Abstract:
The invention relates to a method for identifying a subpopulation of specific cells among a large population of cells, comprising - a step of exposing the cells of said large population to n- reagents, - a step of detecting said n- reagents, - a step of grouping the cells by clusterisation into k different clusters, and - a step of eliminating cells that are not rare cells.
Abstract:
The invention relates to a solid nanocomposite material including: nanoparticles of a metal coordination polymer with CN ligands including Mn+ cations, where M is a transition metal, and n is 2 or 3; and [M' (CN)m]x- anions, where M' is a transition metal, x is 3 or 4, and m is 6 or 8; said Mn+ cations of the coordination polymer being bonded by an organometallic bond to an organic group of an organic graft chemically bonded to the inside of the pores of a porous glass medium. The invention also relates to a method for preparing said material, to a method for fixing an inorganic pollutant, such as radioactive caesium, contained in a solution by placing said solution in contact with said material.
Abstract:
Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
Abstract:
The invention relates to a method for supply to a magnetic coupler comprising several pairs of windings, each pair being formed from a first and a second adjacent paired winding, magnetically coupled to each other by means of a core of magnetic material. The method further consists of supplying (in 34) the first winding of each pair with a supply voltage or current out of phase by an angle a with relation to the supply voltage or current for the second winding of the same pair. The absolute value of the angle a is greater than or equal to 4p/N for at least one pair of windings.
Abstract:
The invention relates to a tripeptide conjugate having general formula I, A-AA1-AA2-AA3-NH 2 , wherein A represents the radical corresponding to a monocarboxylic acid with general formula II, HOOC-R, in which: R represents a linear or branched aliphatic radical at C 1 -C 24 , which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, lipoic acid or the reduced form thereof, dihydrolipoic acid, N- lipoyllysine, or phenylbutyric acid; and AA1, AA2 and AA3, which may be identical or different, represent independently of each other an amino acid selected from His, Phe, Ala, Arg, Lys, Orn, Trp, Nap, Tpi and Tic, on the condition that at least one of AA1, AA2 or AA3 represent Phe, preferably Dphe in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.
Abstract:
The invention relates to a peptide of formula W-DPhe-Arg- Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a monocarboxylic acid of general formula HOOC-R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C 1 -C 24 radical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg, Nle-Ala-Arg, Nle-Ala-DTrp or a bond in case of compounds of formula (II), Z is NH 2 , OH and OR, wherein R is a linear or branched aliphatic C 1 -C 24 radical, TrpNH 2 , NapNH 2 , TpiNH 2 , TicNH 2 , AlaNH2 i TrpOH, NapOH, TpiOH, TicOH, AlaOH, PheNH 2 , or PheOH, exempting a peptidic conjugate for which A is a radical corresponding to an acetic acid, W is Nle-Ala-His and Z is TrpNH 2 in the form of enantiomers or diastereoisomer and the mixtures thereof including racemic mixtures. The use of the inventive compounds for cosmetically fighting against canities is also disclosed.
Abstract:
The invention relates to directly swollen liquid crystals, a method for production thereof and use thereof as a reaction medium for various chemical reactions. According to the invention, a directly swollen liquid crystal comprises an aqueous phase of an aqueous solution of at least one ionic compound, an organic phase of an organic solvent not soluble in water, a detergent phase of a non-ionic detergent or a cationic detergent and a co-detergent phase. The above is not coloured or opalescent and has a hexagonal, cubic or sponge structure.
Abstract:
The invention relates to epoxy resins cross-linkable at room temperature, including the product of a reaction of a mixture including at least one epoxy function carrier derivative, chosen from the group consisting of the non-polymeric, non-biosourced reagents and carriers of at least 3 epoxy end functions and the biosourced, epoxidized lipidic derivatives, and at least one crosslinking agent, the ratio between the number of epoxy functions being kept constant independently of the composition of the mixture, the method for manufacturing same, and the use thereof in composite parts for the mechanical engineering or for building construction and in structural parts.
Abstract:
The invention relates to fragments of the DAXX and FADD proteins that inhibit cell apoptosis, in particular cell apoptosis mediated by the Fas receptor. The invention also relates to derivatives of said anti-apoptotic fragments, conjugates comprising said fragments, pharmaceutical compositions comprising said fragments, and to the medical applications of said fragments, derivatives, conjugates, and pharmaceutical compositions thereof in the treatment or prevention of diseases and conditions associated with apoptosis.