公开(公告)号：WO2018078435A2

公开(公告)日：2018-05-03

申请号：PCT/IB2017/001305

申请日：2017-10-27

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： NORD, Janne, I. ,  KAUPPINEN, Juha ,  TOIMELA, Lasse, H.

IPC: A61N5/10

Abstract: An apparatus for use in a treatment planning process or in a treatment process, includes: an input for obtaining a parameter representing a number of beam on-off transitions; and a treatment planner configured to optimize a treatment plan based on parameter representing the number of beam on-off transitions. An apparatus includes: an input configured to obtain a width of a gating window for a treatment plan; and a gating window adjustor configured to adjust the width of the gating window during a treatment session. An apparatus includes: a dose calculator configured to calculate doses for different treatment variations; an evaluator configured to evaluate treatment acceptance criteria against the calculated doses; and a delivery limit module configured to determine one or more limits for one or more delivery parameters based on an evaluation of the treatment acceptance criteria by the evaluator.

Abstract translation: 用于治疗计划过程或治疗过程的设备包括：输入端，用于获得表示光束开关转换次数的参数; 以及治疗计划器，其被配置为基于表示束开关转变的次数的参数来优化治疗计划。 一种设备包括：输入，其被配置为获得治疗计划的门控窗口的宽度; 以及门控窗口调节器，其被配置为在治疗期间调节门控窗口的宽度。 一种设备包括：剂量计算器，其被配置为计算不同治疗变化的剂量; 评估器，其被配置为针对所计算的剂量评估治疗接受标准; 以及递送限制模块，其被配置为基于评估者对治疗接受准则的评估来确定一个或多个递送参数的一个或多个限制。

公开(公告)号：WO2018078435A3

公开(公告)日：2018-05-03

申请号：PCT/IB2017/001305

申请日：2017-10-27

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： NORD, Janne, I. ,  KAUPPINEN, Juha ,  TOIMELA, Lasse, H.

IPC: A61N5/10

Abstract: An apparatus for use in a treatment planning process or in a treatment process, includes: an input for obtaining a parameter representing a number of beam on-off transitions; and a treatment planner configured to optimize a treatment plan based on parameter representing the number of beam on-off transitions. An apparatus includes: an input configured to obtain a width of a gating window for a treatment plan; and a gating window adjustor configured to adjust the width of the gating window during a treatment session. An apparatus includes: a dose calculator configured to calculate doses for different treatment variations; an evaluator configured to evaluate treatment acceptance criteria against the calculated doses; and a delivery limit module configured to determine one or more limits for one or more delivery parameters based on an evaluation of the treatment acceptance criteria by the evaluator.

公开(公告)号：WO2018050886A1

公开(公告)日：2018-03-22

申请号：PCT/EP2017/073441

申请日：2017-09-18

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne ,  KUUSELA, Esa ,  KAUPPINEN, Juha ,  PETAJA, Viljo ,  RUSANEN, Marko

IPC: A61N5/10

Abstract: An optimized radiation treatment plan may be developed in which the total monitor unit (MU) count is taken into account, A planner may specify a maximum treatment time. An optimization algorithm may convert the specified maximum treatment time to a maximum total MU count, which is then used as a constraint in the optimization process. A cost function for the optimization algorithm may include a term that penalizes any violation of the upper constraint for the MU count.

Abstract translation: 可以开发优化的放射治疗计划，其中考虑总监测单位（MU）计数，计划者可以指定最大治疗时间。 优化算法可以将指定的最大处理时间转换为最大总MU计数，然后将其用作优化处理中的约束。 优化算法的成本函数可能包含一个惩罚任何违反MU计数上限约束的术语。

公开(公告)号：WO2022063684A1

公开(公告)日：2022-03-31

申请号：PCT/EP2021/075530

申请日：2021-09-16

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： KAUPPINEN, Juha ,  MAGLIARI, Anthony ,  SABEL, Martin ,  TALAKOUB, Amir

IPC: A61N5/10

Abstract: These teachings provide for accessing optimization information (202) comprising at least one isocenter that corresponds to a body outline for a particular patient (104), field geometry information for a particular radiation treatment platform (114), and dosimetric data. The optimization information can further comprise a model of a body outline for the patient (104). A control circuit (101) optimizes a radiation treatment plan as a function of the optimization information to provide an optimized radiation treatment plan (113) where radiation dose levels delivered to the particular patient (104) from a particular field (403, 405) depends on the relative volume magnitude of field path intersections to thereby reduce radiation dose delivery to healthy patient tissue in regions having relatively more overlapping fields (403, 405).

公开(公告)号：WO2020188372A1

公开(公告)日：2020-09-24

申请号：PCT/IB2020/051444

申请日：2020-02-20

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： IKONEN, Timo ,  BOYLAN, Christopher ,  HARJU, Ari ,  HILTUNEN, Petri ,  KAUPPINEN, Juha ,  KOKKONEN, Petri ,  PETAJA, Viljo ,  RUSANEN, Marko T ,  SILJAMAKI, Sami P ,  TORSTI, Tuomas E ,  KUUSELA, Esa ,  KARJALAINEN, Antti

IPC: A61N5/10

Abstract: A method of calculating radiation dose includes dosimetric projection of a collimator geometry. The method includes defining a three-dimensional (3D) geometry of a collimating device which defines an aperture configured to allow a radiation beam passing through, projecting the collimating device along the radiation beam into a two-dimensional (2D) geometry in a plane, calculating dosimetric opacity values of the collimating device at locations adjacent to the aperture based on the 3D geometry of the collimating device, and calculating transport of the radiation beam through the collimating device based on the 2D geometry projected in the plane and using the dosimetric opacity values of the collimating device at the locations adjacent to the aperture.

