公开(公告)号：WO2010093823A2

公开(公告)日：2010-08-19

申请号：PCT/US2010023946

申请日：2010-02-11

Applicant: VISIOGEN INC ,  LIAO XIUGAO

Inventor： LIAO XIUGAO

IPC: C08F220/18

CPC classification number: A61F2/16 ,  A61F2/1648 ,  A61F2002/1681 ,  C08F220/18 ,  C08F220/36 ,  C08F230/08

Abstract: Some embodiments provide a copolymer comprising: an acrylate recurring unit and an optionally substituted vinylaryl recurring unit, wherein a portion of at least one of the recurring units comprises a vinyldialkylsiloxy pendant group. The copolymers may be useful as soft acrylic haptics for intraocular lenses. Some embodiments further relate to intraocular lenses having a hydrophobic soft acrylic optic and a silicone haptic, such as a dual optic accommodative lens a having hydrophobic soft acrylic anterior and posterior optic bodies and a silicone haptic. Related copolymeric composite materials as well as additional embodiments of intraocular lenses, are also described herein.

Abstract translation: 一些实施方案提供了一种共聚物，其包含：丙烯酸酯重复单元和任选取代的乙烯基芳基重复单元，其中至少一个重复单元的一部分包含乙烯基二烷基甲硅烷氧基侧基。 共聚物可用作眼内透镜的柔软的丙烯酸类触觉剂。 一些实施例进一步涉及具有疏水性柔性丙烯酸光学元件和硅树脂触觉元件的眼内透镜，例如具有疏水柔软的丙烯酸前后视觉体和硅树脂触觉的双光学调节透镜。 相关的共聚合复合材料以及眼内透镜的另外的实施方案也在本文中描述。

公开(公告)号：WO2005104995A2

公开(公告)日：2005-11-10

申请号：PCT/US2005/012032

申请日：2005-04-12

Applicant: VISIOGEN ,  NGUYEN, Tuan, Anh ,  EVANS, Scott ,  ZADNO-AZIZI, Gholam-Reza

Inventor： NGUYEN, Tuan, Anh ,  EVANS, Scott ,  ZADNO-AZIZI, Gholam-Reza

IPC: A61F2/16

CPC classification number: A61F2/1616 ,  A61F2/1629 ,  A61F2/1648

Abstract: An accommodating intraocular lens (200, 300, 400) has an anterior portion (102) including an anterior viewing element (106) and an anterior biasing element (108) connected to the anterior viewing element (106). A posterior portion (104) has a posterior viewing element (118) and a posterior biasing element (120) connected to the posterior viewing element (118). The anterior and posterior biasing elements (108, 120) are connected at first and second apices (112, 116). First and second distending members (134, 136) are connected to the posterior portion (104). The first and second distending members (134, 136) extend to locations significantly anterior of an anterior side of the posterior viewing element (118).

Abstract translation: 容纳人工晶状体（200,300,400）具有前部（102），其包括前观察元件（106）和连接到前观察元件（106）的前偏置元件（108）。 后部部分（104）具有后观察元件（118）和连接到后观察元件（118）的后偏置元件（120）。 前和后偏置元件（108,120）在第一和第二顶点（112,116）处连接。 第一和第二扩张构件（134,136）连接到后部（104）。 第一和第二扩张构件（134,136）延伸到在后观察元件（118）的前侧的显着前方的位置。

公开(公告)号：WO2010093823A3

公开(公告)日：2010-08-19

申请号：PCT/US2010/023946

申请日：2010-02-11

Applicant: VISIOGEN, INC. ,  LIAO, Xiugao

Inventor： LIAO, Xiugao

IPC: C08F220/18

Abstract: Some embodiments provide a copolymer comprising: an acrylate recurring unit and an optionally substituted vinylaryl recurring unit, wherein a portion of at least one of the recurring units comprises a vinyldialkylsiloxy pendant group. The copolymers may be useful as soft acrylic haptics for intraocular lenses. Some embodiments further relate to intraocular lenses having a hydrophobic soft acrylic optic and a silicone haptic, such as a dual optic accommodative lens a having hydrophobic soft acrylic anterior and posterior optic bodies and a silicone haptic. Related copolymeric composite materials as well as additional embodiments of intraocular lenses, are also described herein.

公开(公告)号：WO2010054255A1

公开(公告)日：2010-05-14

申请号：PCT/US2009/063635

申请日：2009-11-06

Applicant: VISIOGEN, INC. ,  PORTNEY, Valdemar ,  NGUYEN, Tuan, Anh ,  KASTHURIRANGAN, Sanjeev

Inventor： PORTNEY, Valdemar ,  NGUYEN, Tuan, Anh ,  KASTHURIRANGAN, Sanjeev

IPC: A61F2/16

CPC classification number: A61F2/1648 ,  A61F2/1613 ,  A61F2/1629

Abstract: An intraocular lens (100A) can comprise first and second viewing elements ( 106. 1 18). At least one of the viewing elements can comprise an optic having an anterior surface and a posterior surface. The anterior surface can comprise an aspheric region (164) having increased longitudinal aberration as compared to a spherical lens (100) to increase depth of focus. Alternatively, the aspheric region (164) can be located on the posterior surface of the optic, or both the anterior surface and the posterior surface can comprise aspheric regions.

