公开(公告)号：WO2013016148A3

公开(公告)日：2013-03-21

申请号：PCT/US2012047492

申请日：2012-07-19

Applicant: MEDTRONIC INC ,  VAN ANTWERP WILLIAM ,  JUDD DIANNE ,  WALSH ANDREW ,  LUO LIAN

Inventor： VAN ANTWERP WILLIAM ,  JUDD DIANNE ,  WALSH ANDREW ,  LUO LIAN

IPC: A61K38/22 ,  A61P9/00 ,  C07K14/575

CPC classification number: C07K14/58 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/2242 ,  A61K47/02 ,  A61K47/10

Abstract: Therapeutic compositions containing natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing natriuretic peptides are further described.

Abstract translation: 描述了含有利尿钠肽的治疗组合物用于单独治疗慢性肾病，单独心力衰竭或伴有心力衰竭的慢性肾病。 治疗组合物具有增强的稳定性特征，以便于在高温和机械应力条件下通过供应设备进行储存和输送。 进一步描述了增加含利尿钠肽的治疗组合物稳定性的方法。

公开(公告)号：WO2012115772A3

公开(公告)日：2013-01-10

申请号：PCT/US2012024207

申请日：2012-02-07

Applicant: MEDTRONIC INC ,  VAN ANTWERP WILLIAM ,  WALSH ANDREW J L ,  MANDA VENKATESH R ,  BURNES JOHN

Inventor： VAN ANTWERP WILLIAM ,  WALSH ANDREW J L ,  MANDA VENKATESH R ,  BURNES JOHN

IPC: A61K9/08 ,  A61K38/22

CPC classification number: A61K38/2242 ,  A61K9/0019 ,  A61K47/18 ,  A61M5/14228 ,  A61M5/14276

Abstract: Medical systems and methods for treating kidney disease alone, heart failure alone, chronic kidney disease with concomitant heart failure, or cardiorenal syndrome are described. The systems and methods are based on delivery of a natriuretic peptide such as Vessel Dilator to a subject. Methods for increasing and maintaining peptide levels at a certain concentration include direct peptide delivery via either an external or implantable programmable pump.

Abstract translation: 描述单独治疗肾脏疾病，单独心力衰竭，伴有心力衰竭的慢性肾脏疾病或心脏肾综合征的医疗系统和方法。 系统和方法基于将利钠肽如血管释放器递送至受试者。 在一定浓度下增加和维持肽水平的方法包括通过外部或可植入的可编程泵的直接肽递送。

公开(公告)号：WO2012035017A1

公开(公告)日：2012-03-22

申请号：PCT/EP2011/065860

申请日：2011-09-13

Applicant: F. HOFFMANN-LA ROCHE AG ,  HARNETT, Gerard, John ,  HAYES, John ,  REENTS, Reinhard ,  SMITH, Dennis, A. ,  WALSH, Andrew

Inventor： HARNETT, Gerard, John ,  HAYES, John ,  REENTS, Reinhard ,  SMITH, Dennis, A. ,  WALSH, Andrew

IPC: C07C253/30 ,  C07C51/06 ,  C07C51/08 ,  C07C51/60 ,  C07C61/08 ,  C07C319/06 ,  C07C319/22 ,  C07C327/06 ,  C07C255/46 ,  C07C321/28

CPC classification number: C07C253/30 ,  C07C51/06 ,  C07C51/08 ,  C07C51/60 ,  C07C231/02 ,  C07C231/06 ,  C07C231/12 ,  C07C319/06 ,  C07C319/22 ,  C07C327/30 ,  C07C2601/14 ,  C07C255/46 ,  C07C323/40 ,  C07C61/08

Abstract: A process for the preparation of a compound of formula (I) which are useful as intermediates in the preparation of pharmaceutically active compounds.

Abstract translation: 一种制备式（I）化合物的方法，其可用作制备药学活性化合物的中间体。

公开(公告)号：WO2011139594A3

公开(公告)日：2011-12-29

申请号：PCT/US2011033540

申请日：2011-04-22

Applicant: MEDTRONIC INC ,  YUNKER LAURIE ,  LOWENTHAL WALSH ANDREW JAMES

Inventor： YUNKER LAURIE ,  LOWENTHAL WALSH ANDREW JAMES

IPC: A61M5/142 ,  A61K9/00

CPC classification number: A61M5/14276 ,  A61K9/0024 ,  A61M2210/08

Abstract: The invention describes methods and devices for treating a tissue within a synovial joint in a patient in need of such treatment. The methods and devices involve inserting a drug delivery device through the synovial joint and anchoring the drug delivery device within the synovial joint capsule so that the drug delivery device does not substantially interfere with movement of the joint. The drug delivery device comprises a deformable polymeric delivery device having a reservoir portion and a dispensing portion extending from the reservoir portion and at least one pharmaceutical agent contained within the drug delivery device.

