公开(公告)号：WO2008052153A3

公开(公告)日：2008-06-26

申请号：PCT/US2007082623

申请日：2007-10-26

Applicant: CORNELL RES FOUNDATION INC ,  XU CHRIS ,  VAN HOWE JAMES

Inventor： XU CHRIS ,  VAN HOWE JAMES

IPC: G02F1/035

CPC classification number: G02F1/3513 ,  G01N21/6408 ,  G01N21/6458 ,  G01N2021/653 ,  G01N2201/0696 ,  G02B6/02009 ,  G02B6/02214 ,  G02B6/03644 ,  G02B21/06 ,  G02B21/16 ,  G02F2203/17 ,  G02F2203/26 ,  G02F2203/54

Abstract: An apparatus for producing optical pulses of a desired wavelength includes an optical pulse source operable to generate input optical pulses at a first wavelength, and a higher order mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by soliton self-frequency shift (SSFS). The present invention also relates to a method of producing optical pulses having a desired wavelength. This method includes generating input optical pulses using an optical pulse source, where the input optical pulses have a fist wavelength and a first spatial mode. The input optical pulses are delivered into an HOM fiber module to alter the wavelength of the input optical pulses from the first wavelength to a desired wavelength by soliton serf-frequency shift (SSFS) within the HOM fiber module, thereby producing output optical pulses having the desired wavelength.

Abstract translation: 用于产生所需波长的光脉冲的装置包括可用于产生第一波长的输入光脉冲的光脉冲源和可操作以接收第一波长的输入光脉冲的高阶模（HOM）光纤模块，此后 通过孤子自频移（SSFS）产生所需波长的输出光脉冲。 本发明还涉及一种产生具有所需波长的光脉冲的方法。 该方法包括使用光脉冲源产生输入光脉冲，其中输入光脉冲具有第一波长和第一空间模式。 输入光脉冲被输送到HOM光纤模块中，以通过HOM光纤模块内的孤子serf-frequency shift（SSFS）将输入光脉冲的波长从第一波长改变到期望的波长，从而产生具有 所需波长。

公开(公告)号：WO2009064753A1

公开(公告)日：2009-05-22

申请号：PCT/US2008/083174

申请日：2008-11-12

Applicant: CORNELL UNIVERSITY ,  WEBB, Watt W. ,  XU, Chris

Inventor： WEBB, Watt W. ,  XU, Chris

IPC: A61B5/00 ,  A61B5/048 ,  A61B5/05

CPC classification number: A61B5/0059 ,  A61B5/4088 ,  G01N21/6428

Abstract: Apparatus and methods relating to non-imaging, multiphoton fluorescence and optical second harmonic generation (SHG) (and higher harmonic generation) emission and detection. A weakly focused excitation beam is used to generate fluorescence emission in a volume of between about 0.1 cm 3 to one cubic centimeter (1 cm 3 ), which is significantly larger than the conventional MPM focal volume. A method for shaping and/or controlling (confining) the focal volume of a non-imaging, fluorescence emission excitation field in a target medium involves decoupling the axial dimension dependence of the focal volume from the lateral spot size of the excitation field. The method involves the step of spatially separating at least some of the spectral components of a short duration, multichromatic excitation field outside of the focal volume and spatially recombining the spectral components in a short duration, high intensity, weakly focused field incident on the target medium. The apparatus and methods described herein are particularly suitable for, but not limited to, non-invasive, in-vivo biological assay and disease state indication in target tissue and, more particularly, to potential early detection of Alzheimer's and other diseases.

Abstract translation: 与非成像，多光子荧光和光二次谐波产生（SHG）（和高次谐波产生）发射和检测相关的装置和方法。 使用弱聚焦的激发光束产生体积在约0.1cm 3至1立方厘米（1cm 3）之间的荧光发射，其明显大于常规MPM焦点体积。 用于成形和/或控制（限制）目标介质中的非成像荧光发射激发场的焦点体积的方法包括将焦点体积的轴向尺寸依赖性与激励场的横向光点尺寸相分离。 该方法包括将聚焦体外外的短持续时间多色激发场中的至少一些光谱分量空间分离的步骤，并且在入射到目标介质上的短持续时间，高强度，弱聚焦场中空间重组光谱分量 。 本文描述的装置和方法特别适用于但不限于靶组织中的非侵入性，体内生物测定和疾病状态指示，更具体地说，涉及阿尔茨海默病和其他疾病的潜在早期检测。

