公开(公告)号：WO2015057645A9

公开(公告)日：2015-04-23

申请号：PCT/US2014/060397

申请日：2014-10-14

申请人： CHENG, Gang ,  CAO, Bin ,  THE UNIVERSITY OF AKRON

发明人： CHENG, Gang ,  CAO, Bin

IPC分类号： C08F290/10

摘要： The present invention is directed to a method of zwitteration of polysaccharides or other polymers with carboxybetaine (CB) or another zwitterionic betaine. Zwitterionic CB functional groups were seamlessly integrated onto dextran backbone via a one pot reaction. Different degrees of substitution were achieved by repeating the reaction and controlling the ratio of reactants. CB side groups in CB-functionalized dextran (CB-Dex) can switch between cationic and zwitterionic forms under acidic and neutral conditions. The ring structure formation was confirmed by heteronuclear multiple-bond correlation (gHMBC) 2D-NMRAntifouling properties of CB-Dex were tested in the form of hydrogel using a fluorescent method. The amount of adsorbed protein decreases dramatically with the increase of CB content. For the cell attachment study, there was almost no cell attaching on the CB-Dex hydrogel surface with the higher CB content. Further, the optical transparency was enhanced by increasing the CB content.

公开(公告)号：WO2017058871A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/054111

申请日：2016-09-28

申请人： CHENG, Gang ,  THE UNIVERSITY OF AKRON

发明人： CHENG, Gang

IPC分类号： A61K47/30 ,  A61L27/34 ,  A61L31/10

CPC分类号： A61L31/10 ,  C08G61/126 ,  C08G2261/1424 ,  C08G2261/143 ,  C08G2261/1452 ,  C08G2261/3223 ,  C08G2261/44 ,  C08G2261/51 ,  C08G2261/94 ,  H01L51/0037 ,  C08L41/00

摘要： In one or more embodiments, the present invention provides a method of forming compact, flexible, stable and biocompatible conducting polymer coating for bioelectronics devices. In one or more embodiments, the present invention relates to a novel method of synthesizing a sulfobetaine-functionalized conjugated polymer platform using 3,4-ethylenedioxythiophene (EDOT) as the conducting backbone (SBEDOT). This SBEDOT monomer is highly water-soluble and can be directly polymerized to form a densely packed film/coating on conductive or semi-conductive surfaces through electro-polymerization in a 100% aqueous solution without the need for organic solvents or surfactants. These polySBEDOT (PSBEDOT) coated surfaces have been shown to have electro-switchable antimicrobial/antifouling properties and excellent electrically conducting properties, which minimize infection, increase biocompatibility, and improve the performance of bioelectronics.

摘要翻译： 在一个或多个实施方案中，本发明提供了一种形成用于生物电子器件的紧凑，柔性，稳定和生物相容的导电聚合物涂层的方法。 在一个或多个实施方案中，本发明涉及使用3,4-亚乙二氧基噻吩（EDOT）作为导电主链（SBEDOT）合成磺基甜菜碱官能化的共轭聚合物平台的新方法。 该SBEDOT单体是高度水溶性的，并且可以直接聚合，以在100％水溶液中电聚合而不需要有机溶剂或表面活性剂，在导电或半导体表面上形成密集的膜/涂层。 已经显示这些polySBEDOT（PSBEDOT）涂层表面具有可切换的抗微生物/防污性能和优异的导电性能，其最小化感染，增加生物相容性并提高生物电子学的性能。

公开(公告)号：WO2015054484A1

公开(公告)日：2015-04-16

申请号：PCT/US2014/059885

申请日：2014-10-09

申请人： CHENG, Gang ,  THE UNIVERSITY OF AKRON

发明人： CHENG, Gang

IPC分类号： A61K47/30

CPC分类号： C08G61/126 ,  A01N43/10 ,  A01N43/90 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  C08G2261/1426 ,  C08G2261/143 ,  C08G2261/1432 ,  C08G2261/145 ,  C08G2261/1452 ,  C08G2261/147 ,  C08G2261/1644 ,  C08G2261/3223 ,  C08G2261/3243 ,  C08G2261/43 ,  C08G2261/51 ,  C08G2261/514 ,  C08G2261/522 ,  C08G2261/94 ,  C09D5/14 ,  C09D5/16 ,  C09D5/24 ,  C09D165/00