Abstract translation: 本发明描述了用于治疗需要这种治疗的患者中滑膜关节内的组织的方法和装置。 所述方法和装置包括通过滑膜关节插入药物递送装置并将药物递送装置锚定在滑膜关节囊内，使得药物递送装置基本上不干扰关节的移动。 药物递送装置包括可变形聚合物递送装置，其具有储存部分和从储存部分延伸的分配部分和包含在药物递送装置内的至少一种药剂。

公开(公告)号：WO2006077408A1

公开(公告)日：2006-07-27

申请号：PCT/GB2006/000183

申请日：2006-01-19

Applicant: WALSH, Andrew, David

Inventor： WALSH, Andrew, David

IPC: H05B39/02

CPC classification number: H05B39/02

Abstract: A wall switch (2) or ceiling rose for supplying electric current to at least on filament-containing light bulb, the wall switch (2) or ceiling rose comprising resistor means (8) which is wired to the wall switch (2) or ceiling rose, and the resistor means (8) having a resistance which is less than the start-up resistance of the light bulb whereby in use the resistor means (8) reduces the start-up or inrush current to the light bulb and thereby increases the life of the light bulb.

Abstract translation: 墙壁开关（2）或天花板上升，用于至少在含有灯丝的灯泡上提供电流，壁开关（2）或天花板玫瑰包括电阻装置（8），其连接到壁开关（2）或天花板 并且电阻器装置（8）的电阻小于灯泡的启动电阻，由此在使用中，电阻器装置（8）减小了对灯泡的启动或浪涌电流，从而增加了 灯泡的寿命。

公开(公告)号：WO2005025624A3

公开(公告)日：2005-05-26

申请号：PCT/EP2004010308

申请日：2004-09-15

Applicant: CENIX BIOSCIENCE GMBH ,  ECHEVERRI CHRISTOPHE ,  HYMAN ANTHONY ,  GOENCZY PIERRE ,  SOENNICHSEN BIRTE ,  JONES STEVEN ,  WALSH ANDREW ,  KOSKI LIISA

Inventor： ECHEVERRI CHRISTOPHE ,  HYMAN ANTHONY ,  GOENCZY PIERRE ,  SOENNICHSEN BIRTE ,  JONES STEVEN ,  WALSH ANDREW ,  KOSKI LIISA

IPC: A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/435 ,  C07K14/47 ,  C12N15/113 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/17 ,  A61K39/395 ,  C07K14/395 ,  C12N15/11 ,  C12N15/12 ,  C12N15/31 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53

CPC classification number: C12N15/113 ,  A61K38/17 ,  A61K39/00 ,  A61K48/00 ,  C07K14/43545 ,  C07K14/43581 ,  C07K14/4738 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/6893 ,  G01N2500/00

Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

Abstract translation: 本发明涉及几种秀丽隐杆线虫基因及其相应基因产物在细胞分裂期间细胞周期进程中的重要功能作用，可通过RNA介导的干扰（RNAi）鉴定和鉴定和分离功能 所述基因的直系同源物包括其所有生物功能衍生物。 本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们用于诊断和治疗增殖性和其它疾病的用途。 特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

公开(公告)号：WO2013033675A1

公开(公告)日：2013-03-07

申请号：PCT/US2012/053578

申请日：2012-09-02

Applicant: MEDTRONIC, INC. ,  NILE THERAPEUTICS, INC. ,  VAN ANTWERP, William ,  WALSH, Andrew, J.L. ,  LUO, Lian ,  JUDD, Dianne, L.

Inventor： VAN ANTWERP, William ,  WALSH, Andrew, J.L. ,  LUO, Lian ,  JUDD, Dianne, L.

IPC: A61K38/22 ,  C07K14/58 ,  A61P3/00

CPC classification number: A61K38/2242 ,  A61K9/0019 ,  A61K9/08 ,  A61K38/22 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  C07K14/58 ,  C07K2319/00

Abstract: Therapeutic compositions containing chimeric natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing chimeric natriuretic peptides are further described.

