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公开(公告)号：WO2007032362A1
公开(公告)日：2007-03-22
申请号：PCT/JP2006/318103
申请日：2006-09-13
IPC分类号： C07C311/14 , A61K31/215 , A61K31/336 , A61K31/343 , A61K31/357 , A61K31/385 , A61K31/39 , A61K31/40 , A61K31/4025 , A61K31/443 , A61K31/5375 , A61P43/00 , C07D207/50 , C07D303/36 , C07D307/94 , C07D311/96 , C07D317/72 , C07D319/08 , C07D327/04 , C07D339/06 , C07D339/08 , C07D405/12 , C07D413/12 , C07D493/10
CPC分类号： C07C311/14 , C07C2601/16 , C07C2602/50 , C07D303/38 , C07D307/94 , C07D317/72 , C07D319/08 , C07D321/10 , C07D327/04 , C07D339/06 , C07D339/08 , C07D493/04 , C07D493/10
摘要： It is intended to provide a substituted cycloalkene derivative represented by the general formula (I) which has an action of suppressing intracellular signal transduction or cell activation caused by endotoxin and a cell response such as hyperproduction of an inflammatory mediator caused by them, a pharmacologically acceptable salt thereof, a method for producing the same, and a pharmaceutical containing the cycloalkene derivative as an active ingredient, which is excellent in prevention and/or treatment of a disease such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure or the like). General formula (I): {In the formula, X and Y represent a group which forms the ring A with the carbon atom of the ring B to which X and Y are bound or the like. l and m independently represent an integer of 0 to 3 and l+m is 1 to 3. R 1 represents an aliphatic hydrocarbon group which may be substituted or the like. n represents an integer of 0 to 3. R 2 represents a hydrogen atom, an alkyl group which may be substituted or the like, R 3 represents a phenyl group which may be substituted or the like, and R 5 represents a hydrogen atom, an alkyl group which may be substituted or the like.}
摘要翻译： 本发明提供由通式（I）表示的取代的环烯烃衍生物，其具有抑制由内毒素引起的细胞内信号转导或细胞活化的作用，以及细胞应答，例如由它们引起的炎性介质的过量产生，药理学上可接受的 其盐，其制备方法和含有环烯烃衍生物作为活性成分的药物，其在预防和/或治疗诸如败血症（脓毒性休克，弥漫性血管内凝血，多器官功能衰竭或 喜欢）。 通式（I）：{在该式中，X和Y表示与结合X和Y的环B的碳原子形成环A的基团等。 l和m独立地表示0〜3的整数，l + m为1〜3。R 1表示可以被取代的脂肪族烃基等。 n表示0〜3的整数。R 2表示氢原子，可被取代的烷基等，R 3表示可以是 取代基等，R 5表示氢原子，可被取代的烷基等。}
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公开(公告)号：WO2004111037A1
公开(公告)日：2004-12-23
申请号：PCT/JP2004/008492
申请日：2004-06-10
IPC分类号： C07D401/14
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444
摘要： A cyclic tertiary amine compound which is capable of inhibiting the production of inflammatory cytokine. It is either a compound having a structure represented by the following general formula (I): (I) (wherein A represents an optionally substituted trivalent group derived from pyrimidine, pyrrole, or the like; R represents optionally substituted aryl or heteroaryl; R represents optionally substituted heteroaryl; and R represents cyclic tertiary amino) or a pharmacologically acceptable salt of the compound.
摘要翻译： 能够抑制炎性细胞因子产生的环状叔胺化合物。 它是具有由以下通式（I）表示的结构的化合物：（I）（其中A表示任选取代的衍生自嘧啶，吡咯等的三价基团; R 1表示任选取代的芳基或杂芳基 R 2表示任选取代的杂芳基; R 3表示环状叔氨基）或化合物的药学上可接受的盐。
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公开(公告)号：WO2004009592A1
公开(公告)日：2004-01-29
申请号：PCT/JP2003/009110
申请日：2003-07-17
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A bicyclic unsaturated tertiary amine compound which can inhibit the production of inflammatory cytokine. It is a compound represented by the following general formula (I), pharmacologically acceptable salt thereof, pharmacologically acceptable ester thereof, or pharmacologically acceptable other derivative thereof: (I) wherein A represents pyrrole or pyrazole; R represents optionally substituted aryl or heteroaryl; R represents optionally substituted heteroaryl; and R represents indolizine.
摘要翻译： 可抑制炎性细胞因子产生的双环不饱和叔胺化合物。 它是由以下通式（I）表示的化合物，其药理学上可接受的盐，其药理学可接受的酯或其药学上可接受的其它衍生物：其中A表示吡咯或吡唑; R 1表示任选取代的芳基或杂芳基; R 2表示任选取代的杂芳基; 并且R 3表示中氮茚。
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