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1.发明申请A CHIMERIC PROTEIN COMPRISING NON-TOXIC PSEUDOMONAS EXOTOXIN A AND TYPE IV PILIN SEQUENCES 审中-公开包含非毒性PSEUDOMONAS EXOTOXIN A和IV型PILIN序列的CHIMERIC蛋白
公开(公告)号：WO02060935A2
公开(公告)日：2002-08-08
申请号：PCT/US0149143
申请日：2001-12-20
Applicant: US GOV HEALTH & HUMAN SERV , FITZGERALD DAVID
Inventor： FITZGERALD DAVID
IPC: C12N15/09 , A61K38/00 , A61K39/00 , A61P9/00 , A61P11/00 , A61P27/02 , A61P29/00 , A61P31/04 , C07K14/21 , C07K14/22 , C07K14/28 , C07K14/285 , C07K14/40 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/31 , C12P21/08 , A61K39/104 , A61K48/00 , C12N15/62 , C12N15/63
CPC classification number: C07K14/21 , A61K39/00 , A61K2039/53 , C07K2319/00
Abstract: The invention provides chimeric proteins comprising a non-toxic Pseudomonas exotoxin A sequence and a Type IV pilin loop sequence, wherein the Type IV loop sequence is inserted within the non-toxic Pseudomonas exotoxin A. The invention also provides polynucleotides encoding the chimeric proteins, and compositions comprising the polynucleotides or the chimeric proteins. The invention also provides methods for using the chimeric proteins, polynucleotides and compositions of the invention.
Abstract translation: 本发明提供了包含无毒假单胞菌外毒素A序列和IV型胆碱环序列的嵌合蛋白，其中IV型环序列插入无毒假单胞菌外毒素A内。本发明还提供了编码嵌合蛋白的多核苷酸，以及 包含多核苷酸或嵌合蛋白的组合物。 本发明还提供了使用本发明的嵌合蛋白，多核苷酸和组合物的方法。
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Patent Agency Ranking2.发明申请A CHIMERIC PROTEIN COMPRISING NON-TOXIC PSEUDOMONAS EXOTOXIN A AND TYPE IV PILIN SEQUENCES 审中-公开包含非毒性PSEUDOMONAS EXOTOXIN A和IV型PILIN序列的CHIMERIC蛋白
公开(公告)号：WO02060935A8
公开(公告)日：2004-01-15
申请号：PCT/US0149143
申请日：2001-12-20
Applicant: US GOV HEALTH & HUMAN SERV , FITZGERALD DAVID
Inventor： FITZGERALD DAVID
IPC: C12N15/09 , A61K38/00 , A61K39/00 , A61P9/00 , A61P11/00 , A61P27/02 , A61P29/00 , A61P31/04 , C07K14/21 , C07K14/22 , C07K14/28 , C07K14/285 , C07K14/40 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/31 , C12P21/08 , A61K39/104 , A61K48/00 , C12N15/62 , C12N15/63
CPC classification number: C07K14/21 , A61K39/00 , A61K2039/53 , C07K2319/00
Abstract: The invention provides chimeric proteins comprising a non-toxic Pseudomonas exotoxin A sequence and a Type IV pilin loop sequence, wherein the Type IV loop sequence is inserted within the non-toxic Pseudomonas exotoxin A. The invention also provides polynucleotides encoding the chimeric proteins, and compositions comprising the polynucleotides or the chimeric proteins. The invention also provides methods for using the chimeric proteins, polynucleotides and compositions of the invention.
Abstract translation: 本发明提供了包含无毒假单胞菌外毒素A序列和IV型胆碱环序列的嵌合蛋白，其中IV型环序列插入无毒假单胞菌外毒素A内。本发明还提供了编码嵌合蛋白的多核苷酸，以及 包含多核苷酸或嵌合蛋白的组合物。 本发明还提供了使用本发明的嵌合蛋白，多核苷酸和组合物的方法。
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公开(公告)号：WO2007016150A3
公开(公告)日：2007-08-09
申请号：PCT/US2006028986
申请日：2006-07-25
Applicant: US GOV HEALTH & HUMAN SERV , PASTAN IRA H , ONDA MASANORI , NAGATA SATOSHI , FITZGERALD DAVID , KREITMAN ROBERT , LEE BYUNGKOOK
Inventor： PASTAN IRA H , ONDA MASANORI , NAGATA SATOSHI , FITZGERALD DAVID , KREITMAN ROBERT , LEE BYUNGKOOK
IPC: C07K14/195 , A61K38/16 , A61K47/48 , C07K14/21 , C07K19/00
CPC classification number: A61K47/48484 , A61K38/00 , A61K47/6829 , C07K14/21 , C07K2319/33
Abstract: The invention provides mutated Pseudomonas exotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided.
Abstract translation: 本发明提供与含有天然序列的PE相比具有降低的免疫原性的突变假单胞菌外毒素（PE）。 本发明的PE具有减少抗体与一个或多个PE表位结合的PE天然序列位置的一个或多个单独突变。 还提供了编码突变PE的核酸，包含它们的嵌合分子，包含嵌合分子的组合物和使用它们的方法。
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公开(公告)号：WO2009140282A2
公开(公告)日：2009-11-19
申请号：PCT/US2009043634
申请日：2009-05-12
Applicant: WHAM O INC , FITZGERALD DAVID , MACCOLL IAN COATS
Inventor： FITZGERALD DAVID , MACCOLL IAN COATS
CPC classification number: B62B7/00 , A63C11/001 , B62B13/16 , B62B13/18 , B62B15/00
Abstract: A collapsible stroller like device is described. The device includes a base portion to permit a child to be pushed or pulled across the snow or other surface.
Abstract translation: 描述了可折叠婴儿车类设备。 该装置包括一个基部，以允许一个孩子被推或拉过雪或其他表面。
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公开(公告)号：WO0010189A8
公开(公告)日：2007-08-23
申请号：PCT/US9917534
申请日：1999-08-02
Applicant: FITZGERALD DAVID
Inventor： FITZGERALD DAVID
IPC: H01J45/00
CPC classification number: H01J45/00
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公开(公告)号：WO03027499A3
公开(公告)日：2003-07-31
申请号：PCT/US0229763
申请日：2002-09-19
Applicant: FITZGERALD DAVID
Inventor： FITZGERALD DAVID
Abstract: A propulsion device which takes advantage of the fact that the mass of an object will decrease if the energy density of the object changes rapidly. The energy density is changed by causing rapid changes in stress on the bonds between the atoms of the object. By this means, the mass of a rotating (20) object is decreased to one side of its axis of rotation, creating an unbalanced centrifugal force that acts on the rotating object as a propulsive force in the direction from the lower mass half toward the higher mass half. The propulsive force is used to propel an object or hold an object in position in opposition to an outside force or provide mechanical energy for a purpose such as the generation of electricity.
Abstract translation: 一种推进装置，其利用物体的质量如果物体的能量密度快速变化的事实将减少的事实。 能量密度通过引起物体原子之间的键上的应力的快速变化而改变。 通过这种方式，旋转（20）物体的质量减小到其旋转轴线的一侧，产生作用在旋转物体上的不平衡离心力，作为从下质量半部朝向较高的方向的推进力 质量一半。 推进力用于推动物体或将物体保持在与外力相反的位置，或者提供机械能用于诸如发电的目的。
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