Abstract translation: 描述了含有用于单独治疗慢性肾脏疾病，单独心力衰竭或伴有心力衰竭的慢性肾脏疾病的嵌合利尿钠肽的治疗组合物。 治疗组合物具有增强的稳定性特征，以便在高温和机械应力的条件下通过供应装置的储存和递送。 进一步描述了增加含有嵌合利钠肽的治疗组合物的稳定性的方法。

公开(公告)号：WO2013016148A2

公开(公告)日：2013-01-31

申请号：PCT/US2012/047492

申请日：2012-07-19

Applicant: MEDTRONIC, INC. ,  VAN ANTWERP, William ,  JUDD, Dianne ,  WALSH, Andrew ,  LUO, Lian

Inventor： VAN ANTWERP, William ,  JUDD, Dianne ,  WALSH, Andrew ,  LUO, Lian

IPC: A61K38/22 ,  C07K14/575 ,  A61P9/00

CPC classification number: C07K14/58 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/2242 ,  A61K47/02 ,  A61K47/10

Abstract: Therapeutic compositions containing natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing natriuretic peptides are further described.

Abstract translation: 描述了含有用于单独治疗慢性肾脏疾病，单独心力衰竭或伴有心力衰竭的慢性肾脏疾病的利尿钠肽的治疗组合物。 治疗组合物具有增强的稳定性特征，以便在高温和机械应力的条件下通过供应装置的储存和递送。 进一步描述了增加含利钠肽的治疗组合物的稳定性的方法。

公开(公告)号：WO2013007712A1

公开(公告)日：2013-01-17

申请号：PCT/EP2012/063455

申请日：2012-07-10

Applicant: F. HOFFMANN-LA ROCHE AG ,  BIRRER, Beat ,  CLARKE, Leo ,  DEICHTMANN, Walter ,  HAYES, John ,  JEISY, Julius ,  LAUTZ, Christian ,  MARTIN, Rainer E. ,  MEADE, Michael ,  PINTAO, Joaquim ,  SCALONE, Michelangelo ,  SCHAEFER, Juergen ,  SMITH, Dennis ,  STAEMPFLI, Andreas ,  VEITS, Joachim ,  WALCH, Christian ,  WALSH, Andrew ,  ZOGG, Andreas

Inventor： BIRRER, Beat ,  CLARKE, Leo ,  DEICHTMANN, Walter ,  HAYES, John ,  JEISY, Julius ,  LAUTZ, Christian ,  MARTIN, Rainer E. ,  MEADE, Michael ,  PINTAO, Joaquim ,  SCALONE, Michelangelo ,  SCHAEFER, Juergen ,  SMITH, Dennis ,  STAEMPFLI, Andreas ,  VEITS, Joachim ,  WALCH, Christian ,  WALSH, Andrew ,  ZOGG, Andreas

IPC: C07C327/30 ,  C07C51/06 ,  C07C51/08 ,  C07C61/08 ,  C07C319/06 ,  C07C319/20

CPC classification number: C07C319/20 ,  C07C51/02 ,  C07C51/06 ,  C07C51/08 ,  C07C319/06 ,  C07C327/30 ,  C07C2601/14 ,  C07C323/40 ,  C07C61/08

Abstract: A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.

Abstract translation: 制备式（I）化合物的方法：其可用作制备中间体。 药物活性化合物。

公开(公告)号：WO2007146616A3

公开(公告)日：2008-04-10

申请号：PCT/US2007070174

申请日：2007-06-01

Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F ,  GROSS JEFFREY M ,  TRIEU HAI H ,  ROY JOSEE ,  DRAPEAU SUSAN J ,  SCHENDEL MICHAEL J ,  WALSH ANDREW J L

Inventor： MCKAY WILLIAM F ,  GROSS JEFFREY M ,  TRIEU HAI H ,  ROY JOSEE ,  DRAPEAU SUSAN J ,  SCHENDEL MICHAEL J ,  WALSH ANDREW J L

IPC: A61B5/00 ,  A61B5/03 ,  A61B5/06 ,  A61B17/00 ,  A61B17/56 ,  C12Q1/00 ,  G01N33/94

CPC classification number: A61B5/14546 ,  A61B5/0031 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/032 ,  A61B5/14539 ,  A61B5/4514 ,  A61B5/4561 ,  A61B5/4824 ,  A61B5/4896 ,  A61B5/6848 ,  G01N33/54366 ,  G01N33/6896 ,  G01N2800/2842

Abstract: The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.

Abstract translation: 本发明提供了用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的装置和相关方法和组合，以及用于筛选潜在地可用于治疗或不发生神经根病变的轴向疼痛的测试化合物的方法。 或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。 退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。