公开(公告)号：WO2017004359A1

公开(公告)日：2017-01-05

申请号：PCT/US2016/040364

申请日：2016-06-30

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： LEWIS, Richard, Thomas ,  JONES, Philip ,  PETROCCHI, Alessia ,  REYNA, Naphtali ,  HAMILTON, Matthew ,  SOTH, Michael, J. ,  HEFFERNAN, Timothy ,  HAN, Michelle ,  BURKE, Jason, P.

IPC: A61K31/501 ,  C07D417/14 ,  C07D207/00

CPC classification number: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/501 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  A61K2300/00

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLSl mediated diseases, such as cancer, having the structure of Formula (I). Methods of inhibition GLSl activity in a human or animal subject are also provided.

Abstract translation: 本文公开了可用于治疗具有式（I）结构的GLS1介导的疾病例如癌症的化合物和组合物。 还提供了抑制人或动物受试者的GLS1活性的方法。

公开(公告)号：WO2016145383A1

公开(公告)日：2016-09-15

申请号：PCT/US2016/022138

申请日：2016-03-11

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： LEWIS, Richard, Thomas ,  JONES, Philip ,  PETROCCHI, Alessia ,  REYNA, Naphtali ,  HAMILTON, Matthew, Michael ,  LEO, Elisabetta

IPC: A61K31/506 ,  A61K31/505 ,  A61P35/00 ,  C07D403/04 ,  C07D473/16

CPC classification number: C07D403/04 ,  A61K45/06 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/52 ,  C07D239/70 ,  C07D239/95 ,  C07D253/075 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D487/08 ,  C07D491/048

Abstract: Disclosed herein are compounds and compositions having the structure of Formula I, which are useful in the treatment of diseases, such as cancer, where inhibition of MTHl is expected to confer an advantage to a patient. Methods of inhibition of MTHl activity in a human or animal subject are also provided.

Abstract translation: 本文公开了具有式I结构的化合物和组合物，其可用于治疗诸如癌症的疾病，其中MTH1的抑制预期赋予患者优势。 还提供了在人或动物受试者中抑制MTH1活性的方法。

公开(公告)号：WO2016033416A1

公开(公告)日：2016-03-03

申请号：PCT/US2015/047361

申请日：2015-08-28

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  PALMER, Wylie ,  JONES, Philip ,  LIU, Gang ,  PETROCCHI, Alessia ,  REYNA, Naphtali ,  SUBRUMANIAN, Govindan ,  THEROFF, Jay ,  YAU, Anne

Inventor： PALMER, Wylie ,  JONES, Philip ,  LIU, Gang ,  PETROCCHI, Alessia ,  REYNA, Naphtali ,  SUBRUMANIAN, Govindan ,  THEROFF, Jay ,  YAU, Anne

IPC: A01N41/02

CPC classification number: C07D471/04 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/498 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098 ,  C07D235/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  Y02A50/411 ,  A61K2300/00

Abstract: Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibiting activity of a bromodomain-containing protein in a human or animal subject are also provided.

Abstract translation: 本文公开了可用于治疗含有溴结构域的蛋白质介导的疾病（例如癌症）的化合物和组合物，其具有式I的结构：还提供了抑制人类或动物受试者中含有溴结构域的蛋白质的活性的方法。