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    MAMMALIAN CELL LINES MODIFIED FOR THE PRODUCTION OF RECOMBINANT GLYCOPROTEINS
    1.
    发明申请
    MAMMALIAN CELL LINES MODIFIED FOR THE PRODUCTION OF RECOMBINANT GLYCOPROTEINS 审中-公开
    用于生产重组型糖蛋白的马马里亚细胞系

    公开(公告)号：WO2005033303A1

    公开(公告)日：2005-04-14

    申请号：PCT/IT2004/000529

    申请日：2004-09-27

    Applicant: KERYOS S.P.A. ,  TONON, Giancarlo ,  POZZUOLO, Sabrina ,  MONACO, Lucia

    Inventor： TONON, Giancarlo ,  POZZUOLO, Sabrina ,  MONACO, Lucia

    IPC: C12N9/02

    CPC classification number: C12N9/0073 ,  C12P21/005

    Abstract: Novel, genetically modified mammalian cell lines are described, which can produce glycoconjugates the oligosaccharide portions of which are more similar to the human one than those of the same glycoconjugates produced by cells which have not been genetically modified. The lines in question can be used for the production of recombinant glycoconjugates which are of therapeutic interest, in particular for the production of glycoproteins for use in human therapy, since the glycoconjugates produced in these modified lines have a lower immunogenic potential for man than corresponding glycoconjugates produced in cells which have not been genetically modified.

    Abstract translation: 描述了新型的遗传修饰的哺乳动物细胞系，其可以产生糖缀合物，其寡糖部分比与未经遗传修饰的细胞产生的相同的糖缀合物的寡糖部分更相似。 所讨论的线可用于生产具有治疗兴趣的重组糖缀合物，特别是用于生产用于人类治疗的糖蛋白，因为在这些修饰的线中产生的糖缀合物对人的免疫原性潜力低于相应的糖缀合物 在未经遗传修饰的细胞中产生。

    MACHINE FOR MULTIPLE BEVERAGE DISPENSING, PARTICULARLY FOR COFFEE AND/OR STILL WATER AND/OR HOT AND/OR CHILLED BEVERAGES
    2.
    发明申请
    MACHINE FOR MULTIPLE BEVERAGE DISPENSING, PARTICULARLY FOR COFFEE AND/OR STILL WATER AND/OR HOT AND/OR CHILLED BEVERAGES 审中-公开
    用于多种饮料分配的机器，特别是咖啡和/或静止水和/或热和/或冷冻饮料

    公开(公告)号：WO2011029747A1

    公开(公告)日：2011-03-17

    申请号：PCT/EP2010/062727

    申请日：2010-08-31

    Applicant: VOVO S.R.L. ,  BASSO, Davide ,  TONON, Giancarlo ,  CERVELLIN, Francesco

    Inventor： BASSO, Davide ,  TONON, Giancarlo ,  CERVELLIN, Francesco

    IPC: B67D1/00 ,  B67D1/04 ,  B67D1/08 ,  B67D3/00 ,  A47J31/00

    CPC classification number: B67D1/0057 ,  A47J31/00 ,  A47J31/465 ,  A47J31/54 ,  B67D1/0001 ,  B67D1/0406 ,  B67D1/0857 ,  B67D3/0022 ,  B67D3/0035 ,  B67D3/0038

    Abstract: An machine (1) for multiple beverage dispensing, particularly for coffee and/or still or carbonated water and/or hot and/or chilled beverages, comprising a container of water (2), which can be associated with a box-like support (3), to which a first tank (9) for water at room temperature and a contiguous second refrigeration tank (10) are connected, respectively to a first duct (11) and to a second duct (12). The second duct (12) is connected to means for carbonating the water and downstream of the first duct (11) for the selective dispensing of water at room temperature or chilled water. The first duct (11) is further connected, by way of a third duct (22), to means for the selective dispensing of hot beverages or coffee. The machine (1) allows to combine in a single solution several functions that are currently present in separate devices, achieving high functional versatility, space optimization and reduced transport and packaging costs.

