公开(公告)号：WO2017019513A1

公开(公告)日：2017-02-02

申请号：PCT/US2016/043580

申请日：2016-07-22

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： DELANEY, JR., Joseph T. ,  WULFMAN, David R. ,  AREMU, Adeniyi ,  ADENUSI, Adegbola O.

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/056 ,  D01D5/24

Abstract: A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region, a conductor disposed within the insulative lead body and extending from the proximal region to the distal region, an electrode disposed on the insulative lead body and in electrical contact with the conductor, and a fibrous matrix disposed on at least part of the electrode. The fibrous matrix includes fibers. The fibers include a polyvinylidene fluoride-based (PVDF-based) polymer and a crystal-modifying additive. The PVDF-based polymer includes an amorphous PVDF phase and a crystalline PVDF phase. The crystalline PVDF phase includes a beta form crystalline structure in an amount exceeding any other crystalline structure form in the crystalline PVDF phase.

Abstract translation: 医疗用电线包括从远端区域延伸到近端区域的绝缘引线体，设置在绝缘引线主体内并从近端区域延伸到远端区域的导体，设置在绝缘引线体上并与电接触的电极 与导体和设置在电极的至少一部分上的纤维矩阵。 纤维基质包括纤维。 纤维包括聚偏二氟乙烯（PVDF）聚合物和晶体改性添加剂。 PVDF基聚合物包括非晶PVDF相和结晶PVDF相。 结晶PVDF相包括在结晶PVDF相中超过任何其它结晶结构形式的β型晶体结构。

公开(公告)号：WO2016171975A1

公开(公告)日：2016-10-27

申请号：PCT/US2016/027294

申请日：2016-04-13

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： DELANEY, JR., Joseph T. ,  WULFMAN, David R. ,  AREMU, Adeniyi ,  ADENUSI, Adegbola O.

IPC: C08J3/09 ,  C08J7/02 ,  C08J3/02

CPC classification number: C08J3/09 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2420/02 ,  A61L2420/06 ,  C08J3/092 ,  C08J3/095 ,  C08J2323/22 ,  C08J2375/04 ,  C08J2375/08 ,  C09D123/22 ,  C09D175/08 ,  C08L23/22

Abstract: A method of making a solution including a block copolymer includes dissolving the block copolymer in a solvent mixture to form a solution, the solvent mixture including at least two solvent components. The solubility of the block copolymer in the solvent mixture is at least about 7 wt. % at about 64 °C. The solvent mixture is non-reactive with the block copolymer. The solubility of the block copolymer in a single solvent solution consisting of any one of the at least two solvent components and the block copolymer is not greater than about 1 wt. % at about 64 °C. The block copolymer includes polyisobutylene segments and polyurethane segments.

Abstract translation: 制备包括嵌段共聚物的溶液的方法包括将嵌段共聚物溶解在溶剂混合物中以形成溶液，溶剂混合物包含至少两种溶剂组分。 嵌段共聚物在溶剂混合物中的溶解度为至少约7wt。 ％，约64℃。 溶剂混合物与嵌段共聚物不反应。 嵌段共聚物在由至少两种溶剂组分和嵌段共聚物中的任何一种组成的单一溶剂溶液中的溶解度不大于约1wt。 ％，约64℃。 嵌段共聚物包括聚异丁烯链段和聚氨酯链段。

公开(公告)号：WO2015112489A1

公开(公告)日：2015-07-30

申请号：PCT/US2015/012013

申请日：2015-01-20

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： ADENUSI, Adegbola ,  ROHL, James P. ,  WULFMAN, David R. ,  DELANEY, JR, Joseph T. ,  AREMU, Adeniyi

IPC: A61L29/06 ,  A61L29/08 ,  A61L29/14 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  A61L29/04 ,  A61L31/04 ,  A61N1/36

CPC classification number: A61M39/08 ,  A61L29/041 ,  A61L29/06 ,  A61L29/085 ,  A61L29/145 ,  A61L29/146 ,  A61L31/048 ,  A61L31/06 ,  A61L31/10 ,  A61L31/145 ,  A61L31/146 ,  A61M39/00 ,  A61N1/0541 ,  A61N1/056 ,  B32B1/08 ,  B32B5/02 ,  B32B5/022 ,  B32B27/08 ,  B32B27/12 ,  B32B2262/0238 ,  B32B2535/00 ,  D01D5/0023 ,  D01D5/0076 ,  D01D5/0084 ,  D01D5/0985 ,  Y10T428/1372 ,  C08L71/02 ,  C08L39/06 ,  C08L75/04 ,  C08L83/04

Abstract: A method for making a tubular medical device having a hybrid polymeric structure includes forming a first layer comprising a non-woven fibrous matrix made of a first polymeric material and forming a second layer comprising a second polymeric material about the first layer such that at least a portion of the second polymeric material of the second layer embeds into at least a portion of the first polymeric material of the first layer.

Abstract translation: 制备具有复合聚合物结构的管状医疗装置的方法包括形成包含由第一聚合物材料制成的非织造纤维基质的第一层，并形成围绕第一层的第二聚合物材料的第二层，使得至少一 第二层的第二聚合物材料的部分嵌入第一层的第一聚合物材料的至少一部分。