公开(公告)号：WO2008070537A2

公开(公告)日：2008-06-12

申请号：PCT/US2007/086014

申请日：2007-11-30

申请人： INGENIOUS TARGETING LABORATORY, INC. ,  WENG, Wei ,  ZHU, Liqun

发明人： WENG, Wei ,  ZHU, Liqun

IPC分类号： G06Q10/00

CPC分类号： A43D1/025 ,  A43D3/021

摘要： This invention relates to a system and the methods of making custom footwear. A multi-level customization process is employed in the system of the invention. First, shoe last is customized according to the biometric features of the foot. Secondly, the components of the footwear are fine-tuned through a set of interactive measurements for the wearer' needs, while the appearance of the footwear is custom-designed according to the taste of the wearer. Major components of the custom footwear include: a custom upper that best-fits the shape of wearer's foot; a multi-layered custom insole with its surface conforming to the plantar surface of the foot; and a custom sole that sandwiching a heel pad with custom height. The methods for customOmaking of the footwear include: custom last database construction, reverse-engineering for the 3-D foot model, measurement and analysis for foot features, expert system-guided automatic last look-up for the best- fit last, modification and tune-up on the best- fit last, custom- making of shoe upper using the custom last, custom-making of multi-layered insole according to the plantar surface geometry of the foot, making of custom sole, and the integration of custom upper, insole and sole into final custom footwear. In the preferred embodiment, the custom footwear is made through the following process. First, a custom last database is constructed, which stores the geometric features of custom-designed lasts along multiple dimensions. In the last database, one last table corresponds to a footwear style. A reverse- engineering process is used to acquire a 3-D computer model of the foot. The 3- D model of the foot is further measured and analyzed to extract the 3- dimensional features of the foot. In the foot measurement process, not only the foot geometries along last dimensions are measured, but also the 3-D shape and locations of any foot abnormalities are recorded. Automatic last look-up is then carried out according to the extracted foot features, which iterate the last table of the desired style. In this process, fitting indices of all lasts are computed by fitting algorithms derived from a set of rules from an expert system. The fitting indices show the fitting levels between the last features and those of the foot. A best-fit last is chosen from the last database after sorting all the fitting indices of the lasts. The 3-D shape of the best-fit last may further be tuned up and optimized to accommodate any deformities or irregularities of the wearer' s foot. In certain cases, fully customized last would be manufactured if the look-up process is not able to select a best- fit last. Custom upper of the footwear is then made using the finalized custom last. For the insole, a thermal-plastic forming mould is made by Computer Numerical Controlled (CNC) machining process referring to the 3-D shape of the plantar surface of the foot. A multi-layered plate, comprising a layer of shell material, a layer of cushioning material, and a layer of lining material, is then thermal-plastically-formed and trimmed into the custom insole. A custom sole is made by trimming the outlines of the midsole and outsole according to the contour of the bottom of the custom last, and by sandwiching a custom-made heel-pad between the midsole and outsole. Finally, the custom upper, insole, and sole are integrated into the custom footwear, with the colors, materials and other accessories of the footwear customized according to the wearer's preferences.

摘要翻译： 本发明涉及制造定制鞋类的系统和方法。 在本发明的系统中采用多级定制过程。 首先，鞋子根据脚的生物特征定制。 其次，通过针对佩戴者的需要的一组交互式测量来对鞋类的部件进行微调，而鞋类的外观根据穿着者的口味定制设计。 定制鞋类的主要部件包括：最适合佩戴者脚部形状的定制鞋面; 一种多层定制的鞋垫，其表面符合脚的脚底表面; 和一个定制的鞋底，夹着具有定制高度的脚跟垫。 定制鞋类的方法包括：定制最后一个数据库构建，3-D脚型的逆向工程，脚特征的测量和分析，专家系统引导的自动上次查找，适合最后，修改和 调整最适合的最后，定制鞋面使用定制的最后，定制多层鞋垫根据脚底表面几何形状的脚，制作定制鞋底，并整合定制鞋面 ，鞋垫和鞋底成为最终定制鞋类。 在优选实施例中，通过以下过程制造定制鞋类。 首先，构建一个自定义的最后一个数据库，它存储沿着多个维度定制设计的最后几何的几何特征。 在最后一个数据库中，最后一个表格对应于鞋类样式。 逆向工程过程用于获取脚的3-D计算机模型。 进一步测量和分析脚的三维模型以提取足部的三维特征。 在脚部测量过程中，不仅测量最后尺寸的脚几何形状，还记录了3-D形状和任何脚异常的位置。 然后根据提取的脚特征执行自动的最后查找，该特征迭代所需样式的最后一个表。 在该过程中，通过从专家系统的一组规则得到的拟合算法来计算所有最后的拟合索引。 拟合指数显示了最后一个特征与脚的特征之间的拟合水平。 在最后一个数据库中选择最适合的最后一个数据库，然后排序最后的所有拟合索引。 最佳配合最后的3-D形状可以进一步调整和优化，以适应佩戴者脚的任何畸形或不规则。 在某些情况下，如果查找过程无法选择最适合的最后一个，则将完全定制最后一个。 然后，使用最后定制的鞋面定制鞋面。 对于鞋垫，热塑性成形模具是通过计算机数控（CNC）加工过程制造的，参考脚底的三维形状。 然后将包括一层壳材料，一层缓冲材料和一层衬里材料的多层板热塑性地形成并修整到定制的鞋垫中。 通过根据最后定制底部的轮廓修剪中底和外底的轮廓，并通过在中底和外底之间夹住定制的脚跟垫来制作定制鞋底。 最后，定制鞋面，鞋垫和鞋底整合到定制鞋类中，鞋类的颜色，材料和其他配件根据佩戴者的喜好定制。

