中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

5 records (took 0.013 seconds)

    DETECTING VARYING CONDUCTANCE INDICATIVE OF SEQUENTIAL INTERACTIONS BETWEEN NUCLEOBASES
    1.
    发明申请
    DETECTING VARYING CONDUCTANCE INDICATIVE OF SEQUENTIAL INTERACTIONS BETWEEN NUCLEOBASES 审中-公开

    公开(公告)号：WO2023086416A1

    公开(公告)日：2023-05-19

    申请号：PCT/US2022/049451

    申请日：2022-11-09

    Applicant: ADAPTIVE BIOTECHNOLOGIES CORPORATION

    Inventor： BIELAS, Jason H. ,  ROBINS, Harlan S.

    IPC: C12Q1/6869 ,  G06F3/00 ,  G06N3/00 ,  G06N20/00

    Abstract: Provided are methods comprising causing relative movement of a first nucleic acid through an opening formed at least in part by an electrolyzed second nucleic acid. Such methods comprise, during the relative movement, detecting a varying conductance along the first nucleic acid, or a varying conductance between the first nucleic acid and an electrode proximate to the first nucleic acid, wherein the varying conductance is indicative of sequential interactions between nucleobases of the first nucleic acid and one or more nucleobases of the electrolyzed second nucleic acid. The varying conductance comprises conductance fingerprints for the different nucleobases in the first nucleic acid. In certain embodiments, the methods comprise determining the identity of one or more nucleotide, optionally determining a sequence, of the first nucleic acid based on the varying conductance. Computer-readable media and systems that find use, e.g., in practicing the methods of the present disclosure, are also provided.

    CROHN'S DISEASE-ASSOCIATED T CELL RECEPTOR-RELATED METHODS
    4.
    发明申请
    CROHN'S DISEASE-ASSOCIATED T CELL RECEPTOR-RELATED METHODS 审中-公开

    公开(公告)号：WO2022192662A1

    公开(公告)日：2022-09-15

    申请号：PCT/US2022/019938

    申请日：2022-03-11

    Applicant: ADAPTIVE BIOTECHNOLOGIES CORPORATION

    Inventor： ROBINS, Harlan S. ,  SNYDER, Thomas M.

    IPC: G16B20/30 ,  G16B30/00 ,  C07K14/705 ,  C12N5/00 ,  C07K14/7051 ,  C12N5/0636

    Abstract: Provided are methods for assessing T cell receptor β chain complementary determining region 3 (TCRβ CDR3) sequences. In certain embodiments, prior to the assessing, the subject has been identified as having, or is suspected of having, inflammatory bowel disease (IBD). According to some embodiments, at the time of the assessing, the subject has one or more non-specific symptoms consistent with Crohn's disease. Also provided are methods comprising administering a Crohn's disease therapy to a subject identified as comprising T cells that express a T cell receptor β chain (TCRβ) comprising a TCRβ CDR3 sequence set forth in the present disclosure. Computer readable media and systems for assessing TCRβ CDR3 sequences are also provided.

    METHODS FOR DEFINING AND PREDICTING IMMUNE RESPONSE TO ALLOGRAFT
    5.
    发明申请
    METHODS FOR DEFINING AND PREDICTING IMMUNE RESPONSE TO ALLOGRAFT 审中-公开
    用于定义和预测免疫应答对ALLOGRAFT的方法

    公开(公告)号：WO2015106161A1

    公开(公告)日：2015-07-16

    申请号：PCT/US2015/010904

    申请日：2015-01-09

    Applicant: ADAPTIVE BIOTECHNOLOGIES CORPORATION ,  NORTHWESTERN UNIVERSITY

    Inventor： EMERSON, Ryan O. ,  ROBINS, Harlan S. ,  KIRSCH, Ilan ,  MATHEW, James ,  LEVENTHAL, Joseph

    IPC: C12Q1/68

    CPC classification number: C12Q1/6881 ,  C12Q2600/118 ,  C12Q2600/156

    Abstract: Methods are provided for predicting and determining a subject's immune response to allograft. Methods include assessing immune response to an allograft by characterizing the diversity and distribution of clones of the adaptive immune repertoire. Methods are also provided for characterizing the adaptive immune response of a subject to an allograft using a mixed lymphocyte reaction culture.

    Abstract translation: 提供了用于预测和确定受试者对同种异体移植物的免疫应答的方法。 方法包括通过表征适应性免疫谱的克隆的多样性和分布来评估同种异体移植物的免疫应答。 还提供了使用混合淋巴细胞反应培养物来表征受试者对同种异体移植物的适应性免疫应答的方法。

Patent Agency Ranking