-
公开(公告)号：WO2014153168A3
公开(公告)日：2015-02-12
申请号：PCT/US2014029394
申请日：2014-03-14
发明人： LIPKIN W IAN , FIRTH CADHLA , HESSE RICHARD A , HARDHAM JOHN MORGAN , REDDY SUDHIR KEESARA , OPRIESSNIG TANJA I , HALBUR PATRICK G , MARX JACQUELINE GAYLE
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2770/12011 , C12N2770/12034
摘要： The invention is directed to isolated porcine astroviruses associated with porcine periweaning failure to thrive syndrome, high morbidity and mortality syndrome in growing pigs, mulberry heart disease, porcine respiratory disease, porcine gastrointestinal disease, or reproductive failure. The invention also relates to isolated nucleic acids sequences and polypeptides derived from porcine astroviruses. Additionally, the invention relates to antibodies against antigens from porcine astroviruses. The invention also relates to iRNAs which target nucleic acid sequences of the porcine astrovirus. The invention is further related to methods for detecting the presence or absence of porcine astroviruses in an animal. The invention is also related to immunogenic compositions for inducing an immune response against porcine astroviruses in an animal.
摘要翻译： 本发明涉及分离的猪星状病毒，所述分离的猪星状病毒与猪周期性失败以促进综合症，生长猪，桑树心脏病，猪呼吸道疾病，猪胃肠疾病或生殖障碍中的高发病率和死亡综合症有关。 本发明还涉及分离的核酸序列和源自猪星状病毒的多肽。 此外，本发明涉及针对来自猪星状病毒的抗原的抗体。 本发明还涉及靶向猪星状病毒的核酸序列的iRNA。 本发明进一步涉及用于检测动物中存在或不存在猪星状病毒的方法。 本发明还涉及用于在动物中诱导针对猪星状病毒的免疫应答的免疫原性组合物。
-
公开(公告)号：WO2014022788A3
公开(公告)日：2014-05-01
申请号：PCT/US2013053454
申请日：2013-08-02
发明人： SELLERS HOLLY S , MUNDT EGBERT
IPC分类号： C07K14/465
CPC分类号： A61K39/12 , A61K2039/525 , A61K2039/552 , C12N7/00 , C12N2770/12011 , C12N2770/12021 , C12N2770/12034 , C12Q1/701 , G01N33/6854 , G01N2333/08 , G01N2469/20
摘要： The present invention includes isolated astrovirases capable of reproducing the full Runting Stunting Syndrome (RSS) disease spectrum in poultry, including a chicken astrovirus isolated from the gut of chickens (CkAstV-Gut), a cell culture chicken astrovirus CkAstV-p5, and a chicken astrovirus isolated after back passage in chicken (CkAstV-p5-Ckp5), and infected cell lines, cell culture supernatants, polynucleotide sequences, vectors, polypeptides, compositions, and vaccines thereof. The present invention also includes diagnostic methods based on such isolated viruses and infected cell lines, cell culture supematants, polynucleotide sequences, vectors, and polypeptides thereof, and methods of protecting poultry, including chickens, against RSS by the administration of such isolated viruses and infected cell lines, cell culture supernatants, polynucleotide sequences, vectors, polypeptides, compositions, and vaccines thereof.
摘要翻译： 本发明包括能够在家禽中再现全部狩猎发育迟缓综合征（RSS）疾病谱的孤立的天花病毒，包括从鸡肠（CkAstV-Gut）分离的鸡星状病毒，细胞培养鸡星状病毒CkAstV-p5和鸡 在鸡（CkAstV-p5-Ckp5）中回送后分离的星状病毒，感染的细胞系，细胞培养物上清液，多核苷酸序列，载体，多肽，组合物和疫苗。 本发明还包括基于这种分离的病毒和感染的细胞系，细胞培养上清液，多核苷酸序列，载体和多肽的诊断方法，以及通过施用这种分离的病毒和感染的保护家禽（包括鸡）免于RSS的方法 细胞系，细胞培养物上清液，多核苷酸序列，载体，多肽，组合物和疫苗。
-
公开(公告)号：WO2014022788A2
公开(公告)日：2014-02-06
申请号：PCT/US2013/053454
申请日：2013-08-02
发明人： SELLERS, Holly, S. , MUNDT, Egbert
CPC分类号： A61K39/12 , A61K2039/525 , A61K2039/552 , C12N7/00 , C12N2770/12011 , C12N2770/12021 , C12N2770/12034 , C12Q1/701 , G01N33/6854 , G01N2333/08 , G01N2469/20
摘要： The present invention includes isolated astrovirases capable of reproducing the full Runting Stunting Syndrome (RSS) disease spectrum in poultry, including a chicken astrovirus isolated from the gut of chickens (CkAstV-Gut), a cell culture chicken astrovirus CkAstV-p5, and a chicken astrovirus isolated after back passage in chicken (CkAstV-p5-Ckp5), and infected cell lines, cell culture supernatants, polynucleotide sequences, vectors, polypeptides, compositions, and vaccines thereof. The present invention also includes diagnostic methods based on such isolated viruses and infected cell lines, cell culture supematants, polynucleotide sequences, vectors, and polypeptides thereof, and methods of protecting poultry, including chickens, against RSS by the administration of such isolated viruses and infected cell lines, cell culture supernatants, polynucleotide sequences, vectors, polypeptides, compositions, and vaccines thereof.
