公开(公告)号：WO2009079553A1

公开(公告)日：2009-06-25

申请号：PCT/US2008/087156

申请日：2008-12-17

Applicant: ETHICON, INC. ,  CONTILIANO, Joseph, H. ,  ZHANG, Qiang

Inventor： CONTILIANO, Joseph, H. ,  ZHANG, Qiang

IPC: A61F2/90

CPC classification number: A61F2/915 ,  A61F2/91 ,  A61F2002/91558 ,  A61F2250/0018 ,  A61F2250/0019 ,  A61F2250/0029 ,  A61F2250/0036 ,  A61F2250/0068

Abstract: An expandable, implantable medical device, such as an intraluminal stent (10) fabricated from polymeric materials, includes a plurality of elongated struts (16) in consecutive series and alternating stress concentration junctions (18) interconnecting ends of adjacent struts (16). When the stent (10) is in an expanded condition, the adjacent struts (16) form expanded substantial V- shapes and stresses are concentrated within the junctions (18). The junctions (18) define pivot points (P) for the respective attached, adjacent struts (16). Each of the pivot points (P) is located substantially on a line bisecting the V-shapes formed by the struts (16), when the stent (10) is ex anded.

Abstract translation: 可扩展的可植入医疗装置，例如由聚合物材料制成的管腔内支架（10）包括连续串联的多个细长支柱（16）和互相连接相邻支柱（16）端部的交替应力集中结（18）。 当支架（10）处于膨胀状态时，相邻的支柱（16）形成扩张的大致V形并且应力集中在结（18）内。 连接点（18）为相应的相邻的支柱（16）限定枢轴点（P）。 当支架（10）离开时，每个枢轴点（P）基本上位于由支柱（16）形成的V形二等分线上。

公开(公告)号：WO2009140256A1

公开(公告)日：2009-11-19

申请号：PCT/US2009/043590

申请日：2009-05-12

Applicant: ETHICON, INC. ,  CONTILIANO, Joseph, H. ,  ZHANG, Qiang

Inventor： CONTILIANO, Joseph, H. ,  ZHANG, Qiang

IPC: A61F2/90

CPC classification number: A61F2/915 ,  A61F2/91 ,  A61F2002/9155 ,  A61F2210/0071 ,  A61F2240/001 ,  A61F2250/0028 ,  A61F2250/0048

Abstract: Methods of manufacturing polymeric intraluminal stents and intraluminal stents are disclosed. The methods provide a method of manufacturing polymeric intraluminal stents (10) having a structure with hybrid strut configuration containing at least one circumferential ring element (40) in the structure in combination with geometric strut columns (20).

Abstract translation: 公开了制造聚合物腔内支架和腔内支架的方法。 所述方法提供了一种制造具有混合支柱结构的结构的聚合物腔内支架（10）的方法，所述结构具有在结构中与几何支柱（20）组合的至少一个周向环形元件（40）。

公开(公告)号：WO2010110811A1

公开(公告)日：2010-09-30

申请号：PCT/US2009/046576

申请日：2009-06-08

Applicant: ETHICON, INC. ,  CONTILIANO, Joseph, H. ,  ZHANG, Qiang

Inventor： CONTILIANO, Joseph, H. ,  ZHANG, Qiang

IPC: A61F2/90

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/9155 ,  A61F2002/91575 ,  A61F2240/001 ,  A61F2250/0039

Abstract: Methods of manufacturing polymeric intraluminal stents are disclosed. Specifically, a method of manufacturing polymeric intraluminal stents by inducing molecular orientation into the stent by radial expansion.

Abstract translation: 公开了制造聚合物腔内支架的方法。 具体地说，一种通过径向扩张诱导分子取向进入支架的方法来制造聚合物腔内支架。

公开(公告)号：WO2009121048A1

公开(公告)日：2009-10-01

申请号：PCT/US2009/038723

申请日：2009-03-30

Applicant: ETHICON, INC. ,  CONTILIANO, Joseph, H. ,  ZHANG, Qiang

Inventor： CONTILIANO, Joseph, H. ,  ZHANG, Qiang

IPC: A61F2/90

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91575

Abstract: Methods of manufacturing polymeric intraluminal stents and intraluminal stent are disclosed. A method of manufacturing polymer stents comprising the steps of : a. providing a polymer tubing having a first diameter A; b. radially expanding the polymer tubing to a second diameter B, thereby inducing molecular orientation in the polymer tubing; and c. cutting the polymer tubin having diameter B to form a stent comprising a plurality of ring members connected by bridge members.

