公开(公告)号：WO2019142141A1

公开(公告)日：2019-07-25

申请号：PCT/IB2019/050431

申请日：2019-01-18

Applicant: ENGEL, Holger ,  CARRERA FABRA, Jordi ,  COMENGÉS CASAS, Anna ,  MARTÍN BLANCO, Ricard ,  LEE, Martin Alan ,  LEE, Diane Rachel

Inventor： ENGEL, Holger ,  CARRERA FABRA, Jordi ,  COMENGÉS CASAS, Anna ,  MARTÍN BLANCO, Ricard ,  LEE, Martin Alan ,  LEE, Diane Rachel

IPC: B01L3/00 ,  B65D25/10

CPC classification number: B01L3/502715 ,  B01J19/0093 ,  B01J2219/00891 ,  B01L3/523 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2200/18 ,  B01L2300/041 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/048 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2300/16

Abstract: A microfluidic system is presented that includes a cartridge, a container, and a lid for the container. The cartridge includes a plurality of microfluidic channels coupled to one or more chambers. The container holds dry chemicals and includes a housing with a first opening and a second opening smaller than the first opening. The container is designed to be inserted into an opening of the cartridge, such that the container is independently secured within the opening. The insertion of the container allows for the container to be fluidically coupled with a microfluidic channel of the plurality of microfluidic channels via the second opening. The lid includes a column that extends from the lid into the container.

公开(公告)号：WO2017013562A1

公开(公告)日：2017-01-26

申请号：PCT/IB2016/054246

申请日：2016-07-15

Applicant: ENGEL, Holger ,  CARRERA FABRA, Jordi

Inventor： ENGEL, Holger ,  CARRERA FABRA, Jordi

IPC: F26B5/06 ,  B01L3/00 ,  G01N1/42 ,  G01N35/10

CPC classification number: B01L3/523 ,  B01L3/502715 ,  B01L3/508 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0621 ,  B01L2200/0678 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0867 ,  F26B5/06 ,  G01N1/42 ,  G01N2035/1055

Abstract: A microfluidic system is presented that includes a cartridge and a container. The cartridge includes a plurality of microfluidic channels coupled to one or more chambers. The container holds dry chemicals and includes a housing with a first opening and a second opening smaller than the first opening. The container is designed to be inserted into an opening of the cartridge, such that the container is independently secured within the opening. The insertion of the container allows for the container to be fluidically coupled with a microfluidic channel of the plurality of microfluidic channels via the second opening.

Abstract translation: 提出了一种微流体系统，其包括盒和容器。 盒包括耦合到一个或多个室的多个微流体通道。 容器保持干燥的化学品，并且包括具有第一开口和小于第一开口的第二开口的壳体。 容器被设计成插入到盒的开口中，使得容器独立地固定在开口内。 容器的插入允许容器经由第二开口与多个微流体通道的微流体通道流体耦合。

公开(公告)号：WO2013164424A1

公开(公告)日：2013-11-07

申请号：PCT/EP2013/059185

申请日：2013-05-02

Applicant: STAT-DIAGNOSTICA & INNOVATION S.L. ,  CARRERA FABRA, Jordi ,  BRU GIBERT, Rafael ,  COMENGES CASES, Anna

Inventor： CARRERA FABRA, Jordi ,  BRU GIBERT, Rafael ,  COMENGES CASES, Anna

IPC: G01N1/38 ,  A61B10/00 ,  B01L3/00

CPC classification number: G01N1/10 ,  B01L3/502715 ,  B01L3/5029 ,  B01L2200/027 ,  B01L2300/0809 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0433 ,  B01L2400/0481 ,  B01L2400/0487 ,  G01N1/38 ,  G01N21/75 ,  G01N2001/028 ,  G01N2001/4061

Abstract: A system and method for eluting a sample from a swab are presented. The system includes a chamber dimensioned to receive at least a portion of the length of at least one swab, a fluidic channel connected to the chamber, and an actuator. The chamber has at least one wall being a flexible film. The fluidic channel is configured to at least one of introduce and expel liquids from the chamber. The actuator is configured to contact an outer surface of the flexible film such that movement of the actuator against the outer surface of the flexible film causes a respective movement of the at least one swab when the at least one swab is disposed next to an inner surface of the flexible film. The respective movement of the at least one swab elutes the sample from the at least one swab into the chamber.