摘要翻译： 本发明包括能够在家禽中再生全发性发育迟缓综合征（RSS）疾病谱的分离的星状病毒，包括从鸡肠道分离的鸡星状病毒（CkAstV-Gut），细胞培养鸡 星状病毒CkAstV-p5和在鸡中回传后分离的鸡星状病毒（CkAstV-p5-Ckp5），以及感染的细胞系，细胞培养上清液，多核苷酸序列，载体，多肽，组合物和疫苗。 本发明还包括基于这种分离的病毒和感染的细胞系，细胞培养上清液，多核苷酸序列，载体及其多肽的诊断方法，以及通过施用此类分离的病毒和感染而保护包括鸡在内的家禽免受RSS的方法 细胞系，细胞培养物上清液，多核苷酸序列，载体，多肽，组合物和疫苗。
-
公开(公告)号：WO2014153168A4
公开(公告)日：2015-03-26
申请号：PCT/US2014029394
申请日：2014-03-14
发明人： LIPKIN W IAN , FIRTH CADHLA , HESSE RICHARD A , HARDHAM JOHN MORGAN , REDDY SUDHIR KEESARA , OPRIESSNIG TANJA I , HALBUR PATRICK G , MARX JACQUELINE GAYLE
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2770/12011 , C12N2770/12034
摘要： The invention is directed to isolated porcine astroviruses associated with porcine periweaning failure to thrive syndrome, high morbidity and mortality syndrome in growing pigs, mulberry heart disease, porcine respiratory disease, porcine gastrointestinal disease, or reproductive failure. The invention also relates to isolated nucleic acids sequences and polypeptides derived from porcine astroviruses. Additionally, the invention relates to antibodies against antigens from porcine astroviruses. The invention also relates to iRNAs which target nucleic acid sequences of the porcine astrovirus. The invention is further related to methods for detecting the presence or absence of porcine astroviruses in an animal. The invention is also related to immunogenic compositions for inducing an immune response against porcine astroviruses in an animal.
摘要翻译： 本发明涉及与生长猪，桑树心脏病，猪呼吸道疾病，猪胃肠道疾病或生殖衰竭中的猪周围血管破裂综合征，高发病率和死亡率综合征相关的孤立的猪星状病毒。 本发明还涉及源自猪星状病毒的分离的核酸序列和多肽。 另外，本发明涉及针对来自猪星状病毒的抗原的抗体。 本发明还涉及靶向猪星状病毒核酸序列的iRNA。 本发明还涉及用于检测动物中猪星状病毒存在或不存在的方法。 本发明还涉及用于诱导针对动物的猪星状病毒的免疫应答的免疫原性组合物。
-
公开(公告)号：WO2014153168A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/029394
申请日：2014-03-14
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , KANSAS STATE UNIVERSITY RESEARCH FOUNDATION , ZOETIS LLC
发明人： LIPKIN, W., Ian , FIRTH, Cadhla , HESSE, Richard, A. , HARDHAM, John, Morgan , REDDY, Sudhir, Keesara , OPRIESSNIG, Tanja, I. , HALBUR, Patrick, G. , MARX, Jacqueline, Gayle
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2770/12011 , C12N2770/12034
摘要： The invention is directed to isolated porcine astroviruses associated with porcine periweaning failure to thrive syndrome, high morbidity and mortality syndrome in growing pigs, mulberry heart disease, porcine respiratory disease, porcine gastrointestinal disease, or reproductive failure. The invention also relates to isolated nucleic acids sequences and polypeptides derived from porcine astroviruses. Additionally, the invention relates to antibodies against antigens from porcine astroviruses. The invention also relates to iRNAs which target nucleic acid sequences of the porcine astrovirus. The invention is further related to methods for detecting the presence or absence of porcine astroviruses in an animal. The invention is also related to immunogenic compositions for inducing an immune response against porcine astroviruses in an animal.
