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公开(公告)号：WO2009029130A3
公开(公告)日：2009-05-07
申请号：PCT/US2008006735
申请日：2008-05-28
Applicant: WYETH CORP , WU STEPHEN QITU , GILL MICHAEL A , CHU HSIEN-JUE
Inventor： WU STEPHEN QITU , GILL MICHAEL A , CHU HSIEN-JUE
IPC: C12N15/86
CPC classification number: C12N15/86 , A61K2039/5256 , C12N9/1211 , C12N2710/24043 , C12N2750/10034 , C12N2770/10034
Abstract: The present invention relates to a new recombinant raccoon poxvirus vector vaccine in which the vector expresses one or more antigenic proteins encoded by multiple open reading frames, preferably the ORF5, ORF6 and/or ORF3/ORF4/ORF7, of one or more porcine reproductive and respiratory syndrome virus strains alone or in combination with an open reading frame of porcine circovirus type 2 (PCV-2), preferably ORF2, at the hemagglutinin (ha) and/or thymidine kinase (tk) loci.
Abstract translation: 本发明涉及一种新的重组浣熊痘病毒载体疫苗，其中所述载体表达一种或多种由多个开放阅读框编码的抗原蛋白，优选ORF5，ORF6和/或ORF3 / ORF4 / ORF7编码的一种或多种猪繁殖和/ 呼吸综合征病毒株单独或与猪圆环病毒2型（PCV-2）（优选ORF2）在血凝素（ha）和/或胸苷激酶（tk）基因座的开放阅读框组合。
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2.发明申请
公开(公告)号：WO2008079342A3
公开(公告)日：2008-08-14
申请号：PCT/US2007026184
申请日：2007-12-20
Applicant: MALLINCKRODT INC , PARK JAE HAN , WU STEPHEN H , HOLMAN KEVIN M , HERMAN CLIFF J
Inventor： PARK JAE HAN , WU STEPHEN H , HOLMAN KEVIN M , HERMAN CLIFF J
CPC classification number: A61K9/0056 , A61K9/2009 , A61K9/2018 , A61K9/2027
Abstract: An improved orally dissolving tablet (ODT) and method of manufacture is provided. The improved ODT disclosed herein are prepared by direct compression of a mixture of pharmaceutical excipients including at least one water-insoluble hydrophobic inorganic salt in combination with at least one water-insoluble inorganic salt with less hydrophobicity compared to the water-insoluble hydrophobic inorganic salt component. These components may be formed into granules, and may include other commonly used excipients. In an illustrative embodiment, the granules are formed into tablets by direct compression, optionally using a lubricant. The fast disintegrating tablets prepared using these components exhibit desirable performance properties such as sufficient hardness, low friability, quick disintegration time and good mouth-feel when compared to conventional ODT. A further advantage is that the improved ODT may be manufactured using commonly available manufacturing equipment for granulation, blending and tableting.
Abstract translation: 提供了改进的口服溶解片剂（ODT）及其制备方法。 本文公开的改进的ODT通过直接压缩药物赋形剂的混合物，包括至少一种不溶于水的疏水性无机盐与至少一种与水不溶性疏水性无机盐组分相比具有较小疏水性的水不溶性无机盐的组合 。 这些组分可以形成颗粒，并且可以包括其它常用的赋形剂。 在说明性的实施方案中，颗粒通过直接压缩形成片剂，任选地使用润滑剂。 与常规ODT相比，使用这些组分制备的快速崩解片剂表现出所需的性能，例如足够的硬度，低脆性，快速崩解时间和良好的口感。 另外的优点是改进的ODT可以使用通常可用的造粒，混合和压片制造设备来制造。
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公开(公告)号：WO2008079342A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/026184
申请日：2007-12-20
Applicant: MALLINCKRODT INC. , PARK, Jae, Han , WU, Stephen, H. , HOLMAN, Kevin, M. , HERMAN, Cliff, J.
Inventor： PARK, Jae, Han , WU, Stephen, H. , HOLMAN, Kevin, M. , HERMAN, Cliff, J.