摘要： The present invention is directed to a versatile and high performance zwitterionic CP platform, which integrates all desired functions into one material. This zwitterionic CP consists of the conducting backbone and multifunctional zwitterionic side chains. Non-conducting zwitterionic materials gain electronic conductivity through the conducting backbone and CPs obtain excellent biocompatibility, sensitivity to environmental stimuli and controllable antifouling properties via multifunctional zwitterionic side chains. Unique properties from two distinct materials (conducting materials and zwitterionic materials) are integrated into one material without sacrificing any properties. This platform can potentially be adapted for a range of applications (e.g. bioelectronics, tissue engineering, wound healing, robotic prostheses, biofuel cell, etc.), which all require high performance conducting materials with excellent antifouling/biocompatibility at complex biointerfaces. This conducting material platform will significantly advance the development of conducting polymers in the field of biomedicine and biotechnology.

摘要翻译： 本发明涉及通用和高性能的两性离子CP平台，其将所有期望的功能集成到一种材料中。 该两性离子CP由导电骨架和多功能两性离子侧链组成。 非导电两性离子材料通过导电骨架获得电子导电性，CP通过多功能两性离子侧链获得优异的生物相容性，对环境刺激的敏感性和可控防污性能。 来自两种不同材料（导电材料和两性离子材料）的独特性能被集成到一种材料中，而不牺牲任何性质。 该平台可以适用于一系列应用（例如生物电子学，组织工程，伤口愈合，机器人假体，生物燃料电池等），这些都需要在复杂生物界面具有优异的防污/生物相容性的高性能导电材料。 这种导电材料平台将显着促进生物医药和生物技术领域的导电聚合物的发展。

公开(公告)号：WO2014194268A1

公开(公告)日：2014-12-04

申请号：PCT/US2014/040353

申请日：2014-05-30

申请人： THE UNIVERSITY OF AKRON ,  CHENG, Gang ,  CAO, Bin

发明人： CHENG, Gang ,  CAO, Bin

IPC分类号： C08L39/00 ,  C07C229/22

CPC分类号： C09D133/14 ,  A01N37/12 ,  C07C227/02 ,  C07C227/16 ,  C07C227/18 ,  C07C229/12 ,  C07C233/38 ,  C08F20/34 ,  C08F22/385 ,  C08F120/36 ,  C08F222/385 ,  C09D5/14 ,  C09D133/26 ,  C09D139/00

摘要： Various embodiments of the present invention are directed to switchable carboxybetaine-based polymers, hydrogels, and/or elastomers, along with novel related monomers, crosslinkers, and methods. Under acidic conditions, the materials undergo self-cyclization and can catch and kill bacteria. Under neutral/basic conditions, these materials undergo ring-opening and can release killed bacterial cells and resist protein adsorption and bacterial attachment. These smart polymers, hydrogels and elastomers also show excellent mechanical properties making them highly desirable for many biomedical applications.

摘要翻译： 本发明的各种实施方案涉及可切换的基于羧基甜菜碱的聚合物，水凝胶和/或弹性体，以及新的相关单体，交联剂和方法。 在酸性条件下，材料经历自环化，可以捕获和杀死细菌。 在中性/碱性条件下，这些材料开环，可以释放杀死的细菌细胞，抵抗蛋白质吸附和细菌附着。 这些智能聚合物，水凝胶和弹性体也显示出优异的机械性能，使得它们对于许多生物医学应用是非常需要的。

公开(公告)号：WO2009067562A1

公开(公告)日：2009-05-28

申请号：PCT/US2008/084095

申请日：2008-11-19

申请人： UNIVERSITY OF WASHINGTON ,  JIANG, Shaoyi ,  CHEN, Shengfu ,  ZHANG, Zheng ,  CHENG, Gang ,  XUE, Hong ,  CARR, Louisa, R.

