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公开(公告)号：WO2019139583A1
公开(公告)日：2019-07-18
申请号：PCT/US2018/013216
申请日：2018-01-10
Applicant: LEE, Patrice A. , CHANTRY, David , WINSKI, Shannon L.
Inventor： LEE, Patrice A. , CHANTRY, David , WINSKI, Shannon L.
IPC: A61K31/17 , A61K31/175 , A61K31/428
Abstract: This invention relates to a method of treating cancer by administering a combination therapy comprising a combination of CSF-1R inhibitor, which is ARRY-382 or a pharmaceutically acceptable salt thereof, and a PD-1 binding antagonist, to a patient in need thereof.
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2.发明申请N-(MONOCYCLIC ARYL),N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开作为TRKA激酶抑制剂的N-（单环芳烃），N'-吡唑并 - 尿酸，硫脲，胍和氰基胍化合物
公开(公告)号：WO2014078325A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069732
申请日：2013-11-12
Applicant: ARRAY BIOPHARMA INC. , ANDREWS, Steven Wade , BLAKE, James F. , BRANDHUBER, Barbara J. , KERCHER, Timothy , WINSKI, Shannon L.
Inventor： ANDREWS, Steven Wade , BLAKE, James F. , BRANDHUBER, Barbara J. , KERCHER, Timothy , WINSKI, Shannon L.
IPC: C07D403/12 , C07D401/14 , C07D231/40 , C07D231/44 , C07D401/04 , C07D413/12 , A61K31/4155 , A61P35/00 , A61P29/00 , A61P27/02
CPC classification number: C07D405/12 , A61K31/4155 , C07D231/40 , C07D231/44 , C07D231/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D413/12
Abstract: Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Abstract translation: 式（I）化合物或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药，其中环A，环C和X如本文所定义，是TrkA激酶的抑制剂，并且可用于治疗可以 用TrkA激酶抑制剂治疗，如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征。
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3.发明申请BICYCLIC HETEROARYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开作为TRKA激酶抑制剂的双相异构尿素，硫脲，胍和氰基化合物
公开(公告)号：WO2014078408A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069886
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , BRANDHUBER, Barbara J. , CONDROSKI, Kevin Ronald , HUANG, Lily , KERCHER, Timothy , WINSKI, Shannon L.
Inventor： ALLEN, Shelley , BRANDHUBER, Barbara J. , CONDROSKI, Kevin Ronald , HUANG, Lily , KERCHER, Timothy , WINSKI, Shannon L.
IPC: C07D231/56 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , A61K31/4985 , A61K31/437 , A61K31/416 , A61P29/00 , A61P35/00 , A61P25/00 , A61P31/00
CPC classification number: C07D487/04 , C07D231/56 , C07D403/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Abstract translation: 其中环A，环C和X如本文所定义的式I或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药的化合物是TrkA激酶的抑制剂，并且可用于治疗可以用 一种TrkA激酶抑制剂，如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎和骨盆疼痛综合征。
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4.发明申请THIAZOLYL AND OXAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开作为TRKA激酶抑制剂的THIAZOLYL和OXAZOLYL UREA，THIOUREA，GUANIDINE和CYANOGUANIDINE化合物
公开(公告)号：WO2014078322A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069728
申请日：2013-11-12
Applicant: ARRAY BIOPHARMA INC. , BRANDHUBER, Barbara, J. , JIANG, Yutong , KOLAKOWSKI, Gabrielle, R. , WINSKI, Shannon, L.
IPC: C07D263/48 , C07D277/46 , C07D403/12
CPC classification number: C07D417/14 , C07D413/14 , C07D417/12
Abstract: Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Abstract translation: 式（I）化合物或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药，其中环A，环C和X如本文所定义，是TrkA激酶的抑制剂，并且可用于治疗可以 用TrkA激酶抑制剂治疗，如疼痛，癌症，炎症，神经变性疾病，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或盆腔疼痛综合征。
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5.发明申请BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 审中-公开双酚尿素，硫脲，胍和氰尿嘧啶化合物可用于治疗疼痛
公开(公告)号：WO2014078454A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069951
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , THOMAS, Allen, A. , WINSKI, Shannon, L.
Inventor： ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , THOMAS, Allen, A. , WINSKI, Shannon, L.
