公开(公告)号：WO2018236485A1

公开(公告)日：2018-12-27

申请号：PCT/US2018/032512

申请日：2018-05-14

Applicant: CRYTERION MEDICAL, INC.

Inventor： HARMOUCHE, Chadi

IPC: A61B18/02

CPC classification number: A61B18/02 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0268

Abstract: A fluid injection line contamination inhibitor (30) for an intravascular catheter system (10) includes a first check valve (34A) that is in fluid communication with a fluid source (16). The first check valve (34A) is configured to inhibit contaminants in a fluid injection line (28) from moving upstream to near a subcooler (26). The first check valve (34A) is positioned along the fluid injection line (28) downstream from the subcooler (26). The first check valve (34A) can be positioned between a connection port (36) and the subcooler (26), including near the connection port (36) or at the connection port (36). The fluid injection line contamination inhibitor (30) may further include a second check valve (34B) that is in fluid communication with the fluid source (16). The second check valve (34B) is positioned along the fluid injection line (28) downstream from the subcooler (26) and the first check valve (34A).

公开(公告)号：WO2013067421A2

公开(公告)日：2013-05-10

申请号：PCT/US2012/063411

申请日：2012-11-02

Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. ,  BIRDSALL, Matthew

Inventor： BIRDSALL, Matthew ,  BRENNAN, Gabriel ,  BERTRAND, Anthony ,  CHANG, Stacey ,  DOERKSEN, Kyle ,  DONLON, Brian ,  DUFFY, Angela ,  HARRINGTON, Kara ,  HOFF, Mark ,  HUYNH, Tim ,  KELLY, Brian ,  KELLY, Grace ,  MORIARTY, Micheal ,  NASH, Stephen ,  OBERWELZ, Elger ,  SAATCHI, Sanaz ,  SWEENEY, Fiachra ,  TRUDEL, Julie ,  TUROVSKIY, Roman

IPC: A61B18/14

CPC classification number: A61B18/02 ,  A61B34/25 ,  A61B90/39 ,  A61B2018/00041 ,  A61B2018/00166 ,  A61B2018/00172 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00642 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00744 ,  A61B2018/00761 ,  A61B2018/00821 ,  A61B2018/00863 ,  A61B2018/0212 ,  A61B2018/0268 ,  A61B2090/064

Abstract: Cryotherapeutic systems and cryotherapeutic-system components configured for renal neuromodulation are disclosed herein. A cryotherapeutic system configured in accordance with a particular embodiment of the present technology can include a console having a cartridge housing, a cartridge connector adjacent to the cartridge housing, and a supply passage fluidly connected to the cartridge connector. The console can further include a supply valve along the supply passage and a control assembly including a supply-valve actuator and a user interface. The supply-valve actuator can be operably connected to the supply valve, and the control assembly can be configured to signal the supply-valve actuator to open the supply valve in response to a signal from the user interface.

Abstract translation: 本文公开了配置用于肾神经调节的冷冻治疗系统和冷冻治疗系统组件。 根据本技术的特定实施例配置的冷冻治疗系统可以包括具有盒壳体，与盒壳体相邻的盒式连接器的控制台和与盒连接器流体连接的供应通道。 控制台还可以包括沿着供应通道的供给阀和包括供给阀致动器和用户界面的控制组件。 供应阀致动器可以可操作地连接到供应阀，并且控制组件可以被配置为响应于来自用户界面的信号而使供应阀致动器发信号以打开供应阀。

公开(公告)号：WO2010003547A1

公开(公告)日：2010-01-14

申请号：PCT/EP2009/004525

申请日：2009-06-23

Applicant: ERBE ELEKTROMEDIZIN GMBH ,  GEISELHART, Franz ,  VOIGTLÄNDER, Matthias ,  KEGREISS, Horst

Inventor： GEISELHART, Franz ,  VOIGTLÄNDER, Matthias ,  KEGREISS, Horst

IPC: A61B18/14

CPC classification number: A61B18/148 ,  A61B2018/00023 ,  A61B2018/0268 ,  A61B2018/0281

Abstract: Die vorliegende Erfindung betrifft ein elektrochirurgisches Gerät zur Devitalisierung von Gewebe. Das elektrochirurgische Gerät umfasst einen Sondenkörper, der mit mindestens einer Elektrode und einer Kühleinrichtung ausgestattet ist. Dieser Sondenkörper ist dazu geeignet, mittels eines HF-Stroms ein Wärmeverteilungsfeld zur Devitalisierung des Gewebes zu generieren. Die Kühleinrichtung verhindert eine Karbonisierung des Gewebes nahe dem Sondenkörper, da hier die maximale Stromdichte auftritt. Erfindungsgemäß wird das elektrochirurgische Gerät derart modifiziert, dass es ermöglicht wird, die Wärmeverteilung über den Sondenkörper einzustellen. Vorzugsweise erfolgt diese Einstellung bzw. Positionierung einer maximalen Kühlzone über das Regeln des Zulaufdrucks, der das elektrochirurgische Gerät mit Kältemittel versorgt.