发明人： JIANG, Shaoyi ,  CHEN, Shengfu ,  ZHANG, Zheng ,  CHENG, Gang ,  XUE, Hong ,  CARR, Louisa, R.

IPC分类号： C08F20/36 ,  C08F20/38 ,  C08F120/36 ,  C08F120/38 ,  C08F220/36 ,  C08F220/38

CPC分类号： A61K8/8158 ,  A61K8/368 ,  A61K2800/5426 ,  A61Q19/00 ,  C08F20/36 ,  C08F20/38 ,  C08F20/54 ,  C08F120/36 ,  C08F120/38 ,  C08F220/36 ,  C08F220/38

摘要： Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems.

摘要翻译： 可水解成两性离子聚合物的阳离子聚合物，用于制备阳离子聚合物的单体，包括聚合物的表面，包括阳离子聚合物的治疗剂递送系统，使用递送系统施用治疗剂的方法，以及制备和使用阳离子聚合物的方法 ，单体，表面和治疗剂递送系统。

公开(公告)号：WO2019241980A1

公开(公告)日：2019-12-26

申请号：PCT/CN2018/092308

申请日：2018-06-22

申请人： HYDRIL USA DISTRIBUTION LLC ,  CHENG, Gang

发明人： CHENG, Gang ,  MEI, Yan ,  SHANG, Weihua ,  QU, Xin ,  WEI, Xiaoyang

IPC分类号： E21B21/08 ,  E21B47/10

摘要： A method for early kick detection in a drilling system with a drilling fluid loop, comprising: collecting flow-in rate and flow-out rate of a drilling fluid; calibrating the flow-out rate to obtain a calibrated flow-out rate of the drilling fluid; determining a flow rate difference between the flow-in rate and the calibrated flow-out rate of the drilling fluid; and identifying the kicks based on the flow rate difference. An apparatus (1) for early kick detection in a drilling system with a drilling fluid loop is also disclosed.

公开(公告)号：WO2014205785A1

公开(公告)日：2014-12-31

申请号：PCT/CN2013/078387

申请日：2013-06-28

申请人： THOMSON LICENSING ,  SONG, Jianping ,  SONG, Wenjuan ,  CHENG, Gang

发明人： SONG, Jianping ,  SONG, Wenjuan ,  CHENG, Gang

IPC分类号： H04N13/04

CPC分类号： H04N13/398 ,  G06T3/40 ,  H04N13/204 ,  H04N13/302 ,  H04N13/351 ,  H04N13/373 ,  H04N13/376 ,  H04N13/383

摘要： A multi-view three-dimensional display system and method with an adaptive number of views are described. The system includes a position sensing unit for detecting a position of an observer, a view disposing unit for determining a number of views and a view arrangement based on the position, such that only a different one of the views is provided to a viewing zone for each eye of the observer, and a multi-view display unit for displaying the number of views in accordance with the view arrangement to enable viewing of a three-dimensional image by the observer.

摘要翻译： 描述具有自适应数量视图的多视图三维显示系统和方法。 该系统包括用于检测观察者的位置的位置感测单元，用于确定多个视图的视图设置单元和基于位置的视图布置，使得仅将不同的视图提供给观看区域 观察者的每个眼睛，以及用于根据观看布置显示视图数量以使得观察者能够观看三维图像的多视图显示单元。

公开(公告)号：WO2012159406A1

公开(公告)日：2012-11-29

申请号：PCT/CN2011/080682

申请日：2011-10-12

申请人： TONGYU COMMUNICATION INC. ,  SHI, Lei ,  WU, Zhonglin ,  YE, Hai'ou ,  CAI, Guihong ,  FANG, Tieyong ,  CHENG, Gang

发明人： SHI, Lei ,  WU, Zhonglin ,  YE, Hai'ou ,  CAI, Guihong ,  FANG, Tieyong ,  CHENG, Gang

