公开(公告)号：WO2016061517A3

公开(公告)日：2016-06-23

申请号：PCT/US2015056040

申请日：2015-10-16

Applicant: ILLUMINA CAMBRIDGE LTD ,  STEEMERS FRANK J ,  GUNDERSON KEVIN L ,  ZHANG FAN ,  BETLEY JASON RICHARD ,  GORMLEY NIALL ANTHONY ,  MEULEMAN WOUTER ,  WEIR JACQUELINE ,  IOANNOU AVGOUSTA ,  JENKINS GARETH ,  JACKSON ROSAMOND ,  MORRELL NATALIE ,  POKHOLOK DMITRY K ,  NORBERG STEVEN J ,  HE MOLLY ,  KIA AMIRALI ,  GORYSHIN IGOR ,  PANTOJA RIGO

Inventor： STEEMERS FRANK J ,  GUNDERSON KEVIN L ,  ZHANG FAN ,  BETLEY JASON RICHARD ,  GORMLEY NIALL ANTHONY ,  MEULEMAN WOUTER ,  WEIR JACQUELINE ,  IOANNOU AVGOUSTA ,  JENKINS GARETH ,  JACKSON ROSAMOND ,  MORRELL NATALIE ,  POKHOLOK DMITRY K ,  NORBERG STEVEN J ,  HE MOLLY ,  KIA AMIRALI ,  GORYSHIN IGOR ,  PANTOJA RIGO

IPC: C12N15/10

CPC classification number: C12N15/1093 ,  C12N15/1065 ,  C12Q2525/191 ,  C12Q2563/179 ,  C12Q2565/514

Abstract: Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.

Abstract translation: 本文提供的实施方案涉及用于制备靶核酸的条形码DNA片段的固定化文库，鉴定基因组变体，确定目标核酸的邻接信息，定相信息和甲基化状态的方法和组合物。

公开(公告)号：WO2016061517A2

公开(公告)日：2016-04-21

申请号：PCT/US2015/056040

申请日：2015-10-16

Applicant: ILLUMINA CAMBRIDGE LIMITED ,  STEEMERS, Frank J. ,  GUNDERSON, Kevin L. ,  ZHANG, Fan ,  BETLEY, Jason Richard ,  GORMLEY, Niall Anthony ,  MEULEMAN, Wouter ,  WEIR, Jacqueline ,  IOANNOU, Avgousta ,  JENKINS, Gareth ,  JACKSON, Rosamond ,  MORRELL, Natalie ,  POKHOLOK, Dmitry K. ,  NORBERG, Steven J. ,  HE, Molly ,  KIA, Amirali ,  GORYSHIN, Igor ,  PANTOJA, Rigo

Inventor： STEEMERS, Frank J. ,  GUNDERSON, Kevin L. ,  ZHANG, Fan ,  BETLEY, Jason Richard ,  GORMLEY, Niall Anthony ,  MEULEMAN, Wouter ,  WEIR, Jacqueline ,  IOANNOU, Avgousta ,  JENKINS, Gareth ,  JACKSON, Rosamond ,  MORRELL, Natalie ,  POKHOLOK, Dmitry K. ,  NORBERG, Steven J. ,  HE, Molly ,  KIA, Amirali ,  GORYSHIN, Igor ,  PANTOJA, Rigo

IPC: C12N15/10

CPC classification number: C12N15/1093 ,  C12N15/1065 ,  C12Q2525/191 ,  C12Q2563/179 ,  C12Q2565/514

Abstract: Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.

Abstract translation: 本文提供的实施方案涉及用于制备靶核酸的条形码化DNA片段的固定文库，鉴定基因组变体，确定靶核酸的邻接信息，定相信息和甲基化状态的方法和组合物 酸