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公开(公告)号：WO2016124909A1
公开(公告)日：2016-08-11
申请号：PCT/GB2016/050235
申请日：2016-02-02
Applicant: ATLAS GENETICS LIMITED
Inventor： EDWARDS, Tom
CPC classification number: B01L3/502738 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/0689 , B01L2200/12 , B01L2300/044 , B01L2300/0887 , B01L2400/0683 , B32B3/266 , B32B3/30 , B32B5/142 , B32B7/045 , B32B7/12 , B32B15/08 , B32B15/20 , B32B27/08 , B32B27/32 , B32B27/36 , B32B2255/06 , B32B2255/10 , B32B2255/26 , B32B2307/31 , B32B2307/50 , B32B2307/582 , B32B2307/7246 , B32B2439/80 , B65B3/003 , B65B9/042 , B65B39/007 , B65B39/12 , B65B47/00 , B65B47/04 , B65D75/367
Abstract: A blister assembly comprises at least one collapsible blister adapted, as it is collapsed, to eject a liquid contained therein. The blister assembly comprises a first layer (130) having at least one blister chamber (150) and a second layer (131) sealed to the first layer at least around a periphery of the at least one blister chamber such that a liquid is contained between the first layer and the second layer. The seal between the first and second layers comprises a first planar portion having a first peel strength and a second planar portion having a second peel strength, wherein the first peel strength is greater than the second peel strength, such that when pressure is applied to the blister, the second portion of the seal breaks to release the liquid contained within the chamber into the liquid inlet. The blister assembly further comprises at least one discontinuity (142) formed in the first and second layers in the region of the first portion of the seal, such that a shear force is required to delaminate the first and second layers in that region.
Abstract translation: 泡罩组件包括至少一个可折叠的泡罩，其可折叠地适于喷射其中容纳的液体。 泡罩组件包括具有至少一个泡罩室（150）的第一层（130）和至少围绕至少一个泡罩室的周边密封到第一层的第二层（131），使得液体包含在 第一层和第二层。 第一和第二层之间的密封包括具有第一剥离强度的第一平面部分和具有第二剥离强度的第二平面部分，其中第一剥离强度大于第二剥离强度，使得当将压力施加到 水泡，密封件的第二部分断开，将容纳在室内的液体释放到液体入口中。 泡罩组件还包括形成在密封件的第一部分区域中的第一和第二层中的至少一个不连续部分（142），使得需要剪切力来分层该区域中的第一和第二层。
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公开(公告)号：WO2016124907A1
公开(公告)日：2016-08-11
申请号：PCT/GB2016/050233
申请日：2016-02-02
Applicant: ATLAS GENETICS LIMITED
Inventor： ARLETT, Ben , EDWARDS, Tom
CPC classification number: B01L3/527 , B01L3/502738 , B01L7/52 , B01L7/525 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/14 , B01L2200/146 , B01L2300/021 , B01L2300/0809 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/1822 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0666 , B01L2400/0683 , G01N35/00029 , G01N35/1002 , G01N2035/1044
Abstract: Instrument for performing a diagnostic test on a fluidic cartridge A cartridge reader is for carrying out a diagnostic test on a sample contained in a fluidic cartridge inserted into the reader. The fluidic cartridge comprises a fluidic layer comprising at least one sample processing region, at least one collapsible blister containing a liquid reagent, a pneumatic interface, an electrical interface and at least one mechanical valve. The reader comprises a housing; an upper clamp occupying a fixed position relative to the reader, anda lower clamp, movable relative to the first clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween. The reader comprises a thermal module comprised in the lower clamp, wherein the thermal module comprises at least one thermal stack for heating the at least one sample processing region of the cartridge inserted into the reader. The reader comprises at least one mechanical actuator for actuating the mechanical valve comprised in the cartridge inserted into the reader.