IPC分类号： H01Q21/24 ,  H01Q1/12 ,  H01Q1/36 ,  H01Q5/01

CPC分类号： H01Q5/00 ,  H01Q1/12 ,  H01Q19/10 ,  H01Q21/24 ,  H01Q21/28

摘要： A dual-band and dual-polarized antenna (10) comprises a metal reflector (1), a first radiator array and a second radiator array coaxially aligned along an axis of the reflector. The first radiator array has a plurality of first dual-polarized radiators (3) for a lower frequency range aligned in front of the reflector. The second radiator array has a plurality of second dual-polarized radiators (2) for a higher frequency range aligned in front of the reflector. Each first radiator has a second radiator encased therein, and two adjacent first radiators have two second dual-polarized radiators inserted therebetween. The antenna of the present invention optimizes the performance of the first radiators for the lower frequency range and the second radiators for the higher frequency. Moreover, the antenna is satisfactorily meeting the antenna requirements of wide frequency range, small size, high gain, wide broadband, simple design, low cost and consistence etc.

摘要翻译： 双频带和双极化天线（10）包括金属反射器（1），第一辐射器阵列和沿着反射器轴线同轴对准的第二辐射器阵列。 第一辐射器阵列具有多个用于在反射器前面对准的较低频率范围的第一双极化辐射器（3）。 第二辐射器阵列具有多个第二双极化辐射器（2），用于在反射器前面对准的较高频率范围。 每个第一散热器具有包围在其中的第二散热器，并且两个相邻的第一散热器具有插入其间的两个第二双极化散热器。 本发明的天线优化了用于较低频率范围的第一辐射器的性能和用于较高频率的第二辐射器的性能。 此外，天线满足天线要求宽，频率范围小，增益高，宽宽，设计简单，成本低廉等优点。

公开(公告)号：WO2014075224A1

公开(公告)日：2014-05-22

申请号：PCT/CN2012/084536

申请日：2012-11-13

申请人： THOMSON LICENSING ,  CHENG, Gang ,  DU, Lin ,  LI, Zhenglong

发明人： CHENG, Gang ,  DU, Lin ,  LI, Zhenglong

IPC分类号： G06T7/00 ,  G06K9/00

CPC分类号： G06T7/162 ,  G06T7/11 ,  G06T7/143 ,  G06T7/194 ,  G06T2207/10021

摘要： Video object segmentation is accomplished utilizing Locality-constrained Linear Coding (LLC) modeling and adaptive model learning. A video object isolator utilizes an LLC segmentor to segment a video object from a video based on the LLC modeling. Additionally, the video object isolator can use an LLC model learner to further adapt the model.

摘要翻译： 视频对象分割使用局部约束线性编码（LLC）建模和自适应模型学习来实现。 视频对象隔离器利用LLC分段器基于LLC建模从视频分割视频对象。 此外，视频对象隔离器可以使用LLC模型学习者进一步调整模型。

公开(公告)号：WO2013026271A1

公开(公告)日：2013-02-28

申请号：PCT/CN2012/071181

申请日：2012-02-16

申请人： TONGYU COMMUNICATION INC. ,  SHI, Lei ,  WU, Zhonglin ,  WAN, Peng ,  FANG, Tieyong ,  YAN, Bo ,  CHENG, Gang

发明人： SHI, Lei ,  WU, Zhonglin ,  WAN, Peng ,  FANG, Tieyong ,  YAN, Bo ,  CHENG, Gang

IPC分类号： H01P1/18 ,  H01P5/12

CPC分类号： H05K7/00 ,  H01P1/184 ,  H01P5/12

摘要： A phase shifting device includes a housing (501, 502, 601, 701, 804), and at least one multipath phase-shifter assembly (601, 602, 801, 802, 901, 902) in the housing, which can obtain multipath outputs and high level of phase shift. The phase shifting device has a compact structure and better performance. The number of phase shifters is flexibly selected to meet the characteristic of broadband and multipath phase shift.

摘要翻译： 相移装置包括壳体（501,502,601,701,804）以及壳体中的至少一个多路径移相器组件（601,602,801,802,901,902），其可以获得多径输出 和高水平的相移。 相移装置结构紧凑，性能更好。 移相器的数量灵活选择，以满足宽带和多径相移的特点。