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1.发明申请KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES 审中-公开酮类化合物和组合物用于胆固醇管理及相关用途
公开(公告)号：WO2005068412A1
公开(公告)日：2005-07-28
申请号：PCT/US2003/041448
申请日：2003-12-24
Inventor： DASSEUX, Jean-Louis , ONICIU, Carmen, Daniela
IPC: C07C49/17
CPC classification number: C07C59/353 , C07C49/17 , C07C49/185 , C07C49/215 , C07C49/245 , C07C49/258 , C07C49/507 , C07C49/723 , C07C49/743 , C07C49/747 , C07C49/784 , C07C49/82 , C07C49/86 , C07C50/30 , C07C59/347 , C07C59/82 , C07C59/84 , C07C59/90 , C07C69/716 , C07C69/738 , C07C235/74 , C07C261/04 , C07C309/07 , C07C309/24 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D233/72 , C07D233/84 , C07D233/86 , C07D257/04 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07F9/093 , C07F9/2425 , C07F9/4423
Abstract: The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
Abstract translation: 本发明涉及新颖的酮化合物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。 本发明的化合物，组合物和方法也可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳痿。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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Patent Agency Ranking2.发明申请
公开(公告)号：WO2004010939A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023458
申请日：2003-07-29
Applicant: ESPERION THERAPEUTICS, INC.
Inventor： ZHU, Lingyu , DASSEUX, Jean-Louis , LALWANI, Narendra, D.
IPC: A61K
CPC classification number: A61K38/1709 , A61K47/543 , A61K47/6905 , A61K2300/00
Abstract: The invention provides methods and compositions for treating disorders using non-human animal Apolipoprotein A-I (ApoA-I) protein. The invention provides methods and compositions for treating disorders in animals, including humans, associated with dyslipidemia, including hyperlipidemia, hyperlipoproteinemia, hypertriglyceridemia, hypercholesterolemia, HDL deficiency, ApoA-I deficiency, cardiovascular disease, atherosclerosis, restenosis, and other disorders such as septic shock and viral infections.
Abstract translation: 本发明提供了使用非人动物载脂蛋白A-I（ApoA-I）蛋白治疗病症的方法和组合物。 本发明提供了用于治疗与血脂异常相关的动物（包括人）的疾病的方法和组合物，包括高脂血症，高脂蛋白血症，高甘油三酯血症，高胆固醇血症，HDL缺乏症，ApoA-I缺乏症，心血管疾病，动脉粥样硬化，再狭窄和其它疾病如败血性休克 和病毒感染。
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3.发明申请FUNCTIONALIZED LONG CHAIN DERIVATIVES AS ACYL COENZYME-A MIMICS, COMPOSITIONS THEREOF, AND METHODS OF CHOLESTEROL MANAGEMENT AND RELATED USES 审中-公开功能性长链衍生物作为ACYL COENZYME-A MIMICS，其组合物，以及胆固醇管理方法及相关用途
公开(公告)号：WO2003087108A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/011467
申请日：2003-04-10
Applicant: ESPERION THERAPEUTICS, INC.
Inventor： DASSEUX, Jean-Louis , ONICIU, Carmen, Daniela
IPC: C07F9/02
CPC classification number: C12Q1/25 , A61K31/075 , A61K31/10 , A61K31/12 , A61K31/13 , A61K31/66 , C07C45/45 , C07C49/17 , C07C49/172 , C07C59/347 , C07C59/353 , C07C69/675 , C07C69/757 , C07C215/12 , C07C235/08 , C07C235/10 , C07C235/16 , C07C237/22 , C07C271/16 , C07C2601/02 , C07D213/40 , C07D309/12 , C07F9/091 , C07F9/093 , C07F9/098 , C07F9/65502 , C07F9/6552 , C12N9/93 , G01N2500/04
Abstract: The invention relates to novel Acyl coenzyme-A mimics, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The Acyl coenzyme-A mimics, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, bacterial infection and impotence. In certain embodiments, the Acyl coenzyme-A mimics, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
Abstract translation: 本发明涉及新颖的酰基辅酶-A模拟物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。 本发明的酰基辅酶A模拟物，组合物和方法也可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血病，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症 ，炎症，细菌感染和阳。。 在某些实施方案中，本发明的酰基辅酶A模拟物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖剂的组合治疗。
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4.发明申请SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES 审中-公开硫代脂肪酸和双硫代磷脂化合物及其组合物用于胆固醇管理及相关用途
公开(公告)号：WO2005047236A1
公开(公告)日：2005-05-26
申请号：PCT/US2003/041614
申请日：2003-12-24
Inventor： DASSEUX, Jean-Louis , ONICIU, Carmen, Daniela
IPC: C07C317/18
CPC classification number: C07C317/04 , C07C59/347 , C07C317/10 , C07C317/14 , C07C317/18 , C07C317/24 , C07C317/44 , C07D233/76 , C07D233/86 , C07D257/04 , C07D261/12 , C07D305/12 , C07D307/32 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/38 , C07D333/48 , C07D335/02 , C07F9/091 , C07F9/094 , C07F9/2408 , C07F9/4407
Abstract: The present invention relates to sulfoxide and bis-sulfoxide compounds of formula (I), formula (II), or formula (III), compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
Abstract translation: 本发明涉及式（I），式（II）或式（III）的亚砜和双亚砜化合物，包含亚砜和双亚砜化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias 和葡萄糖代谢紊乱，包括施用包含醚化合物的组合物。 本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳痿。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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5.发明申请
公开(公告)号：WO2003087108A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/011467
申请日：2003-04-10
Applicant: ESPERION THERAPEUTICS, INC.
Inventor： DASSEUX, Jean-Louis , ONICIU, Carmen, Daniela
IPC: C07C43/13
Abstract: The invention relates to novel Acyl coenzyme-A mimics, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The Acyl coenzyme-A mimics, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, bacterial infection and impotence. In certain embodiments, the Acyl coenzyme-A mimics, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
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公开(公告)号：WO2003087040A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/011468
申请日：2003-04-10
Applicant: ESPERION THERAPEUTICS, INC.
Inventor： DASSEUX, Jean-Louis , ONICIU, Carmen, Daniela
IPC: C07F9/09
Abstract: The invention relates to novel Acyl coenzyme-A mimics, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyshpidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The Acyl coenzyme-A mimics, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, bacterial infection and impotence. In certain embodiments, the Acyl coenzyme-A mimics, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
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