IPC: C07D401/14 , C07D405/14 , C07D231/40 , C07D231/54 , C07D401/12 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D413/12 , C07D453/02 , A61K31/4155 , A61K31/416 , A61K31/4162 , A61P25/00
CPC classification number: C07D491/048 , C07D231/40 , C07D231/52 , C07D231/54 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D453/02 , C07D471/08
Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Abstract translation: 式I化合物或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药，其中环A，环C和X如本文所定义，是TrkA激酶的抑制剂，并且可用于治疗可治疗的疾病 具有TrkA激酶抑制剂如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些感染性疾病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎和骨盆疼痛综合征。
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Patent Agency Ranking6.发明申请N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开作为TRKA激酶抑制剂的N-（ARYLALKYL）-N'-吡唑并 - 尿素，硫脲，胍和氰基胍化合物
公开(公告)号：WO2014078331A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069750
申请日：2013-11-12
Applicant: ARRAY BIOPHARMA INC. , BLAKE, James F. , BRANDHUBER, Barbara J. , HAAS, Julia , NEWHOUSE, Brad , THOMAS, Allen A. , WINSKI, Shannon L.
Inventor： BLAKE, James F. , BRANDHUBER, Barbara J. , HAAS, Julia , NEWHOUSE, Brad , THOMAS, Allen A. , WINSKI, Shannon L.
IPC: C07D403/12 , C07D401/14 , C07D231/40 , C07D231/52 , C07D231/54 , C07D401/04 , C07D401/12 , C07D403/04 , C07D413/12 , C07D495/04 , A61K31/4155 , A61P35/00 , A61P29/00
CPC classification number: C07D231/52 , C07D231/38 , C07D231/40 , C07D231/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D453/02 , C07D495/04
Abstract: Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Abstract translation: 式I或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药的化合物，其中环A，环C，X，R a，R b，R c，R d和n如本文所定义，是TrkA激酶的抑制剂，并且是有用的 治疗可用TrkA激酶抑制剂如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些感染性疾病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征治疗的疾病。
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7.发明申请
公开(公告)号：WO2010118390A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/030634
申请日：2010-04-09
Applicant: ARRAY BIOPHARMA INC. , HUMPHRIES, Michael J. , WINSKI, Shannon L.
Inventor： HUMPHRIES, Michael J. , WINSKI, Shannon L.
IPC: A61K31/437 , A61K31/4745 , A61K31/7068 , A61K45/06 , A61P35/00
CPC classification number: A61K31/437 , A61K31/4745 , A61K31/7068 , A61K45/06 , A61K2300/00
Abstract: A CHK1 inhibitor for administration to a patient with cancer for potentiating a DNA damaging agent is provided.
Abstract translation: 提供了一种用于给患有恶性肿瘤加强DNA损伤剂的患者施用的CHK1抑制剂。
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公开(公告)号：WO2019139581A1
公开(公告)日：2019-07-18
申请号：PCT/US2018/013211
申请日：2018-01-10
Applicant: LEE, Patrice A. , CHANTRY, David , WINSKI, Shannon L.
Inventor： LEE, Patrice A. , CHANTRY, David , WINSKI, Shannon L.
IPC: A61K31/4184 , A61K31/519
Abstract: This invention relates to a method of treating cancer by administering to a patient in need thereof, over a period of time, therapeutic agents that consist essentially of a MEK inhibitor which is binimetinib or a pharmaceutically acceptable salt thereof, and a PD-1 binding antagonist, to a patient in need thereof.
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9.发明申请PYRAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开作为TRKA激酶抑制剂的吡咯烷酮，硫脲，胍和氰基化合物
公开(公告)号：WO2014078417A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069897
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC. , BRANDHUBER, Barbara J. , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , WINSKI, Shannon L.
IPC: C07D403/12 , C07D401/14 , C07D403/14 , A61K31/4155 , A61K31/4412 , A61P29/00
CPC classification number: C07D403/14 , C07D401/14 , C07D403/12
Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Abstract translation: 式I化合物或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药，其中环A，环C和X如本文所定义，是TrkA激酶的抑制剂，并且可用于治疗可治疗的疾病 具有TrkA激酶抑制剂如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些感染性疾病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征。
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10.发明申请PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开吡咯烷酮尿素，硫脲，胍和氰尿嘧啶化合物作为TRKA激酶抑制剂
公开(公告)号：WO2014078378A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069838
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , CONDROSKI, Kevin, Ronald , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , WINSKI, Shannon, L.
Inventor： ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , CONDROSKI, Kevin, Ronald , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , WINSKI, Shannon, L.
IPC: C07D403/12 , C07D401/14 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/4025 , A61P29/00 , A61P35/00 , A61P25/28 , A61P27/02 , A61P13/08 , A61P13/06
CPC classification number: C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R 1 , R 2 , R a , R b , R c , R d , X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Abstract translation: 式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物或前药，其中R 1，R 2，R a，R b，R c，R d，X，环B和环C如本文所定义， 其中环B部分和NH-C（= X）-NH部分处于反式构型，是TrkA激酶的抑制剂，并且可用于治疗可用TrkA激酶抑制剂如疼痛，癌症， 炎症/炎性疾病，神经变性疾病，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎和骨盆疼痛综合征。
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