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公开(公告)号：WO2007057749A2
公开(公告)日：2007-05-24
申请号：PCT/IB2006003223
申请日：2006-11-15
Applicant: PRO NATURA GES FUER GESUNDE ER , WYROBNIK DANIEL HENRY , WYROBNIK ISAAC HARRY , SILCOFF ELLIAD RONEN
Inventor： WYROBNIK DANIEL HENRY , WYROBNIK ISAAC HARRY , SILCOFF ELLIAD RONEN
IPC: A61K38/44
CPC classification number: A61K38/47 , A23L5/20 , A23L29/06 , A23V2002/00 , A61K9/48 , A61K38/443 , A61K38/52 , C12Q1/32 , C12Y101/01124 , C12Y302/0102 , C12Y302/01026 , C12Y503/01005 , G01N2333/904 , G01N2800/04 , G01N2800/38 , A23V2200/328 , A61K2300/00
Abstract: The present invention refers to an agent for use in the case of fructose intolerance and any form of impairment and affliction of health and well being which is caused by the administration of fructose or fructose containing foodstuffs or by the release of fructose in the digestive tract of humans or animals from other substances, such as e.g. sucrose. The agent according to the invention comprises 5-D-fructose dehydrogenase, optionally in combination with invertase and/or maltase and/or glucose isomerase, which enzyme or combination of enzymes is/are used in the medical field for the first time. Preferably the agent is in the form of a pharmaceutical composition which is useful for treatment of fructose intolerance.
Abstract translation: 本发明涉及在果糖不耐受的情况下使用的药剂，以及由果糖或果糖含有食物的给药引起的健康和健康的任何形式的损害和损害，或通过在消化道中释放果糖 人或动物来自其他物质，例如 蔗糖。 根据本发明的药剂包含5-D-果糖脱氢酶，任选地与转化酶和/或麦芽糖酶和/或葡萄糖异构酶组合，该酶或酶组合在医疗领域中首次被使用。 优选地，试剂是药物组合物的形式，其可用于治疗果糖不耐症。
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2.发明申请AGENT FOR REDUCING THE USEABLE CALORIE CONTENT OF FOOD AND FOR THERAPEUTIC REDUCTION OF WEIGHT, IN PARTICULAR FOR USE IN THE CASE OF ADIPOSITY (OBESITY) 审中-公开代理商减少可食用的卡路里含量的食物和减轻体重，特别是在适应性（肥胖）方面的使用
公开(公告)号：WO2007059955A3
公开(公告)日：2007-09-27
申请号：PCT/EP2006011231
申请日：2006-11-23
Inventor： WYROBNIK DANIEL HENRY , WYROBNIK ISAAC HARRY
CPC classification number: A61K38/443 , A23L33/10 , A23L33/20 , A23L33/30 , A23P10/30 , A23V2002/00 , A61K38/52 , C12Y101/99011 , C12Y503/01005 , C12Y503/01018 , A61K2300/00
Abstract: An agent for reducing the useable calorie content of food is described which contains a compound effecting the dehydrogenation of fructose to 5-keto-D-fructose. In addition, a combination agent is described which also contains a compound that converts glucose to fructose. These agents can be used in particular in the therapy of adiposity (obesity).
Abstract translation: 描述了一种降低食物中可用卡路里含量的试剂，其含有使果糖脱氢成5-酮基-D-果糖的化合物。 另外，描述了还包含将葡萄糖转化为果糖的化合物的组合剂。 这些药物可以特别用于治疗肥胖症（肥胖症）。
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公开(公告)号：WO2008101672A3
公开(公告)日：2009-06-18
申请号：PCT/EP2008001294
申请日：2008-02-20
Applicant: VITACARE GMBH & CO KG , WYROBNIK DANIEL HENRY , WYROBNIK ISAAC HARRY
Inventor： WYROBNIK DANIEL HENRY , WYROBNIK ISAAC HARRY
CPC classification number: A61K38/52 , A23L29/06 , A23L33/10 , A23L33/18 , A23L33/20 , A23V2002/00 , A61K9/485 , A61K9/4858 , A61K38/44 , A61K38/54 , A61K2300/00 , A61P1/00 , C12Y101/99011 , C12Y302/0102 , C12Y302/01026 , C12Y503/01005
Abstract: An agent is described that, with the help of glucose isomerase, converts fructose into glucose and thus, alone or in combination with 5-D-fructose dehydrogenase, reduces the bioavailability of fructose in the human or animal body. This agent can be used in particular in the therapy of fructose intolerance.
