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    QUANTIFICATION OF OPTICAL ABSORPTION COEFFICIENTS USING ACOUSTIC SPECTRA IN PHOTOACOUSTIC TOMOGRAPHY
    1.
    发明申请
    QUANTIFICATION OF OPTICAL ABSORPTION COEFFICIENTS USING ACOUSTIC SPECTRA IN PHOTOACOUSTIC TOMOGRAPHY 审中-公开
    光学吸收光谱吸收光谱数据的量化

    公开(公告)号：WO2011127428A2

    公开(公告)日：2011-10-13

    申请号：PCT/US2011/031823

    申请日：2011-04-08

    Applicant: WASHINGTON UNIVERSITY ,  GUO, Zijian ,  WANG, Lihong

    Inventor： GUO, Zijian ,  WANG, Lihong

    IPC: G01N21/31 ,  G01N21/27 ,  G01N29/46

    CPC classification number: A61B5/0095 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/417 ,  A61B5/7257 ,  A61B8/13 ,  A61B8/5215 ,  A61B2576/00 ,  G01N21/1702

    Abstract: Accurately quantifying optical absorption coefficient using acoustic spectra of photoacoustic signals. Optical absorption is closely associated with many physiological parameters, such as the concentration and oxygen saturation of hemoglobin, and it can be used to quantify the concentrations of non-fluorescent molecules. A sample is illuminated by, for example, a pulsed laser and following the absorption of optical energy, a photoacoustic pressure is generated via thermo-elastic expansion. The acoustic waves then propagate and are detected by a transducer. The optical absorption coefficient of the sample is quantified from spectra of the measured photoacoustic signals. Factors, such as system bandwidth and acoustic attenuation, may affect the quantification but are canceled by dividing the acoustic spectra measured at multiple optical wavelengths.

    Abstract translation: 使用光声信号的声谱精确量化光吸收系数。 光吸收与许多生理参数密切相关，如血红蛋白的浓度和氧饱和度，可用于量化非荧光分子的浓度。 样品通过例如脉冲激光照射，并且随着光能的吸收，通过热弹性膨胀产生光声压力。 然后声波传播并由换能器检测。 样品的光吸收系数由测量的光声信号的光谱量化。 诸如系统带宽和声衰减的因素可能影响量化，但是通过除以在多个光波长处测量的声谱被抵消。

    QUANTIFICATION OF OPTICAL ABSORPTION COEFFICIENTS USING ACOUSTIC SPECTRA IN PHOTOACOUSTIC TOMOGRAPHY
    3.
    发明申请
    QUANTIFICATION OF OPTICAL ABSORPTION COEFFICIENTS USING ACOUSTIC SPECTRA IN PHOTOACOUSTIC TOMOGRAPHY 审中-公开
    光学吸收光谱吸收系数的定量

    公开(公告)号：WO2011127428A3

    公开(公告)日：2012-02-23

    申请号：PCT/US2011031823

    申请日：2011-04-08

    Applicant: UNIV WASHINGTON ,  GUO ZIJIAN ,  WANG LIHONG

    Inventor： GUO ZIJIAN ,  WANG LIHONG

    IPC: G01N21/31 ,  G01N21/27 ,  G01N29/46

    CPC classification number: A61B5/0095 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/417 ,  A61B5/7257 ,  A61B8/13 ,  A61B8/5215 ,  A61B2576/00 ,  G01N21/1702

    Abstract: Accurately quantifying optical absorption coefficient using acoustic spectra of photoacoustic signals. Optical absorption is closely associated with many physiological parameters, such as the concentration and oxygen saturation of hemoglobin, and it can be used to quantify the concentrations of non-fluorescent molecules. A sample is illuminated by, for example, a pulsed laser and following the absorption of optical energy, a photoacoustic pressure is generated via thermo-elastic expansion. The acoustic waves then propagate and are detected by a transducer. The optical absorption coefficient of the sample is quantified from spectra of the measured photoacoustic signals. Factors, such as system bandwidth and acoustic attenuation, may affect the quantification but are canceled by dividing the acoustic spectra measured at multiple optical wavelengths.