公开(公告)号：WO2009064746A2

公开(公告)日：2009-05-22

申请号：PCT/US2008/083164

申请日：2008-11-12

Applicant: CORNELL UNIVERSITY ,  WEBB, Watt, W. ,  XU, Chris

Inventor： WEBB, Watt, W. ,  XU, Chris

IPC: A61B1/00 ,  A61B1/07

CPC classification number: A61B5/0071 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/00188 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0062 ,  A61B5/0086 ,  G02B13/146 ,  G02B21/04 ,  G02B23/243 ,  G02B26/103

Abstract: Embodiments of the invention include an optical system and an optical system module, coupled to a distal end of a fluorescence emission endoscope apparatus, an optical waveguide-based fluorescence emission endoscopy system, and a method for remotely- controlled, multi -magnification imaging of a target or fluorescence emission collection from a target with a fluorescence emission endoscope apparatus. An exemplary system includes an objective lens disposed in a distal end of an endoscope apparatus. The lens is adapted to transmit both a visible target illumination and a fluorescence-emission-inducing target illumination as well as fluorescence-emission and visible light from the target. Thee system can thus simultaneously provide low magnification, large field of view imaging and high magnification, high-resolution multiphoton imaging with a single lens system.

Abstract translation: 本发明的实施例包括耦合到荧光发射内窥镜装置的远端的光学系统和光学系统模块，基于光波导的荧光发射内窥镜检查系统，以及用于远程控制的多放大成像 用荧光发射内窥镜装置从靶标靶或荧光发射采集。 示例性系统包括设置在内窥镜装置的远端中的物镜。 透镜适于透射可见目标照明和荧光发射诱导目标照明以及来自靶的荧光发射和可见光。 因此，您可以通过单个透镜系统同时提供低倍率，大视野成像和高倍率，高分辨率多光子成像。

公开(公告)号：WO2008094274A1

公开(公告)日：2008-08-07

申请号：PCT/US2007/067636

申请日：2007-04-27

Applicant: CORNELL RESEARCH FOUNDATION, INC . ,  VAN HOWE, James, W. ,  ZHU, Guanghao ,  XU, Chris (Chris)

Inventor： VAN HOWE, James, W. ,  ZHU, Guanghao ,  XU, Chris (Chris)

IPC: H04J14/02 ,  H04B10/12

CPC classification number: H04B10/255

Abstract: Methods and systems for compensation of Self-Phase Modulation 35 in fiber-based amplifier systems 20.

Abstract translation: 用于补偿光纤放大器系统中的自相位调制35的方法和系统20。

公开(公告)号：WO2006093962A3

公开(公告)日：2008-05-15

申请号：PCT/US2006007088

申请日：2006-03-01

Applicant: CORNELL RES FOUNDATION INC ,  ZHU GUANGHAO ,  XU CHRIS

Inventor： ZHU GUANGHAO ,  XU CHRIS

IPC: G02B27/10 ,  G01B11/24 ,  G01J3/30 ,  G02B1/10 ,  G02B5/28 ,  G02B27/44 ,  G02B27/46 ,  H04J14/02

CPC classification number: G02B21/06 ,  G02B21/16

Abstract: A technique for simultaneous spatial and temporal focusing of femtosecond pulses improves the signal-to-background ratio (SBR) in multiphoton imaging. This is achieved by spatially separating spectral components of pulses into a "rainbow beam" and recombining these components at the spatial focus of an imaging system (100). The temporal pulse width becomes a function of distance, with the shortest pulse width confined to the spatial focus. The technique can significantly improve the axial confinement and reduce the background excitation in multiphoton microscopy, and thereby increase the imaging depth in highly scattering biological specimens.

Abstract translation: 飞秒脉冲同时空间和时间聚焦的技术提高了多光子成像中的信号背景比（SBR）。 这通过将脉冲的频谱分量空间分离成“彩虹波束”并在成像系统（100）的空间焦点处重组这些分量来实现。 时间脉冲宽度成为距离的函数，其中最短的脉冲宽度限于空间焦点。 该技术可以显着改善轴向限制，并减少多光子显微镜中的背景激发，从而增加高散射生物样本中的成像深度。

公开(公告)号：WO2008052155A2

公开(公告)日：2008-05-02

申请号：PCT/US2007/082625

申请日：2007-10-26

Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  XU, Chris ,  VAN HOWE, James ,  LEE, Jennifer

Inventor： XU, Chris ,  VAN HOWE, James ,  LEE, Jennifer

IPC: G02F1/035

CPC classification number: G02F1/3513 ,  G01N21/6408 ,  G01N21/6458 ,  G01N2021/653 ,  G01N2201/0696 ,  G02B6/02009 ,  G02B6/02214 ,  G02B6/03644 ,  G02B21/06 ,  G02B21/16 ,  G02F2203/17 ,  G02F2203/26 ,  G02F2203/54

Abstract: The present invention includes an apparatus and method for producing optical pulses of a desired wavelength. The apparatus includes an optical pulse source operable to generate input optical pulses at a first wavelength. The apparatus further includes a higher-order-mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by exciting Cherenkov radiation using the input optical pulses. The present invention also relates to a method of producing optical pulses having a desired wavelength, where the input optical pulses have a first wavelength and a first spatial mode and the output optical pulses have a second wavelength and a second spatial mode, which may be converted to another spatial mode.

