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公开(公告)号：WO2023075707A2
公开(公告)日：2023-05-04
申请号：PCT/SG2022/050786
申请日：2022-10-31
摘要： The present disclosure generally relates to a planter (100) and method for growing plants (200) with air pruning. The planter (100) comprises an outer container (110) for a planting material (210) to grow the plants (200), and an inner container (120) to reduce the volume of the outer container (110). The inner container (120) comprises an inner space (130) and holes (132 / 134) to expose the plant roots (202) to air in the inner space (130) to air prune the exposed roots (202).
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公开(公告)号：WO2019216829A1
公开(公告)日：2019-11-14
申请号：PCT/SG2019/050261
申请日：2019-05-10
发明人： CHUA, Kaw Bing , TAO, Meng
IPC分类号： A61K31/655 , A61P31/14 , A61K31/404 , A61K31/185
摘要： Methods and compositions are provided for inhibiting or treating enterovirus infections, particularly EV71 and coxsackievirus infections, and diseases associated with enterovirus infections, including hand, foot and mouth disease (HFMD), polio, aseptic meningitis, encephalitis, acute flaccid paralysis, and acute cardiopulmonary dysfunction, using food dyes, particularly azo dyes and sulfonated azo dyes. Preferably, the food dyes are E102 Tartrazine, El 10 Sunset Yellow FCF, E122 Carmoisine, E123 Amaranth, El 24 Ponceau 4R, El 26 Ponceau 6R, El 29 Allura Red or E151 Brilliant Black BN (Black PN).
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公开(公告)号：WO2018147799A1
公开(公告)日：2018-08-16
申请号：PCT/SG2018/050045
申请日：2018-01-29
发明人： JI, Lianghui , LIU, Yanbin , KOH, Chong Mei John , YAP, Sihui Amy , NGOH, Si Te
摘要： The present invention relates to the field of fungal production fatty alcohols. More specifically, the present invention relates to genetically modified host cells, nucleic acid constructs and culture medium for the production of fatty alcohols in Rhodosporidium .
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公开(公告)号：WO2016122403A1
公开(公告)日：2016-08-04
申请号：PCT/SG2016/050031
申请日：2016-01-25
发明人： CHUA, Kaw Bing
CPC分类号： A61K49/0008 , A01K2267/0337 , C12N7/00 , C12N2770/32321 , C12N2770/32322 , C12N2770/32371
摘要： The present invention relates to Enterovirus 71 (EV71), the development of an animal model and screening of candidate anti-EV71 compounds. More specifically, the present invention relates to the discovery that Enterovirus 71 (EV71 ) strains that have been adapted to infect rodent cell lines or cloned derived virus containing mutations in VP1 can cause disease in immuno-competent rodents.
摘要翻译： 本发明涉及肠病毒71（EV71），动物模型的开发和候选抗EV71化合物的筛选。 更具体地，本发明涉及已经适应于感染啮齿动物细胞系的肠道病毒71（EV71）菌株或在VP1中含有突变的克隆衍生病毒可以引起免疫耐受性啮齿类动物疾病的发现。
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公开(公告)号：WO2014070109A1
公开(公告)日：2014-05-08
申请号：PCT/SG2013/000462
申请日：2013-10-29
发明人： KWANG, Hwei-Sing Jimmy , JIA, Qiang
CPC分类号： C07K16/1009 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C12N5/163 , Y02A50/466
摘要： There is provided at least one isolated antibody or fragment thereof, wherein the antibody or fragment thereof is capable of specifically binding to at least one EV71 derived peptide. In particular the antibody or fragment thereof is capable of binding a conformational epitope on the VP3 capsid.
摘要翻译： 提供至少一种分离的抗体或其片段，其中所述抗体或其片段能够特异性结合至少一种EV71衍生的肽。 特别地，抗体或其片段能够结合VP3衣壳上的构象表位。
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公开(公告)号：WO2012033462A1
公开(公告)日：2012-03-15
申请号：PCT/SG2010/000324
申请日：2010-09-06
发明人： YIN, Zhong Chao , GU, Ke Yu , TIAN, Dong Sheng
CPC分类号： C12N15/8281 , C07K14/415 , C12N15/8239
摘要： The present invention provides nucleic acids and methods for conferring resistance to bacterial disease in plants. The present invention also provides promoters and promoter sequences useful for controlling expression in transgenic plants.
摘要翻译： 本发明提供了赋予植物细菌性疾病抗性的核酸和方法。 本发明还提供了可用于控制转基因植物中表达的启动子和启动子序列。
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公开(公告)号：WO2011136738A1
公开(公告)日：2011-11-03
申请号：PCT/SG2011/000059
申请日：2011-02-09
申请人： TEMASEK LIFE SCIENCES LABORATORY LIMITED , MOOKKAN, Prabakaran , HE, Fang , KWANG, Hwei-Sing, Jimmy
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/55566 , A61K2039/70 , C12N2710/14143 , C12N2760/16134
摘要： The present invention relates to a universal H5N1 vaccine. More specifically, the present invention relates to the identification of three H5N1 strains which cover the entire variants in the neutralizing epitopes of hemagglutinin among most H5N1 lineages. The present invention further relates a universal H5N1 vaccine that comprises the three H5N1 strains or that comprises hemagglutinin peptides of each of these three strains.