摘要翻译： 本发明涉及与生长猪，桑树心脏病，猪呼吸道疾病，猪胃肠道疾病或生殖衰竭中的猪周围血管破裂综合症，高发病率和死亡率综合征相关的孤立猪星状病毒。 本发明还涉及源自猪星状病毒的分离的核酸序列和多肽。 另外，本发明涉及针对来自猪星状病毒的抗原的抗体。 本发明还涉及靶向猪星状病毒核酸序列的iRNA。 本发明还涉及用于检测动物中猪星状病毒存在或不存在的方法。 本发明还涉及用于诱导针对动物的猪星状病毒的免疫应答的免疫原性组合物。
-
6.发明申请ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING SSRNA VIRAL INFECTION 审中-公开反义抗病毒化合物和治疗SSRNA病毒感染的方法
公开(公告)号：WO2006033933A3
公开(公告)日：2006-07-27
申请号：PCT/US2005032815
申请日：2005-09-15
发明人： IVERSEN PATRICK L , STEIN DAVID A
IPC分类号： C12Q1/70 , C12N15/11 , C12N15/113
CPC分类号： C12N15/1131 , C07K19/00 , C12N15/111 , C12N2310/11 , C12N2310/314 , C12N2310/3233 , C12N2310/3513 , C12N2310/531 , C12N2320/11 , C12N2770/00011 , C12N2770/10011 , C12N2770/12011 , C12N2770/16011 , C12N2770/20011 , C12N2770/24011 , C12N2770/28011 , C12N2770/32011 , C12N2770/36011
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Arteriviridae, Coronaviridae, Astroviridae and Hepeviridae families in the treatment of a viral infection. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with stem-loop secondary structure within the 5'-terminal end 40 bases of the positive-sense RNA strand of the virus.
摘要翻译： 本发明提供了反义抗病毒化合物及其在抑制病毒感染治疗中黄病毒科，Picornoviridae，杯状病毒科，披膜病毒科，动脉炎病毒科，冠状病毒科，星状病毒科和Hepeviridae科病毒生长中的应用和生产的方法。 反义抗病毒化合物是基本上不带电荷的吗啉代寡核苷酸，其具有12-40个亚基的序列，包括至少12个亚基，其具有与在5'-末端40个碱基中与茎环二级结构相关的区域互补的导向序列 病毒的正义RNA链。
-
7.发明申请ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING SSRNA VIRAL INFECTION 审中-公开抗病毒复合物和治疗SSRNA病毒感染的方法
公开(公告)号：WO2006033933A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/032815
申请日：2005-09-15
CPC分类号： C12N15/1131 , C07K19/00 , C12N15/111 , C12N2310/11 , C12N2310/314 , C12N2310/3233 , C12N2310/3513 , C12N2310/531 , C12N2320/11 , C12N2770/00011 , C12N2770/10011 , C12N2770/12011 , C12N2770/16011 , C12N2770/20011 , C12N2770/24011 , C12N2770/28011 , C12N2770/32011 , C12N2770/36011
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Arteriviridae, Coronaviridae, Astroviridae and Hepeviridae families in the treatment of a viral infection. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with stem-loop secondary structure within the 5'-terminal end 40 bases of the positive-sense RNA strand of the virus.
摘要翻译： 本发明提供了反义抗病毒化合物及其在抑制黄病毒科，皮病毒科，杯状病毒科，披膜病毒科，动脉病毒科，科罗亚病毒科，蛔虫科和乙肝病毒科的病毒生长方面的应用和生产方法。 反义抗病毒化合物是具有12-40个亚基序列的基本上不带电荷的吗啉代寡核苷酸，包括至少12个亚基，其具有与在5'-末端40个碱基内的茎环二级结构相关的区域互补的靶向序列 病毒的正义RNA链。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.014 秒)
