公开(公告)号：WO2009059806A3

公开(公告)日：2009-10-29

申请号：PCT/EP2008009619

申请日：2008-11-10

Applicant: TOPASS GMBH ,  PISON ULRICH ,  SHAVVA ALEXANDER GRIGORIEVICH ,  MOROZKINA SVETLANA NIKOLAEVNA

Inventor： PISON ULRICH ,  SHAVVA ALEXANDER GRIGORIEVICH ,  MOROZKINA SVETLANA NIKOLAEVNA

IPC: C07J73/00 ,  A61K31/56 ,  A61K31/566 ,  A61P5/30

CPC classification number: C07J73/003

Abstract: The invention is related to the area of new 6-Oxa-8a-steroid estrogen analogues and the synthesis of these new biological active steroid estrogen analogues, namely, to the preparation of 6-oxa-8a-steroid estrogens and their use as estrogen receptor modulators. These new estrogen analogues are ligands for estrogen receptors and as such may be useful for the treatment and prevention of a variety of conditions related to estrogen functioning. These conditions include bone and cartilage disorders, increased levels of LDL cholesterol, cardiovascular diseases, impairment of cognitive function, cerebral degeneration disorders, endometriosis and other types of inflammation, the metabolic syndrome, and cancer, in particular of the breast, uterus and prostate.

Abstract translation: 本发明涉及新的6-Oxa-8a-类固醇雌激素类似物的面积和这些新的生物活性类固醇雌激素类似物的合成，即6-氧杂-8a类固醇雌激素的制备及其作为雌激素受体的用途 调制器。 这些新的雌激素类似物是雌激素受体的配体，因此可用于治疗和预防与雌激素功能相关的各种病症。 这些病症包括骨和软骨障碍，LDL胆固醇水平升高，心血管疾病，认知功能障碍，脑变性障碍，子宫内膜异位症和其他类型的炎症，代谢综合征和癌症，特别是乳腺，子宫和前列腺。

公开(公告)号：WO2007093451A2

公开(公告)日：2007-08-23

申请号：PCT/EP2007001567

申请日：2007-02-19

Applicant: TOPASS GMBH ,  PISON ULRICH

Inventor： PISON ULRICH

IPC: A61K49/04 ,  A61K49/18 ,  A61K51/12

CPC classification number: A61K49/0404 ,  A61K49/0002 ,  A61K49/0041 ,  A61K49/0093 ,  A61K49/0423 ,  A61K49/0485 ,  A61K49/1878 ,  A61K51/1255 ,  B82Y5/00

Abstract: The present invention pertains to a three compartment structured polymer nanoparticle (core-shell-corona) for multimodal imaging with specificity for cells or cellular components, thus enabling more advanced diagnostic approaches and targeted therapy on the cellular level without the use of additional biologically active materials.

Abstract translation: 本发明涉及用于对细胞或细胞成分具有特异性的多模式成像的三室结构聚合物纳米颗粒（核 - 壳 - 电晕），从而使得能够在细胞水平上进行更先进的诊断方法和靶向治疗而不使用额外的生物活性物质 。

公开(公告)号：WO2014127772A1

公开(公告)日：2014-08-28

申请号：PCT/DE2014/100064

申请日：2014-02-20

Applicant: TOPASS GMBH

Inventor： ROEPKE, Katharina ,  THORE, Dietrich ,  HASEGAWA, Etsuko ,  PISON, Ulrich ,  GIERSIG, Michael

IPC: A61K49/18

CPC classification number: A61K49/18 ,  A61K49/1818 ,  A61K49/1887

Abstract: Die Erfindung betrifft eine pharmazeutisch annehmbare kolloidale Suspension, die eine Mikrokapsel umfasst, die von einem Container ("Doppelcontainer") umgeben ist, wobei die Mikrokapseln magnetische Partikel in einer kolloidalen Lösung aufweisen. Die Erfindung betrifft weiterhin die Verwendung dieser pharmazeutisch annehmbaren kolloidalen Suspension als orales Kontrastmittel für die Diagnostik des Gastrointestinaltraktes sowie die Verwendung des Kontrastmittels zur Diagnose von proliferativen Erkrankungen, inflammatorischen und Autoimmunerkrankungen sowie von Infektionserkrankungen und hormonellen sowie Erberkrankungen im Gastrointestinaltrakt.

Abstract translation: 本发明涉及一种包括容器的微胶囊（“双层容器”）药学上可接受的胶态悬浮体包围，其特征在于，所述微胶囊具有在胶体溶液的磁性粒子。 本发明还涉及使用药学上可接受的胶态悬浮体作为口服造影剂在胃肠道的诊断和于使用造影剂的增殖性疾病，炎症和自身免疫性疾病和感染性疾病和激素和遗传性疾病的在胃肠道中的诊断。

公开(公告)号：WO2009059806A2

公开(公告)日：2009-05-14

申请号：PCT/EP2008/009619

申请日：2008-11-10

Applicant: TOPASS GMBH ,  PISON, Ulrich ,  SHAVVA, Alexander Grigorievich ,  MOROZKINA, Svetlana, Nikolaevna

Inventor： PISON, Ulrich ,  SHAVVA, Alexander Grigorievich ,  MOROZKINA, Svetlana, Nikolaevna

IPC: C07J73/00

CPC classification number: C07J73/003

Abstract: The invention is related to the area of new 6-Oxa-8α-steroid estrogen analogues and the synthesis of these new biological active steroid estrogen analogues, namely, to the preparation of 6-oxa-8α-steroid estrogens and their use as estrogen receptor modulators. These new estrogen analogues are ligands for estrogen receptors and as such may be useful for the treatment and prevention of a variety of conditions related to estrogen functioning. These conditions include bone and cartilage disorders, increased levels of LDL cholesterol, cardiovascular diseases, impairment of cognitive function, cerebral degeneration disorders, endometriosis and other types of inflammation, the metabolic syndrome, and cancer, in particular of the breast, uterus and prostate.

Abstract translation: 本发明涉及新的6-Oxa-8α-类固醇雌激素类似物的领域以及这些新的生物活性类固醇雌激素类似物的合成，即制备6-氧杂-8α- 类固醇雌激素及其作为雌激素受体调节剂的用途。 这些新的雌激素类似物是雌激素受体的配体，因此可用于治疗和预防与雌激素功能有关的各种病症。 这些病症包括骨和软骨疾病，LDL胆固醇水平升高，心血管疾病，认知功能障碍，脑变性疾病，子宫内膜异位和其他类型的炎症，代谢综合征和癌症，特别是乳房，子宫和前列腺癌。

公开(公告)号：WO2007093451A3

公开(公告)日：2007-08-23

申请号：PCT/EP2007/001567

申请日：2007-02-19

Applicant: TOPASS GMBH ,  PISON, Ulrich ,  PAULKE, Bernd-Reiner ,  PIETSCHMANN, Silvia ,  CARTIER, Regis ,  KAUFNER, Lutz

Inventor： PISON, Ulrich ,  PAULKE, Bernd-Reiner ,  PIETSCHMANN, Silvia ,  CARTIER, Regis ,  KAUFNER, Lutz

IPC: A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K51/12

Abstract: The present invention pertains to a three compartment structured polymer nanoparticle (core-shell-corona) for multimodal imaging with specificity for cells or cellular components, thus enabling more advanced diagnostic approaches and targeted therapy on the cellular level without the use of additional biologically active materials.