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公开(公告)号：WO2022173722A1
公开(公告)日：2022-08-18
申请号：PCT/US2022/015582
申请日：2022-02-08
发明人： AMMANN, Stephen E. , CANALES, Eda Y. , CHANG, Weng K. , CODELLI, Julian A. , JIANG, Lan , KINFE, Henok H. , LAZERWITH, Scott E. , MITCHELL, Michael L. , SCHROEDER, Scott D. , SHORE, Daniel G.
IPC分类号： C07D495/04 , A61K31/407 , A61P3/10 , A61P19/00 , A61P29/00
摘要： The present disclosure relates generally to thioeno[3, 2-], pyrrole derivatives pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.
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公开(公告)号：WO2020092375A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058573
申请日：2019-10-29
发明人： BLOMGREN, Peter A. , CAMPBELL, Taryn , CHANDRASEKHAR, Jayaraman , CLARK, Christopher T. , CODELLI, Julian A. , CURRIE, Kevin S. , KROPF, Jeffrey E. , MOAZAMI, Yasamin , NAVA, Nicole , PATEL, Leena , PERREAULT, Stephane , PERRY, Jason K. , SEDILLO, Kassandra F. , SEEGER, Natalie , STEVENS, Kirk L. , TREIBERG, Jennifer Anne , YEUNG, Suet C. , ZHAO, Zhongdong
IPC分类号： C07D215/14 , C07D215/18 , C07D215/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D475/02 , C07D491/06 , A61K31/47 , A61P29/00
摘要： The present disclosure provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
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公开(公告)号：WO2020092528A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058813
申请日：2019-10-30
发明人： BALAN, Gayatri , BARTLETT, Mark J. , CHANDRASEKHAR, Jayaraman , CODELLI, Julian A. , CONWAY, John H. , COSMAN, Jennifer L. , KALLA, Rao V. , KIM, Musong , LEE, Seung H. , LO, Jennifer R. , LOYER-DREW, Jennifer A. , MITCHELL, Scott A. , PERRY, Thao D. , PHILLIPS, Gary B. , SALVO, Patrick J. , VAN VELDHUIZEN, Joshua J. , YEUNG, Suet C. , ZABLOCKI, Jeff
IPC分类号： A61P31/18 , A61P31/20 , A61P35/00 , C07D471/04 , C07D519/00 , A61K31/444 , A61K31/4545
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：WO2020092401A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058610
申请日：2019-10-29
发明人： BLOMGREN, Peter A. , CAMPBELL, Taryn , CHANDRASEKHAR, Jayaraman , CLARK, Christopher T. , CODELLI, Julian A. , CURRIE, Kevin S. , KROPF, Jeffrey E. , MOAZAMI, Yasamin , NAVA, Nicole , PATEL, Leena , PERREAULT, Stephane , PERRY, Jason K. , SEDILLO, Kassandra F. , SEEGER, Natalie , STEVENS, Kirk L. , TREIBERG, Jennifer Anne , YEUNG, Suet C. , ZHAO, Zhongdong
IPC分类号： A61P29/00 , C07C233/73 , C07D213/61 , C07D215/14 , C07D239/46 , C07D249/06 , C07D311/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , A61K31/40
摘要： The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
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公开(公告)号：WO2020092394A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058599
申请日：2019-10-29
发明人： BLOMGREN, Peter A. , CAMPBELL, Taryn , CHANDRASEKHAR, Jayaraman , CLARK, Christopher T. , CODELLI, Julian A. , CURRIE, Kevin S. , KROPF, Jeffrey E. , MOAZAMI, Yasamin , NAVA, Nicole , PATEL, Leena , PERREAULT, Stephane , PERRY, Jason K. , SEDILLO, Kassandra F. , SEEGER, Natalie , STEVENS, Kirk L. , TREIBERG, Jennifer Anne , YEUNG, Suet C. , ZHAO, Zhongdong
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P29/00
摘要： The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
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公开(公告)号：WO2022271659A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034286
申请日：2022-06-21
IPC分类号： C07D471/04 , C07D471/14 , C07D519/00 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , A61K31/437 , A61K31/4375
摘要： The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：WO2022271650A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034270
申请日：2022-06-21
发明人： CODELLI, Julian A. , GRAUPE, Michael , GUERRERO, Juan A. , JACOBSEN, Jesse M. , KOBAYASHI, Tetsuya , MEDLEY, Jonathan William , MOAZAMI, Yasamin , PATEL, Leena , XU, Jie , YEUNG, Suet C.
IPC分类号： C07D471/14 , C07D487/04 , C07D519/00 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , A61K31/519
摘要： The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：WO2021130638A1
公开(公告)日：2021-07-01
申请号：PCT/IB2020/062229
申请日：2020-12-18
发明人： SAWA, Masaaki , ARAI, Mai , NAKAI, Ryoko , MATSUMOTO, Hirokazu , PUGH, Catherine , HU, Eric , GUERRERO, Juan , JACOBSEN, Jesse , MEDLEY, Jonathan William , XU, Jie , LAD, Latesh , PATEL, Leena , GRAUPE, Michael , ZHU, Qingming , HOLMBO, Stephen , KOBAYASHI, Tetsuya , WATKINS, Will , MOAZAMI, Yasamin , YEUNG, Suet C. , CODELLI, Julian A. , WEAVER, Heath A.
IPC分类号： A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P35/00 , A61P35/02 , A61P35/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/553 , A61K31/5415
摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：WO2020237025A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/033955
申请日：2020-05-21
发明人： AKTOUDIANAKIS, Evangelos , CHANDRASEKHAR, Jayaraman , CODELLI, Julian A. , CONWAY, John H. , ELBEL, Kristyna M. , KALLA, Rao V. , METOBO, Samuel E. , MITCHELL, Scott A. , PERRY, Thao , SIMONOVICH, Scott P. , ZIEBENHAUS, Christopher A.
IPC分类号： A61P35/00 , C07D413/14 , C07D498/04 , A61K31/538 , A61K31/5383
摘要： The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：WO2020092621A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058932
申请日：2019-10-30
发明人： BALAN, Gayatri , BARTLETT, Mark J. , CHANDRASEKHAR, Jayaraman , CODELLI, Julian A. , CONWAY, John H. , COSMAN, Jennifer L. , KALLA, Rao V. , KASUN, Zachary A. , KIM, Musong , LEE, Seung H. , LO, Jennifer R. , LOYER-DREW, Jennifer A. , MITCHELL, Scott A. , PERRY, Thao D. , PHILLIPS, Gary B. , SALVO, Patrick J. , SWAMINATHAN, Sundaramoorthi , VAN VELDHUIZEN, Joshua J. , YEUNG, Suet C. , ZABLOCKI, Jeff
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P35/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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