SWITCHABLE ANTIMICROBIAL AND ANTIFOULING CARBOXYBETAINE-BASED HYDROGELS
    10.
    发明申请
    SWITCHABLE ANTIMICROBIAL AND ANTIFOULING CARBOXYBETAINE-BASED HYDROGELS 审中-公开
    可切换的抗微生物反应和基于羧基乙酸的氢化反应

    公开(公告)号:WO2014194268A1

    公开(公告)日:2014-12-04

    申请号:PCT/US2014/040353

    申请日:2014-05-30

    发明人: CHENG, Gang CAO, Bin

    IPC分类号: C08L39/00 C07C229/22

    摘要: Various embodiments of the present invention are directed to switchable carboxybetaine-based polymers, hydrogels, and/or elastomers, along with novel related monomers, crosslinkers, and methods. Under acidic conditions, the materials undergo self-cyclization and can catch and kill bacteria. Under neutral/basic conditions, these materials undergo ring-opening and can release killed bacterial cells and resist protein adsorption and bacterial attachment. These smart polymers, hydrogels and elastomers also show excellent mechanical properties making them highly desirable for many biomedical applications.

    摘要翻译: 本发明的各种实施方案涉及可切换的基于羧基甜菜碱的聚合物,水凝胶和/或弹性体,以及新的相关单体,交联剂和方法。 在酸性条件下,材料经历自环化,可以捕获和杀死细菌。 在中性/碱性条件下,这些材料开环,可以释放杀死的细菌细胞,抵抗蛋白质吸附和细菌附着。 这些智能聚合物,水凝胶和弹性体也显示出优异的机械性能,使得它们对于许多生物医学应用是非常需要的。