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    SYSTEM AND METHOD FOR PROCESSING ELECTRONIC MEDICAL AND GENETIC/GENOMIC INFORMATION USING MACHINE LEARNING AND OTHER ADVANCED ANALYTICS TECHNIQUES
    2.
    发明申请
    SYSTEM AND METHOD FOR PROCESSING ELECTRONIC MEDICAL AND GENETIC/GENOMIC INFORMATION USING MACHINE LEARNING AND OTHER ADVANCED ANALYTICS TECHNIQUES 审中-公开

    公开(公告)号：WO2018175435A3

    公开(公告)日：2018-09-27

    申请号：PCT/US2018/023355

    申请日：2018-03-20

    Applicant: CELMATIX INC.

    Inventor： BEIM, Piraye, Yurttas ,  ADAMS, Mark ,  CLEMENT, Caterina ,  REHMAN, Anila ,  KIEL, Ryan, Mark

    IPC: G06F19/24 ,  G06F19/18

    Abstract: Embodiments of the present disclosure relate to a machine-learning system for processing medical information. The system comprises a communications interface configured to access electronic medical data. An automated retrieval processor is configured to analyze the electronic medical data to identify and retrieve relevant electronic data based on predefined search criteria. A learning processor is configured to update and optimize the automated retrieval processor based on received electronic metadata associated with the identified relevant electronic data. Other embodiments relate to a machine-learning method for processing electronic medical information. The method comprises accessing electronic medical data from a public database and/or a private database. In addition, the method comprises analyzing the electronic medical data to identify and retrieve relevant electronic data based on predefined search criteria. Also, the method includes performing adaptive learning based on received electronic metadata associated with the identified relevant electronic data.

    A MEASUREMENT SYSTEM AND METHOD FOR DEFINING AND DETERMINING AN OVARIAN RESERVE
    3.
    发明申请
    A MEASUREMENT SYSTEM AND METHOD FOR DEFINING AND DETERMINING AN OVARIAN RESERVE 审中-公开

    公开(公告)号：WO2018200820A1

    公开(公告)日：2018-11-01

    申请号：PCT/US2018/029582

    申请日：2018-04-26

    Applicant: CELMATIX INC.

    Inventor： BEIM, Piraye, Yurttas ,  COHN, Karen, Hunter ,  SANTISTEVAN, Anthony

    IPC: A61B5/00

    Abstract: Embodiments of the present disclosure relate an ovarian characteristic measurement method and system. A data interface is configured to receive a set of reproductive health data of a patient. The reproductive health data is processed using an ovarian characteristic data structure stored in memory. The data structure is generated from an ovarian characteristic data model that defines the ovarian characteristic. For instance, the data model defines a processing of the reproductive health data to yield a measurement of the ovarian characteristic. Accordingly, a format of the ovarian data structure is selected to optimize computing resources required to process the set of reproductive health data. The method and system then determine a value of the ovarian characteristic of the patient based on the processing of the set of reproductive health data.

    METHOD FOR ASSESSING FERTILITY BASED ON MALE AND FEMALE GENETIC AND PHENOTYPIC DATA
    4.
    发明申请
    METHOD FOR ASSESSING FERTILITY BASED ON MALE AND FEMALE GENETIC AND PHENOTYPIC DATA 审中-公开
    基于男性和女性遗传和表型数据评估育龄妇女的方法

    公开(公告)号：WO2017210327A1

    公开(公告)日：2017-12-07

    申请号：PCT/US2017/035259

    申请日：2017-05-31

    Applicant: CELMATIX INC.

    Inventor： BEIM, Piraye, Yurttas

    IPC: G06F19/18 ,  G06F19/28

    Abstract: The present invention generally relates to systems and methods for assessing female fertility and infertility, male fertility and infertility and the combined fertility profile of a male and a female. Systems and methods of the invention determine the fertility potential of a female and a male combined by conducting an assay on a sample obtained from the male and female to determine the presence of one or more fertility-associated genetic variants, obtain fertility-associated phenotypic and/or environmental data from the male and the female, accepting as input data, the genetic variants determined from the female and male and phenotypic and/or environmental exposure data from the male and female, analyze the input data using a prognosis predictor correlated with fertility, and generate a fertility profile that reflects the fertility potential of the male and the female combined by using the prognosis predictor on the input data.

    Abstract translation: 本发明一般涉及用于评估女性生育力和不育，男性生育力和不育以及男性和女性的综合生育力特征的系统和方法。 本发明的系统和方法通过对从男性和女性获得的样品进行测定以确定一种或多种生育力相关遗传变体的存在，获得与生育力相关的表型和 /或来自男性和女性的环境数据，接受作为输入数据，由女性和男性确定的遗传变异以及来自男性和女性的表型和/或环境暴露数据，使用与生育力相关的预后预测因子分析输入数据 ，并通过使用输入数据中的预后预测因子生成反映男性和女性的生育力潜力的生育率概况。

    METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AND OVULATORY FUNCTION DISORDERS
    5.
    发明申请
    METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AND OVULATORY FUNCTION DISORDERS 审中-公开

    公开(公告)号：WO2017156279A2

    公开(公告)日：2017-09-14

    申请号：PCT/US2017/021583

    申请日：2017-03-09

    Applicant: CELMATIX INC.