Abstract translation: 眼内透镜（100A）可以包括第一和第二观察元件（106.188）。 至少一个观察元件可以包括具有前表面和后表面的光学元件。 与球面透镜（100）相比，前表面可以包括具有增加的纵向像差的非球面区域（164），以增加焦深。 或者，非球面区域（164）可以位于光学元件的后表面上，或者前表面和后表面都可以包括非球面区域。

公开(公告)号：WO2007016533A2

公开(公告)日：2007-02-08

申请号：PCT/US2006029852

申请日：2006-07-31

Applicant: VISIOGEN INC ,  NGUYEN TUAN ANH ,  ZADNO-AZIZI GHOLAM-REZA ,  EVANS SCOTT ,  PORTNEY VALDEMAR

Inventor： NGUYEN TUAN ANH ,  ZADNO-AZIZI GHOLAM-REZA ,  EVANS SCOTT ,  PORTNEY VALDEMAR

IPC: A61F2/16

CPC classification number: A61F2/1613 ,  A61F2/1627 ,  A61F2/1629 ,  A61F2/1632 ,  A61F2/1648

Abstract: An accommodating intraocular lens implantable in an eye. The lens comprises an anterior portion having an anterior biasing element and an anterior optic having refractive power. The lens further comprises a posterior portion having a posterior biasing element and a posterior optic having refractive power. The anterior optic and the posterior optic are relatively moveable in response to action of the ciliary muscle to change the separation between the optics and the refractive power of the lens. The lens has an aberration-inducing force characteristic of about 70 mg to about 115 mg to allow aberration-inducing relative movement of the optics when the lens is in the eye, thereby adding optical aberration to the lens which increases depth of focus of the lens. In one variation, the lens has an aberration-inducing force characteristic of 70 mg to 115 mg. Related methods are also disclosed.

Abstract translation: 可植入眼睛的适应性眼内透镜。 透镜包括具有前偏压元件的前部和具有屈光力的前光学元件。 透镜还包括具有后偏置元件的后部部分和具有屈光力的后视镜。 前视神经和后视镜相对于睫状肌的作用相对移动以改变光学元件与透镜的屈光力之间的分离。 透镜具有约70mg至约115mg的像差诱导力特征，以允许当透镜在眼睛中时像差引起的光学元件的相对运动，从而增加透镜的光学像差，从而增加透镜的焦深的光学像差 。 在一个变型中，透镜具有70mg至115mg的像差诱导力特征。 还公开了相关方法。

公开(公告)号：WO2004073560A3

公开(公告)日：2004-09-02

申请号：PCT/US2004/004033

申请日：2004-02-11

Applicant: VISIOGEN INC. ,  AYTON, Ian ,  EVANS, Scott ,  NGUYEN, Tuan

Inventor： EVANS, Scott ,  NGUYEN, Tuan

IPC: A61F2/16

Abstract: Disclosed is an apparatus for compacting an intraocular lens. The apparatus comprises a lens compactor having a first configuration for retaining the intraocular lens in an unstressed condition and a second configuration in which the compactor stresses the lens into an at least partially compacted condition without advancing the lens along an injection axis of the compactor. The compactor accomplishes this by applying a compacting force in a direction generally orthogonal to the optical axis of the lens. The compactor is responsive to a compactor actuator that is movable by a user to change the compactor from the first configuration to the second configuration. Additional apparatus and methods are disclosed as well.

公开(公告)号：WO2010048096A1

公开(公告)日：2010-04-29

申请号：PCT/US2009/061194

申请日：2009-10-19

Applicant: VISIOGEN, INC. ,  TSAI, George

Inventor： TSAI, George

IPC: A61F2/16

CPC classification number: A61F2/167

Abstract: An injector (100) for an intraocular lens includes an injector body (104) having a longitudinal axis (A-A). The body includes a first housing (108) configured to receive the lens and a second housing (112) configured to move relative to the first housing (108) in the direction of the longitudinal axis (A-A). The injector (100) also includes a lens engagement surface configured to engage a first, but not a second, viewing element of the lens. The injector (100) includes opposing lens compaction members configured to move from a first position in which the lens compaction surfaces are spaced from each other to a second position in which the lens compaction surfaces are closer to each other and in which a lens positioned therebetween is compacted. A retention member is configured to apply a longitudinal retention force on the lens compaction members to retain the compaction members in the second position.