摘要翻译： 本发明涉及通用H5N1疫苗。 更具体地说，本发明涉及在大多数H5N1谱系中鉴定涵盖血凝素中和表位的整个变体的三种H5N1菌株。 本发明还涉及包含三种H5N1菌株或包含这三种菌株中的每一种的血凝素肽的通用H5N1疫苗。
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公开(公告)号：WO2011040880A1
公开(公告)日：2011-04-07
申请号：PCT/SG2010/000339
申请日：2010-09-15
申请人： TEMASEK LIFE SCIENCES LABORATORY LIMITED , YE, Jian , CHUA, Nam-Hai , QU, Jing , GAO, Shi-Qiang
发明人： YE, Jian , CHUA, Nam-Hai , QU, Jing , GAO, Shi-Qiang
IPC分类号： C12N15/83
CPC分类号： C12N15/8218 , C12N15/8285 , C12N15/8286 , Y02A40/162 , Y02A40/164
摘要： The present invention relates to the field of controlling pests, such as insects, using a virus to express pest genes in hosts. More specifically, the present invention relates to a method for rapidly screening for pest genes which can lead to mortality of the pest when the pest has ingested host tissues expressing virus-linked pest gene sequences. The present invention also relates to a method for controlling pests by viral expression of target pest sequences to modify endogenous expression of pest genes in cells or tissues of the pest.
摘要翻译： 本发明涉及使用病毒来在宿主中表达有害生物基因的昆虫等害虫防治领域。 更具体地说，本发明涉及一种用于快速筛选有害生物基因的方法，当害虫摄入表达病毒连接的害虫基因序列的宿主组织时，可导致害虫死亡。 本发明还涉及通过靶病毒序列的病毒表达来控制害虫的方法，以修饰害虫的细胞或组织中害虫基因的内源性表达。
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9.发明申请JATROPHA CURCAS CURCIN GENES, TISSUE-SPECIFIC PROMOTERS AND GENERATION OF CURCIN-DEFICIENT TRANSGENIC JATROPHA PLANTS 审中-公开格涅·柯辛麻疯树，面料和GENERATION麻疯特异性启动子受损转基因麻疯树
公开(公告)号：WO2010140981A1
公开(公告)日：2010-12-09
申请号：PCT/SG2010/000206
申请日：2010-06-02
申请人： TEMASEK LIFE SCIENCES LABORATORY LIMITED , YIN, Zhong Chao , WU, Li Fang , MAO, Hui Zhu , QIU, Cheng Xiang
发明人： YIN, Zhong Chao , WU, Li Fang , MAO, Hui Zhu , QIU, Cheng Xiang
CPC分类号： C07K14/415 , C12N15/8218 , C12N15/8225 , C12N15/8234 , C12N15/8238 , C12N15/8239 , C12N15/8242 , C12N15/8251 , C12N2310/14
摘要： The present invention relates to the isolation of Jatropha curcas curcin genes and tissue-specific promoters and to the production of curcin-deficient Jatropha plants. More specifically, the present invention relates to the isolation of Jatropha curcas Curcin 1, Curcin 2 and Curcin 2 A. The present invention further relates to of the Curcin 1, Curcin 2 A and Curcin 2 genes and more particularly to tissue specific promoters of the Curcin 1 and Curcin 2A genes. The present invention further relates to production of curcin-deficient transgenic jatropha plants by using RNAi technology to suppress curcin gene expression.
摘要翻译： 本发明涉及的基因麻疯树毒蛋白麻疯树和组织特异性启动子，和产生缺陷的麻风树毒蛋白麻风树的分离。 本发明更具体地涉及1个麻风树毒蛋白的分离，麻疯树毒蛋白2和2A麻疯树毒蛋白麻疯树。 本发明还涉及基因的分离麻疯树毒蛋白1，麻疯树毒蛋白麻疯树毒蛋白2A和2，并且更具体地组织特异性启动子和基因的麻疯树毒蛋白1个麻疯树毒蛋白2A。 本发明进一步涉及使用所述RNA干扰技术来抑制格涅·柯辛的表达生产转基因麻风树毒蛋白缺陷的。
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公开(公告)号：WO2010080071A1
公开(公告)日：2010-07-15
申请号：PCT/SG2009/000481
申请日：2009-12-16
发明人： YE, Jian , CHUA, Nam Hai , QU, Jing
CPC分类号： C12N15/8218
摘要： The present invention relates to the field of functional analysis of Jatropha genes on a genomic scale. More specifically, the present invention relates to a method for high-throughtput functional analysis of Jatropha curcas genes on a genomic scale using virus-induced gene silencing. The method involves use of the tobacco rattle virus (TRV).
摘要翻译： 本发明涉及基因组尺度上的麻疯树基因的功能分析领域。 更具体地，本发明涉及使用病毒诱导的基因沉默在基因组规模上高麻醉麻疯树基因的高通量功能分析的方法。 该方法涉及使用烟草拨浪鼓病毒（TRV）。
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