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    METHOD FOR PREPARING MICROSPHERES FOR EMBOLI, AND METHOD FOR PREPARING MICROSPHERES TO WHICH DRUG-CONTAINING CARRIER IS BOUND
    1.
    发明申请
    METHOD FOR PREPARING MICROSPHERES FOR EMBOLI, AND METHOD FOR PREPARING MICROSPHERES TO WHICH DRUG-CONTAINING CARRIER IS BOUND 审中-公开
    制备用于栓塞的微球的方法和用于制备含药物载体的微球的方法

    公开(公告)号：WO2014035206A3

    公开(公告)日：2014-04-24

    申请号：PCT/KR2013007867

    申请日：2013-08-30

    Applicant: UNIV CHUNG ANG IND

    Inventor： LEE JAE HWI ,  KWAK BYUNG KOOK ,  KIM HYEONG MIN ,  LEE GA HYEON

    IPC: A61K9/16 ,  A61K9/127 ,  A61P27/00

    CPC classification number: A61L24/08 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/1652 ,  A61K9/19 ,  A61K9/5123 ,  A61K31/704 ,  A61K47/26 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0042 ,  A61L31/042 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/626 ,  A61L2430/36 ,  C08L5/08

    Abstract: The present invention relates to a process for optimizing the recoverability of lyophilized microspheres for emboli and to chitosan microspheres to which a drug-containing carrier is bound. More particularly, the present invention relates to a recoverability optimization process for adding trehalose as a lyophilization protectant prior to a lyophilization for the stable storage of microspheres, and swirling the lyophilized microspheres in order to rehydrate the microspheres. The present invention also relates to microspheres in which the quantity of the drug released from the chitosan microspheres having a drug-containing nanocarrier bound thereto is adjusted based on a drug/chitosan ratio, thus enabling precise drug release adjustment. The present invention also relates to a method for preparing the microspheres. The optimization process of the present invention has the advantages of maintaining the physical properties, shape, and the drug release speed of the microspheres even after the lyophilization of the microspheres for emboli. The chitosan microspheres to which a drug-containing carrier is bound according to the present invention may stably cause emboli in blood vessels, and may precisely adjust the release of a drug and therefore can be used in cancer treatment.

    Abstract translation: 本发明涉及优化用于栓子的冻干微球体和结合有含药物载体的壳聚糖微球体的可恢复性的方法。 更具体地说，本发明涉及用于在冻干之前添加海藻糖作为冻干保护剂以稳定储存微球体并涡旋冻干微球体以再水化微球体的可恢复性优化方法。 本发明还涉及微球，其中基于药物/壳聚糖比率调节从其上结合有含药纳米载体的壳聚糖微球释放的药物的量，由此能够精确地进行药物释放调节。 本发明还涉及制备微球体的方法。 本发明的优化方法具有保持微球体的物理性质，形状和药物释放速度的优点，甚至在冻干微球体用于栓子后也是如此。 根据本发明的含有药物的载体所结合的壳聚糖微球体可以稳定地在血管中引起栓子，并且可以精确地调节药物的释放，因此可以用于癌症治疗。

    METHOD FOR ENHANCING THE PRODUCTION YIELD OF HUMAN PAPILLOMAVIRUS L1 PROTEIN
    2.
    发明申请
    METHOD FOR ENHANCING THE PRODUCTION YIELD OF HUMAN PAPILLOMAVIRUS L1 PROTEIN 审中-公开
    用于增强人羊毛病L1蛋白生产力的方法

    公开(公告)号：WO2012173390A3

    公开(公告)日：2013-03-14

    申请号：PCT/KR2012004667

    申请日：2012-06-13

    Applicant: UNIV CHUNG ANG IND ,  KIM HONG JIN ,  KIM HYOUNG JIN

    Inventor： KIM HONG JIN ,  KIM HYOUNG JIN

    IPC: C12N15/33 ,  C07K14/025 ,  C12N1/19 ,  C12N15/81

    CPC classification number: C07K14/005 ,  C12N1/18 ,  C12N2710/20022 ,  C12N2710/20051 ,  C12P21/02

    Abstract: The present invention relates to a method for enhancing the production yield of human papillomavirus (HPV) L1 protein, comprising a step of culturing cells expressing HPV L1 protein in a medium containing a high concentration of a total carbon source. According to the culturing method using a medium containing a high concentration of a carbon source, the production yield of HPV L1 protein can be remarkably enhanced, and furthermore, the immunogenicity of the produced L1 protein can be greatly increased.

