公开(公告)号：WO2011056021A3

公开(公告)日：2011-11-03

申请号：PCT/KR2010007806

申请日：2010-11-05

申请人： SNU R&DB FOUNDATION ,  KIM SUNGHOON ,  CHOI JIN WOO ,  LEE JIN YOUNG ,  KIM DAE GYU ,  HAN GYOON HEE ,  YANG JEE SUN ,  LEE CHUL HO

发明人： KIM SUNGHOON ,  CHOI JIN WOO ,  LEE JIN YOUNG ,  KIM DAE GYU ,  HAN GYOON HEE ,  YANG JEE SUN ,  LEE CHUL HO

IPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61P35/00

CPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/428

摘要： The present invention relates to a novel use of benzo-heterocycle derivatives, and more particularly, to a composition for preventing and treating cancer, comprising benzo-heterocycle derivatives or pharmaceutically acceptable salts thereof as active ingredients. The inventors of the present invention have found that KRS interacts with 67LR to promote the migration of cancer (or tumor) cells and thus affects the metastasis of cancer, and also have identified that the substance which inhibits the interaction between the KRS and 67LR suppresses the metastasis of cancer cells, and thus can be used for preventing and treating cancer. Accordingly, the composition of the present invention suppresses the metastasis of cancer, and therefore provides a novel means for preventing and treating cancer.

摘要翻译： 本发明涉及苯并杂环衍生物的新用途，更具体地，涉及用于预防和治疗癌症的组合物，其包含苯并杂环衍生物或其药学上可接受的盐作为活性成分。 本发明的发明人已经发现，KRS与67LR相互作用以促进癌症（或肿瘤）细胞的迁移，从而影响癌症的转移，并且还确定了抑制KRS和67LR之间的相互作用的物质抑制 癌细胞转移，因此可用于预防和治疗癌症。 因此，本发明的组合物抑制癌症的转移，因此提供了预防和治疗癌症的新手段。

公开(公告)号：WO2009093872A3

公开(公告)日：2009-11-05

申请号：PCT/KR2009000375

申请日：2009-01-23

申请人： KOREA RES INST OF BIOSCIENCE ,  SEOUL PHARMA CO LTD ,  IND ACADEMIC COOP ,  HAN GYOONHEE ,  YANG JEE SUN ,  NAM MIHEE ,  LEE CHUL HO ,  SONG DOONA ,  WON MISUN ,  CHUNG KYUNG-SOOK ,  KIM DONG-MYUNG ,  YOO HYANG-SOOK ,  KIM HWAN MOOK ,  PARK SONG-KYU ,  LEE KIHO ,  LEE CHANG WOO ,  KO WONJIN ,  RYOO BYUNG-HWAN ,  CHOI NAM-SONG ,  JEONG YONG-MI

发明人： HAN GYOONHEE ,  YANG JEE SUN ,  NAM MIHEE ,  LEE CHUL HO ,  SONG DOONA ,  WON MISUN ,  CHUNG KYUNG-SOOK ,  KIM DONG-MYUNG ,  YOO HYANG-SOOK ,  KIM HWAN MOOK ,  PARK SONG-KYU ,  LEE KIHO ,  LEE CHANG WOO ,  KO WONJIN ,  RYOO BYUNG-HWAN ,  CHOI NAM-SONG ,  JEONG YONG-MI

IPC分类号： C07C211/62

CPC分类号： C07C311/05 ,  C07C233/36 ,  C07C233/43 ,  C07C311/08

摘要： The present invention relates to a novel diamine compound or pharmaceutically acceptable salts thereof, method for preparing same, and a pharmaceutical composition for treating cancers containing same. The compound of the present invention exhibits superior effects of suppressing growth of tumor cells, and therefore can be valuable in treating cancer disease.

摘要翻译： 本发明涉及新型二胺化合物或其药学上可接受的盐，其制备方法和用于治疗含有其的癌症的药物组合物。 本发明的化合物表现出抑制肿瘤细胞生长的优异效果，因此在治疗癌症方面是有价值的。

公开(公告)号：WO2008018778A1

公开(公告)日：2008-02-14

申请号：PCT/KR2007/003861

申请日：2007-08-10

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  SEOUL PHARMA. CO., LTD. ,  HAN, Gyoon Hee ,  CHOI, Eun Hyun ,  YANG, Jee Sun ,  HONG, Sung Hee ,  KIM, Myung Sook ,  WON, Mi Sun ,  CHUNG, Kyung Sook ,  KIM, Dong Myung ,  YOO, Hyang Sook ,  KIM, Hwan Mook ,  PARK, Song Kyu ,  LEE, Ki Ho ,  LEE, Chang Woo ,  CHOI, Youn Woong ,  JEONG, Yong Mi ,  MIN, Byung Gu

发明人： HAN, Gyoon Hee ,  CHOI, Eun Hyun ,  YANG, Jee Sun ,  HONG, Sung Hee ,  KIM, Myung Sook ,  WON, Mi Sun ,  CHUNG, Kyung Sook ,  KIM, Dong Myung ,  YOO, Hyang Sook ,  KIM, Hwan Mook ,  PARK, Song Kyu ,  LEE, Ki Ho ,  LEE, Chang Woo ,  CHOI, Youn Woong ,  JEONG, Yong Mi ,  MIN, Byung Gu

IPC分类号： C07D295/185 ,  C07D241/04 ,  C07D243/08 ,  A61P35/00

CPC分类号： C07D295/185 ,  C07D243/08 ,  C07D295/26

摘要： The present invention relates to new heterocyclic compounds containing nitrogen atoms or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a phar¬ maceutical composition comprising the same for treatment of cancer. The compounds according to the present invention induce DNA damage due to reactive oxygen species to activate c-abl and p53, induce RhoB to generate apoptosis, and induce cell death by down-regulating Bcl2 involved in cell survival, which is generated by dysregulated signals via the mitochondria pathway, thereby inhibiting tumor cell growth and inducing apoptosis. Accordingly, the composition according to the present invention can be used to treat cancer.

摘要翻译： 本发明涉及含有氮原子的新型杂环化合物或其药学上可接受的盐，其制备方法和包含其的用于治疗癌症的药物组合物。 根据本发明的化合物诱导由于活性氧物质引起的DNA损伤以激活c-abl和p53，诱导RhoB产生细胞凋亡，并通过下调参与细胞存活的Bcl2诱导细胞死亡，其由失调信号通过 线粒体途径，从而抑制肿瘤细胞生长并诱导细胞凋亡。 因此，本发明的组合物可以用于治疗癌症。