公开(公告)号：WO2013158044A1

公开(公告)日：2013-10-24

申请号：PCT/SG2013/000156

申请日：2013-04-19

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： RAHMAN, Abdur Rub Abdur ,  JEGATHA, Chandran ,  SHANKAR, Lakshmi ,  WONG, Chee Chung

IPC: A61M1/36 ,  G01N1/40 ,  G01N15/05

CPC classification number: C12N13/00 ,  B01L3/502753 ,  B01L2200/06 ,  B01L2300/0681 ,  B03C1/30 ,  B03C2201/22 ,  G01N33/54333 ,  G01N33/54386 ,  G01N33/56966 ,  G01N35/0098

Abstract: According to embodiments of the present invention, an apparatus for separating a biological entity from a sample volume is provided. The apparatus includes an input chamber including an inlet configured to receive the volume sample, and an outlet, at least one magnetic element adjacent a portion of the input chamber, the magnetic element configured to provide a magnetic field in a vicinity of the portion of the input chamber to trap at least some leukocytes from the sample volume, and a filter in fluid communication with the outlet, the filter configured to separate the biological entity. According to further embodiments of the present invention, a method for separating a biological entity from a sample volume is also provided.

Abstract translation: 根据本发明的实施例，提供了一种用于从样品体积分离生物体的装置。 该装置包括输入腔室，该输入腔室包括构造成容纳体积样本的入口和出口，与输入腔室的一部分相邻的至少一个磁性元件，该磁性元件构造成在该部分附近提供磁场 输入室以从样品体积捕获至少一些白细胞，以及与出口流体连通的过滤器，所述过滤器被配置为分离生物实体。 根据本发明的另外的实施方案，还提供了用于从样品体积分离生物体的方法。

公开(公告)号：WO2013158045A1

公开(公告)日：2013-10-24

申请号：PCT/SG2013/000157

申请日：2013-04-19

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： ARYA, Sunil Kumar ,  RAHMAN, Abdur Rub Abdur ,  JEGATHA, Chandran ,  WONG, Chee Chung

IPC: B01D25/00 ,  B01D29/50 ,  G01N33/00 ,  G01N27/30 ,  A61M1/34

CPC classification number: G01N1/4077 ,  B01D61/147 ,  B01D67/0034 ,  B01D67/0062 ,  B01D69/12 ,  B01D71/44 ,  B01L3/502753 ,  B01L2200/0668 ,  B01L2300/0681 ,  B01L2400/043 ,  B01L2400/0487 ,  G01N2001/4088

Abstract: According to embodiments of the present invention, a microfilter is provided. The microfilter includes a first porous layer and a second porous layer arranged one over the other, wherein the first porous layer includes a plurality of first pores defined through the first porous layer, wherein the second porous layer includes a plurality of second pores defined through the second porous layer, and wherein one or more respective second pores are arranged to at least substantially overlap with each respective first pore such that a respective opening defined between a perimeter of the each respective first pore and a perimeter of each of the one or more respective second pores is smaller than a diameter of each first pore. According to further embodiments of the present invention, an apparatus for separating a biological entity from a sample volume is also provided.

Abstract translation: 根据本发明的实施例，提供了一种微过滤器。 微滤器包括一个彼此排列的第一多孔层和第二多孔层，其中第一多孔层包括通过第一多孔层限定的多个第一孔，其中第二多孔层包括多个第二孔， 第二多孔层，并且其中一个或多个相应的第二孔布置成与每个相应的第一孔至少基本重叠，使得限定在每个相应的第一孔的周边和所述一个或多个相应的每个的每个的周长之间的相应开口 第二孔小于每个第一孔的直径。 根据本发明的另外的实施例，还提供了一种用于将样品体积分离出来的装置。