    Abstract translation: 使用光声信号的声谱精确地量化光吸收系数。 光吸收与许多生理参数密切相关，如血红蛋白的浓度和氧饱和度，可用于量化非荧光分子的浓度。 样品通过例如脉冲激光照射，并且随着光能的吸收，通过热弹性膨胀产生光声压力。 然后声波传播并由换能器检测。 样品的光吸收系数由所测量的光声信号的光谱量化。 诸如系统带宽和声衰减的因素可能影响量化，但是通过划分在多个光波长处测量的声谱被抵消。

    MINIATURIZED PHOTOACOUSTIC IMAGING APPARATUS INCLUDING A ROTATABLE REFLECTOR
    5.
    发明申请
    MINIATURIZED PHOTOACOUSTIC IMAGING APPARATUS INCLUDING A ROTATABLE REFLECTOR 审中-公开
    微型摄影成像设备，包括可旋转反射器

    公开(公告)号：WO2010080991A2

    公开(公告)日：2010-07-15

    申请号：PCT/US2010/020488

    申请日：2010-01-08

    Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS ,  WANG, Lihong ,  MASLOV, Konstantin ,  YANG, Joon-Mo

    Inventor： WANG, Lihong ,  MASLOV, Konstantin ,  YANG, Joon-Mo

    IPC: A61B1/00

    CPC classification number: A61B5/0095 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/08 ,  A61B5/0873 ,  A61B8/12 ,  A61B8/4461

    Abstract: A reflection-mode photoacoustic endoscope includes a light source configured to emit a light pulse, a signal detection or transmission unit configured to detect or emit an ultrasonic pulse, and a rotatable reflector. The rotatable reflector is configured to reflect at least one of the light pulse and the ultrasonic pulse into a target area of an object, and reflect a response signal to the signal detection unit. The response signal is one of a photoacoustic wave generated by the object responsive to the light pulse and an ultrasonic pulse echo generated by the object responsive to the ultrasonic pulse.

    Abstract translation: 反射型光声内窥镜包括配置为发射光脉冲的光源，被配置为检测或发射超声脉冲的信号检测或发送单元和可旋转反射器。 可旋转反射器被配置为将光脉冲和超声波脉冲中的至少一个反射到物体的目标区域中，并将响应信号反映到信号检测单元。 响应信号是响应于光脉冲的物体产生的光声波和响应于超声波脉冲的物体产生的超声脉冲回波之一。

    MINIATURIZED PHOTOACOUSTIC IMAGING APPARATUS INCLUDING A ROTATABLE REFLECTOR
    8.
    发明申请
    MINIATURIZED PHOTOACOUSTIC IMAGING APPARATUS INCLUDING A ROTATABLE REFLECTOR 审中-公开
    小型化光声成像装置，包括可旋转的反射镜

    公开(公告)号：WO2010080991A3

    公开(公告)日：2010-11-04

    申请号：PCT/US2010020488

    申请日：2010-01-08

    Applicant: UNIV ST LOUIS ,  WANG LIHONG ,  MASLOV KONSTANTIN ,  YANG JOON-MO

    Inventor： WANG LIHONG ,  MASLOV KONSTANTIN ,  YANG JOON-MO

    IPC: A61B1/00

    CPC classification number: A61B5/0095 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/08 ,  A61B8/12 ,  A61B8/4461

    Abstract: A reflection-mode photoacoustic endoscope includes a light source configured to emit a light pulse, a signal detection or transmission unit configured to detect or emit an ultrasonic pulse, and a rotatable reflector. The rotatable reflector is configured to reflect at least one of the light pulse and the ultrasonic pulse into a target area of an object, and reflect a response signal to the signal detection unit. The response signal is one of a photoacoustic wave generated by the object responsive to the light pulse and an ultrasonic pulse echo generated by the object responsive to the ultrasonic pulse.

    Abstract translation: 反射模式光声内窥镜包括被配置为发射光脉冲的光源，被配置为检测或发射超声脉冲的信号检测或发送单元，以及可旋转反射器。 可旋转反射器被配置为将光脉冲和超声脉冲中的至少一个反射到对象的目标区域中，并将响应信号反射到信号检测单元。 响应信号是由响应于光脉冲的物体产生的光声波和响应于超声脉冲的物体产生的超声脉冲回波之一。

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