公开(公告)号：WO2021170722A1

公开(公告)日：2021-09-02

申请号：PCT/EP2021/054687

申请日：2021-02-25

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： ROCHFORD, Ronan ,  HARJU, Ari ,  KAUPPINEN, Juha ,  IKONEN, Timo

IPC: A61N5/10 ,  G21K1/04

Abstract: A beam-blocking leaf (200) includes a body portion (202) and a head (portion 204). The head portion is movable relative to the body portion, thereby allowing an end surface (206) of the head portion to change an orientation relative to the body portion. A collimator including the beam-blocking leaf and a method of collimating a radiation beam using the collimator are also provided.

公开(公告)号：WO2020139590A1

公开(公告)日：2020-07-02

申请号：PCT/US2019/066430

申请日：2019-12-16

Applicant: VARIAN MEDICAL SYSTEMS, INC. ,  VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： RIEGER, Rachel ,  KAUPPINEN, Juha ,  MAGLIARI, Anthony ,  BAIC, Dusan

IPC: A61N5/10

Abstract: A multileaf collimator includes a plurality of beam-blocking leaves of a first type and a plurality of beam-blocking leaves of a second type. The beam-blocking leaves of the first type are alternatingly arranged with the beam-blocking leaves of the second type side by side. Each of the beam-blocking leaves of the first type has a trapezoidal geometry viewed in the leaf longitudinal moving direction comprising a wider end and a narrower end with the wider end being proximal to a source. Each of the beam-blocking leaves of the second type has a trapezoidal geometry viewed in the leaf longitudinal moving direction comprising a wider end and a narrower end with the wider end being distal to the source.

公开(公告)号：WO2018050883A1

公开(公告)日：2018-03-22

申请号：PCT/EP2017/073422

申请日：2017-09-18

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne ,  KUUSELA, Esa ,  KAUPPINEN, Juha ,  PETAJA, Viljo ,  RUSANEN, Marko

IPC: A61N5/10

Abstract: In a radiation treatment plan that includes a plurality of treatment fields of multiple treatment modalities, such as IMRT modality and dynamic treatment path modality (e.g., VMAT and conformal arc therapy), an optimized spatial point sequence may be determined that optimizes the total treatment time, which includes both the beam-on time (i.e., during the delivery of radiation dose) and the beam-off time (i.e., during transitions between consecutive treatment fields). The result is a time-ordered field trajectory that intermixes and interleaves different treatment fields, in one embodiment, a dynamic treatment path may be cut into a plurality of sections, and one or more IMRT fields may be inserted between the plurality of sections.

Abstract translation: 在包括诸如IMRT模态和动态治疗路径模态（例如，VMAT和共形电弧治疗）的多个治疗模态的多个治疗场的放射治疗计划中，优化的空间点序列可以 被确定为优化总治疗时间，其包括射束开启时间（即，在辐射剂量的递送期间）和射束关闭时间（即，在连续治疗区域之间的过渡期间）。 结果是混合并交织不同处理区域的时间有序的场轨迹。在一个实施例中，动态处理路径可以被切割成多个区段，并且可以在多个区段之间插入一个或多个IMRT字段。 / p>

公开(公告)号：WO2017167654A1

公开(公告)日：2017-10-05

申请号：PCT/EP2017/057046

申请日：2017-03-24

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： NORD, Janne I. ,  PELTOLA, Jarkko Y. ,  KAUPPINEN, Juha

IPC: A61N5/10 ,  G06F19/00

Abstract: A radiation-treatment plan that comprises a plurality of dose-delivery fractions can be optimized by using fraction dose objectives and at least one other, different dose objective. This use of fraction dose objectives can comprise accumulating doses delivered in previous dose-delivery fractions. The other, different dose objective can comprise a remaining total dose objective, a predictive dose objective, or some other dose objective of choice. An existing radiation-treatment plan having a corresponding resultant quality and that is defined, at least in part, by at least one delivery parameter can be re-optimized by specifying at least one constraint as regards that delivery parameter as a function, at least in part, of that resultant quality and then applying that constraint when re-optimizing the existing radiation-treatment plan.

Abstract translation: 包含多个剂量递送部分的放射治疗计划可通过使用部分剂量目标和至少一个其他不同剂量目标来优化。 分数剂量目标的这种使用可以包括在之前的剂量递送部分中递送的累积剂量。 另一种不同的剂量目标可以包括剩余的总剂量目标，预测剂量目标或某个其他剂量选择目标。 至少部分地通过至少一个输送参数定义的具有相应的合成质量的现有放射治疗计划可以通过指定关于该输送参数作为函数的至少一个约束来重新优化， 部分原因是由此产生的质量，然后在重新优化现有的辐射治疗计划时应用该限制。