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    THREADED VALVED INFLATION NEEDLE FOR FACILITATING INFLATION OF PNEUMATIC OBJECTS
    1.
    发明申请
    THREADED VALVED INFLATION NEEDLE FOR FACILITATING INFLATION OF PNEUMATIC OBJECTS 审中-公开
    用于促进气动对象通气的螺纹阀控通气针

    公开(公告)号：WO2012009534A3

    公开(公告)日：2012-03-29

    申请号：PCT/US2011044004

    申请日：2011-07-14

    Applicant: REVELC LLC ,  COE JOTHAM WADSWORTH ,  GRAY DAVID LAWRENCE FIRMAN ,  COE MILES NICHOLAS

    Inventor： COE JOTHAM WADSWORTH ,  GRAY DAVID LAWRENCE FIRMAN ,  COE MILES NICHOLAS

    IPC: F16K24/02 ,  F16K15/20 ,  F16K24/04 ,  F16K24/06

    CPC classification number: F16K15/20 ,  A63B41/12 ,  A63B2210/50

    Abstract: This invention relates to a threaded valved inflation needle designed for controlled inflation or deflation of balls and toys by communicating with standard air sources, inflation methods and pressure monitoring devices. The invention is useful for adjustment and monitoring of internal pressure in balls that utilize a rubber valve of the type that commonly appears in recreational balls. The invention is also useful for controlled inflation of toys that utilize plastic pull out valves for communicating with external air sources. The utility and convenience of the threaded valved inflation needle is further enhanced by a cover designed to hold, protect, and lubricate the threaded valved inflation needle when not in use.

    Abstract translation: 本发明涉及一种螺纹阀式充气针头，其设计用于通过与标准空气源，充气方法和压力监测装置进行通信来控制球和玩具的充气或放气。 本发明对于利用通常出现在休闲球中的类型的橡胶阀的球的内部压力的调节和监测是有用的。 本发明对于利用塑料拉出阀用于与外部空气源连通的玩具的受控充气也是有用的。 带螺纹带阀的充气针的实用性和便利性通过设计用于在不使用时保持，保护和润滑带螺纹带阀的充气针的盖来进一步增强。

    THREADED VALVED INFLATION NEEDLE FOR FACILITATING INFLATION OF PNEUMATIC OBJECTS
    2.
    发明申请
    THREADED VALVED INFLATION NEEDLE FOR FACILITATING INFLATION OF PNEUMATIC OBJECTS 审中-公开
    用于促进气动对象充气的螺纹穿透针

    公开(公告)号：WO2012009534A2

    公开(公告)日：2012-01-19

    申请号：PCT/US2011/044004

    申请日：2011-07-14

    Applicant: REVELC, LLC ,  COE, Jotham, Wadsworth ,  GRAY, David, Lawrence, Firman ,  COE, Miles, Nicholas

    Inventor： COE, Jotham, Wadsworth ,  GRAY, David, Lawrence, Firman ,  COE, Miles, Nicholas

    IPC: F16K24/02 ,  F16K15/20 ,  F16K24/04 ,  F16K24/06

    CPC classification number: F16K15/20 ,  A63B41/12 ,  A63B2210/50

    Abstract: This invention relates to a threaded valved inflation needle designed for controlled inflation or deflation of balls and toys by communicating with standard air sources, inflation methods and pressure monitoring devices. The invention is useful for adjustment and monitoring of internal pressure in balls that utilize a rubber valve of the type that commonly appears in recreational balls. The invention is also useful for controlled inflation of toys that utilize plastic pull out valves for communicating with external air sources. The utility and convenience of the threaded valved inflation needle is further enhanced by a cover designed to hold, protect, and lubricate the threaded valved inflation needle when not in use.

    Abstract translation: 本发明涉及一种用于通过与标准空气源，膨胀方法和压力监测装置通信来控制球和玩具的受控的充气或放气的螺纹阀门充气针。 本发明可用于调节和监测使用通常出现在休闲球中的橡胶阀的球内部压力。 本发明对于利用塑料拉出阀与外部空气源通信的玩具的控制充气也是有用的。 通过设计成在不使用时保持，保护和润滑带螺纹的充气针的盖子进一步增强了带螺纹的充气针的效用和便利性。

    N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS
    5.
    发明申请
    N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS 审中-公开
    N-吡咯烷-3-基酰胺衍生物作为丝氨酸和诺达霉素重新吸收抑制剂

    公开(公告)号：WO2006064351A3

    公开(公告)日：2006-10-12

    申请号：PCT/IB2005003791

    申请日：2005-12-08

    Applicant: PFIZER LTD ,  ANDREWS MARK DAVID ,  BROWN ALAN DANIEL ,  FISH PAUL VINCENT ,  FRAY MICHAEL JONATHAN ,  LANSDELL MARK IAN ,  RYCKMANS THOMAS ,  STOBIE ALAN ,  VAKENHUT FLORIAN ,  GRAY DAVID LAWRENCE FIRMAN

