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公开(公告)号：WO2020154137A1
公开(公告)日：2020-07-30
申请号：PCT/US2020/013585
申请日：2020-01-15
Applicant: GENERAL ELECTRIC COMPANY , UNIVERSITY HEALTH NETWORK
Inventor： MADHAVAN, Radhika , BOUTET, Alexandre , JOEL, Suresh , HANCU, Ileana , ASHE, Jeffrey , LOZANO, Andres M.
Abstract: A system for optimizing parameters of a DBS pulse signal for treatment of a patient is provided. In predicting optimal DBS parameters, functional brain data is input into a predictor system (1), the functional brain data acquired responsive to a sweeping across a multi-dimensional parameter space of one or more DBS parameters. Statistical metrics of brain response are extracted from the functional brain data for one or more ROIs or voxels of the brain via the predictor system (1), and a DBS functional atlas is accessed, via the predictor system (1), that comprises disease-specific brain response maps derived from DBS treatment at optimal DBS parameter settings for a plurality of diseases or neurological conditions. One or more optimal DBS parameters are predicted for the patient based on the statistical metrics of brain response and the DBS functional atlas via the predictor system (1).
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公开(公告)号：WO2020154138A1
公开(公告)日：2020-07-30
申请号：PCT/US2020/013589
申请日：2020-01-15
Applicant: GENERAL ELECTRIC COMPANY , ALBANY MEDICAL COLLEGE
Inventor： MADHAVAN, Radhika , ASHE, Jeffrey , JOEL, Suresh , HANCU, Ileana , PILITSIS, Julie , DIMARZIO, Marisa
Abstract: A system and method for optimizing parameters of a DBS pulse signal for treatment of a patient is provided. In predicting optimal DBS parameters, functional brain data is input into a predictor system (1), the functional brain data acquired responsive to a sweeping across a multi-dimensional parameter space of one or more DBS parameters. Statistical metrics of brain response are extracted from the functional brain data for one or more ROIs or voxels of the brain via the predictor system (1), and a DBS functional atlas is accessed, via the predictor system (1), that comprises disease-specific brain response maps derived from DBS treatment at optimal DBS parameter settings for a plurality of diseases or neurological conditions. One or more optimal DBS parameters are predicted for the patient based on the statistical metrics of brain response and the DBS functional atlas via the predictor system (1).
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3.发明申请
公开(公告)号：WO2019164785A1
公开(公告)日：2019-08-29
申请号：PCT/US2019/018455
申请日：2019-02-19
Applicant: GENERAL ELECTRIC COMPANY
Inventor： RAMANI, Sathish , SCHULTE, Rolf , HANCU, Ileana , ASHE, Jeffrey , MCKINNON, Graeme C.
Abstract: A system and method for localizing a deep brain stimulation electrode (12) in vivo in a subject or object is provided. A magnetic resonance imaging system (36) obtains MR image data from a volume-of-interest by way of a zero echo time (ZTE) or ultrashort echo time (UTE) pulse sequence, with one or more of a phase domain image and a magnitude domain image being analyzed from the MR image data acquired by the ZTE or UTE pulse sequence. One or more electrodes (12) are localized within the volume-of-interest based on an analysis of the phase domain image and/or magnitude domain image. In localizing the electrodes (12), a multi-scale correlation-based analysis of the volume-of-interest is performed to estimate at least one of an electrode center (96) and electrode contact (28) locations of the electrode (12), with the localization being achieved with a fast scan-time and with a high level of accuracy and precision.
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公开(公告)号：WO2018132664A1
公开(公告)日：2018-07-19
申请号：PCT/US2018/013499
申请日：2018-01-12
Applicant: GENERAL ELECTRIC COMPANY
Inventor： FIVELAND, Eric, William , HANCU, Ileana , ASHE, Jeffrey
IPC: A61N1/36 , A61N1/05 , A61B5/0482 , A61B5/00
Abstract: A system and method for predicting an excitation pattern of a deep brain stimulation (DBS) from monitored bioelectrical signals includes an apparatus having a housing having a signal input and a signal output and an electrical circuit disposed within the housing. The electrical circuit is electrically coupled between the signal input and the signal output and is configured to receive bioelectrical signals corresponding to an excitation signal transmitted by a pulse generator during a DBS. The electrical circuit is also configured to convert the bioelectrical signals into digital logic pulses, predict a future timing pattern of the excitation signal from the digital logic pulses, and generate an output from the future timing pattern, the output comprising a log of time stamps predictive of future active transmission periods of neurological excitation.
