公开(公告)号：WO2011017009A1

公开(公告)日：2011-02-10

申请号：PCT/US2010/042844

申请日：2010-07-22

Applicant: MERCK PATENT GMBH ,  SUTTON, Amanda E. ,  BRUGGER, Nadia ,  RICHARDSON, Thomas E. ,  VANDEVEER, Harold George ,  HUCK, Bayard R. ,  LAN, Ruoxi ,  POTNICK, Justin

Inventor： SUTTON, Amanda E. ,  BRUGGER, Nadia ,  RICHARDSON, Thomas E. ,  VANDEVEER, Harold George ,  HUCK, Bayard R. ,  LAN, Ruoxi ,  POTNICK, Justin

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D333/02 ,  C07D487/04

Abstract: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

Abstract translation: 本发明提供根据式（I）的新型取代的氮杂环化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。

公开(公告)号：WO2010093419A1

公开(公告)日：2010-08-19

申请号：PCT/US2010/000313

申请日：2010-02-04

Applicant: MERCK PATENT GMBH ,  SUTTON, Amanda E. ,  RICHARDSON, Thomas E. ,  HUCK, Bayard R. ,  KARRA, Srinivasa R. ,  CHEN, Xiaoling ,  XIAO, Yufang ,  GOUTOPOULOS, Andreas ,  LAN, Ruoxi ,  PERREY, David ,  VANDEVEER, Harold, George ,  LIU-BUJALSKI, Lesley ,  STIEBER, Frank ,  HODOUS, Brian L. ,  QIU, Hui ,  JONES, Reinaldo C. ,  HEASLEY, Brian

Inventor： SUTTON, Amanda E. ,  RICHARDSON, Thomas E. ,  HUCK, Bayard R. ,  KARRA, Srinivasa R. ,  CHEN, Xiaoling ,  XIAO, Yufang ,  GOUTOPOULOS, Andreas ,  LAN, Ruoxi ,  PERREY, David ,  VANDEVEER, Harold, George ,  LIU-BUJALSKI, Lesley ,  STIEBER, Frank ,  HODOUS, Brian L. ,  QIU, Hui ,  JONES, Reinaldo C. ,  HEASLEY, Brian

IPC: C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  A61K31/517 ,  A61P35/00

CPC classification number: C07D215/04 ,  A61K31/47 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04

Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

Abstract translation: 本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。