公开(公告)号：WO2018195409A1

公开(公告)日：2018-10-25

申请号：PCT/US2018/028549

申请日：2018-04-20

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： AKKUS, Ozan ,  YOUNESI, Mousa ,  EROL, Umil Levent

IPC: C25D1/18 ,  A61L27/24 ,  B05D1/04

Abstract: Devices suitable for the production of electrochemically aligned materials such as strands, threads or fibers. The device includes a substantially horizontally aligned electrochemical cell in one embodiment, with the arrangement producing highly compacted materials. Materials including electrochemically aligned and compacted compounds are also disclosed, along with methods for making and using the materials.

公开(公告)号：WO2014126876A1

公开(公告)日：2014-08-21

申请号：PCT/US2014/015683

申请日：2014-02-11

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： AKKUS, Ozan ,  KISHORE, Vipuil ,  YOUNESI, Mousa ,  ISLAM, Anowarul

IPC: A61F2/02 ,  A61L15/32 ,  A61L27/24 ,  C07K14/78 ,  C08J9/28

CPC classification number: C25D1/18 ,  A61L26/0033 ,  A61L27/24 ,  A61L27/26 ,  B05D1/18 ,  C07K14/78 ,  D01D5/0076 ,  D01F4/00

Abstract: Electrochemically aligned and compacted molecules, nanoparticles and microparticles with ampholytic nature, such as collagen, elastin, keratin and charged nanoparticle materials, methods of making and using the materials and associated production-related devices. In one embodiment, a device for producing continuous electrochemically aligned strands, threads or fibers is disclosed. In a further embodiment, fabrication of compositionally and geometrically complex anatomical forms by 3D-electrochemical compaction of biomolecules is disclosed. In yet another embodiment, methods for fabricating patterned lattice structures, in particular having controlled pore size and morphology, and the lattice structures themselves are also disclosed.

Abstract translation: 电化学排列和压实的分子，具有两性性质的纳米颗粒和微粒，例如胶原蛋白，弹性蛋白，角蛋白和带电的纳米颗粒材料，制备和使用材料以及相关生产相关装置的方法。 在一个实施例中，公开了一种用于生产连续电化学排列的线，线或纤维的装置。 在另一个实施方案中，公开了通过生物分子的3D电化学压实制备组成和几何复杂的解剖形式。 在另一个实施方案中，还公开了用于制造图案化晶格结构，特别是具有可控孔径和形态以及晶格结构本身的方法。

公开(公告)号：WO2022246326A2

公开(公告)日：2022-11-24

申请号：PCT/US2022/030561

申请日：2022-05-23

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： GURKAN, Umut ,  SEKYONDA, Zoe ,  AKKUS, Ozan ,  AN, Ran

IPC: A61B5/145 ,  A61B5/00 ,  A61B10/00 ,  G01N2800/22 ,  G01N33/49 ,  G01N33/721

Abstract: A method of determining at least one of hemoglobin oxygen affinity, rate of hemoglobin deoxygenation, or the presence of hemoglobin variants in blood of a subject, the method includes determining differences of absorption spectra of oxygenated and deoxygenated hemoglobin, red blood, and/or blood obtained from the subject and comparing the determined absorption spectra differences to a control value, wherein the absorption spectra differences are indicative of hemoglobin oxygen affinity, rate of hemoglobin deoxygenation, or the presence of hemoglobin variants in the blood of the subject.

公开(公告)号：WO2014201088A1

公开(公告)日：2014-12-18

申请号：PCT/US2014/041863

申请日：2014-06-11

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： AKKUS, Ozan ,  SLIPCHENKO, Mikhail ,  AKKUS, Anna ,  YANG, Shan ,  LI, Bolan

IPC: G01J3/44 ,  G01N21/62 ,  G01N21/65 ,  G01N25/14

CPC classification number: C12Q1/40 ,  C12Q1/37 ,  G01N1/4077 ,  G01N21/65 ,  G01N2001/4088 ,  G01N2201/121 ,  G01N2333/928 ,  G01N2333/958 ,  G01N2800/107 ,  G01N2800/345

Abstract: Methods for determining whether certain compounds, in particular crystals, are present in a sample of a biological fluid that indicates an individual has a particular disease or condition, such as but not limited to gout, pseudogout or urinary tract stones. In some embodiments, the methods include the steps of digestion and filtration of a sample of synovial fluid in order to isolate, if present, monosodium urate monohydrate (MSU), calcium pyrophosphate dihydrate (CPPD), or calcium phosphate crystals from the sample, wherein the filtrate is analyzed with a Raman device to ascertain the presence and type of the crystals. Devices for performing steps of the method are disclosed.

Abstract translation: 用于确定某些化合物，特别是晶体是否存在于指示个体的生物流体样品中具有特定疾病或病症（例如但不限于痛风，假结肠或泌尿道结石）的方法。 在一些实施方案中，所述方法包括以下步骤：消化和过滤滑液样品，以便从样品中分离（如果存在的话）单酸一钠水溶液（MSU），焦磷酸钙二水合物（CPPD）或磷酸钙晶体，其中 用拉曼装置分析滤液以确定晶体的存在和类型。 公开了用于执行该方法的步骤的装置。