Abstract translation: 提出了从棉签中洗脱样品的系统和方法。 该系统包括尺寸设置成容纳至少一个拭子长度的至少一部分的腔室，连接到腔室的流体通道和致动器。 该室具有至少一个壁，其为柔性膜。 流体通道构造成从腔室引入和排出液体中的至少一个。 所述致动器构造成接触所述柔性膜的外表面，使得所述致动器相对于所述柔性膜的外表面的运动在所述至少一个拭子邻近内表面设置时引起所述至少一个棉签的相应移动 的柔性膜。 所述至少一个棉签的相应运动将样品从至少一个拭子洗脱到室中。

公开(公告)号：WO2023014802A1

公开(公告)日：2023-02-09

申请号：PCT/US2022/039290

申请日：2022-08-03

Applicant: DEEPULL DIAGNOSTICS S.L. ,  CARRERA FABRA, Jordi ,  BRU GIBERT, Rafael ,  IVEY, Richard Max

Inventor： CARRERA FABRA, Jordi ,  BRU GIBERT, Rafael ,  IVEY, Richard Max

IPC: G01N33/50 ,  C12Q1/68 ,  G01J3/44 ,  H01S3/108 ,  G06N20/00

Abstract: A sepsis detection system includes a first subsystem configured to detect a presence of an infection in a patient, a second subsystem configured to detect a presence of a dysregulated host response in the patient, a third subsystem configured to detect organ dysfunction in the patient, a fourth subsystem configured to detect antimicrobial resistance (AMR) of a pathogen in the patient, and a processing device. The first, second, third, and fourth subsystems and the processing device are communicatively coupled together via a network. The processing device is configured to determine a presence of sepsis in the patient based on the presence of the infection, the presence of the dysregulated host response, and clinical data indicative of the organ dysfunction in the patient. The subsystems utilize at least one of polymerase chain reaction (PCR) processing, Raman spectroscopy, clinical data, electronic health record (EHR) data, and antimicrobial susceptibility testing (AST).

公开(公告)号：WO2013167716A2

公开(公告)日：2013-11-14

申请号：PCT/EP2013/059692

申请日：2013-05-09

Applicant: STAT-DIAGNOSTICA & INNOVATION, S.L. ,  BRU GIBERT, Rafael ,  CARRERA FABRA, Jordi ,  COMENGES CASES, Anna ,  GARCÍA SÁNCHEZ, José Antonio

Inventor： BRU GIBERT, Rafael ,  CARRERA FABRA, Jordi ,  COMENGES CASES, Anna ,  GARCÍA SÁNCHEZ, José Antonio

IPC: B01L3/00

CPC classification number: B01L3/502 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2300/0627 ,  B01L2300/0848 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0475 ,  C12Q1/6806 ,  G01N21/75 ,  G01N33/50 ,  G01N33/5306

Abstract: A fluidic testing system is presented that includes a plurality of test chambers, a plurality of inlet channels, and a fluidic network that connects the inlet channels to one or more other chambers. The plurality of test chambers are each characterized by a length and a hydraulic diameter. The length of each test chamber is aligned substantially parallel to a gravity vector. Each of the test chambers has only one opening disposed along the length of the corresponding test chamber. Additionally, each of the test chambers is coupled via its respective opening to only one of the plurality of inlet channels.

Abstract translation: 提出了一种流体测试系统，其包括多个测试室，多个入口通道和将入口通道连接到一个或多个其它室的流体网络。 多个测试室的特征在于长度和水力直径。 每个测试室的长度基本上平行于重力向量排列。 每个测试室仅具有沿着相应测试室的长度设置的一个开口。 此外，每个测试室通过其相应的开口连接到多个入口通道中的仅一个。

公开(公告)号：WO2013153176A1

公开(公告)日：2013-10-17

申请号：PCT/EP2013/057625

申请日：2013-04-11

Applicant: STAT-DIAGNOSTICA & INNOVATION, S.L. ,  CARRERA FABRA, Jordi ,  COMENGES CASES, Anna ,  MARTIN BLANCO, Ricard ,  BRU GIBERT, Rafael

Inventor： CARRERA FABRA, Jordi ,  COMENGES CASES, Anna ,  MARTIN BLANCO, Ricard ,  BRU GIBERT, Rafael

IPC: B01F7/00 ,  B01F13/10 ,  C12M1/00 ,  C12N1/06 ,  G01N1/38

CPC classification number: G01N1/28 ,  B01F7/00116 ,  B01F7/00216 ,  B01F7/00258 ,  B01F7/00291 ,  B01F7/00491 ,  B01F7/00941 ,  B01F13/1044 ,  B01F2013/1086 ,  B01L3/502 ,  B02C17/16 ,  C12M47/06 ,  C12N1/066 ,  G01N1/286 ,  G01N2001/2866

Abstract: A system for at least one of homogenization and lysis of a sample includes one or more walls forming an enclosed chamber having an inlet and a plurality of fluidic connections. A first fluidic network is coupled to at least one of the plurality of fluidic connections and a second fluidic network is coupled to at least one of the plurality of fluidic connections. The system further includes a rotary element within the chamber, and an actuator configured to rotate the rotary element. The first fluidic network is configured to introduce at least a sample into the chamber from at least one first reservoir. The second fluidic network is configured to expel at least the sample from the chamber to at least one second reservoir. The rotary element is rotated by the actuator about an axis extending along a length of the rotary element.

