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1.
公开(公告)号:WO2023275027A1
公开(公告)日:2023-01-05
申请号:PCT/EP2022/067695
申请日:2022-06-28
Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG , VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH & CO, KG
Inventor: PFEILER, Tina , VANDERSTRAETEN, Reynald , ROSSI, Michiko , HUTH, Isabel , PETAJA, Viljo
IPC: A61N5/10 , A61N2005/1034 , A61N2005/1087 , A61N2005/1089 , A61N5/103 , A61N5/1031 , A61N5/1071 , G21K5/04
Abstract: Presented systems and methods enable efficient and effective robust radiation treatment planning and treatment, including analysis of dose rate robustness. In one embodiment, a method (1900) comprising accessing (1910) treatment plan information, accessing (1920) information corresponding to an uncertainty associated with implementation of the radiation treatment plan, and generating (1930) a histogram, wherein the histogram conveys a characteristic of the treatment plan including an impact of the uncertainty on the characteristic. The histogram can be a dose rate volume histogram (700, 710) and can be utilized to test a degree of robustness of a treatment plan (e.g., including allowance for uncertainty scenarios, etc.). The uncertainty can be associated with potential variation associated with tolerances (e.g., radiation system/machine performance tolerance, patient characteristic tolerances, etc.) and set up issues (e.g., variation in initial system/machine set up, variation patient setup/position, etc.)
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公开(公告)号:WO2022200283A1
公开(公告)日:2022-09-29
申请号:PCT/EP2022/057371
申请日:2022-03-21
Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
Inventor: PAYSAN, Pascal , WALCZAK, Michal , ZHU, Liangjia , ROGGEN, Toon , SCHEIB, Stefan
IPC: G06T7/246
Abstract: Embodiments described herein provide for determining a probability distribution of a three- dimensional point in a template feature map matching a three-dimensional point in space. A dual-domain target structure tracking end-to-end system receives projection data in one dimension or two dimensions and a three-dimensional simulation image. The end-to-end system extracts a template feature map from the simulation image using segmentation. The end-to-end system extracts (206) features from the projection data, transforms the features of the projection data into three-dimensional space, and sequences the three-dimensional space to generate a three-dimensional feature map. The end-to-end system compares (210) the template feature map to the generated three-dimensional feature map, determining (212) an instantaneous probability distribution of the template feature map occurring in the three-dimensional feature map.
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公开(公告)号:WO2022129144A1
公开(公告)日:2022-06-23
申请号:PCT/EP2021/085848
申请日:2021-12-15
Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
Inventor: BASIRI, Shahab , HAKALA, Mikko , KUUSELA, Esa , CZEIZLER, Elena
IPC: G16H20/40
Abstract: Disclosed herein are systems and methods for iteratively training artificial intelligence models using reinforcement learning techniques. With each iteration, a training agent applies a random radiation therapy treatment attribute corresponding to the radiation therapy treatment attribute associated with previously performed radiation therapy treatments when an epsilon value indicative of a likelihood of exploration and exploitation training of the artificial intelligence model satisfies a threshold. When the epsilon value does not satisfy the threshold, the agent generates (242), using an existing policy, a first predicted radiation therapy treatment attribute, and generates (244), using a predefined model, a second predicted radiation therapy treatment attribute. The agent applies (246) one of the first predicted radiation therapy treatment attribute or the second predicted radiation therapy treatment attribute that is associated with a higher reward. The agent iteratively repeats (248) training the artificial intelligence model until the existing policy satisfies an accuracy threshold.
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公开(公告)号:WO2022005488A1
公开(公告)日:2022-01-06
申请号:PCT/US2020/040812
申请日:2020-07-03
Inventor: JOHNSON, Leigh Scott , KUNZ, Patrick Niklaus , MORGAN, Andrea , ATTANASI, Francesca , SCHEIB, Stefan Georg , HONEGGER, Jonas Michael
IPC: G06T19/00 , G06T2210/41
Abstract: Systems and methods for cardiac radioablation treatment planning are disclosed. In some examples, a computing device receives an image volume and a dose matrix data. The computing device generates a first mesh of organ substructures for the organ based on substructure contours for the organ. Further, the computing device generates a second mesh of an isodose volume based on the dose matrix data. The computing device displays the first mesh of the organ substructures and the second mesh of the isodose volume within a same scene. In some examples, the computing device samples a plurality of dosage values, determines representative dosage values for each of a plurality of points along surfaces of a dose matrix, and generates an image for display based on the representative dosage values. In some examples, a segmentation model is generated for display based on the representative dosage values.