公开(公告)号：WO2006044492A3

公开(公告)日：2006-08-31

申请号：PCT/US2005036742

申请日：2005-10-14

申请人： INGENIOUS TARGETING LAB INC ,  HE WEI ,  WENG WEI

发明人： HE WEI ,  WENG WEI

IPC分类号： C12N15/09 ,  C12N5/0735

CPC分类号： C12N5/0606 ,  A01K2217/075 ,  A01K2227/105 ,  C12N2501/155 ,  C12N2501/235 ,  C12N2502/13

摘要： The present invention provides novel methods for isolating rat embryo-derived cells and modifying the genome of the rat cells which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a "targeting DNA); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.

摘要翻译： 本发明提供了分离大鼠胚胎衍生细胞和修饰大鼠细胞基因组的新方法，其通常包括以下步骤：构建其中在DNA片段中包含期望的序列修饰的DNA分子（“靶向DNA”）， ;将靶向DNA构建体引入细胞（例如，通过显微注射，电穿孔，转染或磷酸钙沉淀）;以及通过同源重组选择其中所需的序列修饰已导入基因组的细胞。

公开(公告)号：WO2005074676A1

公开(公告)日：2005-08-18

申请号：PCT/US2005/003027

申请日：2005-01-27

申请人： INGENIOUS TARGETING LABORATORY, INC. ,  HE, Wei ,  WENG, Wei

发明人： HE, Wei ,  WENG, Wei

IPC分类号： A01K67/00

CPC分类号： A01K67/0275 ,  A01K2227/105 ,  C12N15/873 ,  C12N2517/10

摘要： The present invention relates generally to the field of generating genetically modified C57 mice. More particularly, the present invention pertains to 1) blastocyst-derived mouse embryonic stem cell (ES) cell lines including, but not limited to, the IC1, IC2, IAC1, IAC2, IAC3, IAC4, IAC5, IAC6, IAC7 or IAC8 ES cell line, 2) to efficient methods of making genetically modified C57 mice by introducing the modified C57 ES cells into the mouse blastocysts of either the same mouse strain and/or color of albino C57 strain, or other C57 strain, to generate genetically modified novel, useful and hereto unknown models of C57 mice, and to methods for identifying the chimerism of chimeras which can be not known by coat color.

摘要翻译： 本发明一般涉及生产转基因C57小鼠的领域。 更具体地说，本发明涉及1）囊胚衍生的小鼠胚胎干细胞（ES）细胞系，包括但不限于IC1，IC2，IAC1，IAC2，IAC3，IAC4，IAC5，IAC6，IAC7或IAC8 ES 细胞系，2）通过将修饰的C57ES细胞引入与白化C57株或其他C57株相同的小鼠品系和/或颜色的小鼠胚泡中来生产经遗传修饰的C57小鼠的有效方法，以产生转基因小鼠 ，有用的和未知的C57小鼠模型，以及用于鉴定嵌合体的嵌合体的方法，其可以不被外壳颜色所知。