Abstract translation: 描述了在葡萄糖异构酶的帮助下，将果糖转化为葡萄糖并因此单独或与5-D-果糖脱氢酶组合的药剂降低了人体或动物体内果糖的生物利用度。 该药剂特别可用于果糖不耐症的治疗。
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Patent Agency Ranking4.发明申请AGENT FOR USE IN THE CASE OF DISORDERS OF BLOOD SUGAR METABOLISM, INCLUDING DIABETES 审中-公开用于血糖代谢异常病例的药物，包括糖尿病
公开(公告)号：WO2007059956A1
公开(公告)日：2007-05-31
申请号：PCT/EP2006/011232
申请日：2006-11-23
Applicant: PRO NATURA GESELLSCHAFT FÜR GESUNDE ERNÄHRUNG MBH , WYROBNIK, Daniel, Henry , WYROBNIK, Isaac, Harry
Inventor： WYROBNIK, Daniel, Henry , WYROBNIK, Isaac, Harry
CPC classification number: A61K38/54 , A21D8/042 , A21D13/062 , A23K20/189 , A23L29/06 , A23L33/20 , A23L33/30 , A23P10/30 , A23V2002/00 , A61K38/443 , A61K38/47 , A61K38/52 , A61K2300/00 , A23V2200/328 , A23V2200/3322
Abstract: An agent for use in the case of disorders of blood sugar metabolism, including diabetes, is described, which reduces the glucose content of food and other substances with the help of 5-D-fructose dehydrogenase and glucose isomerase.
Abstract translation: 描述了在糖代谢障碍（包括糖尿病）的情况下使用的药剂，其借助于5-D-果糖脱氢酶和葡萄糖异构酶降低了食物和其他物质的葡萄糖含量。
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公开(公告)号：WO2007057749A3
公开(公告)日：2007-05-24
申请号：PCT/IB2006/003223
申请日：2006-11-15
Applicant: PRO NATURA GESELLSCHAFT FÜR GESUNDE ERNÄHRUNG MBH , WYROBNIK, Daniel, Henry , WYROBNIK, Isaac, Harry , SILCOFF, Elliad, Ronen
Abstract: The present invention refers to an agent for use in the case of fructose intolerance and any form of impairment and affliction of health and well being which is caused by the administration of fructose or fructose containing foodstuffs or by the release of fructose in the digestive tract of humans or animals from other substances, such as e.g. sucrose. The agent according to the invention comprises 5-D-fructose dehydrogenase, optionally in combination with invertase and/or maltase and/or glucose isomerase, which enzyme or combination of enzymes is/are used in the medical field for the first time. Preferably the agent is in the form of a pharmaceutical composition which is useful for treatment of fructose intolerance.
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6.发明申请A COMPOSITION FOR USE IN THE THERAPY OF LACTOSE INTOLERANCE OR CONDITIONS ARISING FROM LACTASE DEFICIENCY 审中-公开用于乳酸脱氢酶或不利条件的乳酸脱氢酶治疗的组合物
公开(公告)号：WO2011095339A1
公开(公告)日：2011-08-11
申请号：PCT/EP2011/000510
申请日：2011-02-04
Applicant: VITACARE GMBH & CO. KG , WYROBNIK, Daniel, Henry , WYROBNIK, Isaac, Harry
Inventor： WYROBNIK, Daniel, Henry , WYROBNIK, Isaac, Harry
CPC classification number: A61K35/747 , A61K35/74 , A61K35/744 , A61K38/47 , C12Y302/01108 , A61K2300/00
Abstract: The invention provides a composition for use in therapy of lactose intolerance or conditions arising from lactase deficiency, wherein the composition is a non-dairy solid dosage form comprising: (a) a lactase; and (b) one or more lactase-producing and/or lactase containing microorganisms selected from Lactobacillus delbrueckii ssp bulgaricus and Steptococcus thermophilus; wherein the lactase (a) is other than a lactase derived from the said one or more microorganisms (b); and wherein the one or more lactase-producing and/or lactase- containing microorganisms (b) are in dried form. Also provided are uncoated capsule and tablet compositions containing the lactase and the lactase-producing and/or lactase-containing microorganisms.