    Abstract translation: 本发明涉及提高人乳头瘤病毒（HPV）L1蛋白的产量的方法，其包括在含有高浓度总碳源的培养基中培养表达HPV L1蛋白的细胞的步骤。 根据使用含有高浓度碳源的培养基的培养方法，可以显着提高HPV L1蛋白的产生量，而且可以大大提高产生的L1蛋白的免疫原性。

    METHOD USING CAMP EXPRESSION MEASUREMENT TO DIAGNOSE PROSTATE INFLAMMATION, AND DIAGNOSTIC KIT
    5.
    发明申请
    METHOD USING CAMP EXPRESSION MEASUREMENT TO DIAGNOSE PROSTATE INFLAMMATION, AND DIAGNOSTIC KIT 审中-公开
    使用CAMP表达测量法诊断前列腺炎的方法和诊断试剂盒

    公开(公告)号：WO2011105826A3

    公开(公告)日：2012-01-12

    申请号：PCT/KR2011001290

    申请日：2011-02-24

    Applicant: UNIV CHUNG ANG IND ,  MYUNG SOON CHUL ,  KIM WON YONG ,  LEE TAE JIN ,  KIM HAE JONG ,  JUNG JA RANG ,  KIM HEA JIN

    Inventor： MYUNG SOON CHUL ,  KIM WON YONG ,  LEE TAE JIN ,  KIM HAE JONG ,  JUNG JA RANG ,  KIM HEA JIN

    IPC: C12Q1/68 ,  C12N15/12 ,  G01N33/53

    CPC classification number: G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N2800/342

    Abstract: The present invention relates to a method for diagnosing prostate inflammation, and to a kit using the method. More particularly, the present invention relates to a method for diagnosing prostate inflammation by measuring the expression of CAMP (human cathelicidin antimicrobial peptide) in a prostate tissue sample taken from a subject, and to a prostate inflammation diagnostic kit including a primer, probe, or antibody capable of measuring the expression of CAMP. The present invention is based on the correlation between an increase in CAMP expression level in prostate tissue or cells and the occurrence of prostate inflammation. According to the method and kit of the present invention, accurate and quick diagnosis of prostate inflammation can be performed on a large scale using a simple molecular biological analysis.

    Abstract translation: 本发明涉及一种用于诊断前列腺炎症的方法以及使用该方法的试剂盒。 更具体地，本发明涉及一种通过测量取自受试者的前列腺组织样品中的CAMP（人导管肽抗微生物肽）的表达以及前列腺炎症诊断试剂盒来诊断前列腺炎症的方法，所述前列腺炎症诊断试剂盒包括引物，探针或 能够测量CAMP表达的抗体。 本发明基于前列腺组织或细胞中CAMP表达水平的增加与前列腺炎症的发生之间的相关性。 根据本发明的方法和试剂盒，可以使用简单的分子生物学分析大规模地进行准确和快速的前列腺炎症诊断。

    SIGNAL DETECTION APPARATUS AND METHOD IN SPATIAL MULTIPLEXING SYSTEM
    6.
    发明申请
    SIGNAL DETECTION APPARATUS AND METHOD IN SPATIAL MULTIPLEXING SYSTEM 审中-公开
    空间复用系统中的信号检测装置和方法

    公开(公告)号：WO2011049380A3

    公开(公告)日：2011-08-25

    申请号：PCT/KR2010007217

    申请日：2010-10-21

    Applicant: UNIV CHUNG ANG IND ,  CHO YONG-SOO ,  IM TAE-HO

    Inventor： CHO YONG-SOO ,  IM TAE-HO

    IPC: H04B7/08

    CPC classification number: H04B7/0697 ,  H04B7/0434 ,  H04B7/0617 ,  H04B7/0848

    Abstract: The present invention provides a signal detection method and apparatus in a spatial multiplexing system. According to the present invention, the signal detection apparatus of a single receiver is formed with a plurality of antennas in a system in which at least one transmitter transmits data streams by a spatial multiplexing method, the signal detection apparatus comprises: a partial linear coefficient generator which generates a linear weight matrix by using the preset algorithm in a channel matrix that is formed between the at least one transmitter and a single receiver; a partial symbol eliminator which generates a first symbol vector by eliminating all transferable symbols of each transmission antenna in all of the data streams received; and a partial symbol detector which generates a transmission symbol candidate vector by using the first symbol vector and the generated linear weight matrix. Thus, according to the present invention, there is no big performance difference of errors between the data streams.