公开(公告)号：WO2007008715A2

公开(公告)日：2007-01-18

申请号：PCT/US2006026602

申请日：2006-07-07

申请人： INGENIOUS TARGETING LAB INC ,  ZHU LIQUN ,  WANG JIANNING ,  WENG WEI ,  SU RONG

发明人： ZHU LIQUN ,  WANG JIANNING ,  WENG WEI ,  SU RONG

IPC分类号： G06T7/20

CPC分类号： G06T7/20 ,  G06K9/00771 ,  G06K9/209

摘要： The present invention relates to a system for the 3-D monitoring and analysis of motion-related behavior of test subjects. The system comprises an actual camera, at least one virtual camera, a computer connected to the actual camera.and the computer is preferably installed with software capable of capturing the stereo images associated with the 3-D motion-related behavior of test subjects as well as processing these acquired image frames for the 3-D motion parameters of the subjects. The system of the invention comprises hardware components as well as software components. The hardware components preferably comprise a hardware setup or configuration, a hardware-based noise elimination component, an automatic calibration device component, and a lab animal container component. The software components preferably comprise a software-based noise elimination component, a basic calibration component, an extended calibration component, a linear epipolar structure derivation component, a non-linear epipolar structure derivation component, an image segmentation component, an image correspondence detection component, a 3-D motion tracking component, a software-based target identification and tagging component, a 3-D reconstruction component, and a data post-processing component. In a particularly preferred embodiment, the actual camera is a digital video camera, the virtual camera is the reflection of the actual camera in a planar reflective mirror. Therefore, the preferred system is a catadioptric stereo computer vision system.

摘要翻译： 本发明涉及一种用于三维监测和分析测试对象运动相关行为的系统。 该系统包括实际相机，至少一个虚拟相机，连接到实际相机的计算机，并且计算机优选地安装有能够捕获与测试对象的3D动作相关行为相关联的立体图像的软件 作为处理这些获取的图像帧用于受试者的3-D运动参数。 本发明的系统包括硬件组件以及软件组件。 硬件组件优选地包括硬件设置或配置，基于硬件的噪声消除组件，自动校准设备组件和实验室动物容器组件。 软件组件优选地包括基于软件的噪声消除组件，基本校准组件，扩展校准组件，线性对极结构导出组件，非线性对极结构导出组件，图像分割组件，图像对应检测组件， 3-D运动跟踪组件，基于软件的目标识别和标记组件，3-D重建组件和数据后处理组件。 在特别优选的实施例中，实际相机是数字摄像机，虚拟相机是实际相机在平面反射镜中的反射。 因此，优选的系统是反折射立体计算机视觉系统。

公开(公告)号：WO2006044492A2

公开(公告)日：2006-04-27

申请号：PCT/US2005/036742

申请日：2005-10-14

申请人： INGENIOUS TARGETING LABORATORY, INC. ,  HE, Wei ,  WENG, Wei

发明人： HE, Wei ,  WENG, Wei

IPC分类号： C12N15/52 ,  C12N5/06

CPC分类号： C12N5/0606 ,  A01K2217/075 ,  A01K2227/105 ,  C12N2501/155 ,  C12N2501/235 ,  C12N2502/13

摘要： The present invention provides novel methods for isolating rat embryo-derived cells and modifying the genome of the rat cells which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a "targeting DNA); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.

摘要翻译： 本发明提供了用于分离大鼠胚胎来源的细胞和修饰大鼠细胞基因组的新方法，其通常包括以下步骤：构建DNA分子，其中期望的序列修饰包含在区段 DNA（“靶向DNA”）; 将靶向DNA构建体导入细胞（例如通过显微注射，电穿孔，转染或磷酸钙沉淀）; 并选择其中通过同源重组将所需序列修饰引入基因组的细胞。

公开(公告)号：WO2008070537A3

公开(公告)日：2008-08-07

申请号：PCT/US2007086014

申请日：2007-11-30

申请人： INGENIOUS TARGETING LAB INC ,  WENG WEI ,  ZHU LIQUN

发明人： WENG WEI ,  ZHU LIQUN

IPC分类号： A43D11/00

CPC分类号： A43D1/025 ,  A43D3/021

摘要： This invention relates to a system and the methods of making custom footwear. A multi-level customization process is employed in the system of the invention. First, shoe last is customized according to the biometric features of the foot.Secondly, the components of the footwear are fine-tuned through a set of interactive measurements for the wearer' needs, while the appearance of the footwear is custom-designed according to the taste of the wearer. Major components of the custom footwear include a custom upper that best-fits the shape of wearer's foot, a multi-layered custom insole with its surface conforming to the plantar surface of the foot, and a custom sole that sandwiching a heel pad with custom height.

