公开(公告)号：WO2014053946A1

公开(公告)日：2014-04-10

申请号：PCT/IB2013/058809

申请日：2013-09-24

Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Inventor： SALERNO, Marco ,  THORAT, Sanjay ,  DIASPRO, Alberto

IPC: C01F7/02 ,  C04B26/06 ,  C04B38/00 ,  C25D11/04 ,  C25D11/18 ,  A61K6/00 ,  C04B111/00

CPC classification number: A61K6/0073 ,  A61K6/0835 ,  C01F7/02 ,  C01F7/023 ,  C01F7/42 ,  C01P2004/03 ,  C01P2004/61 ,  C01P2006/16 ,  C04B26/06 ,  C04B38/009 ,  C04B2111/00836 ,  C25D1/006 ,  C25D11/045 ,  C25D11/18 ,  C04B35/10 ,  C04B38/0054 ,  C04B14/303 ,  C04B20/008 ,  C04B14/301

Abstract: The present invention relates to anodic porous alumina (APA) in the form of microparticles, characterized in that it contains interconnected through nanopores, and to its use in the preparation of a new composite material, which is useful for example in the field of conservative dentistry. The invention further relates to a process for preparing the nanoporous alumina of the invention in microparticles.

Abstract translation: 本发明涉及微粒形式的阳极多孔氧化铝（APA），其特征在于其包含相互连通的纳米孔，并且其用于制备新的复合材料，其可用于例如保守牙科领域 。 本发明还涉及在微粒中制备本发明的纳米多孔氧化铝的方法。

公开(公告)号：WO2013132455A1

公开(公告)日：2013-09-12

申请号：PCT/IB2013/051804

申请日：2013-03-07

Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Inventor： BERDONDINI, Luca ,  DANTE, Silvia ,  MARCONI, Emanuele ,  SALERNO, Marco ,  DE PIETRI TONELLI, Davide

IPC: G01N33/50

CPC classification number: G01N33/5058 ,  G01N33/5029 ,  G01N33/5032 ,  G01N2500/10

Abstract: The bioassay process for the determination of alterations in neuronal connectivity and/or morphology comprises the operations of: - identifying the critical distance corresponding to which a pair of spaced single neuronal cells, subjected to the assay, is still able to form reciprocally interconnecting neuritic extensions, after a predetermined incubation period under conditions which favour the formation of such neuritic extensions, wherein each of said single neuronal cells is adhered to a respective spot of a substance promoting the adhesion of said neuronal cells, said spots being deposited at a distance from one another onto a substrate inhibiting the adhesion of neuronal cells, and - comparing the critical distance identified with the critical distance determined, under the same conditions, for reference cells, wherein a decrease in said critical distance for the neuronal cells subjected to the assay, relative to the critical distance for the reference cells, is indicative of an alteration in the neuronal connectivity and/or morphology.

Abstract translation: 用于确定神经元连接性和/或形态变化的生物测定方法包括以下操作： - 鉴定对应于经过测定的一对间隔开的单个神经元细胞仍然能够形成相互互连的神经突延伸的临界距离 在有利于形成这种神经突延伸的条件下在预定的孵育期之后，其中每个所述单个神经元细胞粘附到促进所述神经元细胞粘附的物质的各个斑点，所述斑点沉积在距离一个距离处 另一个在抑制神经元细胞粘附的底物上，以及 - 在相同条件下，对于参考细胞比较确定的临界距离的关键距离，其中对经受测定的神经元细胞的所述临界距离的降低相对 到参考细胞的临界距离，表示a 改变神经元连通性和/或形态。