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1.发明申请NOVEL COMPOUNDS DERIVED FROM TAURINE, PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE 审中-公开从TAURINE衍生的新化合物，其制备方法和含有这些化合物的药物组合物
公开(公告)号：WO2009124371A3
公开(公告)日：2010-02-18
申请号：PCT/BR2009000097
申请日：2009-04-09
申请人： EMS SA , UNIV ESTADUAL PAULISTA JULIO D , VIZIOLI EDNIR DE OLIVEIRA , CHIN CHUNG MAN , MENEGON RENATO FARINA , BLAU LORENA , SANTOS JEAN LEANDRO DOS , LONGO MARIA DO CARMO
发明人： VIZIOLI EDNIR DE OLIVEIRA , CHIN CHUNG MAN , MENEGON RENATO FARINA , BLAU LORENA , SANTOS JEAN LEANDRO DOS , LONGO MARIA DO CARMO
IPC分类号： C07C309/14 , A61K31/10
CPC分类号： A61K31/404 , A61K31/185 , A61K45/06 , C07C303/22 , C07C309/15 , C07C317/44 , C07C2601/14 , C07C2602/08 , C07D207/20 , C07D207/333 , C07D207/337 , C07D209/12 , C07D209/26 , C07D209/46 , C07D209/60 , C07D209/88 , C07D213/30 , C07D231/12 , C07D231/36 , C07D231/56 , C07D263/32 , C07D263/57 , C07D277/24 , C07D277/30 , C07D333/22 , C07D333/24 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by means of an amide bond or through an spacing group, to a compound selected from the group of non-steroidal anti inflammatory compounds, cited as derived from taurine presenting the Formula (I): in which R means the component with non-steroidal anti inflammatory activity. In a second embodiment, the invention provides a process for obtaining the compounds of Formula (I) by reaction of taurine with a compound belonging to the group of non-steroidal anti inflammatory (NSAIs), in order to obtain a compound derived from taurine by direct bond or through a spacing group of the taurine to the NSAI. The invention also relates to the pharmaceutical compositions comprising at least one compound derived from taurine presenting non-steroidal anti inflammatory activity.
摘要翻译： 本发明涉及具有非甾体抗炎活性的衍生自牛磺酸的化合物。 在第一个实施方案中，本发明涉及衍生自牛磺酸的化合物，其中牛磺酸通过酰胺键或通过间隔基团直接结合至选自非甾族抗炎化合物的化合物，引用为 衍生自呈现式（I）的牛磺酸：其中R表示具有非甾体抗炎活性的组分。 在第二个实施方案中，本发明提供了通过牛磺酸与属于非甾体抗炎剂（NSAI）的化合物的反应获得式（I）化合物的方法，以便通过以下方法获得衍生自牛磺酸的化合物： 直接结合或通过牛磺酸的间隔组与NSAI。 本发明还涉及包含至少一种衍生自呈现非甾体抗炎活性的牛磺酸的化合物的药物组合物。
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2.发明申请NOVEL COMPOUNDS DERIVED FROM TAURINE, PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE 审中-公开从TAURINE衍生的新化合物，其制备方法和含有这些化合物的药物组合物
公开(公告)号：WO2009124371A2
公开(公告)日：2009-10-15
申请号：PCT/BR2009000097
申请日：2009-04-09
申请人： EMS SA , UNIV ESTADUAL PAULISTA JULIO D , VIZIOLI EDNIR DE OLIVEIRA , CHIN CHUNG MAN , MENEGON RENATO FARINA , BLAU LORENA , SANTOS JEAN LEANDRO DOS , LONGO MARIA DO CARMO
发明人： VIZIOLI EDNIR DE OLIVEIRA , CHIN CHUNG MAN , MENEGON RENATO FARINA , BLAU LORENA , SANTOS JEAN LEANDRO DOS , LONGO MARIA DO CARMO
IPC分类号： C07C309/14 , A61K31/10
CPC分类号： A61K31/404 , A61K31/185 , A61K45/06 , C07C303/22 , C07C309/15 , C07C317/44 , C07C2601/14 , C07C2602/08 , C07D207/20 , C07D207/333 , C07D207/337 , C07D209/12 , C07D209/26 , C07D209/46 , C07D209/60 , C07D209/88 , C07D213/30 , C07D231/12 , C07D231/36 , C07D231/56 , C07D263/32 , C07D263/57 , C07D277/24 , C07D277/30 , C07D333/22 , C07D333/24 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by means of an amide bond or through an spacing group, to a compound selected from the group of non-steroidal anti inflammatory compounds, cited as derived from taurine presenting the Formula (I): in which R means the component with non-steroidal anti inflammatory activity. In a second embodiment, the invention provides a process for obtaining the compounds of Formula (I) by reaction of taurine with a compound belonging to the group of non-steroidal anti inflammatory (NSAIs), in order to obtain a compound derived from taurine by direct bond or through a spacing group of the taurine to the NSAI. The invention also relates to the pharmaceutical compositions comprising at least one compound derived from taurine presenting non-steroidal anti inflammatory activity.