Abstract translation: 本发明包括用于产生所需波长的光脉冲的装置和方法。 该装置包括可用于产生第一波长的输入光脉冲的光脉冲源。 该装置还包括可操作以接收第一波长的输入光脉冲的高阶模（HOM）光纤模块，此后通过使用输入光脉冲激发切伦科夫辐射来产生所需波长的输出光脉冲。 本发明还涉及一种产生具有期望波长的光脉冲的方法，其中输入光脉冲具有第一波长和第一空间模式，并且输出光脉冲具有第二波长和第二空间模式，其可被转换 到另一个空间模式。

公开(公告)号：WO1997011355A1

公开(公告)日：1997-03-27

申请号：PCT/US1996014519

申请日：1996-09-18

Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  WEBB, Watt, W. ,  XU, Chris

Inventor： CORNELL RESEARCH FOUNDATION, INC.

IPC: G01N21/64

CPC classification number: G02B21/002 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/0084

Abstract: A laser scanning micrsocope (10) produces molecular excitation in a target material (14) by simultaneous absorption of three or more photons to thereby provide intrinsic three-dimensional resolution. Fluorophores having single photon absorption in the short (ultraviolet or visible) wavelength range are excited by a beam (16) of strongly focused subpicosecond pulses of laser light of relatively long (red or infrared) wavelength range. The fluorophores absorb at about one third, one fourth or even smaller fraction of the laser wavelength to produce fluoroscent images of living cells and other microscopic objects. The fluoroscent emission from the fluorophores increases cubicly, quarticly or even higher power law with the excitation intensity so that by focusing the laser light, fluorescence as well as photobleaching are confined to the vicinity of the focal plane. This feature provides depth of field resolution comparable to that produced by confocal laser scanning microscopes, and in addition reduces photobleaching and phototoxicity.

Abstract translation: 激光扫描微透镜（10）通过同时吸收三个或更多个光子在目标材料（14）中产生分子激发，从而提供固有的三维分辨率。 在短（紫外或可见）波长范围内具有单光子吸收的荧光团由具有相对较长（红色或红外）波长范围的激光的强烈聚焦的亚秒脉冲的光束（16）激发。 荧光团吸收激光波长的约三分之一，四分之一甚至更小的部分，以产生活细胞和其他微观物体的荧光图像。 来自荧光团的荧光发射随着激发强度增加立方，四方或甚至更高的幂定律，使得通过聚焦激光，荧光和光漂白被限制在焦平面附近。 该特征提供了与共焦激光扫描显微镜产生的景深相当的景深分辨率，并且还减少了光漂白和光毒性。

公开(公告)号：WO2012134427A3

公开(公告)日：2012-12-27

申请号：PCT/US2011022193

申请日：2011-01-24

Applicant: UNIV CORNELL ,  XU CHRIS ,  HOWARD SCOTT ,  STRAUB ADAM ,  ZHU GUANGHAO

Inventor： XU CHRIS ,  HOWARD SCOTT ,  STRAUB ADAM ,  ZHU GUANGHAO

IPC: G01N21/64 ,  G01B9/04

CPC classification number: G01N21/64 ,  G01N21/6408 ,  G01N21/6456 ,  G02F1/01

Abstract: A fluorescence emission imaging method and apparatus allows for high frame rate imaging in scattering medium as well as for fluorescence, phosphorescence, or luminescence lifetime imaging, time-resolved fluorescence, phosphorescence, or luminescence lifetime spectroscopy and imaging. A method involves providing an illumination beam, propagating the illumination beam to a light modulator array, modulating the illumination beam so as to generate an array of point sources, wherein each of the point sources is modulated at a frequency, imaging the modulated illumination beam on the object, and detecting a fluorescent, phosphorescent, or luminescent emission from the object. An optical imaging component in the form of a modulation mask has multiple bands. Each band has alternating transmissive and/or reflective and/or absorptive regions that are patterned such that light scanned over a band will be modulated at a band-related frequency.