Abstract translation: 本发明涉及一种用于失活组织的电手术装置。 电外科装置，包括探头主体，其配备有至少一个电极和一个冷却装置。 该探针主体适于产生热配电箱用于通过高频电流的装置失活在织物上。 该冷却装置防止所述探头主体附近的组织的碳化，由于最大的电流密度进行。 根据本发明的电外科装置被修改，使得它能够调节在所述探头主体中的热分布。 优选地，经由所述入口压力，其与制冷剂供给电外科装置的规则此设置或最大冷却区的定位。

公开(公告)号：WO2008015684A1

公开(公告)日：2008-02-07

申请号：PCT/IL2007/000974

申请日：2007-08-05

Applicant: ARBEL MEDICAL LTD. ,  TOUBIA, Didier ,  LEVIN, Alexander ,  KAGANOVICH, Miron

Inventor： TOUBIA, Didier ,  LEVIN, Alexander ,  KAGANOVICH, Miron

IPC: A61B8/02

CPC classification number: A61B18/02 ,  A61B2018/0268

Abstract: A cryoprobe for surgical and other treatments. The cryoprobe comprises an expandable section that performs displacement of a distal cryotip forwards when there is elevation of the operation pressure in the interior of the cryoprobe. Needle-wise metal elements are installed on the external side of the cryotip. These needle-wise elements are deflecting outwards by a deflecting member fastened on the distal edge of an external shaft of the cryoprobe. This allows a significant enlargement of the frozen volume of the treated tissue with the same operation temperature and the outer diameter of the cryoprobe. In another embodiment, the needle elements are formed in a displaceable metal sheath and a distal section of a cryotip and/or special protrusions on this distal section act as the deflecting member.

Abstract translation: 用于手术和其他治疗的冷冻探针。 冷冻探针包括可膨胀部分，当在冷冻探针的内部存在操作压力升高时，该扩张部分向远侧冷冻滚筒向前移动。 针状金属元件安装在冷冻液的外侧。 这些针状元件由固定在冷冻探针的外部轴的远端上的偏转构件向外偏转。 这允许以相同的操作温度和冷冻探针的外径显着地扩大处理过的组织的冷冻体积。 在另一个实施例中，针元件形成在可移动的金属护套中，并且该远端部分上的冷冻滚筒和/或特殊突起的远端部分用作偏转构件。

公开(公告)号：WO2006017073A2

公开(公告)日：2006-02-16

申请号：PCT/US2005023792

申请日：2005-07-06

Applicant: CRYOCATH TECHNOLOGIES INC ,  LANE MIRIAM

Inventor： LANE MIRIAM ,  ABBOUD MARWAN ,  MAHROUCHE RACHID ,  MIHALIK TERESA ANN

IPC: A61B18/02 ,  A61B17/22

CPC classification number: A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

Abstract: An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.

Abstract translation: 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部室。 可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置， 冷却室周围的绝热体。 一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。 传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

公开(公告)号：WO2003020334A2

公开(公告)日：2003-03-13

申请号：PCT/US2002/027627

申请日：2002-08-29

Applicant: LANE, Miriam

Inventor： LANE, Miriam ,  CAPUANO, Leonilda ,  HOLTAN, David ,  LALONDE, Jean-Pierre ,  LÜCKGE, Claudia ,  PAEGARD, Jean-Luc ,  ABBOUD, Marwan ,  ALASMAR, Johny ,  BENRABAH, Abderrahim ,  CHEN, Ken ,  LEHMANN, John, W. ,  MARCHAND, Philippe ,  MARTIN, Robert ,  MILDER, Frederic, L. ,  NAHON, Daniel

IPC: A61M

CPC classification number: A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

Abstract: An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter.Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.

Abstract translation: 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部室。 在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。可以提供柔性气囊，其中次级外气囊围绕主内气球， 初级球囊充满冷却剂并充当冷却室，次级气球与真空回流腔相连，用作强制性的泄漏容纳装置和围绕冷却室的绝热体。 可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

公开(公告)号：WO02004042A2

公开(公告)日：2002-01-17

申请号：PCT/US2001/021454

申请日：2001-07-05

IPC: A61B17/22 ,  A61B18/02 ,  A61M

CPC classification number: A61B18/02 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0268

Abstract: A method and apparatus for inflating a balloon (14) at a distal portion of an elongated delivery catheter (12) to contact surrounding biological tissue, and expanding a refrigerant adjacent the balloon to cool the biological tissue to render it non-viable. The inflation of the balloon can be accomplished with the expanded refrigerant of with a separate pressurized fluid. The balloon can act as a heat transfer element, or there can be a separate heat transfer element (30) on the catheter adjacent the balloon. The apparatus can be used to perform a dilation procedure, such as angioplasty, in conjunction with cooling of the surrounding tissue.

Abstract translation: 公开了一种用于在细长递送导管的远侧部分处使气囊膨胀以用于接触周围生物组织并用于使位于其中的制冷剂膨胀的方法和设备。 靠近气球来冷却生物组织以使其不可持续。 气囊的膨胀可以通过膨胀的制冷剂或通过单独的加压流体来实现。 球囊可以用作传热元件，或者导管可以在球囊附近具有单独的传热元件。 本发明的装置可用于执行扩张操作，例如血管成形术，以及冷却周围组织。

公开(公告)号：WO2017095756A1

公开(公告)日：2017-06-08

申请号：PCT/US2016/063882

申请日：2016-11-28

Applicant: ADAGIO MEDICAL, INC.