CPC classification number: A61K9/0056 , A61K9/2009 , A61K9/2018 , A61K9/2027
Abstract: An improved orally dissolving tablet (ODT) and method of manufacture is provided. The improved ODT disclosed herein are prepared by direct compression of a mixture of pharmaceutical excipients including at least one water-insoluble hydrophobic inorganic salt in combination with at least one water-insoluble inorganic salt with less hydrophobicity compared to the water-insoluble hydrophobic inorganic salt component. These components may be formed into granules, and may include other commonly used excipients. In an illustrative embodiment, the granules are formed into tablets by direct compression, optionally using a lubricant. The fast disintegrating tablets prepared using these components exhibit desirable performance properties such as sufficient hardness, low friability, quick disintegration time and good mouth-feel when compared to conventional ODT. A further advantage is that the improved ODT may be manufactured using commonly available manufacturing equipment for granulation, blending and tableting.
Abstract translation: 提供改进的口服溶解片剂（ODT）及其制造方法。 本文公开的改进的ODT是通过将药用赋形剂的混合物直接压制而制备的，所述药用赋形剂包含至少一种不溶于水的疏水性无机盐与至少一种疏水性相比为不溶于水的疏水性无机盐的至少一种不溶于水的无机盐 。 这些组分可以形成颗粒，并且可以包含其它常用的赋形剂。 在说明性实施方案中，通过直接压制将颗粒成形为片剂，任选使用润滑剂。 与常规ODT相比，使用这些组分制备的快速崩解片剂表现出期望的性能特性，如与传统ODT相比，具有足够的硬度，低脆碎度，快速崩解时间和良好的口感。 另一个优点是改进的ODT可以使用通常可用的制造设备来制造，用于造粒，混合和压片。
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公开(公告)号：WO2007047047A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/037586
申请日：2006-09-28
Applicant: MALLINCKRODT INC. , CHENG, Brian, K. , WU, Stephen, H.
Inventor： CHENG, Brian, K. , WU, Stephen, H.
IPC: A61K9/14 , A61K9/20 , A61K9/28 , C07D471/04
CPC classification number: C07D471/04 , A61K9/2086
Abstract: A method for converting polymorphs of Zolpidem hemitartrate, the method comprising treating tablets comprising Zolpidem hemitartrate with heat and/or moisture.
Abstract translation: 一种用于转化迟发型酒石酸多晶型物的方法，所述方法包括用加热和/或湿气处理含有泽西汀酒精的片剂。
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公开(公告)号：WO2019005167A1
公开(公告)日：2019-01-03
申请号：PCT/US2017/040510
申请日：2017-06-30
Applicant: INTEL CORPORATION , STRUTT, Nathan , WU, Stephen Y. , ASURI, Namrata S. , GLASSMAN, Timothy E. , GOLONZKA, Oleg , MUKHERJEE, Niloy , SEGHETE, Dragos , WIEGAND, Christopher J.
Inventor： STRUTT, Nathan , WU, Stephen Y. , ASURI, Namrata S. , GLASSMAN, Timothy E. , GOLONZKA, Oleg , MUKHERJEE, Niloy , SEGHETE, Dragos , WIEGAND, Christopher J.
IPC: H01L45/00
CPC classification number: H01L45/08 , H01L27/2436 , H01L45/1233 , H01L45/1253 , H01L45/146 , H01L45/16 , H01L45/1675
Abstract: An approach for integrating a resistive random access memory (RRAM) device on a dual bottom electrode layer is described. In an example, a resistive random access memory (RRAM) device includes a dual bottom electrode disposed above a substrate. The dual bottom electrode includes a first conductive layer disposed above a substrate, a second conductive layer disposed above the first conductive layer and an intermediate layer between the first conductive layer and the second conductive layer, where the intermediate layer includes oxygen. A switching layer is disposed on the dual bottom electrode layer. An oxygen exchange layer is disposed on the switching layer and a top electrode is disposed on the switching layer.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2008153794A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/006736
申请日：2008-05-28
Applicant: WYETH , WU, Stephen, Qitu , GILL, Michael, A. , CHU, Hsien-Jue
Inventor： WU, Stephen, Qitu , GILL, Michael, A. , CHU, Hsien-Jue
IPC: C12Q1/68 , C12Q1/70 , A61K39/275
CPC classification number: A61K39/205 , A61K39/0225 , A61K39/12 , A61K2039/521 , A61K2039/5252 , A61K2039/5256 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N15/86 , C12N2710/10334 , C12N2710/24143 , C12N2750/14034 , C12N2760/18434 , C12N2760/18734 , C12N2760/20134 , C12N2770/20034
Abstract: The present invention relates to recombinant raccoon poxvirus vectors that express the rabies virus glycoprotein gene at the hemagglutinin (ha) locus of the poxvirus genome or express the glycoprotein gene of the same or different rabies strains at the thymidine kinase (tk) and the hemagglutinin (ha) loci of the poxvirus genome, and their use as adjuvant-free vaccines. The raccoon poxvirus vector comprises the nucleic acid molecules encoding the glycoprotein of a Challenge Virus Standard rabies strain inserted and expressed at the tk locus of the poxvirus genome and of a Pasteur-Paris rabies strain inserted and expressed at the ha locus of the poxvirus genome. The vaccine may optionally contain a mixture of additional feline and canine antigens for immunization of animals. Also disclosed are methods for inducing an immune response to rabies in a mammal by administering to the mammal an effective immunizing amount of the vaccine of the invention.
