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    HYDROPHILIC POLYMERS WITH PENDANT FUNCTIONAL GROUPS AND METHOD THEREOF
    8.
    发明申请
    HYDROPHILIC POLYMERS WITH PENDANT FUNCTIONAL GROUPS AND METHOD THEREOF 审中-公开

    公开(公告)号：WO2006124205A3

    公开(公告)日：2006-11-23

    申请号：PCT/US2006/015447

    申请日：2006-04-24

    申请人： NITTO DENKO CORPORATION ,  VAN, Sang ,  YU, Lei

    发明人： VAN, Sang ,  YU, Lei

    IPC分类号： C08G69/40 ,  C08G69/48 ,  A61K47/48

    摘要： A polymer comprising a recurring unit of the formula (I) as defined herein is described. In the formula (I), X is selected from the group consisting of -(CH2CH2O)m-CH2CH2- and -CH2CH2CH2O-(CH2CH2O)m-CH2CH2CH2-, wherein m is an integer in the range of 1 to 100; Y is selected from the group consisting of -C*HCH2-, -C*HCH2CH2-, -C*H-NHC(=O)-CH2CH2-, -C*H-NHC(=O)-CH2CH2CH2-, -CH2CH2N*CH2CH2-, -CH2CH2CH2N* CH2CH2CH2-, C2 to C20 alkyl, and C6 to C20 aryl, wherein C* and N* represent atoms to which Z is bonded; and Z is selected from the group consisting of -NHR1, -NH-C(=O)-(CH2)nC(=O)NR1R2, -NH-C(=O)-(CH2)nC(=O)OR1, -(CH2)nC(=O)NR1R2, -(CH2)nC(=O)OR1, -(CH2)nC(=O)SR1, and -(CH2)nNR1R2, wherein n is an integer in the range of 1 to 3, wherein R1 and R2 are each independently selected from the group consisting of hydrogen, C1 to C20 alkyl, C6 to C20 aryl, anticancer drugs, peptides, antibody fragment, lactose, galactose, mannose, transferrin, magnetic resonance imaging agents, succinimyl, and alkali metal.

    HYDROPHILIC POLYMERS WITH PENDANT FUNCTIONAL GROUPS AND METHOD THEREOF
    9.
    发明申请
    HYDROPHILIC POLYMERS WITH PENDANT FUNCTIONAL GROUPS AND METHOD THEREOF 审中-公开
    具有辅助功能组的亲水聚合物及其方法

    公开(公告)号：WO2006124205A2

    公开(公告)日：2006-11-23

    申请号：PCT/US2006015447

    申请日：2006-04-24

    申请人： NITTO DENKO CORP ,  VAN SANG ,  YU LEI

    发明人： VAN SANG ,  YU LEI

    CPC分类号： C08G69/26 ,  A61K47/595 ,  A61K47/60 ,  C08G69/02

    摘要： A polymer comprising a recurring unit of the formula (I) as defined herein is described. In the formula (I), X is selected from the group consisting of -(CH2CH2O)m-CH2CH2- and -CH2CH2CH2O-(CH2CH2O)m-CH2CH2CH2-, wherein m is an integer in the range of 1 to 100; Y is selected from the group consisting of -C*HCH2-, -C*HCH2CH2-, -C*H-NHC(=O)-CH2CH2-, -C*H-NHC(=O)-CH2CH2CH2-, -CH2CH2N*CH2CH2-, -CH2CH2CH2N* CH2CH2CH2-, C2 to C20 alkyl, and C6 to C20 aryl, wherein C* and N* represent atoms to which Z is bonded; and Z is selected from the group consisting of -NHR1, -NH-C(=O)-(CH2)nC(=O)NR1R2, -NH-C(=O)-(CH2)nC(=O)OR1, -(CH2)nC(=O)NR1R2, -(CH2)nC(=O)OR1, -(CH2)nC(=O)SR1, and -(CH2)nNR1R2, wherein n is an integer in the range of 1 to 3, wherein R1 and R2 are each independently selected from the group consisting of hydrogen, C1 to C20 alkyl, C6 to C20 aryl, anticancer drugs, peptides, antibody fragment, lactose, galactose, mannose, transferrin, magnetic resonance imaging agents, succinimyl, and alkali metal.

    摘要翻译： 描述了包含如本文所定义的式（I）的重复单元的聚合物。 在式（I）中，X选自 - （CH 2 CH 2 O）m -CH 2 CH 2 - 和-CH 2 CH 2 CH 2 O-（CH 2 CH 2 O）m -CH 2 CH 2 CH 2 - ，其中m是1至100的整数; Y选自-C * HCH 2 - ， - C * HCH 2 CH 2 - ， - C * H-NHC（= O）-CH 2 CH 2 - ， - C * H-NHC（= O）-CH 2 CH 2 CH 2 - ， - CH 2 CH 2 N * CH 2 CH 2 - ， - CH 2 CH 2 CH 2 N * CH 2 CH 2 CH 2 - ，C 2至C 20烷基和C 6至C 20芳基，其中C *和N *表示与Z键合的原子; 并且Z选自-NHR1，-NH-C（= O） - （CH2）nC（= O）NR1R2，-NH-C（= O） - （CH2）nC（= O）OR1， - （CH2）nC（= O）NR1R2， - （CH2）nC（= O）OR1， - （CH2）nC（= O）SR1和 - （CH2）nNR1R2，其中n是1 3，其中R1和R2各自独立地选自氢，C1至C20烷基，C6至C20芳基，抗癌药物，肽，抗体片段，乳糖，半乳糖，甘露糖，转铁蛋白，磁共振成像剂，琥珀酰基 ，和碱金属。