摘要翻译： 本发明涉及制造定制鞋类的系统和方法。 在本发明的系统中采用多级定制过程。 首先，鞋子根据脚的生物特征进行定制。其次，通过针对佩戴者需求的一组交互式测量，对鞋类的部件进行微调，而鞋类的外观根据 穿着者的味道。 定制鞋类的主要部件包括最适合穿戴者脚部形状的定制鞋面，多层定制鞋垫，其表面符合足底足底表面，以及定制鞋底，夹具具有定制高度的脚跟垫 。

公开(公告)号：WO2022067088A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/052034

申请日：2021-09-24

申请人： VIDEOJET TECHNOLOGIES INC. ,  WENG, Wei ,  XIAO, Fengfei ,  DENG, Godwin ,  ZHU, Linfang

发明人： WENG, Wei ,  XIAO, Fengfei ,  DENG, Godwin ,  ZHU, Linfang

IPC分类号： B41J2/01 ,  C08L33/08 ,  C08L33/10 ,  C09D11/00 ,  C09D11/106 ,  C09D11/107

摘要： This specification discloses non-aqueous solvent, pigmented ink formulations that are suitable for the electronic and aerospace industries and form printed marks that are resistant to smearing and dissolution by organic solvents commonly used in overcoatings in this industry and others. These ink formulations are based on use of an acidic resin with an inherent acid value of at least about 25 mg KOH/g, preferably at least partially neutralized by a quaternary ammonium hydroxide and/or alcohol amine acid neutralizing or modifying agent.

公开(公告)号：WO2017151668A1

公开(公告)日：2017-09-08

申请号：PCT/US2017/020025

申请日：2017-02-28

申请人： WENG, Wei

发明人： WENG, Wei

IPC分类号： C12N5/10 ,  C12N15/11 ,  C12N15/63 ,  C12N15/90

摘要： Methods and constructs for inserting an intron into a reporter protein coding sequence in a eukaryotic cell and their application of monitoring and reporting genomic modifications are provided. Various related compositions, cells and kits are also provided.

摘要翻译： 提供了用于将内含子插入到真核细胞中的报道蛋白编码序列中的方法和构建体，以及它们在监测和报告基因组修饰方面的应用。 还提供了各种相关的组合物，细胞和试剂盒。

公开(公告)号：WO2007008715A3

公开(公告)日：2007-01-18

申请号：PCT/US2006/026602

申请日：2006-07-07

申请人： INGENIOUS TARGETING LABORATORY, INC. ,  ZHU, Liqun ,  WANG, Jianning ,  WENG, Wei ,  SU, Rong

发明人： ZHU, Liqun ,  WANG, Jianning ,  WENG, Wei ,  SU, Rong

IPC分类号： G06T15/00

摘要： The present invention relates to a system far the 3-D monitoring and analysis of motion-related behavior of test subjects, such as laboratory animals. The system comprises an actual camera, at least one virtual camera, and a computer connected to the actual camera. The computer is preferably installed with software capable of capturing the stereo images associated with the 3-D motion-related behavior of test subjects as well as processing these acquired image frames from the 3-D motion parameters of the subjects.

公开(公告)号：WO2005118145A3

公开(公告)日：2006-10-12

申请号：PCT/US2005017829

申请日：2005-05-20

申请人： INGENIOUS TARGETING LAB INC ,  CHEN ELLEN ,  HE WEI ,  WENG WEI

发明人： CHEN ELLEN ,  HE WEI ,  WENG WEI

IPC分类号： B01L3/00 ,  B01L9/00

CPC分类号： B01L3/50853 ,  B01L3/5085 ,  B01L2300/0809 ,  B01L2300/0829

摘要： The invention provides for improved multi-well plates and platforms that comprise a plurality of wells having increased volume capacity and clustered in a standard multi-well plate format and dimensions, said multi-well plate format being compatible with auxiliary equipment currently used and designed for the particular multi-well plate format. More particularly, the invention provides improved multi-well plates comprising a base to improve wells having one or more said wells having rectangular configuration, better retention of working materials and tissue culture ingredients than observed in conventional round-shaped wells. A cover is provided for protecting the assembly and cell cultures.

摘要翻译： 本发明提供了改进的多孔板和平台，其包括具有增加的体积容量并且以标准多孔板格式和尺寸聚集的多个孔，所述多孔板格式与目前使用和设计的辅助设备兼容 特定的多孔板格式。 更具体地，本发明提供了改进的多孔板，其包括基底，以改进具有一个或多个所述孔的孔，所述孔具有矩形构型，比常规圆形孔中观察到的具有更好的保留作业材料和组织培养成分。 提供了一种保护组装和细胞培养的盖子。