Abstract translation: 用于样品的均化和裂解中的至少一种的系统包括形成具有入口和多个流体连接的封闭室的一个或多个壁。 第一流体网络耦合到多个流体连接中的至少一个，并且第二流体网络耦合到多个流体连接中的至少一个。 该系统还包括腔室内的旋转元件，以及构造成旋转旋转元件的致动器。 第一流体网络被配置为从至少一个第一储存器将至少一个样品引入室中。 第二流体网络构造成将至少将样品从腔室排出到至少一个第二储存器。 旋转元件由致动器围绕沿着旋转元件的长度延伸的轴线旋转。

公开(公告)号：WO2017013561A1

公开(公告)日：2017-01-26

申请号：PCT/IB2016/054245

申请日：2016-07-15

Applicant: CARRERA FABRA, Jordi ,  KUPHAL, Mathias ,  BRU GIBERT, Rafael ,  COMENGÉS CASAS, Anna

Inventor： CARRERA FABRA, Jordi ,  KUPHAL, Mathias ,  BRU GIBERT, Rafael ,  COMENGÉS CASAS, Anna

IPC: B01L3/00

CPC classification number: G01N33/54366 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0457 ,  B01L2400/0487 ,  C12Q1/68

Abstract: A fluidic testing system and method for use are presented. The fluidic testing system includes a microfluidic channel, a first chamber and second chamber. The microfluidic channel has only one port for the introduction and/or extraction of fluid through the microfluidic channel. The first chamber is disposed at a terminal end of the microfluidic channel. The second chamber is coupled to the fluidic channel and is aligned such that each opening to the second chamber is configured to be aligned substantially parallel to a gravity vector during operation.

Abstract translation: 提出了一种流体测试系统和使用方法。 流体测试系统包括微流体通道，第一室和第二室。 微流体通道仅具有一个用于通过微流体通道引入和/或提取流体的端口。 第一室设置在微流体通道的末端。 第二腔室联接到流体通道并且对齐，使得到第二腔室的每个开口被配置为在操作期间基本上平行于重力矢量排列。

公开(公告)号：WO2017013560A1

公开(公告)日：2017-01-26

申请号：PCT/IB2016/054244

申请日：2016-07-15

Applicant: BRU GIBERT, Rafael ,  KUPHAL, Mathias ,  CARRERA FABRA, Jordi ,  MARTIN BLANCO, Ricard ,  RAMÍREZ, Francisco Javier

Inventor： BRU GIBERT, Rafael ,  KUPHAL, Mathias ,  CARRERA FABRA, Jordi ,  MARTIN BLANCO, Ricard ,  RAMÍREZ, Francisco Javier

IPC: B04B5/04 ,  B04B7/08

CPC classification number: B01L3/502753 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2400/0409 ,  B04B5/04 ,  B04B7/02 ,  B04B7/06 ,  B04B7/08 ,  B04B15/08 ,  B04B2007/025

Abstract: A centrifuge device (200) and method for use are presented. The centrifuge device includes a housing (202), a chamber (206), a channel (208), and a cover (222). The housing includes a first port (204) and a vent opening (212) and is designed to rotate about an axis (226) passing through a center of the housing. The chamber is defined within the housing and is coupled to the first port. A first portion of the chamber (206) has a width that tapers between a first width at a first position and a second width at a second position within the chamber, the first width being greater than the second width. The channel (208) is coupled to the second position of the chamber and arranged such that a path exists for gas to travel from the channel to the vent opening (212). The cover (222) provides a wall that seals the chamber.

Abstract translation: 提出了一种离心机装置（200）及其使用方法。 离心机装置包括壳体（202），腔室（206），通道（208）和盖子（222）。 壳体包括第一端口（204）和通气开口（212），并且被设计成围绕穿过壳体的中心的轴线（226）旋转。 腔室被限定在壳体内并联接到第一端口。 腔室（206）的第一部分具有在第一位置处的第一宽度和腔室内的第二位置处的第二宽度之间渐缩的宽度，第一宽度大于第二宽度。 通道（208）联接到腔室的第二位置并且布置成使得存在用于气体从通道行进到通气口（212）的路径。 盖（222）提供密封室的壁。