Abstract translation: 公开了制造聚合物腔内支架和腔内支架的方法。 一种制造聚合物支架的方法，包括以下步骤：a。 提供具有第一直径A的聚合物管; 湾 将聚合物管径向膨胀至第二直径B，由此在聚合物管中引起分子取向; 和c。 切割具有直径B的聚合物管芯，以形成包括通过桥接件连接的多个环构件的支架。

公开(公告)号：WO2012033883A1

公开(公告)日：2012-03-15

申请号：PCT/US2011/050775

申请日：2011-09-08

Applicant: ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC ,  ZHANG, Qiang ,  CONTILIANO, Joseph, H.

Inventor： ZHANG, Qiang ,  CONTILIANO, Joseph, H.

IPC: A61L31/06 ,  A61L31/10

CPC classification number: A61L31/16 ,  A61L31/06 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/426 ,  C08L67/04

Abstract: Methods of manufacturing polymeric intraluminal stents, and stents made by such methods, are disclosed. The methods provide for manufacturing polymeric intraluminal stents by inducing molecular orientation in the stents by radial compression thereby providing stents with low recoil post-deployment.

Abstract translation: 公开了制造聚合物腔内支架的方法和通过这些方法制成的支架。 这些方法通过在径向压缩下在支架中诱导分子取向来提供制造聚合物腔内支架，由此提供具有低反冲后部署的支架。

公开(公告)号：WO2015009611A1

公开(公告)日：2015-01-22

申请号：PCT/US2014/046492

申请日：2014-07-14

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  ABEYWARDANE, Asitha ,  BROADWATER, John Alan ,  BRUNETTE, Steven Richard ,  KIRRANE, Thomas Martin, Jr. ,  RAZAVI, Hossein ,  SIBLEY, Robert ,  SMITH KEENAN, Lana Louise ,  ZHANG, Qiang

Inventor： ABEYWARDANE, Asitha ,  BROADWATER, John Alan ,  BRUNETTE, Steven Richard ,  KIRRANE, Thomas Martin, Jr. ,  RAZAVI, Hossein ,  SIBLEY, Robert ,  SMITH KEENAN, Lana Louise ,  ZHANG, Qiang

IPC: C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  A61P9/00 ,  A61P37/00 ,  A61K31/47

CPC classification number: C07D487/08 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/551 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates to aryl pyrazoles, and pharmaceutically acceptable salts thereof. The aryl pyrazoles of the present invention are useful as inhibitors of leukotriene A 4 hydrolase (LTA 4 H) and treating LTA 4 H related disorders. The present invention also relates to pharmaceutical compositions comprising the aryl pyrazoles of the present invention, methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract translation: 本发明涉及芳基吡唑及其药学上可接受的盐。 本发明的芳基吡唑可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关疾病。 本发明还涉及包含本发明的芳基吡唑的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。

公开(公告)号：WO2012099915A1

公开(公告)日：2012-07-26

申请号：PCT/US2012/021637

申请日：2012-01-18

Applicant: ZHU, Hongwen ,  ZHANG, Qiang

Inventor： ZHU, Hongwen ,  ZHANG, Qiang

IPC: A61K31/496

CPC classification number: C07D403/12 ,  A61K31/496 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention provides deuterated thiazolidine derivatives and compositions comprising these compounds, which are useful agents for the treatment of hyperglycemia diseases or disorders, in particular diabetes mellitus. The disclosure also provides a method of treating hyperglycemia diseases or disorders, in particular diabetes mellitus, using these deuterated thiazolidine derivatives.

