公开(公告)号：WO2009081259A1

公开(公告)日：2009-07-02

申请号：PCT/IB2008/003537

申请日：2008-12-15

Applicant: PFIZER INC. ,  BARTA, nancy Sue ,  CAMPBELL, Brian, Michael ,  DOUNAY Amy, Beth ,  GRAY, David, Lawrence, Firman ,  ZORN, Stevin, Howard

Inventor： BARTA, nancy Sue ,  CAMPBELL, Brian, Michael ,  DOUNAY Amy, Beth ,  GRAY, David, Lawrence, Firman ,  ZORN, Stevin, Howard

IPC: C07D401/04 ,  A61K31/44 ,  A61P25/00

CPC classification number: C07D401/04

Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract translation: 公开了化合物的化合物和药学上可接受的盐，其中化合物具有如说明书中定义的式（I）的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。

公开(公告)号：WO9909025A3

公开(公告)日：1999-04-15

申请号：PCT/IB9801198

申请日：1998-08-05

Applicant: PFIZER PROD INC ,  FLIRI ANTON FRANZ JOSEF ,  MAJCHRZAK MARK JEROME ,  SEYMOUR PATRICIA ANN ,  ZORN STEVIN HOWARD ,  ROLLEMA HANS

Inventor： FLIRI ANTON FRANZ JOSEF ,  MAJCHRZAK MARK JEROME ,  SEYMOUR PATRICIA ANN ,  ZORN STEVIN HOWARD ,  ROLLEMA HANS

IPC: A61K31/496 ,  A61P1/00 ,  A61P9/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/20 ,  A61P25/30 ,  A61P27/02 ,  A61P43/00 ,  C07D209/14 ,  C07D403/12 ,  C07D403/14 ,  C07D417/12

CPC classification number: C07D417/12 ,  C07D209/14 ,  C07D403/12

Abstract: 2(4-Aryl or Heteroaryl-piperazin-1-ylmethyl)-1H-Indole derivatives of formula (I) wherein a, T, V, X, Y, Z, R , R , R , R , R , R , R , R and R are as defined above, their pharmaceutically acceptable salts and pharmaceutical compositions containing such compounds or their salts interacting with the dopamin D4 receptor.

Abstract translation: 式（I）的2-（4-芳基或杂芳基 - 哌嗪-1-基甲基）-1H-吲哚衍生物其中a，T，V，X，Y，Z，R 1，R 2，R 3 R 4，R 5，R 6，R 7，R 8和R 9如上所定义，其药学上可接受的盐和药物组合物含有这些化合物或其盐相互作用 与多巴胺D4受体。