摘要翻译： 本发明涉及具有非甾体抗炎活性的衍生自牛磺酸的化合物。 在第一个实施方案中，本发明涉及衍生自牛磺酸的化合物，其中牛磺酸通过酰胺键或通过间隔基团直接结合至选自非甾族抗炎化合物的化合物，引用为 衍生自呈现式（I）的牛磺酸：其中R表示具有非甾体抗炎活性的组分。 在第二个实施方案中，本发明提供了通过牛磺酸与属于非甾体抗炎剂（NSAI）的化合物的反应获得式（I）的化合物的方法，以便通过以下方法获得衍生自牛磺酸的化合物： 直接结合或通过牛磺酸与NSAI的间隔组。 本发明还涉及包含至少一种衍生自呈现非甾体抗炎活性的牛磺酸的化合物的药物组合物。
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公开(公告)号：WO2010115252A9
公开(公告)日：2010-10-14
申请号：PCT/BR2010/000099
申请日：2010-04-07
申请人： EMS S.A. , Universidade Estadual Paulista Julio de Mesquita Filho - UNESP , SANTOS, Jean Leandro dos Santos , VIZIOLI, Ednir de Oliveira , CHIN, Chung Man , MENEGON, Renato Farina , BLAU, Lorena
发明人： SANTOS, Jean Leandro dos Santos , VIZIOLI, Ednir de Oliveira , CHIN, Chung Man , MENEGON, Renato Farina , BLAU, Lorena
IPC分类号： C07D209/48 , C07D209/28 , C07C229/42 , C07C229/40 , C07C57/40 , C07C65/10 , C07C65/34 , C07C209/28 , C07C245/08 , A61K31/4035 , A61K31/196 , A61K31/192 , A61K31/60 , A61K31/405 , A61K31/655 , A61K31/635 , A61P29/00 , A61P7/02
摘要： A presente invenção se refere a derivados ftalimídicos de compostos antiinflamatórios não-esteróides e/ou moduladores de TNF-α, bem como a um processo de obtenção de ditos derivados, as composições farmacêuticas contendo tais derivados e seus usos, incluindo o uso no tratamento de doenças inflamatórias, principalmente aquelas relacionadas a processos inflamatórios crônicos como artrite reumatóide e doenças inflamatórias intestinais (por exemplo, doença de Crohn) e utilização de ditas composições como medicamentos antipiréticos, analgésicos e anti-agregantes plaquetários.
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4.发明申请PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF-a MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开非甾体抗炎化合物和/或TNF-α调节剂的邻苯二甲酰衍生物，其制备方法，含有该组合物的药物组合物及其用于治疗炎症性疾病的用途
公开(公告)号：WO2010115252A1
公开(公告)日：2010-10-14
申请号：PCT/BR2010000099
申请日：2010-04-07
申请人： EMS SA , UNIV ESTADUAL PAULISTA JULIO D , SANTOS JEAN LEANDRO DOS SANTOS , VIZIOLI EDNIR DE OLIVEIRA , CHIN CHUNG MAN , MENEGON RENATO FARINA , BLAU LORENA
发明人： SANTOS JEAN LEANDRO DOS SANTOS , VIZIOLI EDNIR DE OLIVEIRA , CHIN CHUNG MAN , MENEGON RENATO FARINA , BLAU LORENA
IPC分类号： C07D209/48 , A61K31/192 , A61K31/196 , A61K31/4035 , A61K31/405 , A61K31/60 , A61K31/635 , A61K31/655 , A61P7/02 , A61P29/00 , C07C57/40 , C07C65/10 , C07C65/34 , C07C209/28 , C07C229/40 , C07C229/42 , C07C245/08 , C07D209/28
CPC分类号： C07D209/28 , C07D209/48
摘要： The present invention relates to phthalimide derivatives of non-steroidal anti-inflammatory compounds and/or TNF-a modulators, to a method for producing these derivatives, to pharmaceutical compositions containing these derivatives, and to uses thereof, including the use for the treatment of inflammatory diseases, in particular those associated with chronic inflammatory conditions, such as rheumatoid arthritis, and inflammatory intestinal diseases (such as Crohn's disease), and to the use of these compositions as antipyretics, analgesics and platelet aggregation inhibitors.
摘要翻译： 本发明涉及非甾体抗炎化合物和/或TNF-α调节剂的邻苯二甲酰亚胺衍生物，涉及制备这些衍生物的方法，含有这些衍生物的药物组合物及其应用，包括用于治疗 炎性疾病，特别是与慢性炎性病症如类风湿性关节炎和炎性肠病（如克罗恩病）相关的疾病，以及这些组合物用作解热药，镇痛药和血小板聚集抑制剂。
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5.发明申请
公开(公告)号：WO2009124371A9
公开(公告)日：2009-10-15
申请号：PCT/BR2009/000097
申请日：2009-04-09
申请人： EMS S. A. , UNIVERSIDADE ESTADUAL PAULISTA JULIO DE MESQUITA FILHO - UNESP , VIZIOLI , Ednir de Oliveira , CHIN, Chung Man , MENEGON, Renato Farina , BLAU, Lorena , SANTOS, Jean Leandro dos , LONGO, Maria do Carmo
发明人： VIZIOLI , Ednir de Oliveira , CHIN, Chung Man , MENEGON, Renato Farina , BLAU, Lorena , SANTOS, Jean Leandro dos , LONGO, Maria do Carmo
IPC分类号： C07C309/14 , A61K31/10
摘要： The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by means of an amide bond or through an spacing group, to a compound selected from the group of non-steroidal anti inflammatory compounds, cited as derived from taurine presenting the Formula (I): in which R means the component with non-steroidal anti inflammatory activity. In a second embodiment, the invention provides a process for obtaining the compounds of Formula (I) by reaction of taurine with a compound belonging to the group of non-steroidal anti inflammatory (NSAIs), in order to obtain a compound derived from taurine by direct bond or through a spacing group of the taurine to the NSAI. The invention also relates to the pharmaceutical compositions comprising at least one compound derived from taurine presenting non-steroidal anti inflammatory activity.
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