    Abstract translation: 本发明提供了一种空间复用系统中的信号检测方法和装置。 根据本发明，单个接收机的信号检测装置在其中至少一个发射机通过空间复用方法发射数据流的系统中形成有多个天线，所述信号检测装置包括：部分线性系数发生器 其通过使用在至少一个发射机和单个接收机之间形成的信道矩阵中的预设算法来生成线性权重矩阵; 部分符号消除器，其通过消除接收的所有数据流中的每个发送天线的所有可传送符号来产生第一符号向量; 以及部分符号检测器，其通过使用第一符号向量和所生成的线性权重矩阵来生成发送符号候选向量。 因此，根据本发明，数据流之间的差错没有很大的性能差异。

    A COMPOSITION COMPRISING THE EXTRACT OF RUMEX AQUATICUS HERBA FOR THE PREVENTION AND TREATMENT OF GASTRITIS DISEASE OR ULCER DISEASE AND THE USE THEREOF
    8.
    发明申请
    A COMPOSITION COMPRISING THE EXTRACT OF RUMEX AQUATICUS HERBA FOR THE PREVENTION AND TREATMENT OF GASTRITIS DISEASE OR ULCER DISEASE AND THE USE THEREOF 审中-公开
    一种组合物，用于预防和治疗胃肠疾病或溃疡病及其使用的RUMEX AQUATICUS HERBA的提取物

    公开(公告)号：WO2010056080A3

    公开(公告)日：2010-09-16

    申请号：PCT/KR2009006727

    申请日：2009-11-16

    Applicant: UNIV CHUNG ANG IND ,  SOHN UY DONG ,  WHANG WAN KYUNN

    Inventor： SOHN UY DONG ,  WHANG WAN KYUNN

    IPC: A61K36/70 ,  A61P1/04

    CPC classification number: A61K36/70 ,  A61K9/0019 ,  A61K9/146 ,  A61K9/2059

    Abstract: The present invention is related to a composition comprising the extract of Rumex Aquaticus Herba for the prevention and treatment of gastritis disease or ulcer disease and the use thereof. The inventive extract significantly decreasethe area of damaged gastric lesion caused by acute gastritis when the inventive extract of the present invention was orally administrated to indomethacin-induced acute gastritis animal model. The inventive compositions according to the present invention are useful in the prevention and treatment of gastritis disease or ulcer disease.

    Abstract translation: 本发明涉及包含Rumex Aquaticus Herba提取物用于预防和治疗胃炎疾病或溃疡病的组合物及其用途。 当将本发明的本发明提取物口服给予吲哚美辛诱导的急性胃炎动物模型时，本发明的提取物显着减少由急性胃炎引起的损伤的胃损伤的面积。 根据本发明的本发明组合物可用于预防和治疗胃炎疾病或溃疡病。

    RECOMBINANT EXPRESSION VECTOR FOR EXPRESSING BRAZZEIN, AND NOVEL MULTIPLE MUTATION BRAZZEIN VARIANT HAVING GREATER SWEETNESS
    9.
    发明申请
    RECOMBINANT EXPRESSION VECTOR FOR EXPRESSING BRAZZEIN, AND NOVEL MULTIPLE MUTATION BRAZZEIN VARIANT HAVING GREATER SWEETNESS 审中-公开
    用于表达布拉泽星的重组表达载体，以及具有较大尺寸的新型多重突变布拉泽宁变化