Abstract translation: 本发明提供氘代噻唑烷衍生物和包含这些化合物的组合物，其是用于治疗高血糖疾病或病症，特别是糖尿病的有用试剂。 本公开还提供了使用这些氘代噻唑烷衍生物治疗高血糖疾病或病症，特别是糖尿病的方法。

公开(公告)号：WO2011080141A3

公开(公告)日：2011-07-07

申请号：PCT/EP2010/070246

申请日：2010-12-20

Applicant: TIBOTEC PHARMACEUTICALS ,  SCHACHTER, Deborah M. ,  BAERT, Lieven Elvire Colette ,  KRAUS, Guenter ,  ZHANG, Qiang ,  CHUN, Iksoo

Inventor： SCHACHTER, Deborah M. ,  BAERT, Lieven Elvire Colette ,  KRAUS, Guenter ,  ZHANG, Qiang ,  CHUN, Iksoo

IPC: A61K9/16 ,  A61K9/00

Abstract: A degradable, removable, pharmaceutical implant for the sustained release of one or more drugs in a subject, wherein the pharmaceutical implant is composed of a tube comprising an outer wall made of a degradable polymer completely surrounding a cavity, wherein the outer wall has a plurality of openings and wherein the cavity contains one or more sets of micro-particles, which micro-particles contain an active agent or a combination of two or more active agents, and wherein the size of the microparticles is selected such that the majority of the microparticles cannot pass through the openings.

公开(公告)号：WO2010072844A1

公开(公告)日：2010-07-01

申请号：PCT/EP2009/067933

申请日：2009-12-24

Applicant: SCHACHTER, Deborah M. ,  ZHANG, Qiang ,  BAERT, Lieven Elvire Colette ,  CUI, Han ,  TIBOTEC PHARMACEUTICALS

Inventor： SCHACHTER, Deborah M. ,  ZHANG, Qiang ,  BAERT, Lieven Elvire Colette ,  CUI, Han

IPC: A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K9/00 ,  A61K31/505

CPC classification number: A61K9/0024 ,  A61K31/505 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32

Abstract: The present invention relates to an implantable device comprising a biocompatible, biodegradable polymer mixed with TMC278 and with one or more release-enhancing agents selected from the group consisting of poloxamers, polysorbates, and a combination of dimethyl sulfoxide (DMSO) and poly( vinyl pyrrolidone)(PVP).

Abstract translation: 本发明涉及一种可植入装置，其包括与TMC278混合的生物相容性可生物降解的聚合物和一种或多种选自泊洛沙姆，聚山梨醇酯和二甲基亚砜（DMSO）和聚（乙烯基吡咯烷酮）的组合的释放增强剂 ）（PVP）。

公开(公告)号：WO2007107470A2

公开(公告)日：2007-09-27

申请号：PCT/EP2007/052269

申请日：2007-03-12

Applicant: F. HOFFMANN-LA ROCHE AG ,  ANDERSON, Kevin William ,  FOTOUHI, Nader ,  GILLESPIE, Paul ,  GOODNOW, Robert Alan Jr. ,  GUERTIN, Kevin Richard ,  HAYNES, Nancy-Ellen ,  MYERS, Michael Paul ,  PIETRANICO-COLE, Sherrie Lynn ,  QI, Lida ,  ROSSMAN, Pamela Loreen ,  SCOTT, Nathan Robert ,  THAKKAR, Kshitij Chhabilbhai ,  TILLEY, Jefferson Wright ,  ZHANG, Qiang

Inventor： ANDERSON, Kevin William ,  FOTOUHI, Nader ,  GILLESPIE, Paul ,  GOODNOW, Robert Alan Jr. ,  GUERTIN, Kevin Richard ,  HAYNES, Nancy-Ellen ,  MYERS, Michael Paul ,  PIETRANICO-COLE, Sherrie Lynn ,  QI, Lida ,  ROSSMAN, Pamela Loreen ,  SCOTT, Nathan Robert ,  THAKKAR, Kshitij Chhabilbhai ,  TILLEY, Jefferson Wright ,  ZHANG, Qiang

IPC: C07D403/04 ,  C07D231/12 ,  C07D231/16 ,  C07D231/38 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C07D407/14

CPC classification number: C07D403/04 ,  C07D231/12 ,  C07D231/16 ,  C07D231/38 ,  C07D401/04 ,  C07D403/02 ,  C07D407/14 ,  C07D413/04 ,  C07D417/04

Abstract: Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供了式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。