Abstract translation: 用于眼内透镜的注射器（100）包括具有纵向轴线（A-A）的注射器主体（104）。 主体包括构造成容纳透镜的第一壳体（108）和被配置为在纵向轴线（A-A）的方向上相对于第一壳体（108）移动的第二壳体（112）。 注射器（100）还包括被配置为接合透镜的第一但不是第二观察元件的透镜接合表面。 注射器（100）包括相对的透镜压实构件，其被配置为从透镜压实表面彼此间隔开的第一位置移动到第二位置，在第二位置，透镜压实表面彼此更靠近，并且其中位于其间的透镜 被压实。 保持构件被构造成将纵向保持力施加在透镜压实构件上以将压实构件保持在第二位置。

公开(公告)号：WO2008067416A2

公开(公告)日：2008-06-05

申请号：PCT/US2007/085813

申请日：2007-11-28

Applicant: VISIOGEN, INC. ,  TSAI, George ,  NGUYEN, Phu

Inventor： TSAI, George ,  NGUYEN, Phu

IPC: A61F2/16

CPC classification number: A61F2/1678 ,  A61F2/1648 ,  A61F2002/1683

Abstract: Disclosed are apparatus for delivering an accommodating intraocular lens to an eye. One apparatus includes an injector with a longitudinal injection passage that has a longitudinal injection axis. The apparatus also includes an accommodating intraocular lens having two interconnected viewing elements. The injector has a member for moving the lens into the injection passage of the apparatus. The accommodating intraocular lens has a longitudinal bisection axis and is initially disposed within the injector with the longitudinal bisection axis at an angle which is non-parallel and non-perpendicular to the injection axis. Additional apparatus and methods are disclosed as well.

Abstract translation: 公开了用于将适应性眼内透镜输送到眼睛的装置。 一种装置包括具有纵向注射通道的注射器，其具有纵向注射轴线。 该装置还包括具有两个互连的观察元件的适应性眼内透镜。 注射器具有用于将透镜移动到装置的注射通道中的构件。 适应性眼内透镜具有纵向二等分轴线，并且最初设置在注射器内，其中纵向二等轴线以不平行且不垂直于注射轴线的角度。 公开了另外的装置和方法。

公开(公告)号：WO2007019389A1

公开(公告)日：2007-02-15

申请号：PCT/US2006/030606

申请日：2006-08-07

Applicant: VISIOGEN, INC. ,  PORTNEY, Valdemar

Inventor： PORTNEY, Valdemar

IPC: A61F2/16

CPC classification number: A61F2/1654 ,  A61F2/1635

Abstract: One disclosed embodiment of an intraocular implant includes a lens body. The lens body comprises a diffractive optical surface (115) having diffractive properties which produce an interference pattern. The lens body is sized and shaped for placement in an anterior portion of a human eye. The lens body is sufficiently flexible to change the shape of the diffractive optical surface in response to ciliary muscle (60) action so that the interference pattern is modified.

Abstract translation: 眼内植入物的一个公开实施例包括透镜体。 透镜体包括具有产生干涉图案的衍射特性的衍射光学表面（115）。 透镜体的尺寸和形状适于放置在人眼的前部。 透镜体具有足够的柔性，以响应于睫状肌（60）的作用改变衍射光学表面的形状，使得干涉图案被修改。

公开(公告)号：WO2005074838B1

公开(公告)日：2006-05-18

申请号：PCT/US2005002871

申请日：2005-02-01

Applicant: VISIOGEN INC ,  TSAI GEORGE

Inventor： TSAI GEORGE

IPC: A61F2/16

CPC classification number: A61F2/1678 ,  A61F2/1648 ,  A61F2/1662 ,  A61F2/167

Abstract: Disclosed is an injector (100) which comprises an injector housing (102) having a longitudinal axis (A-A) and an injection probe disposed along the longitudinal axis. The injector further comprises an intraocular lens (200) disposed in the housing. The intraocular lens comprises first and second interconnected viewing elements (202, 204), and the optical axes of the first and second viewing elements are substantially aligned. The optical axes are substantially orthogonal to the longitudinal axis of the housing. The injector further comprises a lens carrier (104) which engages one of the viewing elements. The viewing elements are moveable in response to longitudinal movement of the lens carrier relative to the injector housing. The longitudinal movement causes both (i) the optical axes to be displaced relative to each other and (ii) the viewing elements to be disposed substantially on the longitudinal axis of the injector housing.

Abstract translation: 公开了一种喷射器（100），其包括具有纵向轴线（A-A）和沿纵向轴线设置的喷射探针的喷射器壳体（102）。 注射器还包括设置在壳体中的眼内透镜（200）。 眼内透镜包括第一和第二互连的观察元件（202,204），并且第一和第二观察元件的光轴基本对准。 光轴基本上垂直于壳体的纵向轴线。 喷射器还包括接合其中一个观察元件的透镜托架（104）。 响应于透镜支架相对于注射器壳体的纵向移动，观察元件可移动。 纵向移动导致（i）光轴相对于彼此移位，并且（ii）观察元件基本上设置在注射器壳体的纵向轴线上。