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Patent Agency Ranking
公开(公告)号：WO2018132663A1
公开(公告)日：2018-07-19
申请号：PCT/US2018/013498
申请日：2018-01-12
Applicant: GENERAL ELECTRIC COMPANY
Inventor： FIVELAND, Eric, William , HANCU, Ileana , ASHE, Jeffrey
IPC: A61B5/04 , A61B5/0476
Abstract: A system and method for analyzing bioelectrical signals generated during a deep brain stimulation (DBS) includes an apparatus having a housing having a signal input and a signal output and an electrical circuit disposed within the housing and electrically coupled between the signal input and the signal output. The electrical circuit is configured to receive bioelectrical signals corresponding to a cyclic excitation signal transmitted by a pulse generator during a DBS and generate an output signal comprising a series of timing pulses, wherein each timing pulse simulates an envelope of the cyclic excitation signal. The signal output of the housing is electrically coupleable to an auxiliary trigger input of an imaging system and the series of timing pulses can be used to trigger image data acquisition.
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公开(公告)号：WO2018081826A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/059394
申请日：2017-10-31
Inventor： PULEO, Christopher, Michael , COTERO, Victoria , FAN, Ying , KAANUMALLE, Sireesha , WALLACE, Kirk, Dennis , RIGBY, Kenneth, Wayne , HANCU, Ileana , ROTHMAN, James , KAO, Tzu-Jen , MILLS, David , ASHE, Jeffrey , TRACEY, Kevin, J. , CHAVEN, Sangeeta, S. , BOUTON, Chad, E.
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell.
Abstract translation: 本公开的主题总体上涉及用于组织的神经调节的技术，其包括将能量（例如超声能量）施加到组织中以引起神经元和非神经元之间的突触处的改变的活动 - 神经元细胞。
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公开(公告)号：WO2018081763A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/059163
申请日：2017-10-31
Inventor： TRACEY, Kevin, J. , CHAVAN, Sangeeta, S. , BOUTON, Chad, E. , PULEO, Christopher, Michael , COTERO, Victoria , FAN, Ying , KAO, Tzu-jen , MILLS, David , ASHE, Jeffrey
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of tissue that include applying energy (e.g., electromagnetic energy) into the target tissue to cause altered activity of a neuron in the tissue. In certain embodiments, the altered activity causes a change in one or molecules in the tissue or blood.
Abstract translation: 本公开的主题总体上涉及用于组织的神经调节的技术，其包括将能量（例如，电磁能量）施加到靶组织中以引起组织中神经元的活动改变。 在某些实施方案中，改变的活性引起组织或血液中的一种或多种分子的改变。
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8.发明申请
公开(公告)号：WO2020264370A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/039921
申请日：2020-06-26
Applicant: GENERAL ELECTRIC COMPANY
Inventor： PULEO, Christopher , BECKMAN, Benjamin , ABATE, Victor , FREER, John , VERNOOY, David , ASHE, Jeffrey
Abstract: Systems and methods for management of a distributed ledger including prescription information are disclosed. An example apparatus includes a processor and a logical data structure to configure a device according to an electronic prescription defining an action for a patient, the electronic prescription organized as record(s) in a distributed ledger and processible by the device to apply the action to the patient. The electronic prescription is to cause the device to at least: configure the device to apply the action to the patient; validate the action for the patient using the distributed ledger; and propagate a record of the action to the distributed ledger.
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9.发明申请SYSTEM AND METHOD FOR DETERMINING PHYSIOLOGICAL PARAMETERS BASED ON ELECTRICAL IMPEDANCE MEASUREMENTS 审中-公开基于电气阻抗测量法确定生理参数的系统和方法
公开(公告)号：WO2013127649A2
公开(公告)日：2013-09-06
申请号：PCT/EP2013/053164
申请日：2013-02-18
Applicant: GENERAL ELECTRIC COMPANY , GE HEALTHCARE FINLAND OY
Inventor： ANDARAWIS, Emad , ASHE, Jeffrey , GORE, Amit
IPC: A61B5/00
CPC classification number: A61B5/7282 , A61B5/0402 , A61B5/0531 , A61B5/0816 , A61B5/11 , A61B5/113 , A61B5/7207 , A61B5/7225 , A61B5/7264 , A61B5/7275 , G16H40/63
Abstract: A system and method for determining physiological parameters based on electrical impedance measurements is provided. One method includes obtaining electrical measurement signals acquired from a plurality of transducers coupled to a surface of an object and spatially pre-conditioning the obtained electrical measurement signals. The method also includes performing multiple-input-multiple-output (MIMO) analog to information conversion (AIC) of the spatially pre-conditioned electrical measurement signals to correlate the spatially pre-conditioned electrical measurement signals to separate the electrical measurement signals.
Abstract translation: 提供了一种基于电阻抗测量来确定生理参数的系统和方法。 一种方法包括获得从耦合到对象表面的多个换能器获取的电测量信号，并空间预处理所获得的电测量信号。 该方法还包括对空间预调节的电测量信号执行多输入多输出（MIMO）模拟到信息转换（AIC），以将空间预调节的电测量信号相互关联以分离电测量信号。
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