    Abstract translation: 一种用于多种饮料分配的机器（1），特别是用于咖啡和/或静止或碳酸水和/或热和/或冷冻饮料的饮料，其包括可与箱状支撑件相关联的水（2）的容器 3），室内的水的第一罐（9）和连续的第二制冷箱（10）分别连接到第一管道（11）和第二管道（12）。 第二管道（12）连接到用于碳酸化水和第一管道（11）的下游的装置，用于在室温或冷冻水中选择性分配水。 第一管道（11）通过第三管道（22）进一步连接到用于选择性分配热饮料或咖啡的装置。 机器（1）允许在单个解决方案中组合目前存在于单独设备中的几个功能，实现高功能多功能性，空间优化和减少的运输和包装成本。

    MULTI-CISTRONIC VECTORS FOR GENE TRANSFER PROTOCOLS
    3.
    发明申请
    MULTI-CISTRONIC VECTORS FOR GENE TRANSFER PROTOCOLS 审中-公开
    用于基因转移协议的多独立向量

    公开(公告)号：WO2003031630A1

    公开(公告)日：2003-04-17

    申请号：PCT/IT2002/000646

    申请日：2002-10-10

    Applicant: KERYOS SPA ,  FAZIO, VITO ,  RINALDI, Monica ,  SONZOGNI, Laura ,  TONON, Giancarlo ,  ORSINI, Gaetano

    Inventor： FAZIO, VITO ,  RINALDI, Monica ,  SONZOGNI, Laura ,  TONON, Giancarlo ,  ORSINI, Gaetano

    IPC: C12N15/63

    CPC classification number: C12N15/85 ,  A61K48/00 ,  A61K2039/53 ,  C12N2830/42 ,  C12N2840/203 ,  C12N2840/206

    Abstract: The subject of the present invention is the construction of multicistronic eukaryotic plasmid expression vectors in which it is possible to express from two to four genes simultaneously and which are characterized by differently regulated bicistronic transcription units. The distinctive characteristic of these vectors is the presence of a CAP-independent translation initiation mechanism which is based on the ability of an IRES (internal ribosomal entry site) sequence to translate two proteins under the control of a single promoter. This family of multicistronic vectors can advantageously be used in various biotechnological applications in whcih the simultaneous expression of two or more genes is necessary, such as gene transfer protocols, DNA-immunization, or for the expression of different molecules in the same cell.

    Abstract translation: 本发明的主题是多顺反子真核质粒表达载体的构建，其中可以同时从两个到四个基因表达，其特征在于不同程度的双顺反子转录单位。 这些载体的独特特征是存在CAP独立的翻译起始机制，其基于IRES（内部核糖体进入位点）序列在单个启动子的控制下翻译两种蛋白质的能力。 这种多顺反子载体家族可有利地用于各种生物技术应用中，同时表达两个或多个基因是必需的，例如基因转移方案，DNA免疫或用于在相同细胞中表达不同分子。

    G-CSF SITE-SPECIFIC MONO-CONJUGATES
    4.
    发明申请
    G-CSF SITE-SPECIFIC MONO-CONJUGATES 审中-公开
    G-CSF位点特异性单结合

    公开(公告)号：WO2008017603A1

    公开(公告)日：2008-02-14

    申请号：PCT/EP2007/057824

    申请日：2007-07-30

    Applicant: BIO-KER SRL ,  TONON, Giancarlo ,  ORSINI, Gaetano ,  SCHREPFER, Rodolfo ,  TAYLOR, Geoffrey ,  SERGI, Mauro

    Inventor： TONON, Giancarlo ,  ORSINI, Gaetano ,  SCHREPFER, Rodolfo ,  TAYLOR, Geoffrey ,  SERGI, Mauro

    IPC: C07K14/535 ,  A61K47/48

    CPC classification number: C07K14/535 ,  A61K47/60

    Abstract: Novel site-specific mono-conjugates of Granulocyte Colony Stimulating Factor (G-CSF) are hereby described, with analogues and derivatives thereof, which stimulate proliferation and differentiation of progenitor cells to mature neutrophiles. These conjugates have been obtained using transglutaminase to covalently and site-specifically bind a hydrophilic, non-immunogenic polymer to a single glutamine residue of the human G-CSF native sequence and analogues thereof. These novel site-specific mono-conjugated derivatives are recommended for therapeutic use since they are stable in solution and exhibit significant biological activity in vitro and a longer bloodstream half-life, as compared to the non-conjugated protein, with a consequent prolonged pharmacological activit y.

    Abstract translation: 此处描述了粒细胞集落刺激因子（G-CSF）的新型位点特异性单缀合物，其具有类似物和衍生物，其刺激祖细胞对成熟嗜中性细胞的增殖和分化。 已经使用转谷氨酰胺酶共价并且将亲水的，非免疫原性的聚合物与人G-CSF天然序列的单个谷氨酰胺残基和其类似物结合位点特异性地获得了这些缀合物。 这些新的位点特异性单缀合衍生物被推荐用于治疗用途，因为它们在溶液中稳定并且在体外显示出显着的生物活性，并且与非共轭蛋白相比具有较长的血液半衰期，从而延长药理活性 年。

