公开(公告)号：WO2015066521A1

公开(公告)日：2015-05-07

申请号：PCT/US2014/063518

申请日：2014-10-31

Applicant: C2 THERAPEUTICS, INC.

Inventor： NEWELL, Gabriel, Francis W. ,  HOLLAND, Timothy, Douglas ,  ICO, Cesar, A. ,  WU, Patrick, P. ,  WILLIAMS, Richard, S.

IPC: A61B18/02

CPC classification number: A61B18/02 ,  A61B2017/00398 ,  A61B2017/00477 ,  A61B2018/00041 ,  A61B2018/00202 ,  A61B2018/00208 ,  A61B2018/0022 ,  A61B2018/00482 ,  A61B2018/00488 ,  A61B2018/00494 ,  A61B2018/005 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00815 ,  A61B2018/00916 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268 ,  A61B2090/064 ,  A61B2576/02

Abstract: A cryogenic ablation catheter 12 includes a catheter shaft 16, a balloon 24 and a connector 30 respectively at the catheter shaft proximal and distal ends 18, 20, a refrigerant delivery tube assembly including a refrigerant delivery tube 34 rotatable within the catheter shaft lumen 22, and a refrigerant delivery element 40 with an outlet 42 located inside the balloon which directs refrigerant 44 outwardly against the balloon at different rotary positions as it rotates. A cryogenic balloon ablation system 10 includes the cryogenic ablation catheter, a catheter coupler 119 mating with the connector, a motor 104 including a rotatable hollow motor shaft 102, and a delivery line 100 fluidly coupled to a cryogenic gas source 84 for supplying cryogenic gas to the refrigerant delivery tube. At least one of the refrigerant delivery tube and the delivery line passes at least partway through the hollow motor shaft. The coupling tip 60 of the connector and the refrigerant delivery tube 34 rotate with the motor shaft 102.

Abstract translation: 低温消融导管12包括分别位于导管轴近侧和远端18,20处的导管轴16，球囊24和连接器30，包括可在导管轴腔22内旋转的制冷剂输送管34的制冷剂输送管组件， 以及具有位于球囊内部的出口42的制冷剂输送元件40，其在致动器旋转时在不同的旋转位置向外引导制冷剂44抵靠气球。 低温球囊消融系统10包括低温消融导管，与连接器配合的导管联接器119，包括可旋转的中空电机轴102的电动机104以及与低温气体源84流体耦合以将低温气体供应到 制冷剂输送管。 制冷剂输送管和输送管中的至少一个至少一部分通过中空的电动机轴。 连接器的联接尖端60和制冷剂输送管34与电动机轴102一起旋转。

公开(公告)号：WO2013009700A1

公开(公告)日：2013-01-17

申请号：PCT/US2012/045952

申请日：2012-07-09

Applicant: C2 THERAPEUTICS, INC. ,  WU, Patrick, P. ,  ICO, Cesar, A. ,  WILLIAMS, Richard, S.

Inventor： WU, Patrick, P. ,  ICO, Cesar, A. ,  WILLIAMS, Richard, S.

IPC: A61B18/02 ,  A61M25/00 ,  A61B1/018

CPC classification number: A61B1/018 ,  A61B18/02 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0212

Abstract: One focal ablation assembly (72), used with an endoscope (12) comprising an endoscopic tube (16), comprises a cryogenic catheter (26), a balloon (74) and a reinforcing element (88). The cryogenic catheter is placeable within the endoscopic tube channel (28) and has a distal end (34) placeable at the distal end (24) of the endoscopic tube. The balloon is mountable to the catheter distal end (34) and extends distally of both of the distal ends. The reinforcing element at least partially defines the shape of the balloon in the expanded state. The balloon has a thermally conductive therapeutic region (36) which provides effectively no thermal insulation. Another focal ablation assembly (14) uses a cap (22) instead of the balloon. The cap substantially maintains its shape during use while not causing tissue trauma.

Abstract translation: 与包括内窥镜管（16）的内窥镜（12）一起使用的一个局部消融组件（72）包括低温导管（26），球囊（74）和加强元件（88）。 低温导管可放置在内窥镜管通道（28）内，并且具有可置于内窥镜管的远端（24）处的远端（34）。 气囊可安装到导管远端（34）并且延伸到两个远端的远侧。 增强元件至少部分地限定膨胀状态下的球囊的形状。 球囊具有导热治疗区域（36），其有效地提供绝热。 另一个焦点消融组件（14）使用盖（22）代替气球。 帽子在使用过程中基本保持其形状，同时不会导致组织创伤。

公开(公告)号：WO2010059519A1

公开(公告)日：2010-05-27

申请号：PCT/US2009/064395

申请日：2009-11-13

Applicant: C2 THERAPEUTICS, INC. ,  WILLIAMS, Richard, S. ,  GARCIA-MEZA, Peter

Inventor： WILLIAMS, Richard, S. ,  GARCIA-MEZA, Peter

IPC: A61B18/02

CPC classification number: A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/00488 ,  A61B2018/00714 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268 ,  A61M25/10185 ,  A61M25/1034 ,  A61M2025/1084 ,  A61M2210/105 ,  Y10T29/49826

Abstract: A device (10) for treating esophageal target tissue comprises a catheter (18), a balloon (16) and a refrigerant delivery device (20). The catheter has a distal portion (38) and a refrigerant delivery lumen (22). The balloon is mounted to and the refrigerant delivery device is coupled to the distal portion. The refrigerant delivery device comprises a chamber with the refrigerant delivery lumen opening into the chamber, a refrigerant delivery opening (65) fluidly coupled to the balloon interior (30), and a distribution passageway (59) fluidly coupling the chamber and the refrigerant delivery opening. A refrigerant (24) is deliverable through the refrigerant delivery lumen, into the chamber, through the distribution passageway, through the refrigerant delivery opening and into the balloon interior so to place the balloon into an expanded, cooled state to press against and cool esophageal target tissue. The medical device may include means for sensing a leak in the balloon.

Abstract translation: 用于治疗食管靶组织的装置（10）包括导管（18），气囊（16）和制冷剂输送装置（20）。 导管具有远端部分（38）和制冷剂输送腔（22）。 气囊被安装到并且制冷剂输送装置联接到远端部分。 制冷剂输送装置包括：腔室，其中制冷剂输送腔通向腔室;流体联接到球囊内部的制冷剂输送口（65）;以及分配通道（59），其将腔室和制冷剂输送口 。 制冷剂（24）能够通过制冷剂输送腔输送到腔室中，通过分配通道，通过制冷剂输送口进入气囊内部，以使气囊处于膨胀的冷却状态，以压迫和冷却食管靶 组织。 医疗装置可以包括用于感测气囊中的泄漏的装置。