Abstract translation: 本发明提供了用于治疗乳糖不耐症或由乳糖酶缺乏引起的病症的组合物，其中所述组合物是非乳品固体剂型，其包含：（a）乳糖酶; 和（b）一种或多种选自德氏乳杆菌保加利亚乳杆菌和嗜热链球菌的含乳糖酶生产和/或乳糖酶的微生物; 其中所述乳糖酶（a）不是来自所述一种或多种微生物（b）的乳糖酶; 并且其中所述一种或多种产生乳糖酶的和/或含乳糖酶的微生物（b）是干燥形式。 还提供了含有乳糖酶和产生乳糖酶的和/或含乳糖酶的微生物的未包衣胶囊和片剂组合物。
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公开(公告)号：WO2008101672A2
公开(公告)日：2008-08-28
申请号：PCT/EP2008/001294
申请日：2008-02-20
Applicant: VITACARE GMBH & CO. KG , WYROBNIK, Daniel, Henry , WYROBNIK, Isaac, Harry
Inventor： WYROBNIK, Daniel, Henry , WYROBNIK, Isaac, Harry
CPC classification number: A61K38/52 , A23L29/06 , A23L33/10 , A23L33/18 , A23L33/20 , A23V2002/00 , A61K9/485 , A61K9/4858 , A61K38/44 , A61K38/54 , A61K2300/00 , A61P1/00 , C12Y101/99011 , C12Y302/0102 , C12Y302/01026 , C12Y503/01005
Abstract: An agent is described that, with the help of glucose isomerase, converts fructose into glucose and thus, alone or in combination with 5-D-fructose dehydrogenase, reduces the bioavailability of fructose in the human or animal body. This agent can be used in particular in the therapy of fructose intolerance.
Abstract translation: 描述了在葡萄糖异构酶的帮助下，将果糖转化为葡萄糖并因此单独或与5-D-果糖脱氢酶组合的药剂降低了人或动物体内果糖的生物利用度。 该药剂特别可用于果糖不耐症的治疗。
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8.发明申请AGENT FOR REDUCING THE USEABLE CALORIE CONTENT OF FOOD AND FOR THERAPEUTIC REDUCTION OF WEIGHT, IN PARTICULAR FOR USE IN THE CASE OF ADIPOSITY (OBESITY) 审中-公开用于减少食用的可食用卡路里内容和用于治疗减少体重的具体用途，特别适用于“亲和力”（OBESITY）
公开(公告)号：WO2007059955A2
公开(公告)日：2007-05-31
申请号：PCT/EP2006/011231
申请日：2006-11-23
Applicant: PRO NATURA GESELLSCHAFT FÜR GESUNDE ERNÄHRUNG MBH , WYROBNIK, Daniel, Henry , WYROBNIK, Isaac, Harry
Inventor： WYROBNIK, Daniel, Henry , WYROBNIK, Isaac, Harry
CPC classification number: A61K38/443 , A23L33/10 , A23L33/20 , A23L33/30 , A23P10/30 , A23V2002/00 , A61K38/52 , C12Y101/99011 , C12Y503/01005 , C12Y503/01018 , A61K2300/00
Abstract: An agent for reducing the useable calorie content of food is described which contains a compound effecting the dehydrogenation of fructose to 5-keto-D-fructose. In addition, a combination agent is described which also contains a compound that converts glucose to fructose. These agents can be used in particular in the therapy of adiposity (obesity).
Abstract translation: 描述了一种用于降低食用可卡路里含量的试剂，它含有一种化合物，该化合物使果糖脱氢成为5-酮-D-果糖。 此外，还描述了还含有将葡萄糖转化为果糖的化合物的组合剂。 这些药剂特别可用于肥胖症（肥胖症）的治疗。
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