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1.发明申请PYRIMIDINE-SUBSTITUTED PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开吡啶基取代的吡咯烷衍生物，药物组合物及其用途
公开(公告)号：WO2014170197A1
公开(公告)日：2014-10-23
申请号：PCT/EP2014/057234
申请日：2014-04-10
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： FLECK, Martin , HEIMANN, Annekatrin , HEINE, Niklas , NOSSE, Bernd , ROTH, Gerald Juergen
IPC: C07D405/14 , C07D413/14 , C07D491/08 , C07D403/04 , C07D403/14 , C07D417/14 , C07D491/04 , C07D498/04 , A61P3/00 , A61K31/506 , A61K31/5377 , A61K31/5386
CPC classification number: C07D417/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D491/04 , C07D491/08 , C07D498/04
Abstract: The invention relates to new pyrrolidine derivatives of the formula (I), wherein R 1 to R 3 , Ar, L T and n are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Abstract translation: 本发明涉及式（I）的新的吡咯烷衍生物，其中R 1至R 3，Ar，LT和n如说明书和权利要求中所定义，用作药物用途，用于治疗用途的方法和含有 他们。
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2.发明申请NEW PYRROLIDINE DERIVATIVES AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS 审中-公开新型吡咯烷衍生物及其作为乙酰辅酶C羧酸酶抑制剂的用途
公开(公告)号：WO2014056771A1
公开(公告)日：2014-04-17
申请号：PCT/EP2013/070507
申请日：2013-10-02
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： FLECK, Martin , HEIMANN, Annekatrin , HEINE, Niklas , NOSSE, Bernd , ROTH, Gerald Juergen
IPC: C07D403/12 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D207/12 , C07D207/28 , A61K31/41 , A61P3/04 , A61P3/10
CPC classification number: C07D207/12 , C07D207/28 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: The invention relates to new pyrrolidine derivatives of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Abstract translation: 本发明涉及式（I）的新的吡咯烷衍生物，其用作药物，其治疗用途的方法和含有它们的药物组合物。
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公开(公告)号：WO2019185476A1
公开(公告)日：2019-10-03
申请号：PCT/EP2019/057233
申请日：2019-03-22
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： OOST, Thorsten , FLECK, Martin , KUTTRUFF, Christian, Andreas
IPC: C07H21/02 , A61P29/00 , A61P35/00 , A61K31/7084
Abstract: Compounds of formula (I) wherein Base, R 1 and R 2 are defined as in claim 1, are modulators of STING.
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公开(公告)号：WO2018060323A1
公开(公告)日：2018-04-05
申请号：PCT/EP2017/074608
申请日：2017-09-28
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： OOST, Thorsten , CAROTTA, Sebastian , FLECK, Martin
IPC: C07H21/02 , C07H19/23 , A61K31/7076 , A61P37/00
Abstract: The present invention relates to compounds of general formula (I), wherein the groups R 1 , R 2 and R 3 are defined as in claim 1, which have valuable pharmacological properties, particularly are modulators of STING.
Abstract translation: 本发明涉及通式（I）的化合物，其中基团R 1，R 2和R 3各自独立地为氢， 如权利要求1所定义，其具有有价值的药理学性质，特别是STING的调节剂。
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5.发明申请NEW AZETIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开新AZETIDINE衍生物，药物组合物及其用途
公开(公告)号：WO2013098375A1
公开(公告)日：2013-07-04
申请号：PCT/EP2012/077027
申请日：2012-12-28
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： FLECK, Martin , NOSSE, Bernd , ROTH, Gerald, Juergen
IPC: C07D205/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D498/04 , A61K31/397 , A61K31/4427
CPC classification number: C07D205/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D498/04
Abstract: The invention relates to new azetidine derivatives of the formula (I), to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Abstract translation: 本发明涉及式（I）的新的氮杂环丁烷衍生物，其作为药物的用途，其治疗用途的方法和含有它们的药物组合物。
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Patent Agency Ranking
公开(公告)号：WO2013079668A1
公开(公告)日：2013-06-06
申请号：PCT/EP2012/074110
申请日：2012-11-30
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： ROTH, Gerald Juergen , FLECK, Martin , LEHMANN-LINTZ, Thorsten , NOSSE, Bernd
IPC: C07D211/22 , C07D211/34 , C07D401/04 , A61K31/445 , A61K31/5377 , A61K31/506 , A61P3/00
CPC classification number: C07D211/34 , C07D211/22 , C07D401/04 , C07D413/14
Abstract: The invention relates to new piperidine derivatives of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Abstract translation: 本发明涉及式（I）的新的哌啶衍生物，其用作药物，其治疗用途的方法和含有它们的药物组合物。
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公开(公告)号：WO2018172206A1
公开(公告)日：2018-09-27
申请号：PCT/EP2018/056656
申请日：2018-03-16
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： OOST, Thorsten , FLECK, Martin , KUTTRUFF, Christian, Andreas , CAROTTA, Sebastian
Abstract: Compounds of formula (I) wherein Base 1 and Base 2 are defined as in claim 1 are modulators of STING.
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8.发明申请
公开(公告)号：WO2014184104A1
公开(公告)日：2014-11-20
申请号：PCT/EP2014/059537
申请日：2014-05-09
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： HEINE, Niklas , FLECK, Martin , NOSSE, Bernd , ROTH, Gerald Juergen
IPC: C07D413/14 , A61K31/41 , C07D403/04 , C07D403/14 , C07D417/14 , C07D207/12 , A61P3/00
CPC classification number: C07D403/04 , C07D207/12 , C07D401/04 , C07D403/14 , C07D413/14 , C07D417/14
Abstract: The invention relates to new pyrrolidine derivatives of the formula (I), wherein R 1 to R 5 , Ar 1 , Ar 2 and n are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Abstract translation: 本发明涉及式（I）的新的吡咯烷衍生物，其中R 1至R 5，Ar 1，Ar 2和n如说明书和权利要求中所定义，用作药物用途，用于治疗用途的方法和含有 他们。
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9.发明申请
公开(公告)号：WO2014114578A1
公开(公告)日：2014-07-31
申请号：PCT/EP2014/050981
申请日：2014-01-20
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： FLECK, Martin , HEINE, Niklas , NOSSE, Bernd , ROTH, Gerald Juergen
IPC: C07D401/14 , A61K31/4402 , A61K31/4406 , A61K31/4409 , C07D401/04 , C07D417/14 , A61P9/00
CPC classification number: C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: The invention relates to new pyrrolidine derivatives of the formula (I), to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Abstract translation: 本发明涉及式（I）的新的吡咯烷衍生物，其用作药物，用于治疗用途的方法和含有它们的药物组合物。
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10.发明申请
公开(公告)号：WO2013092976A1
公开(公告)日：2013-06-27
申请号：PCT/EP2012/076592
申请日：2012-12-21
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventor： ROTH, Gerald Juergen , FLECK, Martin , NOSSE, Bernd , LEHMANN-LINTZ, Thorsten
IPC: C07D401/04 , C07D413/12 , C07D417/12 , C07D211/26 , A61K31/451 , A61K31/454 , A61K31/4545 , A61P3/00
CPC classification number: C07D211/26 , C07D401/04 , C07D413/12 , C07D417/12
Abstract: The invention relates to new piperidine derivatives of the formula (I) to their use as medicaments, to methods for their therapeutic use as inhibitors of acetyl-CoA carboxylases and to pharmaceutical compositions containing them.
Abstract translation: 本发明涉及式（I）的新哌啶衍生物，其用作药物，其作为乙酰辅酶A羧化酶抑制剂的治疗用途的方法和含有它们的药物组合物。
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