Abstract translation: 用于对流体盒进行诊断测试的仪器盒读取器用于对包含在插入到读取器中的流体盒中的样品进行诊断测试。 流体盒包括流体层，其包含至少一个样品处理区域，至少一个含有液体试剂的可收缩泡罩，气动界面，电接口和至少一个机械阀。 读者包括一个外壳; 相对于读取器占据固定位置的上夹具，以及相对于第一夹具可移动的下夹具，其中上夹具和下夹具在其间限定盒容纳区域。 阅读器包括下部夹具中的热模块，其中热模块包括至少一个用于加热插入到读取器中的盒的至少一个样品处理区域的热叠层。 阅读器包括至少一个机械致动器，用于致动包括在插入读取器中的盒中的机械阀。
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公开(公告)号：WO2016124905A1
公开(公告)日：2016-08-11
申请号：PCT/GB2016/050231
申请日：2016-02-02
Applicant: ATLAS GENETICS LIMITED
Inventor： ARLETT, Ben , EDWARDS, Tom
CPC classification number: B01L3/527 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2200/025 , B01L2200/04 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/1822 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0666 , B01L2400/0683 , C12Q1/686 , G01N35/00029 , G01N35/1002 , G01N35/1009 , G01N2035/1044
Abstract: A cartridge reader is configured to carry out a diagnostic test on a fluid sample contained within a fluidic cartridge. The cartridge comprises first, second and third collapsible blisters containing at least one reagent for use in the diagnostic test. The cartridge reader comprises an upper clamp, occupying a fixed position relative to the reader and a lower clamp, movable relative to the upper clamp, and wherein the upper clamp and the lower clamp are configured to receive and hold a fluidic cartridge therebetween. First, second and third blister actuators are mounted on the upper clamp, for aligning with first, second and third collapsible blisters of a fluidic cartridge inserted into the reader. The first, second and third blister actuators are movable relative to the upper clamp, between a first position in which the blister actuators are spaced apart from the collapsible blisters comprised on the fluidic cartridge received between the upper and lower clamps, and a second position in which the blister actuators depress the collapsible blisters, thereby collapsing the blisters and ejecting the reagents contained therein into a channel in the microfluidic cartridge.
Abstract translation: 盒读取器被配置为对包含在流体盒中的流体样品进行诊断测试。 该盒包括第一，第二和第三可收缩泡罩，其包含用于诊断测试中的至少一种试剂。 墨盒读取器包括相对于读取器占据固定位置的上部夹具和可相对于上部夹具移动的下部夹具，并且其中上部夹具和下部夹具构造成在其间容纳和保持流体盒。 首先，第二和第三泡罩致动器安装在上夹具上，用于与插入读取器的流体盒的第一，第二和第三可折叠泡罩对准。 第一，第二和第三泡罩致动器可相对于上夹具移动，在第一位置和第二位置之间，第一位置中，泡罩致动器与包含在上下夹具之间的流体盒上的可折叠泡罩间隔开， 其中泡囊致动器压下可折叠的水疱，从而使泡罩塌缩并将其中包含的试剂喷射到微流体盒中的通道中。
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公开(公告)号：WO2016124908A1
公开(公告)日：2016-08-11
申请号：PCT/GB2016/050234
申请日：2016-02-02
Applicant: ATLAS GENETICS LIMITED
Inventor： ARLETT, Ben , EDWARDS, Tom
CPC classification number: B01L3/527 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/025 , B01L2200/04 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/1822 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0633 , B01L2400/0666 , B01L2400/0683 , C12Q1/686 , G01N33/48785 , G01N35/00029 , G01N2035/00128
Abstract: A cartridge reader controlled by processing means for carrying out a diagnostic test on a sample contained in a fluidic cartridge comprises a mechanical valve for isolating the sample with the cartridge. A system for actuating the mechanical valve comprises an actuation member configured to move the mechanical valve from an open position to a closed position and an armature connected to the actuation member. The armature is configured to engage an electromagnet, wherein the electromagnet can be switched between an active state in which it electromagnetically holds the armature and an inactive state in which it does not electromagnetically hold the armature. First biasing means are disposed between the actuation member and a bearing surface, wherein the first biasing means is configured to bias the actuation member into a first position in which it actuates a mechanical valve in a fluidic cartridge inserted into the reader.
Abstract translation: 用于对容纳在流体盒中的样品进行诊断测试的处理装置控制的盒读取器包括用于将样品与盒隔离的机械阀。 用于致动机械阀的系统包括构造成将机械阀从打开位置移动到关闭位置的致动构件和连接到致动构件的衔铁。 衔铁被配置为接合电磁体，其中电磁体可以在其电磁保持电枢的有效状态和不电磁地保持电枢的非活动状态之间切换。 第一偏置装置设置在致动构件和支承表面之间，其中第一偏置装置构造成将致动构件偏置到第一位置，在第一位置，致动构件驱动插入到读取器中的流体盒中的机械阀。
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