公开(公告)号：WO2013153187A2

公开(公告)日：2013-10-17

申请号：PCT/EP2013/057639

申请日：2013-04-11

Applicant: STAT-DIAGNOSTICA & INNOVATION, S.L. ,  CARRERA FABRA, Jordi ,  COMENGES CASES, Anna ,  BRU GIBERT, Rafael ,  LOPEZ FONTANALS, Marta ,  PUEYO CASTELLS, Gemma ,  MAXWELL GAUT, Rupert

Inventor： CARRERA FABRA, Jordi ,  COMENGES CASES, Anna ,  BRU GIBERT, Rafael ,  LOPEZ FONTANALS, Marta ,  PUEYO CASTELLS, Gemma ,  MAXWELL GAUT, Rupert

IPC: B01F13/08

CPC classification number: B01F13/08 ,  B01F11/0082 ,  B01F13/0052 ,  B01F13/0818 ,  B01F15/00376 ,  B01F15/00876 ,  B01F2215/0481 ,  B02C17/24 ,  C12M47/06 ,  C12M47/08 ,  C12N1/066

Abstract: A system for at least one of homogenization and lysis of a sample includes one or more walls forming an enclosed chamber, a permanent magnet within the enclosed chamber, a magnet guide, and one or more magnets located outside the chamber. The enclosed chamber has an inlet and one or more fluidic connections configured to introduce at least the sample into the chamber. The permanent magnet has a positive pole and a negative pole. The magnet guide is configured to laterally guide the permanent magnet between a first position and a second position and maintain a substantially constant orientation of the permanent magnet during the movement. Movement of the magnets outside the chamber changes a magnetic field between the one or more magnets and the permanent magnet. The permanent magnet moves between the first and second positions in response to the changing magnetic field.

Abstract translation: 用于样品的均化和裂解中的至少一种的系统包括形成封闭室的一个或多个壁，封闭室内的永久磁体，磁体引导件和位于室外的一个或多个磁体。 封闭室具有入口和一个或多个流体连接，其构造成将至少将样品引入室中。 永磁体具有正极和负极。 磁体引导件构造成在第一位置和第二位置之间横向地引导永磁体，并且在运动期间保持永磁体的基本上恒定的取向。 在室外的磁体的移动改变了一个或多个磁体和永磁体之间的磁场。 永磁体响应于变化的磁场在第一和第二位置之间移动。

公开(公告)号：WO2007099175A1

公开(公告)日：2007-09-07

申请号：PCT/ES2006/000284

申请日：2006-05-24

Applicant: CORPORACION SANITARIA PARC TAULI ,  LAPORTE ROSELLÓ, Enric ,  PEÑA GONZALEZ, Antonio ,  CARRERA FABRA, Jordi ,  TOMÁS JUSTRIBÓ, Albert

Inventor： LAPORTE ROSELLÓ, Enric ,  PEÑA GONZALEZ, Antonio ,  CARRERA FABRA, Jordi ,  TOMÁS JUSTRIBÓ, Albert

IPC: A61B17/28 ,  A61B17/00 ,  A61B17/32 ,  A61B1/313

CPC classification number: A61B17/29 ,  A61B17/0218 ,  A61B17/320068 ,  A61B34/70 ,  A61B2017/003 ,  A61B2017/292 ,  A61B2017/2925 ,  A61B2017/2927 ,  A61B2017/2929 ,  A61B2017/320044

Abstract: Instrumento quirúrgico para cirugía endoscópica, que permite la simulación de los movimientos de articulación de un dedo del cirujano, que comprende un tubo rígido (3), cuyo extremo distal tiene articulada una primera falange (4), articulada a su vez a segunda falange (5), que está vinculada al tubo rígido (3) mediante unos cables alojados en unos conductos cruzados (12), situados en el interior de la primera falange (4), vinculando el movimiento de la segunda falange (5) al de la primera falange (4), cuya articulación se produce por la actuación de la barra de transmisión (11), siendo el tubo rígido (3) acoplable a una empuñadura (1) que incorpora un controlador (2) para el accionamiento del movimiento de articulación del instrumento por parte del cirujano, que acciona una horquilla (14) que a su vez actúa sobre la barra de transmisión (11).

Abstract translation: 用于内窥镜手术的手术器械，允许外科医生的手指关节运动被模拟，其包括刚性管（3），其刚性的管（3），其远端铰接到另一铰接到第二指骨（5）的第一趾部（4），所述第一趾 通过位于第一趾部（4）内部的交叉导管（12）中的电缆将刚性管（3）连接到刚性管（3），将第二趾部（5）的运动与第一趾骨（4）的移动相连接， 通过传动杆（11）的致动而产生其关节，刚性管（3）可以联接到包括控制器（2）的把手（1），该控制器（2）用于激活仪器的铰接运动 外科医生，其激活叉（14），其又作用在传动杆（11）上。