    公开(公告)号：WO2011105841A3

    公开(公告)日：2012-04-05

    申请号：PCT/KR2011001309

    申请日：2011-02-24

    Applicant: UNIV CHUNG ANG IND ,  KONG KWANG HOON

    Inventor： KONG KWANG HOON

    IPC: C12N15/29 ,  C07K14/415 ,  C12N15/70 ,  C12N15/81 ,  C12P21/02

    CPC classification number: C07K14/43 ,  C12N15/815 ,  C12P21/02

    Abstract: The present invention relates to a recombinant expression vector for expressing brazzein and to a method for the mass production of brazzein using the vector, in which a brazzein expression system is constructed in Kluyveromyces lactis, which is a lactose-fermenting yeast, and particularly, in which an optimum condition is established to achieve significantly superior expression than conventional E. coli or yeast expression systems, thus enabling the mass production of brazzein. In addition, the present invention relates to a novel biquadratic brazzein variant having greater sweetness, which has the same thermal stability as that of conventional brazzein, and a sweetness that is at least 15 to 50 times higher than that of conventional brazzein. Therefore, the brazzein variant of the present invention can be used together with other sweeteners such as sugar (sucrose), and further less brazzein variant may be used as a substitute for the same amount of sugar, and can be variously used as additives in food production.

    Abstract translation: 本发明涉及用于表达brazzein的重组表达载体和使用该载体大规模生产brazzein的方法，其中在乳糖发酵酵母中的克鲁维酵母克鲁维酵母构建了brazzein表达系统，特别是在 其建立了最佳条件以实现比常规大肠杆菌或酵母表达系统显着优异的表达，从而使得大量生产brazzein。 此外，本发明涉及一种具有较高甜度的新颖的双二价乳酪蛋白变体，其具有与常规乳糖凝胶相同的热稳定性，并且甜度比常规乳糖凝胶的甜度高至少15至50倍。 因此，本发明的纤维素变体可以与其他甜味剂如糖（蔗糖）一起使用，而更少的乳糖变体可用作相同量的糖的替代物，并且可以各种用作食物中的添加剂 生产。

    RECOMBINANT EXPRESSION VECTOR FOR EXPRESSING BRAZZEIN, AND NOVEL MULTIPLE MUTATION BRAZZEIN VARIANT HAVING GREATER SWEETNESS
    10.
    发明申请
    RECOMBINANT EXPRESSION VECTOR FOR EXPRESSING BRAZZEIN, AND NOVEL MULTIPLE MUTATION BRAZZEIN VARIANT HAVING GREATER SWEETNESS 审中-公开
    用于表达BRAZZEIN的重组表达载体，以及具有更大的甜度的新的多突变BRAZZEIN变体

    公开(公告)号：WO2011105841A9

    公开(公告)日：2012-01-26

    申请号：PCT/KR2011001309

    申请日：2011-02-24

    Applicant: UNIV CHUNG ANG IND ,  KONG KWANG HOON

    Inventor： KONG KWANG HOON

    IPC: C12N15/29 ,  C07K14/415 ,  C12N15/70 ,  C12N15/81 ,  C12P21/02

    CPC classification number: C07K14/43 ,  C12N15/815 ,  C12P21/02

    Abstract: The present invention relates to a recombinant expression vector for expressing brazzein and to a method for the mass production of brazzein using the vector, in which a brazzein expression system is constructed in Kluyveromyces lactis, which is a lactose-fermenting yeast, and particularly, in which an optimum condition is established to achieve significantly superior expression than conventional E. coli or yeast expression systems, thus enabling the mass production of brazzein. In addition, the present invention relates to a novel biquadratic brazzein variant having greater sweetness, which has the same thermal stability as that of conventional brazzein, and a sweetness that is at least 15 to 50 times higher than that of conventional brazzein. Therefore, the brazzein variant of the present invention can be used together with other sweeteners such as sugar (sucrose), and further less brazzein variant may be used as a substitute for the same amount of sugar, and can be variously used as additives in food production.

    Abstract translation: 本发明涉及用于表达布拉霉素的重组表达载体和使用该载体大量生产布拉霉素的方法，其中在作为乳糖发酵酵母的乳酸克鲁维酵母中构建了布丁蛋白表达系统，并且特别地， 其中建立了最佳条件以实现比常规大肠杆菌或酵母表达系统显着优越的表达，从而能够大规模生产brazzein。 此外，本发明涉及一种具有更高甜度的新颖的双四方形Brazzein变体，其具有与常规Brazzein相同的热稳定性，并且甜度比常规Brazzein高至少15至50倍。 因此，本发明的布氏蛋白变体可以与其他甜味剂如糖（蔗糖）一起使用，并且可以使用更少的布氏蛋白变体作为相同量的糖的替代物，并且可以不同地用作食物中的添加剂 生产。

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