    Inventor： ANDREWS MARK DAVID ,  BROWN ALAN DANIEL ,  FISH PAUL VINCENT ,  FRAY MICHAEL JONATHAN ,  LANSDELL MARK IAN ,  RYCKMANS THOMAS ,  STOBIE ALAN ,  VAKENHUT FLORIAN ,  GRAY DAVID LAWRENCE FIRMAN

    IPC: C07D207/34 ,  A61K31/40 ,  A61P13/00 ,  A61P25/24 ,  A61P29/00 ,  C07D211/58 ,  C07D401/12

    CPC classification number: C07D207/14 ,  C07D211/58 ,  C07D401/12

    Abstract: A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R 1 is H, C 1-6 alkyl, -C(A)Y, C 3-8 cycloalkyl, aryl, het, aryl-C 1-4 alkyl or het-C l-4 alkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted; A is S or O; Y is H, C 1-6 alkyl, aryl, het, aryl-C 1-4 alkyl or het­-C 1-4 alkyl; aryl is independently selected from phenyl, naphthyl, anthracyl or phenanthryl; het is independently selected from an aromatic or non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom; R 2 is aryl 1 or het 1 , each optionally substituted; aryl 1 is independently selected from phenyl, naphthyl, anthracyl, phenanthryl, or indanyl; het 1 is an aromatic 5 to 10 membered heterocyclic ring system which contains at least one N, O or S heteroatom, optionally containing an aryl group; R 3 is H, C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-6 alkyl, C 1-8 alkylSC 1-8 alkyl, het 3 , or het 3 -C 1-4 alkyl, wherein the alkyl, cycloalkyl and het 3 groups are each optionally substituted; het 3 is a non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom; or R 3 is (CH 2 ) a

    Abstract translation: 式（I）化合物及其药学和/或兽医学上可接受的衍生物，其中：R 1是H，C 1-6烷基，-C（A）Y C 3-8环烷基，芳基，苯基，芳基-C 1-4烷基或叔-C 1-4烷基，其中 环烷基，芳基或苯基基团任选被取代; A是S或O; Y是H，C 1-6烷基，芳基，苯基，芳基-C 1-4烷基或叔丁基C 1-4烷基 ; 芳基独立地选自苯基，萘基，蒽基或菲基; 独立地选自芳族或非芳族的4-，5-或6-元杂环，其含有至少一个N，O或S杂原子，任选地与5-或6-元碳环基团或第二4- 含有至少一个N，O或S杂原子的5-或6-元杂环; R 2是每个任选被取代的芳基1或1或1; 芳基1独立地选自苯基，萘基，蒽基，菲基或茚满基; 包含至少一个任选含有芳基的N，O或S杂原子的芳族5至10元杂环系统; R 3是H，C 1-8烷基，C 3-8环烷基，C 3-8环烷基 C 1-6烷基，C 1-8烷基，C 1-6烷基，H 3或H 3 其中烷基，环烷基和叔丁基各自任选被取代; 它是非芳族的4-，5-或6-元杂环，其含有至少一个N，O或S杂原子，任选地与5-或6-元碳环基团或 含有至少一个N，O或S杂原子的第二个4-，5-或6-元杂环; 或者R 3是（CH 2）2。

    NOVEL COMPOUNDS
    6.
    发明申请
    NOVEL COMPOUNDS 审中-公开
    新型化合物

    公开(公告)号：WO2006064351A2

    公开(公告)日：2006-06-22

    申请号：PCT/IB2005/003791

    申请日：2005-12-08

    Applicant: PFIZER LIMITED ,  ANDREWS, Mark, David ,  BROWN, Alan, Daniel ,  FISH, Paul, Vincent ,  FRAY, Michael, Jonathan ,  LANSDELL, Mark, Ian ,  RYCKMANS, Thomas ,  STOBIE, Alan ,  VAKENHUT, Florian ,  GRAY, David, Lawrence, Firman

    Inventor： ANDREWS, Mark, David ,  BROWN, Alan, Daniel ,  FISH, Paul, Vincent ,  FRAY, Michael, Jonathan ,  LANSDELL, Mark, Ian ,  RYCKMANS, Thomas ,  STOBIE, Alan ,  VAKENHUT, Florian ,  GRAY, David, Lawrence, Firman