    Inventor： BEIM, Piraye, Yurttas ,  PARFITT, David, Emlyn ,  HU-SELIGER, Tina ,  SANTISTEVAN, Anthony

    Abstract: The present invention relates to methods and systems for assessing risk of infertility and ovarian dysfunction and/or diminished ovarian reserve and/or for determining an appropriate course of treatment. In some embodiments, the invention provides methods for assessing likelihood of ovarian dysfunction, including identifying a plurality of genetic variants that are filtered into functional biological pathways. The frequency distribution of the variants in each functional pathway is then compared to frequency distributions obtained from reference sets corresponding to each pathway. Further embodiments of the invention comprise clustering subjects based on patterns in their genetic variants, and identifying phenotypic differences with respect to ovarian dysfunction between clusters of patients.

    METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AS A RESULT OF DECLINING OVARIAN RESERVE AND FUNCTION
    6.
    发明申请
    METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AS A RESULT OF DECLINING OVARIAN RESERVE AND FUNCTION 审中-公开
    评估不孕症的方法和系统，作为降低卵巢储备和功能的结果

    公开(公告)号：WO2017070258A1

    公开(公告)日：2017-04-27

    申请号：PCT/US2016/057776

    申请日：2016-10-19

    Applicant: CELMATIX INC.

    Inventor： BEIM, Piraye, Yurttas

    IPC: G06F19/18 ,  G06F19/24 ,  G06F19/26

    CPC classification number: C12Q1/6883 ,  A61K31/138 ,  A61K31/566 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/158 ,  G06F19/24

    Abstract: The present invention relates to methods and systems for assessing ovarian reserve and function in a female subject and informing course of treatment thereof. The invention provides methods for assessing ovarian reserve and function by analyzing both clinical and genetic data/characteristics from a female subject. These methods involve the determination of the presence of one or more mutations in a gene, the gene being associated with fertility and/or ovarian reserve or function. In certain aspects the methods also involve the determination of one or more clinical characteristics associated with fertility and/or ovarian reserve or function. In certain embodiments, the clinical and genetic characteristics obtained from a female subject can be used as data to be input to an ovarian reserve predictor, such that a probability of the female subject suffering from ovarian reserve dysfunction or premature decline can be generated.

    Abstract translation: 本发明涉及用于评估女性受试者的卵巢储备和功能并通知其治疗过程的方法和系统。 本发明提供了通过分析女性受试者的临床和遗传数据/特征来评估卵巢储备和功能的方法。 这些方法涉及确定基因中存在一种或多种突变，该基因与生育力和/或卵巢储备或功能相关。 在某些方面，所述方法还涉及确定与生育力和/或卵巢储备或功能相关的一种或多种临床特征。 在某些实施方案中，从女性受试者获得的临床和遗传特征可以用作输入卵巢储备预测因子的数据，使得可以产生女性受试者患有卵巢储备功能障碍或过早衰退的概率。 p>

    METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AND RELATED PATHOLOGIES
    7.
    发明申请
    METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AND RELATED PATHOLOGIES 审中-公开
    评估感染和相关病理学的方法和系统

    公开(公告)号：WO2016011377A1

    公开(公告)日：2016-01-21

    申请号：PCT/US2015/040947

    申请日：2015-07-17

    Applicant: CELMATIX INC.

    Inventor： BEIM, Piraye, Yurttas ,  PARFITT, David, Emlyn ,  ELASHOFF, Michael

    IPC: C12Q1/68 ,  A61K38/24

    CPC classification number: C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G06F19/20

    Abstract: Methods for assessing infertility and related pathologies and informing treatment type and timing thereof are provided. According to certain embodiments, methods of the invention include determining levels of one or more transcripts present in a sample obtained from a subject suspected of having endometriosis, identifying transcript levels that correspond to a regulation pattern specific to a time-point in a uterine cycle, and characterizing endometriosis of the subject based upon the identified transcript levels. The invention includes methods for assessing age-associated increase in aneuploidy rates based on FSH levels and IVF success rates based on obesity in PCOS patients.

    Abstract translation: 提供了评估不育症及相关病理学信息的方法及其治疗方法及时机。 根据某些实施方案，本发明的方法包括确定从怀疑患有子宫内膜异位症的受试者获得的样品中存在的一种或多种转录物的水平，鉴定对应于子宫周期中时间点特异的调节模式的转录物水平， 并基于鉴定的转录物水平来表征受试者的子宫内膜异位症。 本发明包括基于PCOS患者基于肥胖的FSH水平和IVF成功率来评估非整倍体性年龄相关增加的方法。

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