    NEW ACTIVATED POLY(ETHYLENE GLYCOLS) AND RELATED POLYMERS AND THEIR APPLICATIONS
    5.
    发明申请
    NEW ACTIVATED POLY(ETHYLENE GLYCOLS) AND RELATED POLYMERS AND THEIR APPLICATIONS 审中-公开
    新型活性聚（乙烯甘油）及相关聚合物及其应用

    公开(公告)号：WO2007112794A1

    公开(公告)日：2007-10-11

    申请号：PCT/EP2006/070265

    申请日：2006-12-29

    Applicant: KERYOS SPA ,  VERONESE, Francesco Maria ,  PASUT, Gianfranco ,  TONON, Giancarlo ,  SCHREPFER, RODOLFO

    Inventor： VERONESE, Francesco Maria ,  PASUT, Gianfranco ,  TONON, Giancarlo ,  SCHREPFER, RODOLFO

    IPC: C08G65/329 ,  A61K47/48

    CPC classification number: C08G65/329 ,  A61K47/60 ,  C07K1/1077 ,  C08G65/333

    Abstract: There are disclosed chemically active poly(ethylene glycols) and other hydrophilic polymers that are suitable for coupling to pharmaceutically or diagnostically active agents such as peptides, oligonucleotides, proteins or non- peptide molecules. The compounds are represented by the formula Poly-(X-NH-CO-A) n wherein: Poly is a hydrophilic polymer having a molecular weight of from about 300 to 100000 Daltons; A together with -NH-CO- forms a reactive group; X is a spacer moiety or a bond; n is an integer comprised between 1 and 50. The active agents of interest which may be conjugated to the disclosed compounds may be selected from hemoglobin, insulin, urokinase, alpha- interferon, G-CSF, hGH, asparaginase, adenosine deaminase, superoxide dismutase and catalase.

    Abstract translation: 公开了化学活性聚（乙二醇）和其它亲水性聚合物，其适于与药学或诊断活性剂如肽，寡核苷酸，蛋白质或非肽分子偶联。 所述化合物由下式表示：Poly-（X-NH-CO-A）n N n其中：Poly是分子量为约300至100000道尔顿的亲水性聚合物; A与-NH-CO-一起形成反应性基团; X是间隔部分或键; 可以与所公开的化合物缀合的感兴趣的活性剂可以选自血红蛋白，胰岛素，尿激酶，α-干扰素，G-CSF，hGH，天冬酰胺酶，腺苷脱氨酶，超氧化物歧化酶 和过氧化氢酶。

    SOL-GEL DERIVED SILICA POLYMERS FOR THE SUSTAINED RELEASE OF PROTEINS
    8.
    发明申请
    SOL-GEL DERIVED SILICA POLYMERS FOR THE SUSTAINED RELEASE OF PROTEINS 审中-公开
    溶胶凝胶衍生的二氧化硅聚合物，用于持续释放蛋白质

    公开(公告)号：WO2007115860A1

    公开(公告)日：2007-10-18

    申请号：PCT/EP2007/051762

    申请日：2007-02-23

    Applicant: BIO-KER SRL ,  TONON, Giancarlo ,  MORPURGO, Margherita

    Inventor： TONON, Giancarlo ,  MORPURGO, Margherita

    IPC: C08G77/02

    CPC classification number: C08G77/02

    Abstract: The use of wet silica based polymers obtained by the sol-gel technology for the entrapment and sustained release of macromolecular bioactive compounds and, more specifically, proteins with pharmaceutical applications, is disclosed. The wet-gel formulations are obtained by a method which comprises mixing an alkoxysilane solution, a gelling catalyst and a buffered water solution of a biologically active principle and subsequently casting the thus-obtained mixture into suitable containers without previous or subsequent partial or complete removal of the water solvent; the containers are then sealed after casting in order to preserve the wet state of the gel. The wet-gel formulations may then be used for the manufacture of a ready-to-use injectable solution by mixing the silica wet-gel formulation with water or with a physiological water solution.

    Abstract translation: 公开了通过溶胶 - 凝胶技术获得的湿二氧化硅基聚合物用于大分子生物活性化合物的捕获和持续释放，更具体地，使用药物应用的蛋白质的使用。 湿凝胶制剂通过包括将烷氧基硅烷溶液，胶凝催化剂和具有生物活性原理的缓冲水溶液混合并随后将如此获得的混合物浇铸到合适容器中而不经过或随后部分或完全除去 水溶剂; 然后在浇铸之后密封容器以保持凝胶的湿润状态。 然后可以将湿凝胶制剂用于通过将二氧化硅湿凝胶制剂与水或生理水溶液混合来制备即用型可注射溶液。

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