    IPC: C07D207/34 ,  C07D401/12 ,  C07D211/58 ,  A61K31/40 ,  A61P13/00 ,  A61P25/24 ,  A61P29/00

    CPC classification number: C07D207/14 ,  C07D211/58 ,  C07D401/12

    Abstract: A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R 1 is H, C 1-6 alkyl, -C(A)Y, C 3-8 cycloalkyl, aryl, het, aryl-C 1-4 alkyl or het-C l-4 alkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted; A is S or O; Y is H, C 1-6 alkyl, aryl, het, aryl-C 1-4 alkyl or het­-C 1-4 alkyl; aryl is independently selected from phenyl, naphthyl, anthracyl or phenanthryl; het is independently selected from an aromatic or non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom; R 2 is aryl 1 or het 1 , each optionally substituted; aryl 1 is independently selected from phenyl, naphthyl, anthracyl, phenanthryl, or indanyl; het 1 is an aromatic 5 to 10 membered heterocyclic ring system which contains at least one N, O or S heteroatom, optionally containing an aryl group; R 3 is H, C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-6 alkyl, C 1-8 alkylSC 1-8 alkyl, het 3 , or het 3 -C 1-4 alkyl, wherein the alkyl, cycloalkyl and het 3 groups are each optionally substituted; het 3 is a non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom; or R 3 is (CH 2 ) a , K, wherein a' is 0, 1 or 2 and K is a group selected from: Formula (i) wherein: Z is O, S, NR 12 , (CH 2 ) V or a bond; a is 1, 2, 3 or 4; b is 1, 2 or 3; v is 1 or 2; R 10 and R 11 are each independently H or C 1-4 alkyl; R 12 is H, C 1-6 alkyl, C(O)C 1-6 alkyl, SO 2 -C 1-6 alkyl; and wherein one or more pairs of hydrogen atoms on adjacent carbon or nitrogen atoms may be replaced by a corresponding number of double bonds, provided the ring system is not aromatic; Formula (ii) a carbocyclic spiro group containing 6 to 12 carbon atoms; Formula(iii) wherein: c is 1, 2, 3 or 4; d is 1, 2 or 3; e is 1 or 2; and R 30 is H or C 1-4 alkyl; and wherein one or more pairs of hydrogen atoms on adjacent carbon atoms may be replaced by a corresponding number of double bonds, provided the ring system is not aromatic; Formula (iv) wherein: f is 0, 1, 2 or 3; L is SO, SO 2 or NR 40 ; and R 40 is H, C 1-6 alkyl, C(O)C 1-6 alkyl, SO 2 -C 1-6 alkyl; and wherein one or more pairs of hydrogen atoms on adjacent carbon atoms may be replaced by a corresponding number of double bonds, provided the ring system is not aromatic; Formula (v) wherein: g is 0, 1, 2 or 3; and R 50 is H, C 1-8 alkyl, C 1-8 alkoxy, OH, halo, CF 3 , OCHF 2 , OCF 3, SCF 3 , hydroxy-C 1-6 alkyl, C 1-4 alkoxy-C 1-6 alkyl and C 1-4 alkyl-S-C 1-4 alkyl; and Formula (vi) CH(cyclopropane) 2 ; X is a covalent bond, C 1-8 alkyl or C 3-8 cycloalkyl, wherein if X is C 3-8 cycloalkyl, then R 2 -X may form a fused aryl-cycloalkyl ring system; and n is 1 or 2, provided that when n is 1, m is 0 or 1 and when n is 2, m is 0, wherein if m is 0, then * represents a chiral centre.

    Abstract translation: 式（I）化合物及其药学和/或兽医学上可接受的衍生物，其中：R 1是H，C 1-6烷基，-C（A）Y C 3-8环烷基，芳基，苯基，芳基-C 1-4烷基或叔-C 1-4烷基，其中 环烷基，芳基或苯基基团任选被取代; A是S或O; Y是H，C 1-6烷基，芳基，苯基，芳基-C 1-4烷基或叔丁基C 1-4烷基 ; 芳基独立地选自苯基，萘基，蒽基或菲基; 独立地选自芳族或非芳族的4-，5-或6-元杂环，其含有至少一个N，O或S杂原子，任选地与5-或6-元碳环基团或第二4- 含有至少一个N，O或S杂原子的5-或6-元杂环; R 2是每个任选被取代的芳基1或1或1; 芳基1独立地选自苯基，萘基，蒽基，菲基或茚满基; 包含至少一个任选含有芳基的N，O或S杂原子的芳族5至10元杂环系统; R 3是H，C 1-8烷基，C 3-8环烷基，C 3-8环烷基 C 1-6烷基，C 1-8烷基，C 1-6烷基，H 3或H 3 其中烷基，环烷基和叔丁基各自任选被取代; 它是非芳族的4-，5-或6-元杂环，其含有至少一个N，O或S杂原子，任选地与5-或6-元碳环基团或 含有至少一个N，O或S杂原子的第二个4-，5-或6-元杂环; 或R 3是（CH 2）2，...，

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