Abstract translation: 本发明涉及在痘病毒基因组的血凝素（ha）位点处表达狂犬病病毒糖蛋白基因的重组浣熊痘病毒载体，或表达胸苷激酶（tk）和血凝素（tk）上相同或不同狂犬病毒株的糖蛋白基因 ha）痘病毒基因组的基因座，以及它们作为无佐剂疫苗的用途。 浣熊痘病毒载体包含编码在痘病毒基因组的tk基因座插入和表达的挑战性病毒标准狂犬病毒株的糖蛋白的核酸分子和在痘病毒基因组的ha位点插入和表达的巴斯德巴黎狂犬病毒株。 疫苗可以任选地含有用于免疫动物的另外的猫科动物和犬抗原的混合物。 还公开了通过向哺乳动物施用有效免疫量的本发明的疫苗来诱导对哺乳动物的狂犬病免疫应答的方法。
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公开(公告)号：WO2007047047A3
公开(公告)日：2007-06-07
申请号：PCT/US2006037586
申请日：2006-09-28
Applicant: MALLINCKRODT INC , CHENG BRIAN K , WU STEPHEN H
Inventor： CHENG BRIAN K , WU STEPHEN H
IPC: A61K9/14 , A61K9/20 , A61K9/28 , C07D471/04
CPC classification number: C07D471/04 , A61K9/2086
Abstract: A method for converting polymorphs of Zolpidem hemitartrate, the method comprising treating tablets comprising Zolpidem hemitartrate with heat and/or moisture.
Abstract translation: 一种用于转化唑吡坦半酒石酸盐多晶型物的方法，所述方法包括用热和/或水分处理包含唑吡坦半酒石酸盐的片剂。
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公开(公告)号：WO2009029130A2
公开(公告)日：2009-03-05
申请号：PCT/US2008/006735
申请日：2008-05-28
Applicant: WYETH , WU, Stephen, Qitu , GILL, Michael, A. , CHU, Hsien-Jue
Inventor： WU, Stephen, Qitu , GILL, Michael, A. , CHU, Hsien-Jue
IPC: C12N15/09
CPC classification number: C12N15/86 , A61K2039/5256 , C12N9/1211 , C12N2710/24043 , C12N2750/10034 , C12N2770/10034
Abstract: The present invention relates to a new recombinant raccoon poxvirus vector vaccine in which the vector expresses one or more antigenic proteins encoded by multiple open reading frames, preferably the ORF5, ORF6 and/or ORF3/ORF4/ORF7, of one or more porcine reproductive and respiratory syndrome virus strains alone or in combination with an open reading frame of porcine circovirus type 2 (PCV-2), preferably ORF2, at the hemagglutinin ( ha ) and/or thymidine kinase ( tk ) loci.
