPC: B01D15/08

CPC classification number: G01N30/06 ,  G01N1/4055 ,  G01N30/14 ,  G01N2001/4066 ,  G01N2030/065 ,  G01N2030/143 ,  Y10T436/25875

Abstract: The present disclosure relates to a method for sampling a fluid, such as air. As fluid flows through a device, a scrubbing liquid is positioned in a pattern to contact the fluid and constituents in the fluid are transferred to in the liquid.

Abstract translation: 本公开涉及一种用于对诸如空气的流体进行取样的方法。 当流体流过装置时，洗涤液体以图案定位以接触流体，并将流体中的成分转移到液体中。

公开(公告)号：WO2006086620A3

公开(公告)日：2009-04-16

申请号：PCT/US2006004714

申请日：2006-02-10

Applicant: APPLERA CORP ,  TAN ROY H

Inventor： TAN ROY H

IPC: G01N1/22

CPC classification number: G01N30/06 ,  G01N1/4055 ,  G01N30/14 ,  G01N2001/4066 ,  G01N2030/065 ,  G01N2030/143 ,  Y10T436/25875

Abstract: A method for sampling a fluid, such as air. As fluid flows through a device, a scrubbing liquid is positioned in a pattern to contact the fluid and constituents in the fluid are transferred to the liquid. The sampling method includes providing a sampling fluid in a directional stream, positioning a scrubbing liquid in a pattern to intercept the sampling fluid, contacting the sampling with the scrubbing liquid to remove a constituent from the sampling fluid. Gas is sampled with parallel surfaces, a volume in between, a liquid source chamber connected to the volume, and a collection chamber.

Abstract translation: 用于对诸如空气的流体进行采样的方法。 当流体流过装置时，洗涤液体以图案定位以接触流体，流体中的成分被转移到液体中。 采样方法包括在定向流中提供采样流体，将洗涤液体定位成图案以拦截采样流体，使取样与洗涤液接触以从取样流体中除去成分。 气体采用平行表面，其间的体积，连接到体积的液体源室和收集室进行采样。

公开(公告)号：WO2007143540A3

公开(公告)日：2008-07-03

申请号：PCT/US2007070206

申请日：2007-06-01

Applicant: APPLERA CORP ,  SONG MAENGSEOK ,  YANG JOON MO ,  LEE JULIE C ,  BEARD NIGEL P ,  CHIANG YUH-MIN ,  TAN ROY H ,  SCHEMBRI CAROL

Inventor： SONG MAENGSEOK ,  YANG JOON MO ,  LEE JULIE C ,  BEARD NIGEL P ,  CHIANG YUH-MIN ,  TAN ROY H ,  SCHEMBRI CAROL

IPC: C12M1/34 ,  C12M3/00

CPC classification number: B01L3/502723 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/086 ,  C12Q1/6806 ,  Y10T436/2575

Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation or dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.

Abstract translation: 微流体装置可以包括样品分配网络，所述样品分配网络包括多个样品室，所述样品室被配置为加载生物样品用于在样品室中时对生物样品进行生物测试。 样品分配网络可以进一步包括多个入口通道，每个入口通道与生物样品流动连通并被配置成使生物样品流动到相应的样品室，以及多个出口通道，每个出口通道流动连通并且被配置为 从相应的样品室流出生物样品。 至少一些样品室可以包括被配置为控制弯月面的运动的物理修改，从而控制位于至少一些样品室内靠近入口通道的气泡形成或干燥试剂与至少一些样品流动连通 室。