Inventor： MAZOR, Meital ,  COX, James, L. ,  BABKIN, Alexei ,  KOVALCHECK, Steven, W. ,  CHIEN, Thomas ,  KING, Nicolei

IPC: A61B17/22 ,  A61B18/00 ,  A61B18/02 ,  A61B18/04 ,  A61B18/12 ,  A61B18/14

CPC classification number: A61B18/02 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00041 ,  A61B2018/00285 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/00904 ,  A61B2018/0212 ,  A61B2018/0268 ,  A61M25/0147

Abstract: A method of creating a lesion in cardiac tissue where the method includes deploying a distal treatment section of an ablation catheter into a heart chamber and manipulating the distal treatment section against the cardiac tissue and into a curved shape that encloses a plurality of vessel entries in the heart chamber. The method further includes commencing a first application of ablation energy from the distal treatment section to the cardiac tissue and halting the first application of ablation energy to the cardiac tissue. The first application of ablation energy causes formation of a first continuous lesion in the cardiac tissue that encloses the plurality of vessel entries.

Abstract translation: 一种在心脏组织中产生损伤的方法，其中该方法包括将消融导管的远端治疗部分布置到心脏腔室中，并且将远端治疗部分抵靠心脏组织并操纵成弯曲形状， 将多个血管入口封闭在心脏腔室中。 该方法进一步包括开始消融能量从远端治疗部分到心脏组织的第一次施加，并停止第一次将消融能量施加到心脏组织。 消融能量的第一次施加导致在包围多个血管入口的心脏组织中形成第一连续病变。

公开(公告)号：WO2015057450A1

公开(公告)日：2015-04-23

申请号：PCT/US2014/059684

申请日：2014-10-08

Applicant: ADAGIO MEDICAL, INC.

Inventor： YU, Xiaoyu ,  KOVALCHECK, Steven, W. ,  BABKIN, Alexei, V.

IPC: A61B18/02

CPC classification number: A61B18/02 ,  A61B2017/00862 ,  A61B2017/00867 ,  A61B2018/00041 ,  A61B2018/00059 ,  A61B2018/00166 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongated lengthwise-continuous lesion in tissue comprises an elongated shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes extend through the distal treatment section to transport a near critical fluid to and from the distal tip, The distal treatment section is controUably articulated to match the contour of an anatomical region to be treated. In embodiments the distal treatment section includes a superelastic material and assumes a pre-set shape when released from an outer sleeve member. When the catheter is activated, heat is transferred between a target tissue and the distal treatment section of the catheter thereby creating the elongated lengthwise-continuous lesion in the tissue.

Abstract translation: 用于在组织中产生细长的纵向连续损伤的血管内近临界流体基冷冻消融导管包括细长轴，柔性远端组织治疗部分和远端尖端。 多个柔性管延伸穿过远端处理部分以将近临界流体运送到远侧末梢和远离末梢。远侧治疗部分被可控地铰接以匹配待治疗的解剖区域的轮廓。 在实施例中，远端治疗部分包括超弹性材料，并且当从外套筒构件释放时呈现预设形状。 当导管被激活时，热量在目标组织和导管的远端治疗部分之间转移，从而在组织中产生细长的纵向连续损伤。

公开(公告)号：WO2012058430A2

公开(公告)日：2012-05-03

申请号：PCT/US2011058094

申请日：2011-10-27

Applicant: CRYOMEDIX LLC ,  BABKIN ALEXEI ,  LITTRUP PETER ,  NYDAM WILLIAM

Inventor： BABKIN ALEXEI ,  LITTRUP PETER ,  NYDAM WILLIAM

IPC: A61B18/02 ,  A61B17/3205 ,  A61F7/00

CPC classification number: A61B18/02 ,  A61B2018/0268

Abstract: A cryoablation apparatus includes a distal energy delivery section to facilitate energy transfer to the tissue, resulting in faster achievement of tissue target temperatures. The energy delivery section includes a first heat exchange region and a second heat exchange region having a different heat exchange efficiency than the first heat exchange region. The first heat exchange region may comprise an increased surface area along a radial portion or length of the cryoprobe in contact with surrounding tissue. The heat exchange region may include ridges, texture, threads, and microtubes which serve to increase the thermal-contacting surface area and provide enhanced cryoenergy to the tissue.

Abstract translation: 冷冻消融装置包括远端能量递送部分以促进能量传递到组织，导致更快实现组织目标温度。 能量输送部分包括第一热交换区域和具有与第一热交换区域不同的热交换效率的第二热交换区域。 第一热交换区域可以包括沿着与周围组织接触的冷冻探针的径向部分或长度的增加的表面积。 热交换区域可以包括用于增加热接触表面积并向组织提供增强的低温能量的脊，纹理，线和微管。