Abstract translation: 荧光发射成像方法和装置允许散射介质中的高帧率成像以及荧光，磷光或发光寿命成像，时间分辨荧光，磷光或发光寿命光谱和成像。 一种方法包括提供照明光束，将照明光束传播到光调制器阵列，调制照明光束以产生点光源阵列，其中每个点光源以一个频率被调制，对被调制的照明光束进行成像 并且检测来自物体的荧光，磷光或发光发射。 调制掩模形式的光学成像部件具有多个带。 每个带具有交替的透射和/或反射和/或吸收区域，其被图案化，使得在频带上扫描的光将以带相关频率被调制。

公开(公告)号：WO2008052155A3

公开(公告)日：2008-08-07

申请号：PCT/US2007082625

申请日：2007-10-26

Applicant: CORNELL RES FOUNDATION INC ,  XU CHRIS ,  VAN HOWE JAMES ,  LEE JENNIFER

Inventor： XU CHRIS ,  VAN HOWE JAMES ,  LEE JENNIFER

IPC: H01S3/30

CPC classification number: G02F1/3513 ,  G01N21/6408 ,  G01N21/6458 ,  G01N2021/653 ,  G01N2201/0696 ,  G02B6/02009 ,  G02B6/02214 ,  G02B6/03644 ,  G02B21/06 ,  G02B21/16 ,  G02F2203/17 ,  G02F2203/26 ,  G02F2203/54

Abstract: The present invention includes an apparatus and method for producing optical pulses of a desired wavelength. The apparatus includes an optical pulse source operable to generate input optical pulses at a first wavelength. The apparatus further includes a higher-order-mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by exciting Cherenkov radiation using the input optical pulses. The present invention also relates to a method of producing optical pulses having a desired wavelength, where the input optical pulses have a first wavelength and a first spatial mode and the output optical pulses have a second wavelength and a second spatial mode, which may be converted to another spatial mode.

Abstract translation: 本发明包括用于产生所需波长的光脉冲的装置和方法。 该装置包括可用于产生第一波长的输入光脉冲的光脉冲源。 该装置还包括可操作以接收第一波长的输入光脉冲的高阶模（HOM）光纤模块，此后通过使用输入光脉冲激发切伦科夫辐射来产生所需波长的输出光脉冲。 本发明还涉及一种产生具有期望波长的光脉冲的方法，其中输入光脉冲具有第一波长和第一空间模式，并且输出光脉冲具有第二波长和第二空间模式，其可被转换 到另一个空间模式。

公开(公告)号：WO2008052153A2

公开(公告)日：2008-05-02

申请号：PCT/US2007/082623

申请日：2007-10-26

Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  XU, Chris ,  VAN HOWE, James

Inventor： XU, Chris ,  VAN HOWE, James

IPC: G02F1/035

CPC classification number: G02F1/3513 ,  G01N21/6408 ,  G01N21/6458 ,  G01N2021/653 ,  G01N2201/0696 ,  G02B6/02009 ,  G02B6/02214 ,  G02B6/03644 ,  G02B21/06 ,  G02B21/16 ,  G02F2203/17 ,  G02F2203/26 ,  G02F2203/54

Abstract: The present invention relates to an apparatus for producing optical pulses of a desired wavelength. The apparatus includes an optical pulse source operable to generate input optical pulses at a first wavelength. The apparatus further includes a higher order mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by soliton self- frequency shift (SSFS). The present invention also relates to a method of producing optical pulses having a desired wavelength. This method includes generating input optical pulses using an optical pulse source, where the input optical pulses have a first wavelength and a first spatial mode. The input optical pulses are delivered into an HOM fiber module to alter the wavelength of the input optical pulses from the first wavelength to a desired wavelength by soliton self- frequency shift (SSFS) within the HOM fiber module, thereby producing output optical pulses having the desired wavelength.

Abstract translation: 本发明涉及一种用于产生所需波长的光脉冲的装置。 该装置包括可用于产生第一波长的输入光脉冲的光脉冲源。 该装置还包括可操作以接收第一波长的输入光脉冲的高阶模式（HOM）光纤模块，此后通过孤子自频移（SSFS）产生所需波长的输出光脉冲。 本发明还涉及一种产生具有所需波长的光脉冲的方法。 该方法包括使用光脉冲源产生输入光脉冲，其中输入光脉冲具有第一波长和第一空间模式。 输入光脉冲被输送到HOM光纤模块中，以通过HOM光纤模块内的孤子自频移（SSFS）将输入光脉冲的波长从第一波长改变到期望的波长，从而产生具有 所需波长。