公开(公告)号：WO2002044276A3

公开(公告)日：2002-06-06

申请号：PCT/US2001/044769

申请日：2001-11-28

Applicant: FOCAL, INC.

Inventor： AVILA, Luis, Z. ,  JARRETT, Peter, K. ,  KRAMER, Hildegard ,  PHILBROOK, Michael, C.

IPC: C08L71/02

Abstract: Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity expected from the viscosity of the individual components. The mixture otherwise has similar properties to those of its constituents, and in particular will crosslink to form covalently crosslinked gels if the PEG carries crosslinkable groups. The viscous formulation adheres well to tissue, and has applications as a tissue sealant and in tissue coating, prevention of adhesions, cell immobilization, regeneration of cartilage, bone and other tissue, as well as in controlled delivery of hyaluronic acid to sites in the body. Related materials exhibit similar effects.

公开(公告)号：WO1998012243A1

公开(公告)日：1998-03-26

申请号：PCT/US1997016857

申请日：1997-09-23

Applicant: FOCAL, INC.

Inventor： FOCAL, INC. ,  JARRETT, Peter, K. ,  SAWHNEY, Amarpreet ,  COURY, Arthur, J. ,  RUDOWSKY, Ronald, S. ,  POWELL, Michelle, D. ,  AVILA, Luis, Z. ,  ENSCORE, David, J. ,  GOODRICH, Stephen, D. ,  NASON, William, C. ,  YAO, Fei ,  WEAVER, Douglas ,  BARMAN, Shikha, P.

IPC: C08G65/00

CPC classification number: C08G63/676 ,  A61K9/1635 ,  A61K9/1647 ,  A61K31/137 ,  A61K31/404 ,  A61K31/717 ,  A61K31/722 ,  A61K47/34 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/06 ,  A61L31/10 ,  A61L31/148 ,  A61L2400/04 ,  C08G63/64 ,  C08L67/04

Abstract: Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

Abstract translation: 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备方法和用途。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。

公开(公告)号：WO1996029080A1

公开(公告)日：1996-09-26

申请号：PCT/US1996003177

申请日：1996-03-08

Applicant: FOCAL, INC.

Inventor： FOCAL, INC. ,  COURY, Arthur, J. ,  AVILA, Luis, Z. ,  PATHAK, Chandrashekhar, P. ,  BARMAN, Shikha, P.

IPC: A61K31/74

CPC classification number: A61Q19/00 ,  A61K8/365 ,  A61K8/671 ,  A61K8/73 ,  A61K8/731 ,  A61K8/735 ,  A61K8/85 ,  A61K8/86 ,  A61K8/90 ,  A61K2800/57 ,  A61Q5/006 ,  A61Q17/04 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/08 ,  Y10S514/83 ,  Y10S514/844 ,  Y10S514/847 ,  Y10S514/852 ,  Y10S514/863 ,  Y10S514/865 ,  Y10S514/887 ,  Y10S514/919 ,  Y10S514/944 ,  Y10S514/945 ,  Y10S514/947 ,  Y10S514/969

Abstract: A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.

Abstract translation: 描述了一种减轻化妆品或皮肤病症状的方法。 提供在药学或化妆品可接受的载体中有效量的聚（羟基酸）/聚合物缀合物。 还提供了与另一种化妆品或皮肤病学试剂的缀合物的局部组合物，以及具有附着的生理活性官能团的缀合物的化合物。

公开(公告)号：WO1997033628A1

公开(公告)日：1997-09-18

申请号：PCT/US1997002075

申请日：1997-02-13

Applicant: FOCAL, INC.

Inventor： FOCAL, INC. ,  LEAVITT, Richard, D. ,  AVILA, Luis, Z.

IPC: A61K51/12

CPC classification number: A61K51/06 ,  A61K51/0497 ,  A61K51/1213

Abstract: Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.

Abstract translation: 本地沉积的聚合物储存库用作固定和局部递送放射性核素或放射性药物的载体。 放射性核素作为无机化合物以其元素形式引入，或通过物理或化学方法连接到较大的分子或掺入聚合物中。 可以使用辅助结构来控制释放速率。 可以使用已经用于局部放射治疗的标准放射性核素，例如碘，铱，镭，铯，钇或其它元素的放射性核素。

公开(公告)号：WO1997005185A2

公开(公告)日：1997-02-13

申请号：PCT/US1996012285

申请日：1996-07-26

Applicant: FOCAL, INC.

Inventor： FOCAL, INC. ,  PATHAK, Chandrashekhar, P. ,  BARMAN, Shikha, P. ,  PHILBROOK, C., Michael ,  SAWHNEY, Amarpreet ,  COURY, Arthur, J. ,  AVILA, Luis, Z. ,  KIERAS, Mark, T.

IPC: C08G63/664

CPC classification number: A61K9/5138 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/1274 ,  A61K9/146 ,  A61K9/2027 ,  A61K9/5146 ,  A61K9/7015 ,  A61K47/32 ,  A61K47/34 ,  A61L15/58 ,  A61L15/60 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  C08G63/00 ,  C08G65/329 ,  C08L71/02 ,  Y10S424/13 ,  Y10S524/916 ,  Y10S525/941 ,  C08L71/00 ,  C08L2666/14

Abstract: Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a cross-linkable group are provided. The macromers can be covalently cross-linked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.

Abstract translation: 提供包含至少四个聚合物嵌段的凝胶形成大分子单体，其中至少两个是疏水性的，并且其中至少一个是亲水的，并且包括可交联的基团。 大分子单体可以共价交联以在体内在组织表面上形成凝胶。 由大分子单体形成的凝胶具有包括热敏性和亲脂性的性质的组合，并且可用于各种医学应用，包括药物递送和组织包衣。