Abstract translation: 本发明涉及新的重组浣熊痘病毒载体疫苗，其中载体表达由多个开放阅读框编码的一种或多种抗原蛋白，优选ORF5，ORF6和/或ORF3 / ORF4 / ORF7 ，一种或多种猪繁殖与呼吸综合症病毒毒株单独或与血凝素（ha）的2型猪圆环病毒（PCV-2）（优选ORF2）的开放阅读框和/ 或胸苷激酶（tk）基因座。
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公开(公告)号：WO0128310A9
公开(公告)日：2002-08-15
申请号：PCT/US0029247
申请日：2000-10-23
Applicant: BROADCOM CORP , ROFOUGARAN AHMADREZA , ROFOUGARAN MARYAM , PAN MENG-AN , CHIEN HUNG-MING , KHORRAM SHAHLA , COLLERAN WILLIAM T , RAEL JACOB , SYED MASOOD , IBRAHIM BRIMA , WU STEPHEN , MOLOUDI SHERVIN
Inventor： ROFOUGARAN AHMADREZA , ROFOUGARAN MARYAM , PAN MENG-AN , CHIEN HUNG-MING , KHORRAM SHAHLA , COLLERAN WILLIAM T , RAEL JACOB , SYED MASOOD , IBRAHIM BRIMA , WU STEPHEN , MOLOUDI SHERVIN
IPC: H03H11/12 , H03H21/00 , H04B1/38 , G01R1/00 , H03D7/00 , H03F3/45 , H03H1/00 , H04B1/28 , H04B1/44 , H04B15/00
CPC classification number: H03H21/0012 , H03H11/1291 , H03H21/0001 , H03H2011/0494 , H03H2210/043 , H03J2200/10 , H04B17/14
Abstract: Dans un mode de réalisation. l'invention concerne un émetteur-récepteur décrit et présenté dans la spécification et les dessins, ainsi qu'un générateur oscillateur local (LO), un contrôleur et une unité d'autotest. Toutes ces composantes sont conditionnées aux fins de leur intégration dans un seul CI comprenant notamment des filtres et des inducteurs, le contrôleur de programmation et d'étalonnage adaptatifs du récepteur, de l'émetteur et du générateur LO. L'unité d'autotest permet de déterminer le gain, les caractéristiques de fréquence, la sélectivité, le bruit de fond et le comportement en distorsion du récepteur, de l'émetteur et du générateur LO. Il convient de souligner que le présent abrégé est fourni pour se conformer aux règles voulant qu'un abrégé permette à un chercheur ou autre lecteur de déterminer rapidement l'objet de l'invention technique. Cet abrégé est donc présenté étant entendu que nul ne pourra s'en servir pour interpréter ou limiter la portée ou le sens des revendications.
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公开(公告)号：WO0128310A8
公开(公告)日：2001-09-20
申请号：PCT/US0029247
申请日：2000-10-23
Applicant: BROADCOM CORP , ROFOUGARAN AHMADREZA , ROFOUGARAN MARYAM , PAN MENG AN , CHIEN HUNG MING , KHORRAM SHAHLA , COLLERAN WILLIAM T , RAEL JACOB , SYED MASOOD , IBRAHIM BRIMA , WU STEPHEN , MOLOUDI SHERVIN
Inventor： ROFOUGARAN AHMADREZA , ROFOUGARAN MARYAM , PAN MENG-AN , CHIEN HUNG-MING , KHORRAM SHAHLA , COLLERAN WILLIAM T , RAEL JACOB , SYED MASOOD , IBRAHIM BRIMA , WU STEPHEN , MOLOUDI SHERVIN
IPC: H03H11/12 , H03H21/00 , H04B1/38 , G01R1/00 , H03D7/00 , H03F3/45 , H03H1/00 , H04B1/28 , H04B1/44 , H04B15/00
CPC classification number: H03H21/0012 , H03H11/1291 , H03H21/0001 , H03H2011/0494 , H03H2210/043 , H03J2200/10 , H04B17/14
Abstract: Dans un mode de réalisation. l'invention concerne un émetteur-récepteur décrit et présenté dans la spécification et les dessins, ainsi qu'un générateur oscillateur local (LO), un contrôleur et une unité d'autotest. Toutes ces composantes sont conditionnées aux fins de leur intégration dans un seul CI comprenant notamment des filtres et des inducteurs, le contrôleur de programmation et d'étalonnage adaptatifs du récepteur, de l'émetteur et du générateur LO. L'unité d'autotest permet de déterminer le gain, les caractéristiques de fréquence, la sélectivité, le bruit de fond et le comportement en distorsion du récepteur, de l'émetteur et du générateur LO. Il convient de souligner que le présent abrégé est fourni pour se conformer aux règles voulant qu'un abrégé permette à un chercheur ou autre lecteur de déterminer rapidement l'objet de l'invention technique. Cet abrégé est donc présenté étant entendu que nul ne pourra s'en servir pour interpréter ou limiter la portée ou le sens des revendications.
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