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公开(公告)号:WO2022005487A1
公开(公告)日:2022-01-06
申请号:PCT/US2020/040808
申请日:2020-07-03
Inventor: JOHNSON, Leigh Scott , HONEGGER, Jonas Michael , KUNZ, Patrik Niklaus , SCHEIB, Stefan Georg , ATTANASI, Francesca , MORGAN, Andrea
IPC: G16B20/40
Abstract: Systems and methods for cardiac radioablation treatment planning are disclosed. In some examples, a computing device receives a first signal identifying a first event within a first workspace from a second computing device. The computing device determines a first action to apply to a first image displayed within a second workspace based on the first signal. The computing device generates a second image based on applying the first action to the first image within the second workspace, and displays the second image within the second workspace. In some examples, the first workspace is a radiation oncologist workspace and the second workspace is an electrophysiologist workspace. In some examples, the first workspace is an electrophysiologist oncologist workspace and the second workspace is a radiation oncologist workspace.
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公开(公告)号:WO2021170722A1
公开(公告)日:2021-09-02
申请号:PCT/EP2021/054687
申请日:2021-02-25
Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
Inventor: ROCHFORD, Ronan , HARJU, Ari , KAUPPINEN, Juha , IKONEN, Timo
Abstract: A beam-blocking leaf (200) includes a body portion (202) and a head (portion 204). The head portion is movable relative to the body portion, thereby allowing an end surface (206) of the head portion to change an orientation relative to the body portion. A collimator including the beam-blocking leaf and a method of collimating a radiation beam using the collimator are also provided.
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公开(公告)号:WO2021115847A1
公开(公告)日:2021-06-17
申请号:PCT/EP2020/084117
申请日:2020-12-01
Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
Inventor: MORF, Daniel , KELLER, Simon
Abstract: A radiation therapy system is configured with fast readout of X-ray images with significantly reduced image lag. A reset phase is included in the process of acquiring an X-ray image to reduce image lag in a subsequently acquired X-ray image. During the reset phase, residual charge is concurrently transferred from multiple arrays of pixel detector elements in an X-ray detector panel. As a result, image lag present in a subsequent X-ray image is minimized or otherwise reduced.
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8.
公开(公告)号:WO2020200849A1
公开(公告)日:2020-10-08
申请号:PCT/EP2020/057847
申请日:2020-03-20
Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
Inventor: KUUSELA, Esa , LAAKSONEN, Hannu , HALKO, Lauri
IPC: A61N5/10
Abstract: Cost functions and cost function gradients for use in radiation treatment planning can be computed based on an approximation of an "isodose" surface. Where a clinical goal is expressed by reference to a threshold isodose surface, a corresponding cost function component can be defined directly by reference to that isodose surface 1004, and a corresponding contribution to the cost function gradient can be approximated by identifying voxels that are intersected by the threshold isodose surface and approximating the gradient of the dose distribution within each such voxel.
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公开(公告)号:WO2020139590A1
公开(公告)日:2020-07-02
申请号:PCT/US2019/066430
申请日:2019-12-16
Inventor: RIEGER, Rachel , KAUPPINEN, Juha , MAGLIARI, Anthony , BAIC, Dusan
IPC: A61N5/10
Abstract: A multileaf collimator includes a plurality of beam-blocking leaves of a first type and a plurality of beam-blocking leaves of a second type. The beam-blocking leaves of the first type are alternatingly arranged with the beam-blocking leaves of the second type side by side. Each of the beam-blocking leaves of the first type has a trapezoidal geometry viewed in the leaf longitudinal moving direction comprising a wider end and a narrower end with the wider end being proximal to a source. Each of the beam-blocking leaves of the second type has a trapezoidal geometry viewed in the leaf longitudinal moving direction comprising a wider end and a narrower end with the wider end being distal to the source.
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10.
公开(公告)号:WO2020069421A3
公开(公告)日:2020-04-02
申请号:PCT/US2019/053623
申请日:2019-09-27
Inventor: OLLILA, Santtu , WAREING, Todd Arlin , MCGHEE, John Morton , BARNETT, JR., Douglas Allen , MASLOWSKI, Alexander Enrique
IPC: A61N5/10
Abstract: A method of trajectory optimization for radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs), defining a delivery coordinate space (DCS), for each ROI, solving an adjoint transport to obtain an adjoint solution field from the ROI, for each vertex in the DCS, evaluating an adjoint photon fluence by performing ray tracing of the adjoint solution field, evaluating a dose of the ROI using the adjoint photon fluence, for each vertex in the DCS, evaluating a respective beam's eye view (BEV) score of each pixel of a BEV plane using the doses of the one or more ROIs, determining one or more BEV regions in the BEV plane based on the BEV scores, determining a BEV region connectivity manifold based on the BEV regions, and determining one or more optimal treatment trajectories based on the BEV region connectivity manifold.
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