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    REACTIVE LABELLING COMPOUNDS AND USES THEREOF
    3.
    发明申请
    REACTIVE LABELLING COMPOUNDS AND USES THEREOF 审中-公开
    反应性标签化合物及其用途

    公开(公告)号：WO2015148915A1

    公开(公告)日：2015-10-01

    申请号：PCT/US2015/022977

    申请日：2015-03-27

    Applicant: ACADEMIA SINICA ,  WONG, Chi-Huey

    Inventor： WONG, Chi-Huey ,  FANG, Jim-Min ,  SHIE, Jiun-Jie

    IPC: G01N21/64 ,  C07K7/08

    CPC classification number: G01N33/582 ,  C07D309/14 ,  C07D311/02 ,  C07F5/027 ,  C07K7/08 ,  G01N21/64 ,  G01N2333/924 ,  G01N2458/30

    Abstract: Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

    Abstract translation: 提供式（I）的叠氮基-BODIPY化合物，式（IV）的基于环辛烯的荧光探针和式（VI）的基于活性的探针。 这些化合物经历叠氮炔环加成反应（AAC）以形成三唑基产物。 所提供的化合物可用于检测和成像含炔或叠氮化物的分子。 公开了使用本公开的化合物检测和成像生物分子的方法。

    GLYCAN ARRAYS FOR HIGH THROUGHPUT SCREENING OF VIRUSES
    7.
    发明申请
    GLYCAN ARRAYS FOR HIGH THROUGHPUT SCREENING OF VIRUSES 审中-公开

    公开(公告)号：WO2011130332A1

    公开(公告)日：2011-10-20

    申请号：PCT/US2011/032192

    申请日：2011-04-12

    Applicant: ACADEMIA SINICA ,  WONG, Chi-Huey ,  WU, Chung-Yi ,  LIANG, Chi-Hui ,  YANG, An-Suei

    Inventor： WONG, Chi-Huey ,  WU, Chung-Yi ,  LIANG, Chi-Hui ,  YANG, An-Suei

    IPC: C12Q1/70 ,  C07K16/08

    CPC classification number: G01N33/56983 ,  G01N33/53 ,  G01N33/54346 ,  G01N2333/11 ,  G01N2400/00 ,  G01N2400/38 ,  G01N2458/00

    Abstract: Glycan arrays that can detect and distinguish between various sub-types and strains of influenza virus are provided. Methods for using the glycan arrays with assays using nanoparticle amplification technique are disclosed. Sandwich assays using gold nanoparticles conjugated to phage particles comprising influenza virus-specific antibodies for detecting multiple serotypes using a single reaction are provided. Plurality of glycans directed to specific target HA of influenza virus comprises the array. Detector molecules comprising noble metals conjugated to (a) phage display particles expressing antibodies against hemagglutinin and (b) neuraminidase binding agents are disclosed.

    Abstract translation: 提供了可以检测和区分各种亚型和流感病毒株的糖阵列。 公开了使用纳米颗粒扩增技术的测定法使用聚糖阵列的方法。 提供使用与包含用于使用单个反应检测多种血清型的流感病毒特异性抗体的噬菌体颗粒缀合的金纳米颗粒的三明治测定。 针对流感病毒的特定目标HA的多种聚糖包括阵列。 公开了包含与（a）噬菌体缀合的贵金属的检测分子，其显示表达针对血凝素的抗体的颗粒和（b）神经氨酸酶结合剂。

    GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS
    8.
    发明申请
    GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS 审中-公开
    类聚四氟乙烯涂层玻璃载玻片上的甘氨酸阵列及相关方法

    公开(公告)号：WO2010009271A3

    公开(公告)日：2010-04-22

    申请号：PCT/US2009050754

    申请日：2009-07-15

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  WU CHUNG-YI ,  TSENG SUSAN Y

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSENG SUSAN Y

    IPC: G01N33/50 ,  G01N33/66 ,  G01N33/68

    CPC classification number: G01N33/553 ,  C40B40/12 ,  C40B50/14 ,  G01N33/582 ,  G01N2333/942 ,  G01N2400/10 ,  H01J49/40

    Abstract: Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.

    Abstract translation: 镀铝玻璃载玻片提供了一种新型聚糖阵列平台。 具体而言，镀铝玻璃载玻片增加了基于荧光的测定方法的灵敏度。 此外，镀铝玻璃载玻片允许对碳水化合物进行质谱分析，并为检查纤维素酶的活性提供平台。 ACG玻片的独特性能包括：1）表面的金属氧化物层可以被活化以接枝有机化合物，如修饰的低聚糖; 2）表面保持导电性，并且接枝的低聚糖可以通过质谱和碳水化合物结合测定同时表征; 和3）在结合分析中，载玻片比透明载玻片更敏感。

    COMPOSITIONS AND METHODS FOR IDENTIFYING RESPONSE TARGETS AND TREATING FLAVIVIRUS INFECTION RESPONSES
    9.
    发明申请
    COMPOSITIONS AND METHODS FOR IDENTIFYING RESPONSE TARGETS AND TREATING FLAVIVIRUS INFECTION RESPONSES 审中-公开
    鉴定反应目标的组合物和方法和治疗感染性禽流感的反应

    公开(公告)号：WO2009120225A1

    公开(公告)日：2009-10-01

    申请号：PCT/US2008/065166

    申请日：2008-05-29

    Applicant: ACADEMIA SINICA ,  HSIEH, Shie-Liang ,  WONG, Chi-Huey ,  HSU, Tsui-Ling ,  CHEN, Szu-Ting

    Inventor： HSIEH, Shie-Liang ,  WONG, Chi-Huey ,  HSU, Tsui-Ling ,  CHEN, Szu-Ting

    IPC: G01N33/53

    CPC classification number: C07K16/2851 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/30 ,  G01N2333/18 ,  G01N2333/185 ,  G01N2500/02 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394

    Abstract: Cellular receptors are identified that induce plasma leakage and other negative effects when infected with flaviviruses, such as dengue virus or Japanese encephamyelitis virus. Using fusion proteins disclosed herein, the receptors to which a pathogen, such as flavivirus, binds via glycan binding are determined. Once the receptors are determined, the effect of binding to a particular receptor may be determined, wherein targeting of the receptors causing a particular symptom may be targeted by agents that interrupt binding of the pathogen to the receptor. Accordingly, in the case of dengue virus and Japanese encephamyelitis virus, TNF-α is released when the pathogen binds to the DLVR1/CLEC5A receptor. Interrupting the DLVR1/CLEC5A receptor with monoclonal antibodies reduced TNF-α secretion without affecting secretion of cytokines responsible for viral clearance thereby increasing survival rates in infected mice from nil to around 50%.

    Abstract translation: 鉴定当感染黄病毒如登革热病毒或日本脑炎病毒时诱导血浆渗漏和其它负面影响的细胞受体。 使用本文公开的融合蛋白，确定病原体（例如黄病毒）通过聚糖结合结合的受体。 一旦确定了受体，就可以确定与特定受体结合的作用，其中导致特定症状的受体的靶向可能被阻断病原体与受体结合的试剂所靶向。 因此，在登革热病毒和日本脑炎病毒的情况下，当病原体与DLVR1 / CLEC5A受体结合时，TNF-α被释放。 用单克隆抗体中断DLVR1 / CLEC5A受体降低TNF-α分泌，而不影响负责病毒清除的细胞因子分泌，从而将感染小鼠的存活率从零增加到约50％。

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